Eukaryotic gene transfer with liposomes: Effect of differences in lipid structure

Biotechnology Annual Review

Volumn 5, Issue , 2000, Pages 197-220

  Katsel, Pavel L ^a,b   Greenstein, Robert J ^a  

^a NEW YORK UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Acyl chains; Adenoassociated viral vectors; Amino headgroup; Amphiphiles; Calcium phosphate; Cellular membrane; Cholesterol; Counterions; Cytotoxicity; Detergents; Diacyl glycerol; Disulfide bond; DNA; Electroporation; Endocytosis; Gene therapy; Gene transfer

Indexed keywords

AMPHOPHILE; CATION; CHOLESTEROL DERIVATIVE; DIACYLGLYCEROL; DNA; FUNCTIONAL GROUP; LIPID; LIPOSOME; PHOSPHOLIPID;

CELL MEMBRANE; CHEMICAL STRUCTURE; CYTOPLASM; ENDOSOME; EUKARYOTIC CELL; GENE THERAPY; GENE TRANSFER; LIPID BILAYER; REVIEW; ANIMAL; CHEMISTRY; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION;

EUKARYOTA;

ANIMALS; CATIONS; DNA; GENE TRANSFER TECHNIQUES; HUMANS; LIPIDS; LIPOSOMES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033656468     PISSN: 13872656     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1387-2656(00)05036-5     Document Type: Article

References (140)

1. Kaplitt MG, Pfaus JG, Kleopoulos SP, Hanlon BA, Rabkin SD and Pfaff DW. Expression of a functional foreign gene in vivo transfer via a herpes simplex virus type 1 defective viral vector. Molec Cell Neurosci 1991;2:320-330.
2. Yu DC, Wang AL, Wu CH, Wang CC. Virus-mediated expression of firefly luciferase in the parasitic protozoan Giardia lamblia. Molec Cell Biol 1995;15:4867-4872.
3. Felgner PL, Gadek TR, Holm M, et al. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 1987;84:7413-7417.
4. Curiel DT, Agarwal S, Wagner E, Gotten M. Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proc Natl Acad Sci USA 1991;88:8850-8854.
5. Yang N-S, Burkholder J, Roberts B, Martinell B, McCabe D. In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc Natl Acad Sci USA 1990;87:9568-9572.
6. Wigler M, Silverstein S, Lee L-S, Pellicer A, Cheng Y-C, Axel R. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell 1977;11:223-232.
7. Ishikawa Y, Homey CJ. High efficiency gene transfer into mammalian cells by a double transfection protocol. Nuc Acids Res 1992;20:4367.
8. Whalen RG. Promoters, enhancers, and inducible elements for gene therapy. In: Wolff JA (ed) Gene Therapeutics. Boston: Birkhauser, 1994;60-79.
9. Brewer G. Post-transcriptional considerations of gene expression: translation, mRNA stability, and poly (A) processing. In: Wolff JA (ed) Gene Therapeutics. Boston: Birkhauser, 1994;40-59.
10. Leonetti J-P, Mechti N, Degols G, Gagnor C, Lebleu B. Intracellular distribution of microinjected antisense oligonucleotides. Proc Natl Acad Sci USA 1991;88:2702-2706.
11. Capecchi MR. High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. Cell 1980;22:479-485.
12. Friend DS, Papahadjopoulos D, Debs RJ. Endocytosis and intracellular processing accompanying transfection mediated by cationic liposomes. Biochim Biophys Acta 1996;1278:41-50.
13. Russell DW, Hirata RK. Human gene targeting by viral vectors [see comments]. Nat Genet 1998;18:325-330.
14. Rolls M-P, Delteil C, Golzio M, Dumond P, Cros S, Teissie J. In vivo electrically mediated protein and gene transfer in murine melanoma. Nature Biotechnol 1998;16:168-171.
15. Yang JP, Huang L. Direct gene transfer to mouse melanoma by intratumor injection of free DNA. Gene Ther 1996;3:542-548.
