Regulation of organic anion and drug transporters of the sinusoidal membrane

Journal of Hepatology

Volumn 31, Issue 3, 1999, Pages 563-573

  Kullak Ublick, Gerd A ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN;

ANIMAL TISSUE; ANION TRANSPORT; BINDING SITE; CATION TRANSPORT; DRUG TRANSPORT; HUMAN; HUMAN TISSUE; LIVER CELL MEMBRANE; LIVER SINUSOID; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; TISSUE DISTRIBUTION;

EID: 0033199592     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(99)80054-3     Document Type: Article

References (134)

1. Trauner M, Meier PJ, Boyer JL. Molecular pathogenesis of cholestasis. N Engl J Med. 339:1998;1217-1227.
2. Trauner M, Meier PJ, Boyer JL. Molecular regulation of hepatocellular transport systems in cholestasis. J Hepatol. 31:1999;165-178.
3. Müller M, Jansen PLM. The secretory function of the liver: new aspects of hepatobiliary transport. J Hepatol. 28:1998;344-354.
4. Meier PJ. Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile. Am J Physiol. 269:1995;G801-G812.
5. + on bile acid uptake by isolated rat hepatocytes: evidence for a heterogeneous system. Hoppe-Seyler's Z Physiol Chem. 359:1978;181-192.
6. Scharschmidt BF, Stephens JE. Transport of sodium, chloride and taurocholate by cultured rat hepatocytes. Proc Natl Acad Sci USA. 78:1981;986-990.
7. Yamazaki M, Suzuki H, Hanano M, Sugiyama Y. Different relationships between cellular ATP and hepatic uptake among taurocholate, cholate, and organic anions. Am J Physiol. 264:1993;G693-G701.
8. Boelsterli UA, Zimmerli B, Meier PJ. Identification and characterization of a basolateral dicarboxylate-cholate antiport system in rat hepatocytes. Am J Physiol. 268:1995;G797-G805.
9. Kouzuki H, Suzuki H, Ito K, Ohashi R, Sugiyama Y. Contribution of sodium taurocholate co-transporting polypeptide to the uptake of its possible substrates into rat hepatocytes. J Pharmacol Exp Ther. 286:1998;1043-1050.
10. Caflisch C, Zimmerli B, Reichen J, Meier PJ. Cholate uptake in basolateral rat liver plasma membrane vesicles and in liposomes. Biochim Biophys Acta. 1021:1990;70-76.
11. Green RM, Gollan JL, Hagenbuch B, Meier PJ, Beier D. Regulation of hepatocyte bile salt transporters during hepatic regeneration. Am J Physiol. 273:1997;G621-G627.
12. +-taurocholate cotransport and its encoding mRNA in primary cultures of rat hepatocytes. Hepatology. 18:1993;1162-1166.
13. von Dippe P, Levy D. Expression of the bile acid transport protein during liver development and in hepatoma cells. J Biol Chem. 265:1990;5942-5945.
14. Blumrich M, Zeyen-Blumrich U, Pagels P, Petzinger E. Immortalization of rat hepatocytes by fusion with hepatoma cells. Studies on the transport and synthesis of bile acids in hepatocytoma (HPCT) cells. Eur J Cell Biol. 64:1994;339-347.
15. Kullak-Ublick GA, Beuers U, Paumgartner G. Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells. Hepatology. 23:1996;1053-1060.
16. +/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology. 110:1996;199-209.
17. Green RM, Beier D, Gollan JL. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology. 111:1996;193-198.
18. Bolder U, Ton-Nu H-T, Schteingart CD, Frick E, Hofmann AF. Hepatocyte transport of bile acids and organic anions in endotoxemic rats: impaired uptake and secretion. Gastroenterology. 112:1997;214-225.
19. +/taurocholate cotransport activity and messenger RNA post partum. Biochem J. 303:1994;33-36.
20. +/bile acid cotransport system. Proc Natl Acad Sci USA. 88:1991;10629-10633.
21. +/bile acid cotransporter. J Clin Invest. 93:1994;1326-1331.
