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Volumn 98, Issue 1, 1996, Pages 1-13

Leukotriene antagonists and synthesis inhibitors: New directions in asthma therapy

Author keywords

5 lipoxygenase inhibitors; 5 lipoxygenase activating protein inhibitors; asthma; leukotriene B4 antagonists; leukotriene D4 antagonists; leukotrienes

Indexed keywords

2 CYCLOPENTYL 2 [4 (2 QUINOLINYLMETHOXY)PHENYL]ACETIC ACID; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 (2 QUINOLINYLMETHOXY) 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 4 [4 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY)PROPYLTHIO]PHENYL] 4 HYDROXY 3 METHYLBUTYRIC ACID; 7 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY) 2 HYDROXYPROPOXY] 4 OXO 8 PROPYL 4H 1 BENZOPYRAN 2 CARBOXYLIC ACID; ACEOLASE; ACETYLSALICYLIC ACID; ALLERGEN; ALPHA PENTYL 3 (2 QUINOLYLMETHOXY)BENZYL ALCOHOL; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CROMOGLYCATE DISODIUM; DOCEBENONE; LEUKOTRIENE B4; LEUKOTRIENE RECEPTOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LIPOXYGENASE INHIBITOR; PIRIPROST; POBILUKAST; PRANLUKAST; PROBILUKAST; SALBUTAMOL; THROMBOCYTE ACTIVATING FACTOR; TOMELUKAST; UNCLASSIFIED DRUG; VERLUKAST; ZAFIRLUKAST; ZILEUTON;

EID: 0029739085     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(96)70220-8     Document Type: Article
Times cited : (213)

References (89)
  • 1
    • 0026774013 scopus 로고
    • New aspects of asthma
    • Barnes PJ. New aspects of asthma. J Intern Med 1992;231: 453-61.
    • (1992) J Intern Med , vol.231 , pp. 453-461
    • Barnes, P.J.1
  • 2
    • 0027249231 scopus 로고
    • Pathology of asthma and its clinical implications
    • Beasley R, Burgess C, Crane J, et al. Pathology of asthma and its clinical implications. J Allergy Clin Immunol 1993; 92:148-54.
    • (1993) J Allergy Clin Immunol , vol.92 , pp. 148-154
    • Beasley, R.1    Burgess, C.2    Crane, J.3
  • 3
    • 0027376537 scopus 로고
    • Efficacy and safety of inhaled corticosteroids in asthma
    • Barnes PJ, Pedersen S. Efficacy and safety of inhaled corticosteroids in asthma. Am Rev Respir Dis 1993;148:S1-S26.
    • (1993) Am Rev Respir Dis , vol.148
    • Barnes, P.J.1    Pedersen, S.2
  • 4
    • 0026636419 scopus 로고
    • Inhaled corticosteroids: Benefits and risks
    • Geddes D. Inhaled corticosteroids: benefits and risks. Thorax 1992;47:404-7.
    • (1992) Thorax , vol.47 , pp. 404-407
    • Geddes, D.1
  • 5
    • 0026437935 scopus 로고
    • Epidemiology of asthma
    • Burney PGJ. Epidemiology of asthma. Br Med Bull 1992; 48:10-22.
    • (1992) Br Med Bull , vol.48 , pp. 10-22
    • Burney, P.G.J.1
  • 6
    • 0027177966 scopus 로고
    • Practical issues in asthma management: Correct use of inhalation devices
    • Cockcroft DW. Practical issues in asthma management: correct use of inhalation devices. Ann Allergy 1993;71:83-4.
    • (1993) Ann Allergy , vol.71 , pp. 83-84
    • Cockcroft, D.W.1
  • 7
    • 0026595713 scopus 로고
    • Role of inflammatory mediators in asthma
    • Chung KF, Barnes PJ. Role of inflammatory mediators in asthma. Br Med Bull 1992;48:135-48.