16. Pinkert CA, Irwin MH, Johnson LW, Moffatt RJ. Mitochondria transfer into mouse ova by microinjection. Transgenic Res 1997;6:379-383.
17. Morgan JE, Partridge TA. Cell transplantation and gene therapy in muscular dystrophy. Bioessays 1992;14:641-645.
18. Culver KW, Ram Z, Wallbridge S, Ishii H, Oldfield EH, Blaese RM. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors [see comments]. Science 1992;256:1550-1552.
19. Shubeita HE, Thorburn J, Chien KR. Microinjection of antibodies and expression vectors into living myocardial cells. Development of a novel approach to identify candidate genes that regulate cardiac growth and hypertrophy. Circulation. 1992;85:2236-2246.
20. Paquereau L, Cam AL. Electroporation-mediated gene transfer into hepatocytes: preservation of growth hormone response. Anal Biochem 1992;204:147-151.
21. Sukharev SI, Titomirov AV, Klenchin V. Electrically induced DNA transfer into cells, electrotransfection in vivo. In: Wolff JA (ed) Gene Therapeutics, Boston: Birkhauser, 1994;210-232.
22. Reeves R, Gorman CM, Howard B. Minichromosome assembly of nonintegrated plasmid DNA transfected into mammalian cells. Nucleic Acids Res 1985;13:3599-3615.
23. Findeis MA, Wu CH, Wu GY. Ligand-based carrier systems for delivery of DNA to hepatocytes. Methods Enzymol 1994;247:341-351.
24. Stankovics J, Crane AM, Andrews E, Wu CH, Wu GY, Ledley FD. Overexpression of human methylmalonyl CoA mutase in mice after in vivo gene transfer with asialoglycoprotein/polylysine/DNA complexes. Hum Gene Ther 1994;5:1095-1104.
25. Wu GY, Zhan P, Sze LL, Rosenberg AR, Wu CH. Incorporation of adenovirus into a ligand-based DNA carrier system results in retention of original receptor specificity and enhances targeted gene expression. J Biol Chem 1994;269:11542-11546.
26. Wu CH, Wilson JM, Wu GY. Targeting genes: delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo. J Biol Chem 1989;264:16985-16987.
27. Ferkol T, Perales JC, Mularo F, Hanson RW. Receptor-mediated gene transfer into macrophages. Proc Natl Acad Sci USA 1996;93:101-105.
28. Kawai S, Nishizawa M. New procedure for DNA transfection with polication and dimethyl sulphoxide. Mol Cell Biol 1984;4:1172-1174.
29. Goldman CK, Soroceanu L, Smith N, et al. In vitro and in vivo gene delivery mediated by a synthetic polycationic amino polymer. Nature Biotechnol 1997;15:462-466.
30. Thierry AR, Rabinovich P, Peng B, Mahan LC, Bryant JL, Gallo RC. Characterization of liposome-mediated gene delivery: expression, stability and pharmacokinetics of plasmid DNA. Gene Ther 1997;4:226-237.
31. Jiang C-K, Connolly D, Blumenberg M. Comparison of methods for transfection of human epidermal keratinocytes. J Invest Dermatol 1991;97:969-973.
32. Dong Y, Skoultchi AI, Pollard JW. Efficient DNA transfection of quiescent mammalian cells using poly L-ornithine. Nuc Acids Res 1993;21:771-772.
33. Ruysschaert JM, el Ouahabi A, Willeaume V, et al. A novel cationic amphiphile for transfection of mammalian cells. Biochem Biophys Res Commun 1994;203:1622-1628.
34. Haensler J, Szoka FC. Cells in culture. Bioconjugate Chem. 1993;4:372-379.
35. Truong-Le VL, Mao H-Q, Walsh S, Leong KW August JT. Delivery of DNA vaccine using gelatine-DNA nanospheres. Proceed Intl Symp Control Rel Bioact Mater 1997;24:39-40 (Abstract).
36. Mathiowitz E, Jacob JS, Jong YS, et al. Biologically erodable microspheres as potential oral drug delivery systems. Nature 1997;386:410-414.