22. Cattori V, Eckhardt U, Hagenbuch B. Molecular cloning and functional characterization of two alternatively spliced Ntcp isoforms from mouse liver. Biochim Biophys Acta. 1445:1999;154-159.
23. Wong MH, Oelkers P, Craddock AL, Dawson PA. Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter. J Biol Chem. 269:1994;1340-1347.
24. Shneider BL, Dawson PA, Christie D-M, Hardikar W, Wong MH, Suchy FJ. Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter. J Clin Invest. 95:1995;745-754.
25. Craddock AL, Love MW, Daniel RW, Kirby LC, Walters HC, Wong MH, et al. Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 274:1998;G157-G169.
26. Wright EM, Hager KM, Turk E. Sodium cotransport proteins. Curr Opin Cell Biol. 4:1992;696-702.
27. Meier PJ, Eckhardt U, Schroeder A, Hagenbuch B, Stieger B. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology. 26:1997;1667-1677.
28. von Dippe P, Amoui M, Stellwagen RH, Levy D. The functional expression of sodium-dependent bile acid transport in Madin Darby Canine Kidney Cells transfected with the cDNA for microsomal epoxide hydrolase. J Biol Chem. 271:1996;18176-18180.
29. +/taurocholate cotransport by cyclic AMP. J Biol Chem. 268:1993;17734-17741.
30. +-taurocholate cotransport by translocating transporter to plasma membranes. Am J Physiol. 273:1997;G842-G848.
31. +-independent organic anion transporting polypeptide (oatp-1) in rats with bile duct ligation. J Hepatol. 27:1997;1051-1056.
32. Moseley RH, Wang W, Takeda H, Lown K, Shick L, Ananthanarayanan M, et al. Effect of endotoxin on bile acid transport in rat liver: a potential model for sepsis-associated cholestasis. Am J Physiol. 271:1996;G137-G146.
33. Simon FR, Fortune J, Iwahashi M, Gartung C, Wolkoff AW, Sutherland E. Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters. Am J Physiol. 271:1996;G1043-G1052.
34. Bossard R, Stieger B, O'Neill B, Fricker G, Meier PJ. Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver. J Clin Invest. 91:1993;2714-2720.
35. +/taurocholate cotransporter is regulated in vivo by retention of biliary constituents but not their depletion. Hepatology. 25:1997;284-290.
36. +/taurocholate cotransporting polypeptide (ntcp) in the fetal and neonatal rat liver. Hepatology. 28:1998;789-795.
37. Shneider BL, Fox VL, Schwarz KB, Watson CL, Ananthanarayanan M, Thevananther S, et al. Hepatic basolateral sodiumdependent bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia. Hepatology. 25:1997;1176-1183.
38. Karpen SJ, Sun A-Q, Kudish B, Hagenbuch B, Meier PJ, Ananthanarayanan M, et al. Multiple factors regulate the rat liver basolateral sodium-dependent bile acid cotransporter gene promoter. J Biol Chem. 271:1996;15211-15221.
39. Chiang JYL, Stroup D. Identification and characterization of a putative bile acid-responsive element in cholesterol 7α-hydroxylase gene promoter. J Biol Chem. 269:1994;17502-17507.
40. Stroup D, Crestani M, Chiang JYL. Identification of a bile acid response element in the cholesterol 7α-hydroxylase gene CYP7A. Am J Physiol. 273:1997;G508-G517.
41. Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A, et al. Identification of a nuclear receptor for bile acids. Science. 284:1999;1362-1365.
42. Trauner M, Arrese M, Lee H, Boyer JL, Karpen SJ. Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J Clin Invest. 101:1998;2092-2100.
43. +/taurocholate cotransporter (NTCP). [abstract] Hepatology. 28:1998;428A.
44. Yin M, Yang SQ, Lin HZ, Lane MD, Chatterjee S, Diehl AM. Tumor necrosis factor α promotes nuclear localization of cytokine-inducible CCAAT/Enhancer Binding Protein isoforms in hepatocytes. J Biol Chem. 271:1996;17974-17978.
45. Ganguly TC, O'Brien ML, Karpen SJ, Hyde JF, Suchy FJ, Vore M. Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. J Clin Invest. 99:1997;2906-2914.
