Autocrine nerve growth factor protects human keratinocytes from apoptosis through its high affinity receptor (TRK): A role for BCL-2

Journal of Investigative Dermatology

Volumn 109, Issue 6, 1997, Pages 757-764

  Pincelli, Carlo ^a   Haake, Anne R ^b   Benassi, Luisa ^a   Grassilli, Emanuela ^a   Magnoni, Cristina ^a   Ottani, Daniela ^a   Polakowska, Renata ^b   Franceschi, Claudio ^a   Giannetti, Alberto ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF ROCHESTER   (United States)

Author keywords

HaCat cells; K252; Programmed cell death

Indexed keywords

NERVE GROWTH FACTOR; NERVE GROWTH FACTOR ANTIBODY; NEUTRALIZING ANTIBODY; PROTEIN BCL 2; PROTEIN TYROSINE KINASE INHIBITOR;

APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ELECTRON MICROSCOPY; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL;

EID: 0031465069     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12340768     Document Type: Article

References (68)

1. Alison M, Sarraf CE: Apoptosis: a gene-directed programme of cell death. R Coll Phys Lond 26:25-35, 1992
2. Allsopp TE, Wyatt S, Paterson HF, Davies AM: The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 73:295-307, 1993
3. Ameisen JC, Estaquier J, Idziorek T, De Bels F: Programmed cell death and AIDS, significance, perspectives and unanswered questions. Cell Death Differentiation 2:9-22, 1995
4. Araki S, Shimada Y, Kaji K, Hayashi H: Apoptosis of vascular endothelial cells by fibroblast growth factor deprivation. Biochem Biophys Res Commun 168:1194-1200, 1990
5. Barbacid M: Nerve growth factor: a tale of two receptors. Oncogene 8:2033-2042, 1993
6. Barde YA: Trophic factors and neuronal survival. Neuron 2:1525-1534, 1989
7. Berg MM, Sternberg DW, Parada LF, Chao MV: K-252a inhibits nerve growth factor-induced TRK proto-oncogene tyrosine phosphorylation and kinase activity. J Biol Chem 267:13-16, 1992
8. Bianchi L, Farrace MG, Nini G, Piacentini M: Abnormal Bcl-2 and "tissue" transglutaminase expression in psoriatic skin. J Invest Dermatol 103:829-833, 1994
9. Budtz PE: Epidermal tissue homeostasis I. Cell pool size, cell birth rate and cell loss by moulting in the intact toad. Bufo Bufo. Cell Tissue Kinet 18:521-532, 1985
10. Budtz PE: Expectations of human epidermal kinetic homeostasis. Br J Dermatol 114:645-650, 1986
11. Budtz PE: Tissue Kinetic Homeostasis: Studies on Toad Epidermis. August Krogh Publications, Copenhagen, 1991
12. Budtz PE: Epidermal homeostasis: a new model that includes apoptosis. In: Tomei LD, Cope FO (eds.). Apoptosis II. The Molecular Basis of Apoptosis in Disease. Cold Spring Harbor Laboratory Press, New York., pp 165-185, 1994
13. Carpenter G, Cohen S: Epidermal growth factor. J Biol Chem 265:7709-7712, 1990
14. Carson WE, Haldar S, Baiocchi RA, Croce CM, Caligiuri MA: The c-kit ligand suppresses apoptosis of human natural killer cels through the upregulation of bcl-2. Proc Natl Acad Sci USA 91:7553-7557, 1994
15. Cohen JJ: Apoptosis. Immunol Today 14:126-130, 1993
16. Cohen JJ, Duke RC: Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J Immunol 132:38-42, 1984
17. Danno K, Horio T: Formation of UV-induced apoptosis relates to the cell cycle. Br J Dermatol 107:423-428, 1982
18. Danno K, Horio T, Takigawa M, Imamura S: Role of oxygen intermediates in UV-induced epidermal cell injury. J Invest Dermatol 83:166-168, 1984
19. Di Marco E, Marchisio PC, Bondanza S, Franzi AT, Cancedda R, De Luca M: Growth-regulated synthesis and secretion of biologically active nerve growth factor by human keratinocytes. J Biol Chem 266:21718-21722, 1991