37. Nabel GJ, Nabel EG, Yang ZY, et al. Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc Natl Acad Sci USA 1993;90:11307-11311.
38. Felgner PL, Holm M. Cationic liposome-mediated transfection. FOCUS 1989;11:21-24.
39. Sorscher EJ, Logan JJ, Frizzell RA, et al. Gene therapy for cystic fibrosis using cationic liposome mediated gene transfer: a phase I trial of safety and efficacy in the nasal airway. Hum Gene Ther 1994;5:1259-1277.
40. Gao X, Huang L. Cationic liposome-mediated gene transfer. Gene Ther 1995;2:710-722
41. Malone RW, Felgner PL, Verma IM. Cationic liposome-mediated RNA transfection. Proc Natl Acad Sci USA 1989;86:6077-6081.
42. Caplen NJ, Alton EW, Middleton PG, et al. Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis [see comments] [published erratum appears in Nat Med 1995 Mar;1(3):272]. Nat Med 1995;1:39-46.
43. Singhal A, Huang L. Gene transfer in mammalian cells using liposomes as carriers. In: Wolff JA. Gene Therapeutics, Boston: Birkhauser, 1994;118-142.
44. Porteous DJ, Dorin JR, McLachlan G, et al. Evidence for safety and efficacy of DOTAP cationic liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Gene Ther 1997;4:210-218.
45. Samulski RF. Targeted integration of adeno-associated virus (AAV) into human chromosome 19. EMBO J 1991;10:3941-3950.
46. Tolstoshev P. Gene therapy, concepts, current trials and future directions. Annu Rev Pharmacol Toxicol 1993;33:573-596.
47. Siegfried W Perspectives in gene therapy with recombinant adenoviruses. Exp Clin Endocrinol 1993;101:7-11.
48. Flotte TR. Prospects for virus-based gene therapy for cystic fibrosis. J Bioenerg Biomembr 1993;25:37-42.
49. Bramson JL, Graham FL, Gauldie J. The use of adenoviral vectors for gene therapy and gene transfer in vivo. Curr Opin Biotechnol 1995;6:590-595.
50. Mittal SK, Bett AJ, Prevec L, Graham FL. Foreign gene expression by human adenovirus type 5-based vectors studied using firefly luciferase and bacterial beta-galactosidase genes as reporters. Virology 1995;210:226-230.
51. Cohen J. New role for HIV: a vehicle for moving genes into cells [news; comment]. Science 1996;272:195.
52. Yang Y, Nunes F, Berenczi K, Furth E, Gonczol E, Wilson J. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 1994;91:4407-4411.
53. Dietrich G, Bubert A, Gentschev I, et al. Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide Listeria monocytogenes [see comments]. Nature Biotechnol 1998;16:181-185.
54. Finlay BB, Cossart P. Exploitation of mammalian host cell functions by bacterial pathogens [published erratum appears in Science 1997 Oct 17;278(5337):373]. Science 1997;276:718-725.
55. Rasty S, Thatikunta P, Gordon J, Khalili K, Amini S, Glorioso JC Human immunodeficiency virus tat gene transfer to the murine central nervous system using a replication-defective herpes simplex virus vector stimulates transforming growth factor beta 1 gene expression. Proc Natl Acad Sci USA 1996;93:6073-6078.
56. Wu P, de Fiebre CM, Millard WJ, et al. An AAV promoter-driven neuropeptide Y gene delivery system using Sendai virosomes for neurons and rat brain. Gene Ther 1996;3:246-253.
57. Naldini L, Blomer U, Gallay P, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector [see comments]. Science 1996;272:263-267.
58. Teramoto S, Johnson LG, Huang W, Leigh MW, Boucher RC. Effect of adenoviral vector infection on cell proliferation in cultured primary human airway epithelial cells. Hum Gene Ther 1995;6:1045-1053.
59. Bangham AD, Standish MM, Watkins JC. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol 1965;13:238-252.
60. Fortunati E, Bout A, Zanta MA, Valerio D, Scarpa M. In vitro and in vivo gene transfer to pulmonary cells mediated by cationic liposomes. Biochim Biophys Acta 1996;1306:55-62.
