Are altered pH(i) and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance?

Journal of General Physiology

Volumn 108, Issue 4, 1996, Pages 295-313

  Hoffman, Mary M ^b   Wei, Li Yong ^b   Roepe, Paul D ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b NONE

Author keywords

altered partitioning; intracellular pH; multidrug resistance; P glycoprotein

Indexed keywords

GLYCOPROTEIN P; ANTINEOPLASTIC AGENT; BICARBONATE; HYDROGEN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE POTENTIAL; CELL PH; MULTIDRUG RESISTANCE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN STABILITY; ANIMAL; CHO CELL; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HAMSTER; HUMAN; METABOLISM; PH; PHYSIOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS; BICARBONATES; CHO CELLS; CRICETINAE; DRUG RESISTANCE, MULTIPLE; HUMANS; HYDROGEN; HYDROGEN-ION CONCENTRATION; MEMBRANE POTENTIALS; P-GLYCOPROTEIN; TRANSFECTION;

EID: 0029658663     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.108.4.295     Document Type: Article

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