Mechanisms of occupational asthma

Annals of Allergy, Asthma and Immunology

Volumn 83, Issue 6 II, 1999, Pages 645-664

  Mapp, Cristina ^b   Boschetto, Piera ^a   Miotto, Deborah ^b   De Rosa, Edoardo ^a   Fabbri, Leonardo M ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b Universita degli Studi di Ferrara ^*

Author keywords

[No Author keywords available]

Indexed keywords

ACID ANHYDRIDE; IMMUNOGLOBULIN E; PLATINUM DERIVATIVE;

EOSINOPHIL; FLOUR; GENETIC PREDISPOSITION; GRAIN DUST; HUMAN; MAST CELL; OCCUPATIONAL ASTHMA; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESPIRATORY TRACT MUCOSA; REVIEW;

EID: 0033391438     PISSN: 10811206     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1081-1206(10)62888-8     Document Type: Review

References (219)

1. Fabbri LM, Boschetto P, Caramori G, Mapp CE. Pathophysiology. In: Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI, eds. Asthma in the workplace. New York, Basel: Marcel Dekker Inc., 1999:81-109.
2. Mapp CE, Butcher BT, Fabbri LM. Polyisocyanates and their prepolymers. In: Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI, eds. Asthma in the workplace. New-York, Basel: Marcel Dekker, Inc., 1999:457-478.
3. Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI. Asthma in the workplace. New York, Basel: Marcel Dekker, Inc., 1999.
4. Wiggs B, Moreno R, James A, et al. A model of the mechanics of airway narrowing in asthma. In: Kaliner MA, Barnes PJ, Persson CGA, eds. Asthma: its pathology and treatment. New York: Marcel Dekker, 1991: 73-101.
5. Persson CGA. Microvascular-epithelial exudation of bulk plasma in airway defense, disease and repair. In: Holgate ST, Busse WW, eds. Inflammatory mechanisms in asthma. New York, Base, Hong Kong: Marcel Dekker, 1998:chapter 26.
6. Chan-Yeung M, Grzybowski S. Prognosis in occupational asthma [editorial]. Thorax 1985;40(4):241-243.
7. Allard C, Cartier A, Ghezzo H, Malo JL. Occupational asthma due to various agents. Absence of clinical and functional improvement at an interval of four or more years after cessation of exposure. Chest 1989;96(5): 1046-1049.
8. Cote J, Kennedy S, Chan-Yeung M. Outcome of patients with cedar asthma with continuous exposure. Am Rev Respir Dis 1990; 141(2):373-376.
9. Mapp CE, Corona PC, De Marzo N, Fabbri L. Persistent asthma due to isocyanates. A follow-up study of subjects with occupational asthma due to toluene diisocyanate (TDI). Am Rev Respir Dis 1988;137(6):1326-1329.
10. Vedal S, Enarson DA, Chan H, et al. A longitudinal study of the occurrence of bronchial hyperresponsiveness in western red cedar workers. Am Rev Respir Dis 1988; 137(3):651-655.
11. Panhuysen CI, Vonk JM, Koeter GH, et al. Adult patients may outgrow their asthma: a 25-year follow-up study, [published erratum appears in Am J Respir Crit Care Med 1997 Aug;156(2 Pt 1):674]. Am J Respir Crit Care Med 1997;155(4):1267-1272.
12. Redington AE, Howarth PH. Airway wall remodelling in asthma [editorial] [see comments]. Thorax 1997;52(4):310-312.
13. Redington AE, Sime PJ, Howarth PH, Holgate ST. Fibroblast and the extracellular matrix in asthma. In: Holgate ST, Busse WW, eds. Inflammatory mechanisms in asthma. New York, Basel, Hong Kong: Marcel Dekker, 1998:chapter 21.
14. Macklem PT. Mechanical factors determining maximum bronchoconstriction. Eur Respir J Suppl 1989;6:516s-519s.
15. Ebina M, Yaegashi H, Chiba R, et al. Hyperreactive site in the airway tree of asthmatic patients revealed by thickening of bronchial muscles. A morphometric study. Am Rev Respir Dis 1990;141(5 Pt 1):1327-1332.
16. Paggiaro PL, Paoletti P, Bacci E. Eosinophils in bronchoalveolar lavage (BAL) of patients with toluene diisocyanate (TDI) asthma after cessation of work. Chest 1990(98):536-542.
17. Saetta M, Maestrelli P, Di Stefano A. et al. Effect of cessation of exposure to toluene diisocyanate (TDI) on bronchial mucosa of subjects with TDI-induced asthma. Am Rev Respir Dis 1992;145(1):169-174.
18. Saetta M, Maestrelli P, Turato G, et al. Airway wall remodeling after cessation of exposure to isocyanates in sensitized asthmatic subjects. Am J Respir Crit Care Med 1995; 151(2 Pt 1):489-494.
19. Chan-Yeung M. Occupational asthma. Environ Health Perspect 1995;6:249-252.
20. Venables KM, Chan-Yeung M. Occupational asthma. Lancet 1997;349(9063):1465-1469.
21. O'Byrne PM. Mechanisms of airway hyperresponsiveness. In: Holgate ST, Busse WW, eds. Inflammatory mechanisms in asthma. New York, Basel, Hong Kong: Marcel Dekker, 1998:chapter 34.
22. Hargreave FE, Ramsdale EH, Pugsley SO. Occupational asthma without bronchial hyperresponsiveness. Am Rev Respir Dis 1984; 130(3):513-515.