61. McLachlan G, Davidson DJ, Stevenson BJ, et al. Evaluation in vitro and in vivo of cationic liposome-expression construct complexes for cystic fibrosis gene therapy Gene Ther 1995;2:614-622.
62. Logan JJ, Bebok Z, Walker LC, et al. Cationic lipids for reporter gene and CFTR transfer to rat pulmonary epithelium. Gene Ther 1995;2:38-49.
63. Nabel GJ, Yang ZY, Nabel EG, et al. Direct gene transfer for treatment of human cancer. Ann NY Acad Sci 1995;772:227-231.
64. Hui KM, Ang PT, Huang L, Tay SK. Phase I study of immunotherapy of cutaneous metastases of human carcinoma using allogeneic and xenogeneic MHC DNA-liposome complexes. Gene Ther 1997;4:783-790.
65. Hortobagyi GN, Kilbourn R, Weiden P. A phase I multi-center study of E1A gene therapy for patients with epithelial ovarian cancer. Oregon Bioscience Online 1998;(Abstract).
66. Rubin J, Galanis E, Pilot HC, et al. Phase I study of immunotherapy of hepatic metastases of colorectal carcinoma by direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7. Gene Ther 1997;4:419-425.
67. Oudrhiri N, Vigneron JP, Peuchmaur M, Leclerc T, Lehn JM, Lehn P. Gene transfer by guanidinium-cholesterol cationic lipids into airway epithelial cells in vitro and in vivo. Proc Natl Acad Sci USA 1997;94:1651-1656.
68. Chadwick SL, Kingston HD, Stern M, et al. Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG5000 formulation to the lungs of normal volunteers. Gene Ther 1997;4:937-942.
69. Vance DE, Vance JE. Biochemistry of lipids, lipoproteins and membranes. Vance DE, Vance JE (eds) New York: Elsevier, 1991.
70. Torchilin VP, Lukyanov AN, Klibanov AL, Omelyanenko VG. Interaction between oleic acid-containing pH-sensitive and plain liposomes. Fluorescent spectroscopy studies. FEBS Lett 1992;305:185-188.
71. Leventis R, Silvius JR. Interaction of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles. Biochem Biophys Acta 1990;1023:124-132.
72. Timofeev BA, Bolotin IM, Stepanova LP, et al. Liposomal diamidine (imidocarb): preparation and animal studies. J Microencapsul. 1994;11:627-632.
73. Legendre J-Y, Szoka FC. Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: Comparison with cationic liposomes. Pharm Res 1992;9:1235-1242.
74. Felgner PL, Ringold GM. Cationic liposome-mediated transfection. Nature 1989;337:387-388.
75. Radler JO, Koltover I, Salditt T, Safinya CR. Structure of DNA-cationic liposome complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes [see comments]. Science 1997;275:810-814.
76. Wasan EK, Fairchild A, Bally MB. Cationic liposome-plasmid DNA complexes used for gene transfer retain a significant trapped volume. J Pharm Sci 1998;87:9-14.
77. Sternberg B, Sorgi FL, Huang L. New structures in complex formation between DNA and cationic liposomes visualized by freeze-fracture electron microscopy. FEBS Lett. 1994;356:361-366.
78. Duzgunes N, Goldstein JA, Friend DS, Felgner PL. Fusion of liposomes containing a novel cationic lipid, N-[2,3-(dioleyloxy)propyl]-N,N,N- trimethylammonium: induction by multivalent anions and asymmetric fusion with acidic phospholipid vesicles. Biochemistry 1989;28:9179-9184.
79. Debs RJ, Freedman LP, Edmunds S, Gaensler KL, Duzgunes N, Yamamoto KR. Regulation of gene expression in vivo by liposome-mediated delivery of purified transition factor. J Biol Chem 1990;265:10189-10192.
80. Felgner JH, Kumar R, Sridhar CN, et al. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J Biol Chem 1994;269:2550-2561.
