Rescue of a Drosophila NF1 mutant phenotype by protein kinase A

Science

Volumn 276, Issue 5313, 1997, Pages 791-794

  The, Inge ^a   Hannigan, Gregory E ^b,d   Cowley, Glenn S ^a   Reginald, Shoba ^a   Zhong, Yi ^c   Gusella, James F ^b   Hariharan, Iswar K ^a   Bernards, André ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c Simons Center for Quantitative Biology   (United States)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RAS PROTEIN;

ALLELE; ARTICLE; CELL PROLIFERATION; DROSOPHILA; GENE MUTATION; NEUROFIBROMATOSIS; NONHUMAN; ONCOGENE RAS; PHENOTYPE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; ANIMALS; CELL COUNT; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DROSOPHILA; DROSOPHILA PROTEINS; GENES, INSECT; GTP PHOSPHOHYDROLASES; INSECT PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; NERVE TISSUE PROTEINS; NEUROFIBROMIN 1; PHENOTYPE; PROTEINS; RAS GTPASE-ACTIVATING PROTEINS; RAS PROTEINS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

EID: 0030996903     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.276.5313.791     Document Type: Article

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50. We thank T. Orr-Weaver and F. Shamanski for help with cytogenetic mapping; C. Ngwu for assistance with monoclonal antibody production; G. Bollag for GAP and human NF1 fusion proteins; S. Artavanis-Tsakonas, J. de Celis, S. Harrison, D. Kalderon, T. Laverty, G. Rubin, and G. Struhl for fly stocks; L. Zipursky for stocks and 96F DNA clones; and S. Brill, J. Settleman, and S. van den Heuvel for critical reading of the manuscript. Supported by a grant from the U.S. Army Medical Research and Materiel Command to I.K.H. and A.B., a grant from NF Inc. (Massachusetts Bay Chapter) to J.F.G., NIH grants to J.F.G. (NS22229), I.K.H. (NS36084), Y.Z. (NS34779), and A.B. (NS31747), and a postdoctoral fellowship from the Medical Research Council of Canada to G.E.H.