Human skin contains luteinizing hormone/chorionic gonadotropin receptors

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 7, 1996, Pages 2738-2741

  Pabon, J E ^a   Bird, J S ^a   Li, X ^a   Huang, Z H ^a   Lei, Z M ^a   Sanfilippo, J S ^a   Yussman, M A ^a   Rao, Ch V ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; CHORIONIC GONADOTROPIN RECEPTOR; LUTEINIZING HORMONE RECEPTOR; MESSENGER RNA; RECEPTOR PROTEIN;

ARTICLE; CONTROLLED STUDY; EPIDERMIS; FEMALE; HAIR FOLLICLE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; LIGAND BINDING; PRIORITY JOURNAL; SEBACEOUS GLAND; SKIN; SWEAT GLAND;

CHORIONIC GONADOTROPIN; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; IODINE RADIOISOTOPES; RECEPTORS, ANDROGEN; RECEPTORS, LH; RNA, MESSENGER; SKIN; TISSUE DISTRIBUTION;

EID: 0029946675     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.7.2738     Document Type: Article

References (22)

1. Speroff L, Glass RH, Kase NG Clin Gynecol Endocrinol & Infert. pp 473-490 (Williams & Wilkins, Baltimore, MD, 1994).
2. Cote J Skin care and abnormal lesions. In Comprehensive Management of Menopause ed Lorrain J) (Springer-Verlag, New York, 1994).
3. Bardin CW, Lipsett M 1967 Testosterone and androstenedione blood production rates in normal women and women with idiopathic hirsutism and polycystic ovaries. J Clin Invest 46:891-902.
4. Lawrence D Shaw M, Katz M 1986 Elevated free testosterone concentration in men and women with acne vulgaris. Clin Exp Dermatol 22:263-273.
5. Thomas JP, Oake RJ 1974 Androgen metabolism in the skin of hirsute women. J Clin Endocrinol Metab 38:19-22.
6. Lookingbill DP, Horton R, Demers LM, Egan N, Marks JG, Santen RJ 1985 Tissue production of androgens in women with acne. J Am Acad Dermatol 12:481-487.
7. Dumont M, Luu-The V, Dupond E, Pelletier G, Labrie F 1992 Characterization, expression and immunohistochemical localization of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase in human skin. J Invest Dermatol 99:415-421.
8. Luu-The V, Sugimoto Y, Puy L, Labrie Y, López-Solache I, Singh M, Labrie, F 1994 Characterization, expression and immunochemical localization of 5α-reductase in human skin. J Invest Dermatol 102:221-226.
9. Hasselquist MB, Goldberg N, Schroeter A, Spelsberg TC 1980 Isolation and characterization of the estrogen receptor in human skin. J Clin Endocrinol Metab 50:76-82.
10. Sambrook J, Fritsch EF, Maniatis T Extraction, purification, and analysis of messenger RNA from eukaryotic cells. In Molecular Cloning - A Laboratory Manual (eds Nolan, C., Ford, N., Ferguson, M.) 7.39-7.57 (Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1989).
11. Dunn SD 1986 Effects of the modification of transfer buffer composition and the renaturation of proteins in gels on the recognition of proteins on western blots by monoclonal antibodies. Anal Biochem 157:144-153.
12. Lei ZM, Toth P, Rao ChV, Pridham D 1993 Novel co-expression of human chorionic gonadotropin/human luteinizing hormone receptors and their ligand hCG in human fallopian tubes. J Clin Endocrinol Metab 77:863-871.
13. Reshef E, Lei ZM, Rao ChV, Pridham D, Chegini N, Luborsky JL 1990 The presence of gonadotropin receptors in nonpregnant human uterus, human placenta, fetal membranes, and decidua. J Clin Endocrinol Metab 70:421-430.
14. Tao Y-X, Lei ZM, Hofmann GE, Rao ChV 1995 Human intermediate trophoblasts express chorionic gonadotropin / luteinizing hormone receptor gene. Biol Reprod 53:899-904.
15. Keinänen KP, Kellokumpu S, Metsikko MK, Rajaniemi HJ 1987 Purification and partial characterization of rat ovarian lutropin receptor. J Biol Chem 262:7920-7926.
16. Choudhry R, Hodgins MB, Van der Kwast TH, Brinkmann AO, Boersma WJ 1992 Localization of androgen receptors in human skin by immunohistochemistry; implications for the hormonal regulation of hair growth, sebaceous glands and sweat glands. J Endocrinol 133:466-475.
17. Punnonen R 1972 Effect on castration and peroral estrogen therapy on the skin. Acta Obstet Gynaecol Scand 21(suppl):5-44.
18. Lookingbill DP, Demers LM, Tigelaar RE, Shalita AR 1988 Effect of isotretinoin on serum levels of precursor and peripherally derived androgens in patients with acne. Arch Dermatol 124:540-543.
19. Rao ChV 1996 The beginning of a new era in reproductive biology and medicine: expression of low levels of functional luteinizing hormone/human chorionic gonadotropin receptors in nongonadal tissues. J Physiol Pharmacol; In press.
20. Lunardi-Iskandar Y, Bryant JL, Zeman RA, Lam VH, Samaniego F, Besnier JM, Hermans P, Thierry AR, Gill P, Gallo RC 1995 Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone. Nature 375:64-68.
21. Shenker A, Laue L, Kosugi S, Merendino Jr JJ, Minegishi T, Cutler Jr GB 1993 A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature 365:652-654.
22. Kitanaka C, Matsutani M, Son S, Kitanaka S, Tanae A, Hibi I 1994 Precocious puberty in a girl with an hCG-secreting suprasellar immature teratoma. J Neurosurg 81:601-604.