20. Di Marco E, Mathor M, Bondanza S, Cutuli N, Marchisio PC, Cancedda R, De Luca M: Nerve growth factor binds to normal human keratinocytes through high and low affinity receptors and stimulates their growth by a novel autocrine loop. J Biol Chem 268:22838-22846, 1993
21. Fautini F, Magnoni C, Bracci-Laudiero L, Pincelli C: Nerve growth factor is increased in psoriatic skin. J Invest Dermatol 105:854-855, 1995
22. Fesus LP, Davies JA, Piacentini M: Apoptosis: molecular mechanisms in programmed cells death. Eur J Cell Biol 56:170-177, 1991
23. Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501, 1992
24. Goldsmith LA: Toads and Psoriasis. Arch Dermatol 122:939-940, 1986
25. Grubauer G, Romani N, Kofler H, Stanzl U, Fritsch P, Hintner H: Apoptotic keratin bodies as antoantigens causing the production of IgM-anti-keratin intermediate filament autoantibodies. J Invest Dermatol 87:466-471, 1986
26. Haake AR, Polakowska RR: Cell death by apoptosis in epidermal cell biology. J Invest Dermatol 101:107-112, 1993
27. Haake AR, Polakowska RR: UV-induced apoptosis in skin equivalents: inhibition by phorbol ester and Bcl-2 overexpression. Cell Death Differentiation 2:183-193, 1995
28. Hockenbery DM: Defining apoptosis. Am J Pathology 146:16-19, 1995
29. Hockenbery DM, Nunez G, Milliman C, Schreiber RD, Korsemeyer SJ: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-331, 1990
30. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsemeyer SJ: BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 88:6961-6965, 1991
31. Hockenbery DM, Oltvai ZN, Yin XM, Millman CL, Korsemeyer SJ: Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75:241-251, 1993
32. Johnson D, Lanahan A, Randy Buck C, et al: Expression and structure of the human NGF receptor. Cell 47:545-554, 1986
33. Kane DJ, Sarafin TA, Auton S, et al: Bcl-2 inhibition of neural cell death: decreased generation of reactive oxygen speceis. Science 262:1274-1276, 1993
34. Kannan Y, Usami K, Okada M, Shimizu S, Matsuda H: Nerve growth factor suppresses apoptosis of murine neutrophils. Biochem Biophys Res Commun 186:1050-1056, 1992
35. Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF: The TRK protooncogene product: a signal transducing receptor for nerve growth factor. Science 252:554-558, 1991a
36. Kaplan DR, Martin-Zanca D, Parada LF: Tyrosine phsphorylation and tyrosine kinase activity of the TRK protooncogene product induced by NGF. Nature 350:158-160, 1991b
37. Kase H, Iwahashi K, Nakanishi S, et al: K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem Biophys Res Commun 142:436-440, 1987
38. Kerr JFR, Wyllie AH, Currie AR: Apoptosis: a basie biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer 26:239-257, 1972
39. Koizumi SM, Contreras L, Matsuda Y, Hama T, Lazarovici P, Guroff G: K-252: a specific inhibitor of the action of nerve growth factor on PC12 cells. J Neurosci 8:715-721, 1988
40. Kyprianou NJ, Isaacs T: Avtivation of programmed cell death in the rat ventral prostate after castration. Endocrinology 122:552-562, 1988
41. Levi-Montalcini R: The nerve growth factor 35 years later. Science 237:1154-1162, 1987
42. Marthinuss J, Lawrence L, Seuberg M: Apoptosis in Pam212, an epidermal keratinocyte cell line: a possible role for bcl-2 in epidermal differentiation. Cell Growth Differentiation 6:239-250, 1995
43. Martin DP, Johnson EM: Programmed cell death in the peripheral nervous system. In: Tomei LD, Cope FO (eds.). Apoptosis: The Molecular Basis of Cell Death. Cold Spring Harbor Laboratory Press, New York., pp 247-262, 1991