23. Mapp CE, Dal Vecchio L, Boschetto P, et al. Toluene diisocyanate-induced asthma without airway hyperresponsiveness. Eur J Respir Dis 1986;68(2):89-95.
24. Mapp CE, Di Giacomo GR, Omini C, et al. Late, but not early, asthmatic reactions induced by toluene diisocyanate are associated with increased airway responsiveness to methacholine. Eur J Respir Dis 1986;69(4): 276-284.
25. Cartier A, L'Archeveque J, Malo JL. Exposure to a sensitizing occupational agent can cause a long-lasting increase in bronchial responsiveness to histamine in the absence of significant changes in airway caliber. J Allergy Clin Immunol 1986;78(6):1185-1189.
26. Thorpe JE, Steinberg D, Bernstein IL, Murlas CG. Bronchial reactivity increases soon after the immediate response in dual-responding asthmatic subjects. Chest 1987; 91(1):21-25.
27. Steinberg DR, Bernstein DI, Bernstein IL, Murlas CG. Prednisone pretreatment leads to histaminic airway hyporeactivity soon after resolution of the immediate allergic response. Chest 1989;95(2):314-319.
28. Durham SR, Graneek BJ, Hawkins R, Taylor AJ. The temporal relationship between increases in airway responsiveness to histamine and late asthmatic responses induced by occupational agents. J Allergy Clin Immunol 1987;79(2):398-406.
29. Josephs LK, Gregg I, Mullee MA, Holgate ST. Nonspecific bronchial reactivity and its relationship to the clinical expression of asthma. A longitudinal study. Am Rev Respir Dis 1989;140(2):350-357.
30. Postma DS, Kerstjens HA. Characteristics of airway hyperresponsiveness in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;158(5 Pt 3): S187-92.
31. Banks DE, Rando RJ, Barkman HW, Jr. Persistence of toluene diisocyanate-induced asthma despite negligible workplace exposures. Chest 1990;97(1):121-125.
32. Lam S, LeRiche J, Phillips D, Chan-Yeung M. Cellular and protein changes in bronchial lavage fluid after late asthmatic reaction in patients with red cedar asthma. J Allergy Clin Immunol 1987;80(1):44-50.
33. Chan-Yeung M, Leriche J, Maclean L, Lam S. Comparison of cellular and protein changes in bronchial lavage fluid of symptomatic and asymptomatic patients with red cedar asthma on follow-up examination. Clin Allergy 1988;18(4):359-365.
34. Vandenplas O, Malo JL. Inhalation challenges with agents causing occupational asthma. Eur Respir J 1997;10(11): 2612-2629.
35. Malo JL, L'Archeveque J, Cartier A. Significant changes in nonspecific bronchial responsiveness after isolated immediate bronchospecific reactions caused by isocyanates but not after a late reaction caused by plicatic acid. J Allergy Clin Immunol 1989;83(1): 159-165.
36. Humbert M, Durham SR, Ying S, et al. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. Am J Respir Crit Care Med 1996; 154(5):1497-1504.
37. Humbert M, Ying S, Corrigan C, et al. Bronchial mucosal expression of the genes encoding chemokines RANTES and MCP-3 in symptomatic atopic and nonatopic asthmatics: relationship to the eosinophilactive cytokines interleukin (IL)-5, granulocyte macrophage-colony-stimulating factor, and IL-3. Am J Respir Cell Mol Biol 1997; 16(1):1-8.
38. Ying S, Humbert M, Barkans J, et al. Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, cosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics. J Immunol 1997;158(7): 3539-3544.
39. Humbert M, Durham SR, Kimmitt P, et al. Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma. J Allergy Clin Immunol 1997;99(5): 657-665.
40. Humbert M, Corrigan CJ, Kimmitt P, et al. Relationship between IL-4 and IL-5 mRNA expression and disease severity in atopic asthma. Am J Respir Crit Care Med 1997; 156(3 Pt 1):704-708.
41. Bentley AM, Menz G, Storz C, et al. Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness. Am Rev Respir Dis 1992;146(2):500-506.
42. Humbert M, Grant JA, Taborda-Barata L, et al. High-affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma. Am J Respir Crit Care Med 1996;153(6 Pt 1):1931-1937.
43. Kotsimbos AT, Humbert M, Minshall E, et al. Upregulation of alpha GM-CSF-receptor in nonatopic asthma but not in atopic asthma. J Allergy Clin Immunol 1997;99(5): 666-672.
44. Cookson WOCM. Genetic aspects of atopic allergy. In: Van Hage Hamsten M, Wickman M, eds. 30 years with IgE. Munksgaard: Copenhagen, 1998:13-18.
45. Barnes KC, Marsh DG. The genetics and complexity of allergy and asthma. Immunol Today 1998;19(7):325-332.
46. Guidelines for the diagnosis and management of asthma. National Institutes of health, National Heart, Lung and Blood Institute 1997.
47. Holgate ST. Asthma genetics - waiting to exhale. Nature Genetics 1997;15(3): 227-229.
48. Cookson WO, Sharp PA, Faux JA, Hopkin JM. Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet 1989;1(8650): 1292-1295.
49. Marsh DG, Neely JD, Breazeale DR, et al. Linkage analysis of IL4 and other chromosome 5q31.1 total serum immunoglobulin E concentrations. Science 1994;264(5162): 1152-1156.
50. Meyers DA, Postma DS, Panhuysen C, et al. Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. Genomics 1994;23(2):464-470.