46. Boyer JL, Hagenbuch B, Ananthanarayanan M, Suchy F, Stieger B, Meier PJ. Phylogenic and ontogenic expression of hepatocellular bile acid transport. Proc Natl Acad Sci USA. 90:1993;435-438.
47. Kullak-Ublick GA, Glasa J, Boeker C, Oswald M, Gruetzner U, Hagenbuch B, et al. Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas. Gastroenterology. 113:1997;1295-1305.
48. Kramer W, Wess G, Schubert G, Bickel M, Girbig F, Gutjahr U, et al. Liver-specific drug targeting by coupling to bile acids. J Biol Chem. 267:1992;18598-18604.
49. Hugentobler G, Meier PJ. Multispecific anion exchange in basolateral (sinusoidal) rat liver plasma membrane vesicles. Am J Physiol. 251:1986;G656-G664.
50. Zimmerli B, O'Neill B, Meier PJ. Identification of sodium-dependent and sodium-independent dicarboxylate transport systems in rat liver basolateral membrane vesicles. Pflügers Arch. 421:1992;329-335.
51. Blitzer BL, Terzakis C, Scott KA. Hydroxyl-bile acid exchange: a new mechanism for the uphill transport of cholate by basolateral liver plasma membrane vesicles. J Biol Chem. 261:1986;12042-12046.
52. Veith CM, Thalhammer T, Felberbauer FX, Graf J. Relationship of hepatic cholate transport to regulation of intracellular pH and potassium. Biochim Biophys Acta. 1103:1992;51-61.
53. Frimmer M, Ziegler K. The transport of bile acids in liver cells. Biochim Biophys Acta. 947:1988;75-99.
54. Petzinger E. Transport of organic anions in the liver. An update on bile acid, fatty acid, monocarboxylate, anionic amino acid, cholephilic organic anion, and anionic drug transport. Rev Physiol Biochem Pharmacol. 123:1994;47-211.
55. Anwer MS, Hegner D. Effect of organic anions on bile acid uptake by isolated rat hepatocytes. Hoppe-Seyler's Z Physiol Chem. 359:1978;1027-1030.
56. Elsner RH, Ziegler K. Radiation inactivation of multispecific transport systems for bile acids and xenobiotics in basolateral rat liver plasma membrane vesicles. J Biol Chem. 267:1992;9788-9793.
57. + conductance via uptake through the bilirubin pathway. J Physiol Lond. 471:1993;617-635.
58. Ishii K, Wolkoff AW. Inhibition of rat hepatocyte organic anion transport by bile acids. Am J Physiol. 267:1994;G458-G464.
59. Eaton DL, Klaassen CD. Carrier-mediated transport of ouabain in isolated hepatocytes. J Pharmacol Exp Ther. 205:1978;480-488.
60. Okudaira K, Yamazaki M, Sawada Y, Sugiyama Y, Jga T, Hanano M. Correlation between the inhibitory effects of basic drugs on the uptake of cardiac glycosides and taurocholate by isolated rat hepatocytes. Pharm Res. 9:1992;1152-1156.
61. Steen H, Merema M, Meijer DKF. A multispecific uptake system for taurocholate, cardiac glycosides and cationic drugs in the liver. Biochem Pharmacol. 44:1992;2323-2331.
62. Ziegler K, Lins W, Frimmer M. Hepatocellular transport of cyclosomatostatins: evidence for a carrier system related to the multispecific bile acid transporter. Biochim Biophys Acta. 1061:1991;287-296.
63. Ziegler K, Stuenkel W. Tissue-selective action of pravastatin due to hepatocellular uptake via a sodium-independent bile acid transporter. Biochim Biophys Acta. 1139:1992;203-209.
64. +-independent organic anion transporter. Proc Natl Acad Sci USA. 91:1994;133-137.
65. Noé B, Hagenbuch B, Stieger B, Meier PJ. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc Natl Acad Sci USA. 94:1997;10346-10350.
66. Bergwerk AJ, Shi X, Ford AC, Kanai N, Jacquemin E, Burk RD, et al. Immunologic distribution of an organic anion transport protein in rat liver and kidney. Am J Physiol. 271:1996;G231-G238.
