Neuroendocrinology of the skin

Endocrine Reviews

Volumn 21, Issue 5, 2000, Pages 457-487

  Slominski, Andrzej ^a   Wortsman, Jacobo ^b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ALPHA INTERMEDIN; BETA ENDORPHIN; CATECHOLAMINE DERIVATIVE; COLECALCIFEROL; CORTICOTROPIN; INTERMEDIN; PARATHYROID HORMONE RELATED PROTEIN; UROCORTIN;

ANIMAL CELL; AUTOCRINE EFFECT; DERMIS; EPIDERMIS; HORMONE SYNTHESIS; HYPOTHALAMUS HYPOPHYSIS SYSTEM; NEUROENDOCRINOLOGY; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; RAT; REVIEW; SKIN; STRESS;

EID: 0033694888     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/er.21.5.457     Document Type: Review

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122. Neurotrophin-3 involvement in the regulation of the hair follicle morphogenesis
123. Overexpression of brain-derived neurotrophic factor increase Merkel cell number in murine skin
124. Retardation of hair follicle development by the deletion of trkC, high-affinity neurotrophin-3 receptor
125. Somatostatin immunoreactive cells in lesional psioriatic human skin during peptide T treatment
126. Cloning and functional expression of thyrotropin receptor cDNA from rat fat cells
127. Cultured human fibroblasts and not cultured human keratinocytes express a PTH/PTHrP receptor mRNA
128. Parathyroid hormone-related protein is a positive regulator of keratinocyte growth factor expression by normal dermal fibroblasts
129. 3
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131. Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines
132. A parathyroid antagonist stimulates epidermal proliferation and hair growth in mice
133. Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development
134. Parathyroid hormone stimulates protein kinase C but not adenylate cyclase in mouse epidermal keratinocytes
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169. Competetive polymerase chain reaction quantitiation of c-erbA/β1, c-erbAα1, and c-erbAα2 messenger ribonucleic acid levels in normal, heterozygous, and homozygous fibroblasts of kindreds with thyroid hormone resistance
170. Multi-hormonal regulation of tyrosinase expression in B16/C3 melanoma cells in culture
171. Activation of keratinocyte nicotinic cholinergic receptors stimulates calcium influx and enhances cell differentiation
172. Biological function of keratinocyte cholinergic receptors
173. Identification and mapping of keratinocyte muscarinic acetylcholine receptor subtypes in human epidermis
174. Identification and molecular characterization of a m5 muscarinic receptor in A2058 human melanoma cells. Coupling to inhibition of adenylyl cyclase and stimulation of phospholipase A2
175. Characterization of muscarinic receptors in the human melanoma cell line SK-Mel-28 via calcium mobilization
176. Autoradiographic manning of β adrenoceptors in human skin
177. Binding of β-adrenergic receptors in human skin
178. Production of catecholamines in the human epidermis
179. α(1)-Adrenoceptors in normal and hyperalgesic human skin
180. Anti-inflammatory effect of β(2)-agonists-inhibition of TNF-α release from human mast cells
181. Vascular barrier-enhancing effect of an endogenous β-adrenergic agonist
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189. Can a serotonin type 3 (5-HT3) receptor antagonist reduce experimentally-induced itch?
190. Immunohistochemical localization of 5-HT2A receptors in peripheral sensory axons in rat glabrous skin
191. Human platelets can initiate T cell-dependent contact sensitivity through local serotonin release mediated by IgE antibodies
192. Stimulated prostaglandin E-2 release from rat skin, in vitro
193. The mast cell products histamine and serotonin stimulate and TNF-α inhibits the proliferation of murine epidermal keratinocytes in situ
194. Acute immobilization stress triggers skin mast cell degranulation via corticotropin releasing hormone, neurotensin and substance P: A link to neurologic skin disorders
195. H2 histamine receptor-mediated increase in intracellular Ca2+ in cultured human keratinocytes
196. CIS-urocanic acid attenuates histamine receptor-mediated activation of adenylate cyclase and increase intracellular Ca2+
197. Histamine enhances UVB-induced IL-6 production by human keratinocytes
198. Cetirizine and hydrocortisone differentially regulate ICAM-1 expression and chemokine release in cultured human keratinocytes
199. Histamine induces melanogenesis and morphologic changes by protein kinase A activation via H-2 receptors in human normal melanocytes
200. Adenosine and adenine nucleotide stimulation of skin (epidermal) adenylate cyclase
201. Adenosine triphosphate stimulates phsophoinositide metabolism, mobilizes intracellular calcium, and inhibits terminal differentiation of human epidermal keratinocytes
202. Adenosine and adenine nucelotides inhibit the autonomous and epidermal growth factor-mediated proliferation of cultured human keratinocytes
203. Expression of adrenomedullin and its receptor in normal and malignant human skin: A potential pluripotent in the integument