51. Postma DS, Bleecker ER, Amelung PJ, et al. Genetic susceptibility to asthma - Bronchial, hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med 1995; 333(14):894-900.
52. Hall IP, Wheatley A, Wilding P, Liggett SB. Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 1995; 345(8959):1213-1214.
53. Marsh DG, Blumenthal MN, Ishikawa T, et al. HLA and specific immune responsiveness to allergens. In: Tsuji K, M. A, Sasazuki T, eds. HLA 1991, Proceedings of the Eleventh International Histocompatibility Workshop and Conference, vol. 1. Oxford: Oxford University Press, 1992:765-71.
54. Moffatt MF, Hill MR, Cornelis F, et al. Genetic linkage of T-cell receptor α/δ complex to specific IgE responses. Lancet 1994; 343(8913):1597-1600.
55. Barnes KC, Neely JD, Duffy DL, et al. Linkage of asthma and total serum IgE concentration to markers on chromosome 12q -evidence from Afro-Caribbean and Caucasian populations. Genomics 1996; 37(1):41-50.
56. Wilkinson J, Holgate ST. Evidence for and against chromosome 5q as a region of interest in asthma and atopy. Clin Exp Allergy 1996;26(8):861-864.
57. Wilkinson J, Thomas S, Lio P, et al. Evidence for linkage for atopy and asthma to markers on chromosome 12q. Eur Respir J 1996;9(Suppl 23):435s.
58. Daniels SE, Bhattacharrya S, James A, et al. A genome-wide search for quantitative trait loci underlying asthma. Nature 1996; 383(6597):247-250.
59. The Collaborative Study on the Genetics of Asthma (CSGA). A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nature Genetics 1997; 15(4):385-388.
60. Mapp CE. Isocyanate-induced asthma. In: Parker JE, ed. Occupational lung disease. An international perspective. London: Chapman & Hall Medical, 1998:375-379.
61. Bignon JS, Aron Y, Ju LY, et al. HLA class II alleles in isocyanate-induced asthma. Am J Respir Crit Care Med 1994;149(1):71-75.
62. Balboni A, Baricordi OR, Fabbri LM, et al. Association between toluene diisocyanate-induced asthma and DQB1 markers: a possible role for aspartic acid at position 57. Eur Respir J 1996;9(2):207-210.
63. Young RP, Barker RD, Pile KD, et al. The association of HLA-DR3 with specific IgE to inhaled acid anhydrides. Am J Respir Crit Care Med 1995;151(1):219-221.
64. Newman TA, Cullinan P, Lympany PA, et al. Interaction of HLA phenotype and exposure intensity in sensitization to complex platinum salts [In Process Citation]. Am J Respir Crit Care Med 1999;160(2):435-438.
65. Home C, Quintana PA, Keown PA, et al. Distribution of HLA class II DQB1 and DRB1 alleles in patients with occupational asthma due to western red cedar. Am J Respir Crit Care Med 1977(155):A135.
66. Raulf-Heimsoth M, Chen Z, Rihs HP, et al. Analysis of T-cell reactive regions and HLA-DR4 binding motifs on the latex allergen Hev b 1 (rubber elongation factor). Clin Exp Allergy 1998;28(3):339-348.
67. Soriano JB, Ercilla G, Sunyer J, et al. HLA class II genes in soybean epidemic asthma patients. Am J Respir Crit Care Med 1997; 156(5):1394-1398.
68. Rihs HP, Barbalho-Krolls T, Huber H, Baur X. No evidence for the influence of HLA class II in alleles in isocyanate-induced asthma. Am J Ind Med 1997;32(5):522-527.
69. Bernstein JA, Munson J, Lummus ZL, et al. T-cell receptor V beta gene segment expression in diisocyanate-induced occupational asthma. J Allergy Clin Immunol 1997;99(2): 245-250.
70. Maestrelli P, di Stefano A, Occari P, et al. Cytokines in the airway mucosa of subjects with asthma induced by toluene diisocyanate. Am J Respir Crit Care Med 1995;151(3 Pt 1):607-612.
71. Mellman I, Turley SJ, Steinman RM. Antigen processing for amateurs and professionals. Trends Cell Biol 1998;8(6):231-237.
72. McWilliam AS, Holt PG. Immunobiology of dendritic cells in the respiratory tract: steady-state and inflammatory sentinels? Toxicol Lett 1998;103:323-329.
73. Edgeworth JD, Lee TH, Grant VA. Antigen presentation in the asthmatic lung. In: Hoigate ST, Busse WW, eds. Inflammatory mechanisms in asthma. New York, Basel, Hong Kong: Marcel Dekker, 1998:chapter 19.
74. Roitt I, Bronstoff J, Male D. Immunology. London: Mosby, 1998:19.
75. Bertorelli G, Bocchino V, Olivieri D. Heat shock protein interactions with the glucocorticoid receptor. Pulm Pharmacol Ther 1998; 11(1):7-12.
76. Kay AB, Frew AJ, Corrigan CJ, Robinson DS. The T-cell hypotesis of chronic asthma. In: Kay AB, ed. Allergy and allergic diseases. Oxford: Blackwell Science, 1997: 1379-1394.
77. Kay AB. T-cell as orchestrators of the asthmatic response. Ciba Found. Symp. 206, 1997:56-69.
78. Corrigan CJ. T-cells in asthma. In: Hogate ST, Busse WW, eds. Inflammatory mechanisms in asthma. New York, Basel, Hong Kong: Marcel Dekker, 1989:chapter 17.
