Concerted integration of linear retroviral DNA by the avian sarcoma virus integrase in vitro: Dependence on both lone terminal repeat termini

Journal of Virology

Volumn 70, Issue 6, 1996, Pages 3571-3580

  Aiyar, Ashok ^a,d   Hindmarsh, Patrick ^a   Skalka, Anna Marie ^b   Leis, Jonathan ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CURVED DNA; INTEGRASE;

AMINO ACID SEQUENCE; ARTICLE; AVIAN SARCOMA VIRUS; DNA FLANKING REGION; DNA INTEGRATION; DNA SUPERCOILING; GENE DELETION; IN VITRO STUDY; LONG TERMINAL REPEAT; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; RNA SEQUENCE; VIRUS DNA CELL DNA INTERACTION; VIRUS REPLICATION;

AVIAN SARCOMA VIRUSES; BASE SEQUENCE; CARRIER PROTEINS; DNA NUCLEOTIDYLTRANSFERASES; DNA, SUPERHELICAL; HIGH MOBILITY GROUP PROTEINS; HMGB1 PROTEIN; INTEGRASES; MOLECULAR SEQUENCE DATA; REPETITIVE SEQUENCES, NUCLEIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS INTEGRATION;

EID: 0029974222     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Aiyar, A., Z. Ge, and J. Leis. 1994. A specific orientation of RNA secondary structures is required for initiation of reverse transcription. J. Virol. 68:611-618.
2. 1a.Aiyar, A., and J. Leis. Unpublished data.
3. Braiterman, L. T., and J. D. Boeke. 1994. In vitro integration of retrotransposon Tyl: a direct physical assay. Mol. Cell. Biol. 14:5719-5730.
4. Brown, P., B. Bowerraan, H. Varmus, and J. M. Bishop. 1987. Correct integration of retroviral DNA in vitro. Cell 49:347-356.
5. Bushman, F. D., and R. Craigie. 1990. Sequence requirements for integration of Moloney murine leukemia virus DNA in vitro. J. Virol. 64:5645-5648.
6. Bushman, F. D., T. Fujiwara, and R. Craigie. 1990. Retroviral DNA integration directed by HIV integration protein in vitro. Science 249:1555-1558.
7. Cobrinik, D., A, Aiyar, Z. Ge, H. Huang, and J. Leis. 1991. Overlapping retroviral U5 sequence elements are required for efficient integration and initiation of reverse transcription. J. Virol. 65:3864-3872.
8. Chow, C., C. Barnes, and S. Lippard. 1995. A single HMG domain in high-mobility group I protein binds to DNAs as small as 20 base pairs containing the major cisplatin adduct. Biochemistry 34:2956-2964.
9. Coffin, J. M. 1990. Retroviridae and their replication, p. 1437-1500. In B. N. Fields, D. M. Knipe, R. M. Chanock, M. S. Hirsch, J. L. Melnick, T. P. Monath, iind B. Roizman (ed.). Virology, 2nd ed. Raven Press, Ltd., New York.
10. Colicelli, J., and S. Goff. 1985. Mutants and pseudorevertants of Moloney murine leukemia virus with alterations at the integration site. Cell 42:573-580.
11. Craigie, R., A.-T. Fujiwara, and F. Bushman. 1990. The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro. Cell 64:829-837.
12. Donzella, G. A., C. B. Jonsson, and M. J. Roth. 1993. Influence of substrate structure on disintegration activity of Moloney murine virus integrase. J. Viral. 67:7077-7087.
13. Engleman, A., K. Mizuuchi, and R. Craigie. 1991. HIV-1 DNA integration: mechanism of viral DNA cleavage and strand transfer. Cell 67:1211-1221.
14. Fitzgerald, M. L., and D. P. Grandgenett. 1994. Retroviral integration: in vitro host site selection hy avian integrase. J. Virol. 68:4314-4321.
15. Fitzgerald, M. L., A. C. Vora, W. G. Zeh, and D. P. Grandgenett. 1992. Concerted integration of viral DNA termini by purified avian myeloblastosis virus integrase. J. Virol. 66:6257-6263.
16. Fujiwara, T., and R. Craigie. 1989. Integration of mini-retroviral DNA: a cell free reaction for biochemical analysis of retroviral integration. Proc. Natl. Acad. Sci. USA 86:3056-3069.
17. Jones, K. S., J. Coleman, G. W. Merkel, T. M. Laue, and A. M. Skalka. 1992. Retroviral integrase functions as a multimer and can turn over catalytically. J. Biol. Chem. 267:16037-16040.
18. Katz, R., G. Merkel, J. Kulkosky, J. Leis, and A. Skalka. 1990. The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro. Cell 63:87-95.
19. Katzman, M., R. Katz, A. M. Skalka, and J. Leis. 1989. The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration. J. Virol. 63:5319-5327.
20. Kitamura, Y., Y. M. Lee, and J. M. Coffin. 1992. Nonrandom integration of retroviral DNA in vitro: effect of CpG methylation. Proc. Natl. Acad. Sci. USA 89:5532-5536.
21. Kukolj, G., and A. M. Skalka. 1995. Enhanced and coordinated processing of synapsed viral DNA ends by retroviral integrases in vitro. Genes Dev. 9:2556-2567.
22. Lewin, B. 1990. Genes IV. Oxford University Press, Oxford.
23. Murphy, J. E., T. de Los Santos, and S. P. Goff. 1993. Mutational analysis of the sequences at the termini of the Moloney murine leukemia virus DNA required for integration. Virology 195:432-440.
24. Murphy, J. E., and S. P. Goff. 1992. A mutation at one end of Moloney murine leukemia virus DNA blocks cleavage of both ends by the viral integrase in vivo. J. Virol. 66:5092-5095.
25. Pil, P. M., C. S. Chow, and S. J. Lippard. 1993. High-mobility-group I protein mediates DNA bending as determined hy ring closures. Proc. Natl. Acad. Sci. USA 90:9465-9469.
26. Roth, M. J., P. L. Schwartzberg, and S. P. Goff. 1990. Structure of the termini of DNA intermediates in the integration of retroviral DNA: dependence on IN function and terminal DNA sequence. Cell 58:47-54.
27. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual. 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
28. Shih, C. C., J. P. Sloye, and J. M. Coffin. 1988. Highly preferred targets for retroviral integration. Cell 53:531-537.
29. Skalka, A. M. 1993. Retroviral DNA integration: lessons for transposon shuffling. Gene 135:175-182.
30. Tang, Y., S. Cotterill, and C. P. Lichenstein. 1995. Genetic analysis of the terminal 8-bp inverted repeats of transposon Tn7. Gene 162:175-182.
31. Vora, A. C., M. McCord, M. L. Fitzgerald, R. B. Inman, and D. P. Grandgenett. 1994. Efficient concerted integration of retrovirus-like DNA in vitro by avian myeloblastosis virus integrase. Nucleic Acids Res. 224:4454-4461.