Activity of 5-alpha-reductase and 17-beta-hydroxysteroid dehydrogenase in the infrainfundibulum of subjects with and without acne vulgaris

Dermatology

Volumn 196, Issue 1, 1998, Pages 38-42

  Thiboutot, Diane ^a   Knaggs, H ^b   Gilliland, K ^a   Lin, G ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b UNILEVER RESEARCH   (United Kingdom)

Author keywords

17 hydroxysteroid dehydrogenase; 5 reductase; Acne; Androgen; Pilosebaceous follicle

Indexed keywords

ANDROGEN; INTERLEUKIN 1; LINOLEIC ACID; RETINOID; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE;

ACNE VULGARIS; ADULT; CELL CULTURE; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DYSKERATOSIS; ENZYME ACTIVITY; EPIDERMIS; ESSENTIAL FATTY ACID DEFICIENCY; FEMALE; HUMAN; HUMAN CELL; INFUNDIBULUM; KERATINOCYTE; MALE; PRIORITY JOURNAL;

17-HYDROXYSTEROID DEHYDROGENASES; ACNE VULGARIS; ADOLESCENT; ADULT; FEMALE; HUMANS; KERATINOCYTES; MALE; MIDDLE AGED; SEBACEOUS GLANDS; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0031929563     PISSN: 10188665     EISSN: None     Source Type: Journal    
DOI: 10.1159/000017863     Document Type: Conference Paper

References (18)

1. Downing DT, Stewart ME, Wertz PW, Strauss JS: Essential fatty acids and acne. J Am Acad Dermatol 1986;14:221-225.
2. Kligman AM, Fulton JE, Plewig G: Topical vitamin A acid in acne vulgaris. Arch Dermatol 1969;99:469-476.
3. Guy R, Green M, Kealey T: Modeling of acne in vitro. J Invest Dermatol 1996;106:176-182.
4. Cunliffe W, Forster R: Androgen control of the pilosebaceous duct? Br J Dermatol 1987;116: 449.
5. Choudhry R, Hodgins MB, Van der Kwast T, Brinkmann AO, Boersma WJ: Localization of androgen receptors in human skin by immunohistochemistry: Implications for the hormonal regulation of hair growth, sebaceous glands and sweat glands. J Endocrinol 1992;133: 467-475.
6. Hay JB, Hodgins MB, Donnelly JB: Human skin androgen metabolism and preliminary evidence for its control by two forms of 17β-hydroxysteroid oxidoreductase. J Endocrinol 1982;93:403-413.
7. Hay JB, Hodgins MB: Distribution of androgen metabolizing enzymes in isolated tissues of human forehead and axillary skin. J Endocrinol 1978;79:29-39.
8. 4-5-isomerase in human sebaceous glands and their secretory activity in vivo. J Invest Dermatol 1983;81:139-144.
9. Thiboutot D, Knaggs H, Gilliland K, Hagari S: Activity of type 1 5α-reductase is greater in the follicular infrainfundibulum compared with the epidermis. Br J Dermatol 1997;136: 166-171.
10. Luu-The V: Characterization, expression, and immunohistochemical localization of 5α-reductase in human skin. J Invest Dermatol 1994;102:221-226.
11. Labrie F: Intracrinology. Mol Cell Endocrinol 1991;78:C113-C118.
12. Aizawa H, Nakada N, Niimura M: Androgen status in adolescent women with acne vulgaris. J Dermatol 1995;22:530-532.
13. Lookingbill DP, Horton R, Demers LM, Egan N, Marks JG, Santen RJ: Tissue production of androgens in women with acne. J Am Acad Dermatol 1985;12:481-487.
14. Vexiau P: Androgen excess in women with acne alone compared with women with acne and/or hirsutism. J Invest Dermatol 1990;94: 279-283.
15. Walton S, Cunliffe W, Keczkes K, Early A, McGarrigle H, Katz M, Reese R: Clinical, ultrasound, and hormonal markers of androgenicity in acne vulgaris. Br J Dermatol 1995; 133:249-253.
16. Jenkins EP, Andersson S, Imperato-McGinley J, Wilson JD, Russell DW: Genetic and pharmacological evidence for more than one human steroid 5α-reductase. J Clin Invest 1992;89:293-300.
17. Reed M, Rea D, Duncan L, Parker M: Regulation of estradiol 17β-hydroxysteroid dehydrogenase expression and activity by retinoic acid in T47D breast cancer cells. Endocrinology 1994;135:4-9.
18. Duncan L, Coldham N, Reed M: The inter action of cytokines in regulating oestradiol 17β-hydroxysteroid dehydrogenase activity in MCF-7 cells. J Steroid Biochem Mol Biol 1994;49:63-68.