79. Del Prete G. The concept of type-1 and type-2 helper T cells and their cytokines in humans. Int Rev Immunol 1998;16(3-4): 427-455.
80. Krug N, Frew AJ. The Th2 cell in asthma: initial expectations yet to be realised. Clin Exp Allergy 1997;27(2):142-150.
81. Monticelli S, L. D, Vercelli D. Molecular regulation of IgE switching: let's walk hand in hand. In: Van Hage-Hamsten M, Wickman M, eds. 30 years with IgE. Munksgaard: Copenhagen, 1998:9-11.
82. Teran LM, Davies DE. The chemokines: their potential role in allergic inflammation. Clin Exp Allergy 1996;26(9):1005-1019.
83. Ryan JJ. Interleukin-4 and its receptor: essential mediators of the allergic response. J Allergy Clin Immunol 1997:99(1 Pt 1):1-5.
84. Drazen JM, Arm JP, Austen KF. Sorting out the cytokines of asthma [comment]. J Exp Med 1996;183(1):1-5.
85. Holgate ST. Aetiology and pathogenesis of asthma. In: Kay AB, ed. Allergy and allergic diseases. Oxford: Blackwell science, 1997: 1366-1378.
86. Holgate ST. The cellular and mediator basis of asthma in relation to natural history Lancet 1997;350(2):SII5-SII9.
87. Durham SR. Mechanisms of mucosal inflammation in the nose and lungs. Clin Exp Allergy 1998;2:11-16.
88. Costa JJ, Galli SJ, Church MK. Mast cell cytokines in allergic inflammation. In: Holgate ST, Busse WW, eds. Inflammatory mechanisms in asthma. New York, Basel, Hong Kong: Marcel Dekker, 1998:chapter 6.
89. Novey HS, Bernstein IL, Mihalas LS, et al. Guidelines for the clinical evaluation of occupational asthma due to high molecular weight (HMW) allergens. Report of the Subcommittee on the Clinical Evaluation of Occupational Asthma due to HMW Allergens. J Allergy Clin Immunol 1989;84(5 Pt 2): 829-833.
90. Bindslev JC, Poulsen LK. In vitro diagnostic tests. In: Sampson HA, Simons E, Metcalfe DD, eds. Food allergy. Blackwell Scientific, 1996:137-150.
91. Maccia CA, Bernstein IL, Emmett EA, Brooks SM. In vitro demonstration of specific IgE in phthalic anhydride hypersensitivity. Am Rev Respir Dis 1976;113(5): 701-704.
92. Biagini RE, Bernstein IL, Gallagher JS, et al. The diversity of reaginic immune responses to platinum and palladium metallic salts. J Allergy Clin Immunol 1985;76(6):794-802.
93. Cartier A, Grammer L, Malo JL, et al. Specific serum antibodies against isocyanates: association with occupational asthma. J Allergy Clin Immunol 1989;84(4 Pt 1): 507-514.
94. Tse KS, Chan H, Chan-Yeung M. Specific IgE antibodies in workers with occupational asthma due to western red cedar. Clin Allergy 1982;12(3):249-258.
95. Cartier A, Malo JL, Forest F, et al. Occupational asthma in snow crab-processing workers. J Allergy Clin Immunol 1984;74(3 Pt 1):261-269.
96. Mitchell CA, Gandevia B. Respiratory symptoms and skin reactivity in workers exposed to proteolytic enzymes in the detergent industry. Am Rev Respir Dis 1971;104(1): 1-12.
97. Karr RM. Bronchoprovocation studies in coffee worker's asthma. J Allergy Clin Immunol 1979;64(6 pt 2):650-654.
98. Davison AG, Britton MG, Forrester JA, et al. Asthma in merchant seamen and laboratory workers caused by allergy to castor beans: analysis of allergens. Clin Allergy 1983; 13(6):553-561.
99. Merget R, Stollfuss J, Wiewrodt R, et al. Diagnostic tests in enzyme allergy. J Allergy Clin Immunol 1993;92(2):264-277.
100. Bernstein DI, Smith AB, Moller DR, et al. Clinical and immunologic studies among egg-processing workers with occupational asthma. J Allergy Clin Immunol 1987;80(6): 791-797.
101. Tiikkainen U, Klockars M. Clinical significance of IgG subclass antibodies to wheat flour antigens in bakers. Allergy 1990;45(7): 497-504.
102. Popp W, Zwick H, Rauscher H. Short-term sensitizing antibodies in bakers' asthma. Int Arch Allergy Appl Immunol 1988;86(2): 215-219.
103. Tee RD, Cullinan P, Welch J, et al. Specific IgE to isocyanates: a useful diagnostic role in occupational asthma. J Allergy Clin Immunol 1998;101(5):709-715.
104. Nielsen J, Welinder H, Skerfving S. Allergic airway disease caused by methyl tetrahydrophthalic anhydride in epoxy resin. Scand J Work Environ Health 1989;15(2):154-155.
105. Bernstein DI, Gallagher JS, D'Souza L, Bernstein IL. Heterogeneity of specific-IgE responses in workers sensitized to acid anhydride compounds. J Allergy Clin Immunol 1984;74(6):794-801.
106. Zeiss CR, Wolkonsky P, Pruzansky JJ, Patterson R. Clinical and immunologic evaluation of trimellitic anhydride workers in multiple industrial settings. J Allergy Clin Immunol 1982;70(1):15-18.