67. Reichel C, Gao B, Cattori V, Landmann L, Sugiyama Y, Stieger B, et al. Heterogenous expression of the polyspecific organic anion transporter Oatp2 in rat liver and its identification as a cyclic peptide transporter. [abstract] Hepatology. 28:1998;425A.
68. +-independent organic anion transporting polypeptide (oatp) in rat liver and kidney. J Hepatol. 25:1996;932-940.
69. Kakyo M, Sakagami H, Nishio T, Nakai D, Nakagomi R, Tokui T, et al. Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2). FEBS Lett. 445:1999;343-346.
70. Angeletti RH, Novikoff PM, Juvvadi SR, Fritschy J-M, Meier PJ, Wolkoff AW. The choroid plexus epithelium is the site of the organic anion transport protein in the brain. Proc Natl Acad Sci USA. 94:1997;283-286.
71. Gao B, Stieger B, Noe B, Fritschy J-M, Meier PJ. Brain capillary endothelium and choroid plexus epithelium express identical multispecific organic anion and drug transporters. J Histochem Cytochem. 1999;. in press.
72. Abe T, Kakyo M, Sakagami H, Tokui T, Nishio T, Tanemoto M, et al. Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. J Biol Chem. 273:1998;22395-22401.
73. Saito H, Masuda S, Inui K-I. Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney. J Biol Chem. 271:1996;20719-20725.
74. Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW, Schuster VL. Identification and characterization of a prostaglandin transporter. Science. 268:1995;866-869.
75. Lu R, Kanai N, Bao Y, Schuster VL. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA (hPGT). J Clin Invest. 98:1996;1142-1149.
76. Kullak-Ublick GA, Hagenbuch B, Stieger B, Schteingart CD, Hofmann AF, Wolkoff AW, et al. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology. 109:1995;1274-1282.
77. Kullak-Ublick GA, Fisch T, Oswald M, Hagenbuch B, Meier PJ, Beuers U, et al. Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain. FEBS Lett. 424:1998;173-176.
78. van Montfoort JE, Hagenbuch B, Fattinger K, Müller M, Groothuis GMM, Meijer DKF, et al. Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999;. in press.
79. Kullak-Ublick GA, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ. Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Hepatology. 20:1994;411-416.
80. Eckhardt U, Schroeder A, Stieger B, Höchli M, Landmann L, Tynes R, et al. Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. Am J Physiol. 276:1999;G1037-G1042.
81. Bossuyt X, Mueller M, Hagenbuch B, Meier PJ. Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 276:1996;891-896.
82. Kanai N, Lu R, Bao Y, Wolkoff AW, Vore M, Schuster VL. Estradiol 17β-D-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am J Physiol. 270:1996;F326-F331.
83. Eckhardt U, Horz JA, Petzinger E, Stueber W, Reers M, Dickneite G, et al. The peptide-based thrombin inhibitor CRC 220 is a new substrate of the basolateral rat liver organic aniontransporting polypeptide. Hepatology. 24:1996;380-384.
84. Kontaxi M, Eckhardt U, Hagenbuch B, Stieger B, Meier PJ, Petzinger E. Uptake of the mycotoxin Ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide. J Pharmacol Exp Ther. 279:1996;1507-1513.
85. Ishizuka H, Konno K, Naganuma H, Nishimura K, Kouzuki H, Suzuki H, et al. Transport of temocaprilat into rat hepatocytes: role of organic anion transporting polypeptide. J Pharmacol Exp Ther. 287:1998;37-42.
86. van Montfoort JE, Stieger B, Meijer DKF, Weinmann H-J, Meier PJ, Fattinger KE. Hepatic uptake of the MRI-contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1. J Pharmacol Exp Ther. 1999;. in press.
87. 4 as a substrate for Oatp1, the hepatic sinusoidal organic solute transporter. J Biol Chem. 273:1998;16184-16191.
88. Endou H. Recent advances in molecular mechanisms of nephrotoxicity. Toxicol Lett. 102-103:1998;29-33.
89. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, et al. Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 16:1997;871-881.
90. Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM. Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 51:1997;913-921.