44. McCall CA, Cohen JJ: Programmed cell death in terminally differentiating keratinocytes: role of endogenous endonuclease. J Invest Dermatol 97:111-114, 1991
45. Nanney LB, Magid M, Stoscheck CM, King LE: Comparison of epidermal growth factor binding and recptor distribution in normal human epidermis and epidermal appendages. J Invest Dermatol 83:385-393, 1984
46. Norris DA, Duke R, Whang K, Middleton M: Immunologic cytotoxicity in alopecia areata: apoptosis of dermal papilla cells in alopecia areata. J Invest Dermatol 104:8S-9S, 1995
47. Nunez G, London L, Hockenbery DM, Alexander M, McKearn JP, Korsemeyer SJ: Deregulated bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J Immunol 144:3602-3610, 1990
48. Oppenheim RW, Prevette D, Tytell M, Homma S: Naturally occuring and induced neuronal death in the chick embryo in vitro requires protein and RNA synthesis: evidence for the role of cell death genes. Dev Biol 138:104-113, 1990
49. Pincelli C, Sevignani C, Manfredini R, et al: Expression and function of nerve growth factor and nerve growth factor receptor on cultured keratinocytes. J Invest Dermatol 103:13-18, 1994
50. Polakowska RR, Haake AR: Apoptosis: the skin from a new perspective. Cell Death Differentiation 1:19-31, 1994
51. Polakowska RR, Piacentini M, Bartlett R, Goldsmith LA, Haake AR: Apoptosis in human skin development: morphogenesis, periderm, and human stem cells. Dev Dynamics 199:176-188, 1994
52. Punnonen K, Autio P, Kistala U, Ahotupa M: In-vivo effects of solat-simulated ultraviolet irradiation on antioxidant enzymes and lipid peroxidation in human epidermis. Br J Dermatol 125:18-20, 1991
53. Raff MC: Social controls on cell survival and cell death Nature 356:397-400, 1992
54. Read J, Watt F: A model for in vitro studies of epidermal homeostasis: proliferation and involucrin synthesis by cultured human keratinocytes during recovery after stripping of the suprabasal layers. J Invest Dermatol 90:739-743, 1988
55. Reed JC: Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1-6, 1994
56. Rubin LL, Philpott KL, Brooks SF: File cell cycle and cell death. Curr Biol 3:391-394, 1993
57. Schwartz LM, Osborne BA: Programmed cell death, apoptosis and killer genes. Immunology Today 14:582-590, 1993
58. Torcia M, Bracci-Laudiero L, Lucibelo M, et al: Nerve growth factor is an autocrine survival factor for memory B lymphocytes. Cell 85:345-356, 1996
59. Ucker DS: Death by suicide: one way to go in mammalian cellular development? N Biol 3:103-109, 1991
60. Ulrich A, Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212, 1990
61. Weedon D: Apoptosis. Adv Dermatol 5:243-256, 1990
62. Weedon D, Strutton G: Subtle clues to diagnosis by: The recognition of early stages catagen. Am J Dermatopathol 6:553-555, 1984
63. Weinstein GD, McCullough JL, Ross P: Cell proliferation in normal epidermis. J Invest Dermatol 82:623-628, 1984
64. Wyllie AH: Apoptosis. Br J Cancer 67:205-208, 1993
65. Yaar M, Grossman K, Eller M, Gilchrest BA: Evidence for nerve growth factor-mediated paracrine effects in human epidermis. J Cell Biol 115:821-828, 1991
66. Yee NS, Pack I, Besmer P: Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity of White Spotting and Steel mutant mice. J Exp Med 179:1777-1787, 1994
67. Young AR: The sunburn cell. Photodermatology 4:127-134, 1987
68. Zhai S, Yaar M, Doyle SM, Gilchrest BA: Nerve growth factor rescues pigment cells from ultraviolet-induced apoptosis by upregulating BCL-2 levels. Exp Cell Res 224:335-343, 1996