107. Ahmad D, Morgan WK, Patterson R, et al. Pulmonary haemorrhage and haemolytic anaemia due to trimellitic anhydride. Lancet 1979;2(8138):328-330.
108. Patterson R, Addington W, Banner AS, et al. Antihapten antibodies in workers exposed to trimellitic anhydride fumes: a potential immunopathogenetic mechanism for the trimellitic anhydride pulmonary disease - anemia syndrome. Am Rev Respir Dis 1979;120(6): 1259-1267.
109. Turner ES, Pruzansky JJ, Patterson R, et al. Detection of antibodies in human serum using trimellityl-erythrocytes: direct and indirect haemagglutination and haemolysis. Clin Exp Immunol 1980;39(2):470-476.
110. Venables KM, Topping MD, Nunn AJ, et al. Immunologic and functional consequences of chemical (tetrachlorophthalic anhydride)-induced asthma after four years of avoidance of exposure. J Allergy Clin Immunol 1987; 80(2):212-218.
111. Zhang XD, Lotvall J, Skerfving S, Welinder H. Antibody specificity to the chemical structures of organic acid anhydrides studied by in-vitro and in-vivo methods. Toxicology 1997;118(2-3):223-232.
112. Cleare MJ, Hughes EG, Jacoby B, Pepys J. Immediate (type I) allergic responses to platinum compounds. Clin Allergy 1976; 6(2):183-195.
113. Venables KM, Dally MB, Nunn AJ, et al. Smoking and occupational allergy in workers in a platinum refinery. Br Med J 1989; 299(6705):939-942.
114. Pepys J, Parish WE, Cromwell O, Hughes EG. Passive transfer in man and the monkey of Type I allergy due to heat labile and heat stable antibody to complex salts of platinum. Clin Allergy 1979;9(2):99-108.
115. Baker DB, Gann PH, Brooks SM, et al. Cross-sectional study of platinum salts sensitization among precious metals refinery workers. Am J Ind Med 1990;18(6): 653-664.
116. Biagini RE, Klincewicz SL, Henningsen GM, et al. Antibodies to morphine in workers exposed to opiates at a narcotics manufacturing facility and evidence for similar antibodies in heroin abusers. Life Sci 1990;47(10): 897-908.
117. Walker C, Bode E, Boer L, et al. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am Rev Respir Dis 1992;146(1): 109-115.
118. Del Prete GF, De Carli M, D'Elios MM, et al. Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders. Eur J Immunol 1993;23(7): 1445-1449.
119. Maestrelli P, Del Prete GF, De Carli M, et al. CD8 T-cell clones producing interleukin-5 and interferon-gamma in bronchial mucosa of patients with asthma induced by toluene diisocyanate. Scand J Work Environ Health 1994;20(5):376-381.
120. Frew A, Chang JH, Chan H, et al. T-lymphocyte responses to plicatic acid-human serum albumin conjugate in occupational asthma caused by western red cedar. J Allergy Clin Immunol 1998;101(6 Pt 1): 841-847.
121. Gallagher JS, Tse CS, Brooks SM, Bernstein IL. Diverse profiles of immunoreactivity in toluene diisocyanate (TDI) asthma. J Occup Med 1981;23(9):610-616.
122. Shirakawa T, Morimoto K. Brief reversible bronchospasm resulting from bichromate exposure. Arch Environ Health 1996;51(3): 221-226.
123. Lummus ZL, Alam R, Bernstein JA, Bernstein DI. Diisocyanate antigen-enhanced production of monocyte chemoattractant protein-1, IL-8, and tumor necrosis factor-alpha by peripheral mononuclear cells of workers with occupational asthma. J Allergy Clin Immunol 1998;102(2):265-274.
124. Layton GT, Stanworth DR, Amos HE. Factors influencing the immunogenicity of the haptenic drug chiorhexidine in mice. II. The role of the carrier and adjuvants in the induction of IgE and IgG anti-hapten responses. Immunology 1986;59(3):459-465.
125. Maestrelli P, Saetta M, Mapp CE, et al. Occupational asthma due to low molecular weight compounds. In: Banks DE, Parker JE, eds. Occupational lung disease, vol. 23. London: Chapman & Hall, 1998:345-373.
126. Karol MH, Graham C, Gealy R, et al. Structure-activity relationships and computer-assisted analysis of respiratory sensitization potential. Toxicol Lett 1996;86(2-3): 187-191.
127. Burge PS. Occupational asthma, rhinitis, and alveolitis due to colophony. Clin Immunol Allergy 1984(4):55-81.
128. Karlsberg A, Boman A, Nilsson L. Hydrogenisation reduces the allergenicity of colophony (rosin). Contact Derm 1988(19): 22-29.
129. Burge PS, Harries MG, O'Brien I, Pepys J. Bronchial provocation studies in workers exposed to the fumes of electronic soldering fluxes. Clin Allergy 1980;10(2):137-149.
130. Zeiss CR, Patterson R, Pruzansky JJ, et al. Trimellitic anhydride-induced airway syndromes: clinical and immunologic studies. J Allergy Clin Immunol 1977;60(2): 96-103.
131. Taylor AJ, Venables KM, Durham SR, et al. Acid anhydrides and asthma. Int Arch Allergy Appl Immunol 1987;82(3-4):435-439.
132. Venables KM. Low molecular weight chemicals, hypersensitivity, and direct toxicity: the acid anhydrides. Br J Ind Med 1989;46(4): 222-232.