91. Giacomini KM. Membrane transporters in drug disposition. J Pharmacokinet Biopharm. 25:1997;731-741.
92. Shi X, Bai S, Ford AC, Burk RD, Jacquemin E, Hagenbuch B, et al. Stable inducible expression of a functional rat liver organic anion transport protein in HeLa cells. J Biol Chem. 270:1995;25591-25595.
93. 3 exchange. J Biol Chem. 272:1997;26340-26345.
94. Gartung C, Trauner M, Schlosser SF, Hagenbuch B, Meier PJ, Boyer JL. Sodium-independent uptake of bile acids is unaffected by down-regulation of an organic anion transporter (oatp) in rat liver during cholestasis produced by common bile duct ligation (CBDL). [abstract] Hepatology. 24:1996;369A.
95. Gartung C, Gerloff T, Stieger B, Hagenbuch B, Meier PJ, Matern S. Unterschiedliche Expression basolateraler und kanalikulärer organischer Anionentransporter während der Leberregeneration nach partieller Hepatektomie. [abstract] Z Gastroenterol. 37:1999;74.
96. Gerloff T, Gartung C, Stieger B, Hagenbuch B, Meier PJ, Matern S. Differential expression of basolateral and canalicular organic anion transporters during liver regeneration. [abstract] Hepatology. 28:1998;506A.
97. Lu R, Kanai N, Bao Y, Wolkoff AW, Schuster VL. Regulation of renal oatp mRNA expression by testosterone. Am J Physiol. 270:1996;F332-F337.
98. Kullak-Ublick G-A, Beuers U, Fahney C, Hagenbuch B, Meier PJ, Paumgartner G. Indentification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene. Hepatology. 26:1997;991-997.
99. Trauner M, Arrese M, Soroka CJ, Ananthanarayanan M, Koeppel TA, Schlosser SF, et al. The rat canalicular conjugate export pump (mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology. 113:1997;255-264.
100. Oswald M, Kullak-Ublick GA, Beuers U, Paumgartner G. Expression of the hepatocyte canalicular multidrug resistance associated protein 2 (MRP2) in primary biliary cirrhosis. [abstract] Hepatology. 28:1998;544A.
101. Fischer S, Beuers U, Spengler U, Zwiebel FM, Koebe H-G. Hepatic levels of bile acids in end-stage chronic cholestatic liver disease. Clin Chim Acta. 251:1996;173-186.
102. Stravitz RT, Sanyal AJ, Pandak WM, Vlahcevic ZR, Beets JW, Dawson PA. Induction of sodium-dependent bile acid transporter messenger RNA, protein, and activity in rat ileum by cholic acid. Gastroenterology. 113:1997;1599-1608.
103. Sweet DH, Wolff NA, Pritchard JB. Expression cloning and characterization of ROAT1: the basolateral organic anion transporter in rat kidney. J Biol Chem. 272:1997;30088-30095.
104. Miller DS. Protein kinase C regulation of organic anion transport in renal proximal tubule. Am J Physiol. 274:1998;F156-F164.
105. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, et al. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 429:1998;179-182.
106. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, et al. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 274:1999;13675-13680.
107. Kool M, de Haas M, Scheffer GL, Scheper RJ, van Eijk MJT, Juijn JA, et al. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res. 57:1997;3537-3547.
108. Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science. 258:1992;1650-1654.
109. Müller M, Mejer C, Zaman GJR, Borst P, Scheper RJ, Mulder NH, et al. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci USA. 91:1994;13033-13037.
110. Jedlitschky G, Leier I, Buchholz U, Barnouin K, Kurz G, Keppler D. Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res. 56:1996;988-994.
111. Roelofsen H, Vos TA, Schippers IJ, Kuipers F, Koning H, Moshage H, et al. Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells. Gastroenterology. 112:1997;511-521.
112. Paulusma CC, Bosma PJ, Zaman GJR, Bakker CTM, Otter M, Scheffer GL, et al. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science. 271:1996;1126-1128.
113. Kartenbeck J, Leuschner U, Mayer R, Keppler D. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatology. 23:1996;1061-1066.
114. Paulusma CC, Kool M, Bosma PJ, Scheffer GL, Ter Borg F, Scheper RJ, et al. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology. 25:1997;1539-1542.