    • (1992) Br Med Bull , vol.48 , pp. 135-148
    • Chung, K.F.1    Barnes, P.J.2
  • 8
    • 0020597565 scopus 로고
    • Leukotrienes: Mediators of immediate hy persensitivity reactions and inflammation
    • Samuelsson B. Leukotrienes: mediators of immediate hy persensitivity reactions and inflammation. Science 1983; 220:568-75.
    • (1983) Science , vol.220 , pp. 568-575
    • Samuelsson, B.1
  • 9
    • 0025022489 scopus 로고
    • Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis
    • Dixon RA, Diehl RE, Opas E, et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 1990;343:282-4.
    • (1990) Nature , vol.343 , pp. 282-284
    • Dixon, R.A.1    Diehl, R.E.2    Opas, E.3
  • 10
    • 0027972565 scopus 로고
    • Leukotrienes as a target in asthma therapy
    • Chanarin N, Johnston SL. Leukotrienes as a target in asthma therapy. Drugs 1994;47:12-24.
    • (1994) Drugs , vol.47 , pp. 12-24
    • Chanarin, N.1    Johnston, S.L.2
  • 11
    • 0002976110 scopus 로고
    • Leukotrienes in asthma and rhinitis
    • Busse W, Holgate ST, eds. Oxford: Blackwell Scientific Publications
    • Drazen JM. Leukotrienes in asthma and rhinitis. In: Busse W, Holgate ST, eds. Asthma and rhinitis. Oxford: Blackwell Scientific Publications, 1995:838-50.
    • (1995) Asthma and Rhinitis , pp. 838-850
    • Drazen, J.M.1
  • 12
    • 0027281182 scopus 로고
    • Sulphidopeptide leukotrienes in asthma
    • Arm JP, Lee TH. Sulphidopeptide leukotrienes in asthma. Clin Sci (Colch) 1993;84:501-10.
    • (1993) Clin Sci (Colch) , vol.84 , pp. 501-510
    • Arm, J.P.1    Lee, T.H.2
  • 13
    • 0025810991 scopus 로고
    • The potential roles of leukotrienes in bronchial asthma
    • Piacentini GL, Kaliner MA. The potential roles of leukotrienes in bronchial asthma. Am Rev Respir Dis 1991;143: S96-9.
    • (1991) Am Rev Respir Dis , vol.143
    • Piacentini, G.L.1    Kaliner, M.A.2
  • 14
    • 0026605911 scopus 로고
    • 4 antagonists in anti-asthma trials: Early promise for a single mediator antagonist
    • 4 antagonists in anti-asthma trials: early promise for a single mediator antagonist. Pulmon Pharmacol 1992;5:77-80.
    • (1992) Pulmon Pharmacol , vol.5 , pp. 77-80
    • Cheng, J.B.1
  • 18
    • 0027216415 scopus 로고
    • Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa?
    • Sur S, Crotty TB, Kephart GM, et al. Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa? Am Rev Respir Dis 1993;148:713-9.
    • (1993) Am Rev Respir Dis , vol.148 , pp. 713-719
    • Sur, S.1    Crotty, T.B.2    Kephart, G.M.3
  • 20
    • 0026755576 scopus 로고
    • Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects
    • Sehmi R, Wardlaw AJ, Cromwell O, Kurihawa K, Waltmann P, Kay AB. Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects. Blood 1992;79:2952-9.
    • (1992) Blood , vol.79 , pp. 2952-2959
    • Sehmi, R.1    Wardlaw, A.J.2    Cromwell, O.3    Kurihawa, K.4    Waltmann, P.5    Kay, A.B.6
  • 21
    • 0027340416 scopus 로고
    • 4 induces interleukin 5 generation from human T lymphocytes
    • 4 induces interleukin 5 generation from human T lymphocytes. Eur J Immunol 1993;23:2392-8.
    • (1993) Eur J Immunol , vol.23 , pp. 2392-2398
    • Yamaoka, K.A.1    Kolb, J.P.2
  • 25
    • 0026511041 scopus 로고
    • Enhanced leukotriene synthesis in leukocytes of atopic and asthmatic subjects
    • Sampson AP, Thomas RU, Costello JF, Piper PJ. Enhanced leukotriene synthesis in leukocytes of atopic and asthmatic subjects. Br J Clin Pharmacol 1992;33:423-30.