204. Effects of a calcium receptor activator on the cellular response to calcium in human keratinocytes
205. Towards defining receptors for L-tyrosine and L-DOPA
206. Inhibition of melanogenesis as an adjuvant strategy for the treatment of melanotic melanomas. Selective review and hypothesis
207. Melatonin inhibits proliferation and melanogenesis in rodent melanoma cells
208. Murine skin as a target for melatonin bioregulation
209. Melatonin antagonizes α-melanocyte stimulating hormone enhancement of melanogenesis in mouse melanoma cells by blocking the hormone-induced accumulation of the c locus tyrosinase
210. Transactivation of the PTHrP gene in squamous carcinoma predicts the occurrence of hypercalcemia in athymic mice
211. Immunohistochemical localization of parathyroid hormone-related protein (PTHRP) in normal human skin
212. Hypercalcemia in melanoma patients associated with increase levels of parathyroid hormone-related protein
213. Hypercalcemia due to parathyroid hormone-related protein secretion by melanoma
214. Immunohistochemical detection of parathyroid hormone-related protein in a cutaneous squamous cell carcinoma causing hypercalcemia of malignancy
215. Human lymphocytes produce urocortin, but not corticotropin-releasing hormone
216. Localization of corticotropin-releasing factor in primary and secondary lymphoid organs of the rat
217. Detection of the proopiomelanocortin-derived antigens in normal and pathologic human skin
218. Immunoreactivity of α-melanocyte-stimulating hormone, adrenocorticotrophic hormone and β-endorphin in cutaneous malignant melanoma and benign melanocytic naevi
219. Characterization of ACTH peptides in human skin and their activation of melanocortin-1 receptor
220. Identification of β-endorphin, α-MSH and ACTH peptides in cultured human melanocytes, melanoma and squamous cell carcinoma cells by RP-HPLC
221. Proopiomelanocortin gene product regulation in keratinocytes
222. Proopiomelanocortin (POMC) gene expression by normal skin and keloid fibroblasts in culture: Modulation by cytokines
223. Evidence for γ-melanocyte stimulating hormone containing nerves and neutrophilic granulocytes in the human skin by indirect immunofluorescence
224. Spatiotemporal expression, distribution, and processing of POMC and POMC-derived peptides in murine skin
225. Identification and sequencing of a putative variant of proopiomelanocortin in human epidermis and epidermal cells in culture
226. Human epidermal proopiomelanocortin (POMC) cDNA variant is identical to mouse POMC cDNA
227. Human dermal fibroblast cells express prolactin in vitro
228. Observation of production of immunoactive prolactin by normal human connective tissue in cell culture
229. Localization of prolactin-like immunoreactivity in grafted human sweat glands
230. Distribution of a prolactin-like material in human eccrine sweat glands
231. Splicing variants of the human growth hormone mRNA: Detection of pituitary, mononuclear cells and dermal fibroblasts
232. Expression of prolactin mRNA and of prolactin-like proteins in endothelial cells: Evidence for autocrine effects
233. Prolactin receptor signal transduction in cells of the immune system
234. Expression and localization of prolactin mRNA in the human immune system
235. Localization of growth hormone messenger RNA in the human immune system
236. Human skin expresses growth hormone (GH), but not the prolactin (PRL) gene
237. Enkephalin-like immunoreactivity in human skin is found selectively in fractions of CD68 positive dermal cells: Increase of enkephalin positive cells in lesional psoriasis
238. Increased levels of enkephalin following natural sunlight (combined with salt water bathing at the Dead Sea) and ultraviolet A irradiation
239. Immunocytochemical evidence of a met-enkephalin-like substance in the dense-core granules of mouse Merkel cells
240. Localization of met-enkephalin like immunoreactivity in the glabrous skin of the cat rhinarium
241. Proenkephalin A is expressed in mesodermal lineages during organogenesis
242. Regulation of proenkephalin expression in cultured skin mesenchymal cells
243. Decrease in enkephalin levels in psoriatic lesions after calcipotriol and mometasone furoate treatment
244. The role of endogenous opioids and their receptors in the immune system
245. Characterization of opioid peptides in guinea pig heart and skin
246. Occurrence and distribution of neuropeptides in the human skin. An immunocytochemical study on normal skin and blister fluid from inflamed skin
247. An immunohistochemical study of neuroactive substances in the skin of atopic dermatitis
248. Neurochemical markers in human cutaneous Merkel cells. An immunocytochemical investigation
249. Growth-regulated synthesis and secretion of biologically active nerve growth factor by human kerantinocytes
250. Tumor necrosis factor is markedly synergistic with interleukin 1 and interferon-γ in stimulating the production of nerve growth factor in fibroblasts