81. San H, Yang ZY, Pompili VJ, et al. Safety and short-term toxicity of a novel cationic lipid formulation for human gene therapy. Hum Gene Ther 1993;4:781-788.
82. Wheeler CJ, Felgner PL, Tsai YJ, et al. A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung. Proc Natl Acad Sci USA 1996;93:11454-11459.
83. Tang F, Hughes JA. Introduction of a disulfide bond into a cationic lipid enhances transgene expression of plasmid DNA. Biochem Biophys Res Commun 1998;242:141-145.
84. Litzinger DC, Huang L. Phosphatidylethanolamine liposomes: drug delivery, gene transfer and immunodiagnostic applications. Biochim Biophys Acta 1992;1113:201-227.
85. Litzinger DC, Huang L. Biodistribution and immunotargetability of ganglioside-stabilized dioleoylphosphatidylethanolamine liposomes. Biochim Biophys Acta 1992;1104:179-187.
86. Farhood H, Serbina N, Huang L. The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer. Biochim Biophys Acta 1995;1235:289-295.
87. Katsel PL, O'Connell B, Mizuno T , Mobbs CV, Greenstein RJ. Liposome mediated gene transfer into GH3 cells, and rat brain, liver and gut: Comparison of different polar or aliphatic domains. Int J Surgical Invest 1999 (in press).
88. Gao X, Huang L. A novel cationic liposome reagent for effective transfection of mammalian cells. Biochem Biophys Res Commun 1991;179:280-285.
89. Bennett MJ, Nantz MH, Balasubramaniam RP, Gruenert DC, Malone RW. Cholesterol enhances cationic liposome-mediated DNA transfection of human respiratory epithelial cells. Biosci Rep 1995;15:47-53.
90. Liu Y, Mounkes LC, Liggitt HD, et al. Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery. Nature Biotechnol 1997;15:167-173.
91. Zhou MY, Lo SK, Bergenfeldt M, et al. In vivo expression of neutrophil inhibitory factor via gene transfer prevents lipopolysaccharide-induced lung neutrophil infiltration and injury by a beta2 integrin-dependent mechanism. J Clin Invest 1998;101:2427-2437.
92. Takeuchi K, Ishihara M, Kawaura C, Noji M, Furuno T, Nakanishi M. Effect of zeta potential of cationic liposomes containing cationic cholesterol derivatives on gene transfection. FEBS Lett 1996;397:207-209.
93. Farhood H, Bottega R, Epand RM, Huang L. Effect of cationic cholesterol derivatives on gene transfer and protein kinase C activity. Biochim Biophys Acta 1992;1111:239-246.
94. Hara T, Tan Y, Huang L. In vivo gene delivery to the liver using reconstructed chylomicron remnants as a novel nonviral vector. Proc Natl Acad Sci USA 1997;94:14547-14552.
95. Zhou X, Huang L. Targeted delivery of DNA by liposomes and polymers. J Controlled Release 1992;19:269-274.
96. Pinnaduwage P, Schmitt L, Huang L. Use a quaternary ammonium detergent in liposome mediated DNA transfection of mouse L-cells. Biochem Biophys Acta 1989;985:33-37.
97. Philip R, Liggitt D, Philip M, Dazin P, Debs R. In vivo gene delivery. J Biol Chem 1993;268:16087-16090.
98. Aberle AM, Bennett MJ, Malone RW, and Nantz MH. The counterion influence on cationic lipid-mediated transfection of plasmid DNA. Biochim Biophys Acta 1996;1299:281-283.
99. Lichtenberg D, Robson RJ, Dennis EA. Solubilization of phospholipids by detergents. Structural and kinetic aspects. Biochim Biophys Acta 1983;737:285-304.
100. Hsieh C-H, Sue S-C, Lyu P-C, Wu W-G. Membrane packing geometry of diphytanoylphosphatidylcholine is highly sensitive to hydration: Phospholipid polymorphism induced by molecular rearrangement in the headgroup region. Biophys J 1997;73:870-877.