    • (1992) Br J Clin Pharmacol , vol.33 , pp. 423-430
    • Sampson, A.P.1    Thomas, R.U.2    Costello, J.F.3    Piper, P.J.4
  • 27
    • 0027447228 scopus 로고
    • Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: Pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects
    • Bjorck T, Dahlen SE. Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects. Pulmon Pharmacol 1993;6:87-96.
    • (1993) Pulmon Pharmacol , vol.6 , pp. 87-96
    • Bjorck, T.1    Dahlen, S.E.2
  • 29
    • 0003114460 scopus 로고
    • Leukotrienes as mediators of airway obstruction and bronchial hyperresponsiveness
    • Page CP, Gardiner PJ, eds. Oxford: Blackwell Scientific Publications
    • Dahlen S. Leukotrienes as mediators of airway obstruction and bronchial hyperresponsiveness. In: Page CP, Gardiner PJ, eds. Airway hyperresponsiveness: Is it really important for asthma? Oxford: Blackwell Scientific Publications, 1993: 188-205.
    • (1993) Airway Hyperresponsiveness: Is It Really Important for Asthma? , pp. 188-205
    • Dahlen, S.1
  • 30
    • 0024477342 scopus 로고
    • 4 after allergen challenge and in acute asthma and allergic rhinitis
    • 4 after allergen challenge and in acute asthma and allergic rhinitis. Lancet 1989;1:584-8.
    • (1989) Lancet , vol.1 , pp. 584-588
    • Taylor, G.W.1    Black, P.2    Turner, N.3
  • 32
    • 0024474179 scopus 로고
    • 4-receptor antagonist improves pulmonary function in patients with mild chronic asthma
    • 4-receptor antagonist improves pulmonary function in patients with mild chronic asthma. Am Rev Respir Dis 1989;140:1336-9.
    • (1989) Am Rev Respir Dis , vol.140 , pp. 1336-1339
    • Cloud, M.L.1    Enas, G.C.2    Kemp, J.3
  • 33
    • 0026872032 scopus 로고
    • Prevention of exercise-induced bronchoconstriction by a new leukotriene antagonist (SK&F 104353). A double-blind study versus disodium cromoglycate and placebo
    • Robuschi M, Riva E, Fuccella LM, et al. Prevention of exercise-induced bronchoconstriction by a new leukotriene antagonist (SK&F 104353). A double-blind study versus disodium cromoglycate and placebo. Am Rev Respir Dis 1992;145:1285-8.
    • (1992) Am Rev Respir Dis , vol.145 , pp. 1285-1288
    • Robuschi, M.1    Riva, E.2    Fuccella, L.M.3
  • 36
    • 0025255862 scopus 로고
    • The preclinical pharmacology of ICI 204,219, a peptide leukotriene antagonist
    • Krell RD, Aharony D, Buckner CK, et al. The preclinical pharmacology of ICI 204,219, a peptide leukotriene antagonist. Am Rev Respir Dis 1990;141:978-87.
    • (1990) Am Rev Respir Dis , vol.141 , pp. 978-987
    • Krell, R.D.1    Aharony, D.2    Buckner, C.K.3
  • 38
    • 0027469691 scopus 로고
    • The effect of a leukotriene antagonist ONO 1078 on bronchial hyperresponsiveness in patients with asthma
    • Fujimura M, Sakahato S, Kamis Y, Matsuda T. The effect of a leukotriene antagonist ONO 1078 on bronchial hyperresponsiveness in patients with asthma. Respir Med 1993; 87:133-8.
    • (1993) Respir Med , vol.87 , pp. 133-138
    • Fujimura, M.1    Sakahato, S.2    Kamis, Y.3    Matsuda, T.4
  • 42
    • 0027340252 scopus 로고
    • Inhibition of leukotriene D4-induced bronchoconstriction in subjects with asthma: A concentration-effect study of ICI 204,219
    • Smith LJ, Glass M, Minkwitz MC. Inhibition of leukotriene D4-induced bronchoconstriction in subjects with asthma: a concentration-effect study of ICI 204,219. Clin Pharmacol Ther 1993;54:430-6.
