Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases

Journal of Medicinal Chemistry

Volumn 40, Issue 7, 1997, Pages 1130-1135

  Singh, Juswinder ^a   Dobrusin, Ellen M ^b   Fry, David W ^b   Haske, Taraneh ^b   Whitty, Adrian ^a   McNamara, Dennis J ^b  

^a BIOGEN   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' THIOADENOSINE; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; COVALENT BOND; DRUG CONFORMATION; DRUG DESIGN; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HYDROGEN BOND; MOLECULAR MODEL; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR CELLS, CULTURED;

EID: 0030893008     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960380s     Document Type: Article

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