101. Heller WT, He K, Ludtke SJ, Harroun TA, Huang HW. Effect of changing the size of lipid head-group on peptide insertion into membranes. Biophys J 1997;73:239-244.
102. Trail PA, Willner D, Knipe J, et al. Effect of linker variation on the stability, potency, and efficacy of carcinoma-reactive BR64-doxorubicin immunoconjugates. Cancer Res 1997;57:100-105.
103. Williams WP, Quinn PJ, Tsonev LI, Koynova RD. The effects of glycerol on the phase behaviour of hydrated distearoylphosphatidylethanolamine and its possible relation to the mode of action of cryoprotectants. Biochim Biophys Acta 1991;1062:123-132.
104. Cacace MG, Landau EM, Ramsden JJ. The Hofmeister series: salt and solvent effects on interfacial phenomena. Q Rev Biophys 1997;30:241-277.
105. Epand RM, Bryszewska M. Modulation of the bilayer to hexagonal phase transition and solvation of phosphatidylethanolamines in aqueous salt solutions. Biochemistry 1988;27:8776-8779.
106. Lichtenberg D, Felgner PL, Thompson TE. Transition of a liquid crystalline phosphatidylcholine bilayer to the gel phase in a vesicle reduces the internal aqueous volume. Biochim Biophys Acta 1982;684:277-281.
107. Landau EM, Rosenbusch JP. Lipidic cubic phases: a novel concept for the crystallization of membrane proteins. Proc Natl Acad Sci USA 1996;93:14532-14535.
108. Silvius J. Lipid-protein interactions. New York: John Wiley and Sons, 1982.
109. Silvius JR, del Giudice D, Lafleur M. Cholesterol at different bilayer concentrations can promote or antagonize lateral segregation of phospholipids of differing acyl chain length. Biochemistry 1996;35:15198-15208.
110. Wang J, Guo X, Xu Y, Barron L, Szoka FC, Jr. Synthesis and characterization of long chain alkyl acyl carnitine esters. Potentially biodegradable cationic lipids for use in gene delivery. J Med Chem 1998;41:2207-2215.
111. Templeton NS, Lasic DD, Frederik PM, Strey HH, Roberts DD, Pavlakis GN. Improved DNA: liposome complexes for increased systemic delivery and gene expression. Nat Biotechnol 1997;15:647-652.
112. Stegmann T, Legendre JY. Gene transfer mediated by cationic lipids: lack of a correlation between lipid mixing and transfection. Biochim Biophys Acta 1997;1325:71 79.
113. Lasic DD, Ceh B, Stuart MC, Guo L, Frederik PM, Barenholz Y. Transmembrane gradient driven phase transitions within vesicles: lessons for drug delivery. Biochim. Biophys Acta 1995;1239:145-156.
114. Lasic DD. Colloid chemistry. Liposomes within liposomes [news; comment]. Nature 1997;387:26-27.
115. Bogdanov M, Sun J, Kaback HR, Dowhan W. A phospholipid acts as a chaperone in assembly of a membrane transport protein. J Biol Chem 1996;271:11615-11618.
116. Bogdanov M, Dowhan W. Phosphatidylethanolamine is required for in vivo function of the membrane-associated lactose permease of Escherichia coli. J Biol Chem 1995;270:732-739.
117. Pebay-Peyroula E, Rummel G, Rosenbusch, JP, Landau EM. X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases [see comments]. Science 1997;277:1676-1681.
118. Yih-Fu Shiau. Lipid digestion and absorbtion. In: Johnson LR (ed) Physiology of gastrointestinal tract, New York: Raven Press, 1987;1527-1534.
119. Needham D, McIntosh TJ, Evans E. Thermomechanical and transition properties of dimyristoyl-phosphatidylcholine/cholesterol bilayers. Biochemistry 1988;27:4668-4673.
120. Lyte M, Shinitzky M. Cholestryl-phosphoryl-choline in lipid bilayers. Chem Phys Lipids 1979;24:45-55.
121. Bloch K. Sterol molecule: structure, biosynthesis, and function. Steroids. 1992;57:378-383.
122. Zuidam NJ, Barenholz Y. Electrostatic parameters of cationic liposomes commonly used for gene delivery as determined by 4-heptadecyl-7-hydroxycoumarin. Biochim Biophys Acta 1997;1329:211-222.