    • (1993) Clin Pharmacol Ther , vol.54 , pp. 430-436
    • Smith, L.J.1    Glass, M.2    Minkwitz, M.C.3
  • 45
    • 1642299367 scopus 로고
    • 4 antagonist, inhibits exercise-induced bronchoconstriction in asthmatics at the end of a once daily dosing schedule
    • 4 antagonist, inhibits exercise-induced bronchoconstriction in asthmatics at the end of a once daily dosing schedule [abstract]. Am J Respir Crit Care Med 1995;151:A377.
    • (1995) Am J Respir Crit Care Med , vol.151
    • Reiss, T.F.1    Bronsky, E.2    Hendeles, L.3
  • 46
    • 0001557557 scopus 로고
    • 4 receptor antagonist, ICI 204,219, on cold-air-induced bronchoconstriction in patients with asthma
    • 4 receptor antagonist, ICI 204,219, on cold-air-induced bronchoconstriction in patients with asthma [abstract]. J Allergy Clin Immunol 1994;93:295.
    • (1994) J Allergy Clin Immunol , vol.93 , pp. 295
    • Glass, M.1    Snader, L.A.2    Israel, E.3
  • 48
    • 0028266252 scopus 로고
    • Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways
    • Montefort S, Gratziou C, Goulding D, et al. Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways. J Clin Invest 1994;93:1411-21.
    • (1994) J Clin Invest , vol.93 , pp. 1411-1421
    • Montefort, S.1    Gratziou, C.2    Goulding, D.3
  • 49
    • 0027525258 scopus 로고
    • The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthmatic subjects
    • Taniguchi Y, Tamura G, Honma M, et al. The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthmatic subjects. J Allergy Clin Immunol 1993;92:507-12.
    • (1993) J Allergy Clin Immunol , vol.92 , pp. 507-512
    • Taniguchi, Y.1    Tamura, G.2    Honma, M.3
  • 51
    • 0026524337 scopus 로고
    • Effect of the oral leukotriene antagonist, ICI 204,219, on antigen-induced bronchoconstriction in subjects with asthma
    • Findlay SR, Barden JM, Easley CB, Glass M. Effect of the oral leukotriene antagonist, ICI 204,219, on antigen-induced bronchoconstriction in subjects with asthma. J Allergy Clin Immunol 1992;89:1040-5.
    • (1992) J Allergy Clin Immunol , vol.89 , pp. 1040-1045
    • Findlay, S.R.1    Barden, J.M.2    Easley, C.B.3    Glass, M.4
  • 52
    • 0026066945 scopus 로고
    • Effect of the cysteinyl-leukotriene receptor antagonist ICI 204,219 on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjects
    • Taylor IK, O'Shaughnessy KM, Fuller RW, Dollery CT. Effect of the cysteinyl-leukotriene receptor antagonist ICI 204,219 on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjects. Lancet 1991;337: 690-4.
    • (1991) Lancet , vol.337 , pp. 690-694
    • Taylor, I.K.1    O'Shaughnessy, K.M.2    Fuller, R.W.3    Dollery, C.T.4
  • 53
    • 0028125778 scopus 로고
    • Inhaled ICI 204,219 blocks antigen-induced bronchoconstriction in subjects with bronchial asthma
    • Nathan RA, Glass M, Minkwitz MC. Inhaled ICI 204,219 blocks antigen-induced bronchoconstriction in subjects with bronchial asthma. Chest 1994;105:483-8.
    • (1994) Chest , vol.105 , pp. 483-488
    • Nathan, R.A.1    Glass, M.2    Minkwitz, M.C.3
  • 55
    • 0001334232 scopus 로고
    • Effect of Accolate (zafirlukast) on bronchoalveolar lavage fluid (BAL) after segmental antigen bronchoprovocation (SBP) in patients with mild to moderate asthma
    • Calhoun WJ, Lavins BJ, Glass M. Effect of Accolate (zafirlukast) on bronchoalveolar lavage fluid (BAL) after segmental antigen bronchoprovocation (SBP) in patients with mild to moderate asthma [abstract]. Am J Respir Crit Care Med 1995;151:A42.