115. Keppler D, König J, Cui Y, Leier I, Rost D, Nies A. ATP-dependent hepatocellular export pumps of the MRP family. Paumgartner G, Stiehl A, Gerok W, Keppler D, Leuschner U, . Bile Acids and Cholestasis. 1999;Kluwer Academic Publishers, Dordrecht, Boston, London. in press.
116. Stieger B, Meier PJ. Bile acid and xenobiotic transporters in liver. Curr Opin Cell Biol. 10:1998;462-467.
117. Kiuchi Y, Suzuki H, Hirohashi T, Tyson CA, Sugiyama Y. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). FEBS Lett. 433:1998;149-152.
118. Madon J, Hagenbuch B, Gerloff T, Landmann L, Meier PJ, Stieger B. Identification of a novel multidrug resistance-associated protein (mrp6) at the lateral plasma membrane of rat hepatocytes. [abstract] Hepatology. 28:1998;400A.
119. Kool M, van der Linden M, de Haas M, Baas F, Borst P. Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells. Cancer Res. 59:1999;175-182.
120. Lee JM, Trauner M, Soroka CJ, Stieger B, Meier PJ, Boyer JL. Molecular expression of the sister of P-glycoprotein in chronic bile duct obstruction in the rat. Paumgartner G, Stiehl A, Gerok W, Keppler D, Leuschner U, . Bile Acids and Cholestasis. 1999;Kluwer Academic Publishers, Dordrecht, Boston, London. in press.
121. Vos TA, Hooiveld GJEJ, Koning H, Childs S, Meijer DKF, Moshage H, et al. Up-regulation of the multidrug resistance genes, mrpl and mdrlb, and down-regulation of the organic anion transporter, mrp2, and the bile salt transporter, spgp, in endotoxemic rat liver. Hepatology. 28:1998;1637-1644.
122. Zhu Q, Center MS. Cloning and sequence analysis of the promoter region of the MRP gene of HL60 cells isolated for resistance to adriamycin. Cancer Res. 54:1994;4488-4492.
123. Wang Q, Beck WT. Transcriptional suppression of multidrug resistance-associated protein (MRP) gene expression by wild-type p53. Cancer Res. 58:1998;5762-5769.
124. Fromm MF, Leake B, Roden DM, Wilkinson GR, Kim RB. Human MRP3 transporter: identification of the 5′-flanking region, genomic organization and alternative splice variants. Biochim Biophys Acta. 1415:1999;369-374.
125. Roelofsen H, Müller M, Jansen PLM. Regulation of organic anion transport in the liver. Yale J Biol Med. 70:1997;435-445.
126. Ma L, Krishnamachary N, Center MS. Phosphorylation of the multidrug resistance associated protein gene encoded protein P190. Biochemistry. 34:1995;3338-3343.
127. Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M. The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26. Cytogenet Cell Genet. 79:1997;198-200.
128. Gründemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H. Drug excretion mediated by a new prototype of polyspecific transporter. Nature. 372:1994;549-552.
129. Meyer-Wentrup F, Karbach U, Gorboulev V, Arndt P, Koepsell H. Membrane localization of the electrogenic cation transporter rOCT1 in rat liver. Biochem Biophys Res Comm. 248:1998;673-678.
130. Nagel G, Volk C, Friedrich T, Ulzheimer JC, Bamberg E, Koepsell H. A reevaluation of substrate specificity of the rat cation transporter rOCT1. J Biol Chem. 272:1997;31953-31956.
131. Koepsell H. Organic cation transporters in intestine, kidney, liver, and brain. Annu Rev Physiol. 60:1998;243-266.
132. Sinclair CJ, Ward KL, Green RM. Stable expression and kinetic characterization of a novel hepatic organic cation transporter (Orct). [abstract] Hepatology. 28:1998;506A.
133. Green RM, Sinclair C, Ward KL. Functional characterization of organic cation transport in HepG2 cells. [abstract] Hepatology. 28:1998;531A.
134. Cooper PR, Smilinich NJ, Day CD, Nowak NJ, Reid LH, Pearsall RS, et al. Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. Genomics. 49:1998;38-51.