123. Kawaura C, Noguchi A, Furuno T, Nakanishi M. Atomic force microscopy for studying gene transfection mediated by cationic liposomes with a cationic cholesterol derivative. FEBS Lett 1998;421:69-72.
124. Trubetskoy VS, Torchilin VP, Kennel S, Huang L. Cationic liposomes enhance targeted delivery and expression of exogenous DNA mediated by N-terminal modified poly L-lysine-antibody conjugate in mouse lung endothelial cells. Biochem Biophys Acta 1992;1131:311-313.
125. Heath TD. Covalent attachment of proteins to liposomes. Methods Enzymol 1998;149:111-119.
126. Geisert EE, Jr, Del Mar NA, Owens JL, Holmberg EG. Transfecting neurons and glia in the rat using pH-sensitive immunoliposomes. Neurosci Lett 1995;184:40-43.
127. Maruyama K, Kennel SJ, Huang L. Lipid composition is important for highly efficient target binding and retention of immunoliposomes. Proc Natl Acad Sci USA 1990;87:5744-5748.
128. Stavridis JC, Deliconstantinos G, Psallidopoulos MC, Armenakas NA, Hadjiminas DJ, Hadjiminas J. Construction of transferrin-coated liposomes for in vivo transport of exogenous DNA to bone marrow erythroblasts in rabbits. Exp Cell Res 1986;164:568-572.
129. Li XK, Okuyama T, Tamura A, et al. Prolonged survival of recipient rats with Fas-ligand-transfected liver allografts by using HVJ-liposome. Transplant Proc 1998;30:943.
130. Abe A, Miyanohara A, Friedmann T. Enhanced gene transfer with fusogenic liposomes containing vesicular stomatitis virus G glycoprotein. J Virol 1998;72:6159-6163.
131. Mizuno M, Yoshida J. Improvement of transduction efficiency of recombinant adeno-associated virus vector by entrapment in multilamellar liposomes. Jpn J Cancer Res 1998;89:352-354.
132. Wang C-Y, Huang L. Highly efficient DNA delivery mediated by pH-sensitive immunoliposomes. Biochemistry 1989;28:9508-9514.
133. Sorgi FL, Bhattacharya S, Huang L. Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther 1997;4:961-968.
134. Coonrod A, Li FQ, Horwitz M. On the mechanism of DNA transfection: efficient gene transfer without viruses. Gene Ther 1997;4:1313-1321.
135. el Ouahabi A, Thiry M, Pector V, Fuks R, Ruysschaert JM, Vandenbranden M. The role of endosome destabilizing activity in the gene transfer process mediated by cationic lipids. FEBS Lett 1997;414:187-192.
136. Rosenkranz AA, Yachmenev SV, Jans DA, et al. Receptor-mediated endocytosis and nuclear transport of a transfecting DNA construct. Exp Cell Res 1992;199:323-329.
137. Pinnaduwage P, Schmitt L, Huang L. Use of a quaternary ammonium detergent in liposome mediated DNA transfection of mouse L-cells. Biochim Biophys Acta 1989;985:33-37.
138. Brinster RL, Braun RE, Lo D, Avarbock MR, Oram F, Palmiter RD. Targeted correction of a major histocompatibility class II E alpha gene by DNA microinjected into mouse eggs. Proc Natl Acad Sci USA 1989;86:7087-7091.
139. Mirzayans R, Aubin RA and Paterson MC. Differential expression and stability of foreign genes introduced into human fibroblasts by nuclear vs. cytoplasmic microinjection. Mutat Res 1992;281:115-122.
140. Dowty ME, Williams P, Zhang G, Hagstrom JE, Wolff JA. Plasmid DNA entry into postmitotic nuclei of primary rat myotubes. Proc Natl Acad Sci USA 1995;92:4572-4576.