251. Merkel cells in vitro production of nerve growth factor and selective interactions with sensory neurons
252. Human keratinocytes synthesize, secrete, and degrade acetylcholine
253. Modulation of melanocytic activity by acetylcholine
254. Defective tetrahydrobiopterin and catecholamine biosynthesis in the depigmentation disorder vitiligo
255. Cultured human keratinocytes as a peripheral source of mRNA for tyrosine hydroxylase and aromatic L-amino acid decarboxylase
256. Human hair follicles as a peripheral source of tyrosine hydroxylase and aromatic L-amino acid decarboxylase mRNA
257. Phenylethanolamine N-methyltransferase-like imunoreactivity in psoriasis
258. Transplantation of B16/C3 melanoma cells into the brains of rats and mice
259. Inhibition of melanization in human melanoma cells by a serotonin uptake inhibitor
260. Neural differentiation Of melanocytes in vitiliginous skin
261. Increased monoamine oxidase a activity in the epidermis of patients with vitiligo
262. Determination of catechol O-methyltransferase activity in relation to melanin metabolism using high performance liquid chromatography with flourimetric detection
263. The importance of L-phenylalanine transport and its autocrine turnover to L-tyrosine for melanogenesis in human epidermal melanocytes
264. L-tyrosine and nicotine induce synthesis of L-dopa and norepinephrine in human lymphocytes
265. Neurobiology of L-DOPAergic systems
266. L-tyrosine, L-dopa and tyrosinase as positive regulators of the subcellular apparatus of melanogenesis in Bomirski Ab amelanotic melanoma
267. A serotonin-like immunoreactivity is present in human cutaneous melanocytes
268. Localization of serotonin-like immunoreactivity in the Merkel cells of pig snout skin
269. Identification and characterization of two isozymic forms of arylamine N-acetyltransferase in Syrian hamster skin
270. Histological localization of messenger RNAs for rat acetyltransferases that acetylate serotonin and genotoxic arylamines
271. Metabolism of serotonin to N-acetylserotonin, melatonin and 5-hydroxytryptamine in hamster skin culture
272. Glutamate- and aspartate-like immunoreactivities in human normal and inflamed skin
273. Human epidermal keratinocytes in culture convert thyroxine to 3,5,3'-triidothyronine by type II iodothyronine deiodination. A novel endocrine function of the skin
274. Skin is an active site of inner ring monodeiodiation of thyroxine to 3,3',5'-triiodothyronine
275. Keratinocytes convert thyroxine to triidothyronine
276. Cloning and expression of a cDNA for a mammalian type III iodothyronine deiodinase
277. Expression profiles of the three iodothyronine deiodinases, D1, D2, D3, in the developing rat
278. Development effects of thyroid hormone: The role of deiodinases in regulatory control
279. Steroid metabolism by epidermal keratinocytes
280. Opposite effects of prolactin and corticosterone on the expression and activity of 3-β-hydroxysteroid dehydrogenase/δ5-δ 4 isomerase in rat skin
281. Characterization, expression, and immunohistochemical localization of 3β-hydroxysteroid dehydrogenase/δ 5-δ 4 isomerase in human skin
282. Expression of mRNA for androgen receptor, 5α-reductase and 17β-hydroxysteroid dehydrogenase in human dermal papilla cells
283. Activity of 5-α-reductase and 17-β-hydroxysteroid dehdrogenase in the infrainfundibulum of subjects with and without acne vulgaris
284. 5-α-Reductase activity in the human hair follicle concentrates in the dermal papilla
285. Evidence of heterogeneity and quantitative difference of the type 1 5α-reductase expression in cultured human skin cells-evidence of its presence in melanocytes
286. Activity of the Type I 5α-reductase exhibits regional differences in isolated sebaceous glands and whole skin
287. Effects of transforming growth factor β and epidermal growth factor on steroid 5 α-reductase activity in genital skin fibroblasts
288. Predominance of type I 5α-reductase in apocrine sweat glands of patients with excessive of abnormal odour derived from apocrine sweat (osmidrosis)
289. Immunohistochemical localization of types 1 and 2 5α-reductase in human scalp
290. Potential in exploring the biochemistry of human skin
291. Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells
292. Active steroidogenesis in the normal rat skin
293. Hair cycle-dependent changes in adrenergic skin innervation, and hair growth modulation by adrenergic drugs
294. Vitamin D metabolite production and function in keratinocytes
295. The physiology of parathyroid hormone-related protein
296. Urocanic acid photochemistry and photobiology
297. The effects of UVA-I (340-400 nm), UVA-II (320-340 nm) and UVA-I+II on the photoisomerization of urocanic acid in vitro
298. Neuronal structural protein, transmitters, transmitter enzymes and neuropeptides in human Meissner's corpuscles: A reappraisal using immunohistochemistry
299. A simple immnoflouresecence technique for simultaneous visualization of mast cells and nerve fibers reveals selectivity and hair cycle-dependent changes in mast -nerve fiber contacts in murine skin