133. Wass U, Belin L. An in vitro method for predicting sensitizing properties of inhaled chemicals. Scand J Work Environ Health 1990;16(3):208-214.
134. Wass U, Nilsson R, Nordlinder R, Belin L. An optimized assay of specific IgE antibodies to reactive dyes and studies of immunologic responses in exposed workers. J Allergy Clin Immunol 1990;85(3):642-648.
135. Kramps JA, van Toorenenbergen AW, Vooren PH, Dijkman JH. Occupational asthma due to inhalation of chloramine-T. II. Demonstration of specific IgE antibodies. Int Arch Allergy Appl Immunol 1981;64(4): 428-438.
136. Ross DJ, Keynes HL, McDonald JC. SWORD '97: surveillance of work-related and occupational respiratory disease in the UK. Occup Med (Lond) 1998;48(8): 481-485.
137. Warren P, Cherniack RM, Tse KS. Hypersensitivity reactions to grain dust. J Allergy Clin Immunol 1974;53(3):139-149.
138. Broder I, Davies G, Hutcheon M, et al. Variables of pulmonary allergy and inflammation in grain elevator workers. J Occup Med 1983;25(1):43-47.
139. Chan-Yeung M, Wong R, MacLean L. Respiratory abnormalities among grain elevator workers. Chest 1979;75(4):461-467.
140. doPico GA, Reddan W, Anderson S, et al. Acute effects of grain dust exposure during a work shift. Am Rev Respir Dis 1983;128(3): 399-404.
141. Schwartz DA, Thorne PS, Yagla SJ, et al. The role of endotoxin in grain dust-induced lung disease. Am J Respir Crit Care Med 1995;152(2):603-608.
142. Clapp WD, Becker S, Quay J, et al. Grain dust-induced airflow obstruction and inflammation of the lower respiratory tract. Am J Respir Crit Care Med 1994;150(3):611-617.
143. doPico GA, Jacobs S, Flaherty D, Rankin J. Pulmonary reaction to durum wheat; a constituent of grain dust. Chest 1982;81(1):55-61.
144. Boushey HA, Fahy JV. Basic mechanisms of asthma. Environ Health Perspect 1995,6: 229-233.
145. Holgate ST, Bradding P, Sampson AP. Leukolriene antagonists and synthesis inhibitors: new directions in asthma therapy. J Allergy Clin Immunol 1996;98(1):1-13.
146. Li JT. Mechanisms of asthma. Curr Opin Pulm Med 1997;3(1):10-16.
147. Barnes PJ. Airway neuropeptides and their role in asthma. In: Holgate ST, Busse WW, eds. Inflammatory mechanisms in asthma. New York, Basel, Hong Kong: Marcel Dekker, 1998:chapter, 24.
148. Fabbri LM, Danieli D, Crescioli S, et al. Fatal asthma in a subject sensitized to toluene diisocyanate. Am Rev Respir Dis 1988; 137(6):1494-1498.
149. Saetta M, Di Stefano A, Rosina C, et al. Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am Rev Respir Dis 1991;143(1):138-143.
150. Saetta M, Di Stefano A, Maestrelli P, et al. Airway mucosal inflammation in occupational asthma induced by toluene diisocyanate. Am Rev Respir Dis 1992;145(1): 160-168.
151. Bentley AM, Maestrelli P, Saetta M, et al. Activated T-lymphocytes and eosinophils in the bronchial mucosa in isocyanate-induced asthma. J Allergy Clin Immunol 1992:89(4): 821-829.
152. Montefort S, Roberts JA, Beasley R, et al. The site of disruption of the bronchial epithelium in asthmatic and non-asthmatic subjects. Thorax 1992;47(7):499-503.
153. Montefort S, Djukanovic R, Holgate ST, Roche WR. Ciliated cell damage in the bronchial epithelium of asthmatics and nonasthmatics. Clin Exp Allergy 1993;23(3): 185-189.
154. Roche WR, Beasley R, Williams JH, Holgate ST. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1989;1(8637):520-524.
155. Brewster CE, Howarth PH, Djukanovic R, et al. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 1990;3(5):507-511.
156. Frew AJ, Chan H, Lam S, Chan-Yeung M. Bronchial inflammation in occupational asthma due to western red cedar. Am J Respir Crit Care Med 1995;151(2 Pt 1): 340-344.
157. Gautrin D, Boulet LP, Boulet M, et al. Is reactive airways dysfunction syndrome a variant of occupational asthma? J Allergy Clin Immunol 1994;93(1 Pt 1):12-22.
158. Beasley R, Roche WR, Roberts JA, Holgate ST. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 1989:139(3):806-817.
159. Djukanovic R, Roche WR, Wilson JW, et al. Mucosal inflammation in asthma. Am Rev Respir Dis 1990;142(2):434-457.
160. Gizycki MJ, Adelroth E, Rogers AV, et al. Myofibroblast involvement in the allergen-induced late response in mild atopic asthma. Am J Respir Cell Mol Biol 1997;16(6): 664-673.
161. Trigg CJ, Manolitsas ND, Wang J, et al. Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma. Am J Respir Crit Care Med 1994; 150(1):17-22.
162. Crimi E, Spanevello A, Neri M, et al. Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma [see comments]. Am J Respir Crit Care Med 1998;157(1):4-9.
163. Chetta A, Foresi A, Del Donno M, et al. Bronchial responsiveness to distilled water and methacholine and its relationship to inflammation and remodeling of the airways in asthma. Am J Respir Crit Care Med 1996; 153(3):910-917.
