Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG5000 formulation to the lungs of normal volunteers

Gene Therapy

Volumn 4, Issue 9, 1997, Pages 937-942

  Chadwick, S L ^a   Kingston, H D ^b   Stern, M ^a   Cook, R M ^b   O'Connor, B J ^b   Lukasson, M ^c   Balfour, R P ^c   Rosenberg, M ^c   Cheng, S H ^c   Smith, A E ^c   Meeker, D P ^c   Geddes, D M ^a   Alton, E W F W ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b ROYAL BROMPTON HOSPITAL   (United Kingdom)

^c GENZYME CORPORATION   (United States)

Author keywords

Cationic liposome; Clinical trial; Cystic fibrosis; Gene therapy

Indexed keywords

DIOLEOYLPHOSPHATIDYLETHANOLAMINE; GLYCEROPHOSPHOLIPID; LIPOSOME; MACROGOL DERIVATIVE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

AEROSOL; ARTICLE; BLOOD ANALYSIS; CELL SUBPOPULATION; CLINICAL EXAMINATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG SAFETY; EOSINOPHIL; FEMALE; GENE THERAPY; HUMAN; LUNG FUNCTION; LUNG GAS EXCHANGE; LYMPHOCYTE; MACROPHAGE; MALE; NEBULIZATION; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; SEROLOGY; SPIROMETRY; SPUTUM ANALYSIS; THORAX RADIOGRAPHY;

EID: 9844237019     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300481     Document Type: Article

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