300. Characterization of unmyeliniated axons uniting epidermal and dermal immune cells in primate and murine skin
301. Relationship between Merkel cells and nerve endings during embryogenesis in the mouse epidermis
302. Ultrastructural evidence for nerve fibers within all vital layers of the human epidermis
303. The innervation of human epidermis
304. Hair cycle-dependent plasticity of skin hair follicle innervation in normal skin
305. Histaminergic nerves demonstrated in the skin. A new direct mode of neurogenic inflammation?
306. Modulation of keratinocyte proliferation by skin innervation
307. Nitric oxide in human skin; current status and future prospects
308. Skin peptide tyrosine-tyrosine, a member of the pancreatic polypeptide family: Isolation, structure, synthesis, and endocrine activity
309. The pituitary-skin connection in amphibians
310. Adrenocorticotropin (ACTH)- and non-ACTH-mediated regulation of the adrenal cortex: Neural and immune imputs
311. Melanin-related metabolites as markers of melanoma: A review
312. Interleukins and tumor necrosis factor as inhibitors of food intake
313. Regulation of tumour necrosis factor-α release from human adipose tissue in vitro
314. Subdiaphragmatic vagotomy suppresses endotoxin-induced activation of hypothalmic corticotropin-releasing hormone neurons and ACTH secretion
315. UVB stimulates production of corticotropin releasing factor (CRF) by human melanocytes
316. UV light and MSH receptors
317. UV A exposure and pituitary secretion: Variations of human lipotropin concentrations (βLPH) after UVA exposure
318. UVB-induced melanogenesis may be mediated through the MSH-receptor system
319. The effects of ultraviolet radiation on the human immune system
320. The roles of keratinocyte-derived cytokines in the epidermis and their possible response to UVA-irradiation
321. Human keratinocytes are a source for tumor necrosis factor α evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light
322. Interleukin-10 production by cultured human keratinocytes: Regulation by ultraviolet B and ultraviolet A1 radiation
323. Contrasting effects of ultraviolet A1 and ultraviolet B exposure on the induction of tumour necrosis factor-α in human skin
324. Ultraviolet B radiation upregulates the production of macrophage migration inhibitory factor (MIF) in human epidermal keratinocytes
325. Wavelength-specific synergy between ultraviolet radiation and interleukin-1 α in the regulation of matrix-related genes: Mechanistic role for tumor necrosis factor-α
326. Ultraviolet light and interleukin-10 modulate expression of cytokines by transformed human dermal microvascular endothelial cells (HMEC-1)
327. 6-tetrahydrobiopterin functions as a UVB-light switch for de novo melanogenesis
328. Pteridines in the control of pigmentation
329. The role of proopiomelanocortin-derived peptides in skin fibroblast and mast cell functions
330. Neutral endopeptidase expression and distribution in human skin and wounds
331. 3 after its endogenous synthesis
332. 3
333. The effect of season and latitude on in vitro vitamin D formation by sunlight in South Africa
334. 3
335. Sunscreens suppress cutaneous vitamin D3 synthesis
336. Chronic sunscreen use decreases circulating concentrations of 25-hydroxy-vitamin D
337. Clinically prescribed sunscreen (sun protection factor 15) does not decrease serum vitamin D concentration sufficiently either to induce changes in parathyroid function or in metabolic markers
338. 3
339. The optics of human skin
340. 3
341. 3
342. Vitamin D metabolism is altered in Asian Indians in the southern United States: A clinical research center study
343. 3
344. Ethnic variation in vitamin D binding protein (GC): A review of isoelectric focusing studies in human populations
345. 3
346. 3
347. Age, vitamin D, and solar ultraviolet
348. Cutaneous formation of vitamin D in psoriasis
349. 3 formation in progressive systemic sclerosis
350. Decreased bioavailablity of vitmain D in obesity
351. Relations between vitamin D and fatty acid binding property of vitamin D-binding protein
352. 2 levels does not impede the release of vitamin D3 from the skin
353. 3
354. Seasonal changes in plasma 25-hydroxyvitamin D concentration of young American black and white women