164. Olivieri D, Chetta A, Del Donno M, et al. Effect of short-term treatment with low-dose inhaled fluticasone propionate on airway inflammation and remodeling in mild asthma: a placebo-controlled study. Am J Respir Crit Care Med 1997;155(6):1864-1871.
165. Fabbri L, Beghe B, Caramori G, et al. Similarities and discrepancies between exacerbations of asthma and chronic obstructive pulmonary disease. Thorax 1998;53(9): 803-808.
166. Tattersfield AE, Postma DS, Barnes PJ, et al. Exacerbations of asthma. A descriptive study of 425 severe exacerbations [In Process Citation]. Am J Respir Crit Care Med 1999; 160(2):594-599.
167. McIvor RA, Pizzichini E, Turner MO, et al. Potential masking effects of salmeterol on airway inflammation in asthma. Am J Respir Crit Care Med 1998;158(3):924-930.
168. Fahy JV, Kim KW, Liu J, Boushey HA. Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol 1995;95(4): 843-852.
169. Sur S, Crotty TB, Kephart GM, et al. Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa? [see comments]. Am Rev Respir Dis 1993;148(3): 713-719.
170. Shindo K, Fukumura M, Miyakawa K. Leukotriene B4 levels in the arterial blood of asthmatic patients and the effects of prednisolone. Eur Respir J 1995;8(4):605-610.
171. Peters SP, Shaver JR, Zangrilli JO, Fish JE. Airways responses to antigen in asthmatic and nonasthmatic subjects. In: Holgate ST, Busse WW, eds. Inflammatory mechanisms in asthma. New York, Basel, Hong Kong: Marcel Dekker, 1998:chapter 7.
172. Sheth KK, Lemanske RF. The early and late asthmatic reaction to allergen. In: Holgate ST, Busse WW, eds. Inflammatory mechanisms in asthma. New York, Basel, Hong Kong: Marcel Dekker, 1998:chapter 34.
173. Fabbri LM, Boschetto P, Zocca E, et al. Bronchoalveolar neutrophilia during late asthmatic reactions induced by toluene diisocyanate. Am Rev Respir Dis 1987;136(1): 36-42.
174. Chan-Yeung M, Lam S. Evidence for mucosal inflammation in occupational asthma. Clin Exp Allergy 1990;20(1):1-5.
175. Zocca E, Fabbri LM, Boschetto P, et al. Leukotriene B4 and late asthmatic reactions induced by toluene diisocyanate. J Appl Physiol 1990;68(4):1576-1580.
176. White SR, Leff AR. Epithelium as a target. In: Holgate ST, Busse WW, eds. Inflammatory mechanism in asthma. New York, Basel, Hong Kong: Marcel Dekker, 1998:chapter 23.
177. Chan-Yeung M, Chan H, Tse KS, et al. Histamine and leukotrienes release in bronchoalveolar fluid during plicatic acid-induced bronchoconstriction. J Allergy Clin Immunol 1989;84(5 Pt 1):762-768.
178. Manning PJ, Rokach J, Malo JL, et al. Urinary leukotriene E4 levels during early and late asthmatic responses. J Allergy Clin Immunol 1990;86(2):211-220.
179. O'Byrne PM. Leukotrienes in the pathogenesis of asthma. Chest 1997;111(2 Suppl): 27S-34S.
180. Dahlen SE. Leukotrienes. In: Holgate ST, Busse WW, eds. Inflammatory mechanisms in asthma. New York. Basel, Hong Kong: Marcel Dekker, 1998:chapter 18.
181. DeLisser HM, Albelda SM. The function of cell adhesion molecules in lung inflammation: more questions than answers. Am J Respir Cell Mol Biol 1998;19(4):533-536.
182. Bell FP, Bennet B, Manning AM. Leukocyte-endothelial adhesion. In: Holgate ST, Busse WW, eds. Inflammatory mechanisms in asthma. New York, Basel, Hong Kong: Marcel Dekker, 1998:chapter 28.
183. Lamkhioued B, Renzi PM, Abi-Younes S, et al. Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation. J Immunol 1997; 159(9):4593-4601.
184. Lee NA, Lee JJ. Asthma: does IL-5 have a more provocative role? [comment]. Am J Respir Cell Mol Biol 1997;16(5):497-500.
185. Kumar A, Busse WW. Eosinophils in asthma. In: Holgate ST, Busse WW, eds. Inflammatory mechanisms in asthma. New York. Basel, Hong Kong: Marcel Dekker, 1998:chapter 13.
186. Azzawi M, Bradley B, Jeffery PK, et al. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 1990; 142(6 Pt 1): 1407-1413.
187. Djukanovic R, Wilson JW, Britten KM, et al. Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry [see comments]. Am Rev Respir Dis 1990;142(4):863-871.
188. Robinson DS, Hamid Q, Ying S, et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326(5):298-304.
189. Bentley AM, Meng Q, Robinson DS, et al. Increases in activated T lymphocytes, eosinophils, and cytokine mRNA expression for interleukin-5 and
190. Stanciu LA, Shute J, Promwong C, et al. Increased levels of IL-4 in CD8+ T cells in atopic asthma. J Allergy Clin Immunol 1997; 100(3):373-378.
191. Kidney JC, Wong AG, Efthimiadis A, et al. Elevated B cells in sputum of asthmatics. Close correlation with eosinophils. Am J Respir Crit Care Med 1996;153(2):540-544.
192. Humbert M. Pro-eosinophilic cytokines in asthma [editorial]. Clin Exp Allergy 1996; 26(2):123-127.
193. Gleich GJ. Eosinophil granule proteins and bronchial asthma. Allergol Int 1996(45): 35-44.
194. Bousquet J, Chanez P, Lacoste JY, et al. Eosinophilic inflammation in asthma [see comments]. N Engl J Med 1990;323(15): 1033-1039.
195. Laitinen LA, Laitinen A, Haahtela T. A comparative study of the effects of an inhaled corticosteroid, budesonide, and a beta 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial. J Allergy Clin Immunol 1992:90(1):32-42.
196. Durham SR, Loegering DA, Dunnette S, et al. Blood eosinophils and eosinophil-derived proteins in allergic asthma. J Allergy Clin Immunol 1989;84(6 Pt 1):931-936.
197. Durham SR, Kay AB. Eosinophils, bronchial hyperreactivity and late-phase asthmatic reactions. Clin Allergy 1985;15(5):411-418.
198. De Monchy JG, Kauffman HF, Venge P, et al. Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. Am Rev Respir Dis 1985;131(3):373-376.
199. O'Byrne PM, Dolovich J, Hargreave FE. Late asthmatic responses. Am Rev Respir Dis 1987;136(3):740-751.
200. Calhoun WJ, Jarjour NN, Gleich GJ, et al. Effect of nedocromil sodium pretreatment on the immediate and late responses of the airway to segmental antigen challenge. J Allergy Clin Immunol 1996;98(5 Pt 2):S46-50; discussion S64-6.
201. Broide DH, Gleich GJ, Cuomo AJ, et al. Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway. J Allergy Clin Immunol 1991;88(4): 637-648.
202. Bosso JV, Schwartz LB, Stevenson DD. Tryptase and histamine release during aspirin-induced respiratory reactions. J Allergy Clin Immunol 1991;88(6):830-837.
203. Bousquet J, Chanez P, Lacoste JY, et al. Indirect evidence of bronchial inflammation assessed by titration of inflammatory mediators in BAL fluid of patients with asthma. J Allergy Clin Immunol 1991;88(4):649-660.
204. Fabbri LM, Boschetto P, Caramori G, Maestrelli P. Neutrophils and asthma. In: Holgate ST, Busse WW, eds. Inflammatory mechanisms in asthma. New York, Basel, Hong Kong: Marcel Dekker, 1998:chapter 15.
205. Knobil K, Jacoby DB Mediator functions and epithelial cells. In: Holgate ST, Busse WW, eds. Inflammatory mechanisms in asthma. New York, Basel, Hong Kong: Marcel Dekker, 1998:chapter 22.
206. Campbell AM, Vachier I, Chanez P, et al. Expression of the high-affinity receptor for IgE on bronchia) epithelial cells of asthmatics. Am J Respir Cell Mol Biol 1998;19(1): 92-97.
207. Daftary SS, Calhoun WJ, Jarjour NN. Macrophages and macrophage diversity in asthma. In: Holgate ST, Busse WW, eds. Inflammatory mechanisms in asthma. New York, Basel, Hong Kong, 1998:chapter 18.
208. Poulter LW, Janossy G, Power C, et al. Immunological/physiological relationships in asthma: potential regulation by lung macrophages. Immunol Today 1994;15(6):258-261.
209. John M, Lim S, Seybold J, et al. Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma. Am J Respir Crit Care Med 1998;157(1):256-262.
210. Barnes PJ, Baraniuk JN, Belvisi MG. Neuropeptides in the respiratory tract. Part II. Am Rev Respir Dis 1991;144(6):1391-1399.
211. Nadel JA. Neutral endopeptidase modulates neurogenic inflammation. Eur Respir J 1991; 4(6):745-754.
212. Heaney LG, Cross LJ, McGarvey LP, et al. Neurokinin A is the predominant tachykinin in human bronchoalveolar lavage fluid in normal and asthmatic subjects. Thorax 1998; 53(5):357-362.
213. Barnes PJ. NO or no NO in asthma? Thorax 1996;51(2):218-220.
214. Ollerenshaw SL, Jarvis D, Woolcock AJ, et al. Absence of immunoreactive vasoactive intestinal polypeptide in tissue from the lung of patients with asthma. N Engl J Med 1991(320):1244-1248.
215. Ollerenshaw SL, Jarvis D, Sullivan CE, Woolcock AJ. Substance P immunoreactive nerves in airways from asthmatics and nonasthmatics. Eur Respir J 1991;4(6):673-682.
216. Lilly CM, Bai TR, Shore SA, et al. Neuropeptide content of lungs from asthmatic and nonasthmatic patients. Am J Respir Crit Care Med 1995;151(2 Pt 1):548-553.
217. Howarth PH, Springall DR, Redington AE, et al. Neuropeptide-containing nerves in endobronchial biopsies from asthmatic and nonasthmatic subjects. Am J Respir Cell Mol Biol 1995;13(3):288-296.
218. Mapp CE, Lucchini RE, Miotto D, et al. Immunization and challenge with toluene diisocyanate decrease tachykinin and calcitonin gene-related peptide immunoreactivity in guinea pig central airways. Am J Respir Crit Care Med 1998;158(1):263-269.
219. Sheppard D, Thompson JE, Scypinski L, et al. Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase. J Clin Invest 1988;81(4):1111-1115.