    • (1995) Am J Respir Crit Care Med , vol.151
    • Calhoun, W.J.1    Lavins, B.J.2    Glass, M.3
  • 56
    • 0027725249 scopus 로고
    • Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects
    • Dahlen B, Margolskee DJ, Zetterstrom O, Dahlen SE. Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects. Thorax 1993;48:1205-10.
    • (1993) Thorax , vol.48 , pp. 1205-1210
    • Dahlen, B.1    Margolskee, D.J.2    Zetterstrom, O.3    Dahlen, S.E.4
  • 59
    • 0025802839 scopus 로고
    • Lung function improvement in asthma with a cysteinyl-leukotriene receptor antagonist
    • Hui KP, Barnes NC. Lung function improvement in asthma with a cysteinyl-leukotriene receptor antagonist. Lancet 1991;337:1062-3.
    • (1991) Lancet , vol.337 , pp. 1062-1063
    • Hui, K.P.1    Barnes, N.C.2
  • 61
    • 8544244910 scopus 로고
    • The effect of inhaled ICI 204,219 on baseline lung function in moderate asthma
    • Kips JC, Joos GF, Peleman RA, Pauwels RA. The effect of inhaled ICI 204,219 on baseline lung function in moderate asthma [abstract]. Am Rev Respir Dis 1993;147:A297.
    • (1993) Am Rev Respir Dis , vol.147
    • Kips, J.C.1    Joos, G.F.2    Peleman, R.A.3    Pauwels, R.A.4
  • 62
    • 2642657728 scopus 로고
    • 4 receptor antagonist, produces improvements in the signs and symptoms of asthma
    • 4 receptor antagonist, produces improvements in the signs and symptoms of asthma [abstract]. Eur Respir J 1994;7:282s.
    • (1994) Eur Respir J , vol.7
    • Reiss, T.1    Chervinsky, P.2    Altman, L.3
  • 64
    • 0001334235 scopus 로고
    • Thirteen-week dose-response study with Accolate (zafirlukast) in patients with mild to moderate asthma
    • Spector S, Miller CJ, Glass M. Thirteen-week dose-response study with Accolate (zafirlukast) in patients with mild to moderate asthma [abstract]. Am J Respir Crit Care Med 1995;151:A379.
    • (1995) Am J Respir Crit Care Med , vol.151
    • Spector, S.1    Miller, C.J.2    Glass, M.3
  • 65
    • 0008918783 scopus 로고
    • The effect of six weeks therapy with oral doses of ICI 204,219 in asthmatics
    • Spector SL, Glass M, Minkwitz MC. The effect of six weeks therapy with oral doses of ICI 204,219 in asthmatics [abstract]. Am Rev Respir Dis 1992;145:A16.
    • (1992) Am Rev Respir Dis , vol.145
    • Spector, S.L.1    Glass, M.2    Minkwitz, M.C.3
  • 66
    • 0010642728 scopus 로고
    • First clinical experience of the oral leukotriene antagonist, pranlukast (SB205312 / ONO 1078) in N. European patients with mild to moderate asthma
    • Barnes NC, Pujet JC. First clinical experience of the oral leukotriene antagonist, pranlukast (SB205312 / ONO 1078) in N. European patients with mild to moderate asthma [abstract]. Am J Respir Crit Care Med 1995;151: A378.
    • (1995) Am J Respir Crit Care Med , vol.151
    • Barnes, N.C.1    Pujet, J.C.2
  • 69
    • 0005464878 scopus 로고
    • 4 antagonist, U-75,302, inhibits antigen-induced airway hyperresponsiveness but not leukocyte accumulation in sensitised guinea pigs
    • 4 antagonist, U-75,302, inhibits antigen-induced airway hyperresponsiveness but not leukocyte accumulation in sensitised guinea pigs [abstract]. Br J Pharmacol 1995;114:50P.
    • (1995) Br J Pharmacol , vol.114
    • Milne, A.A.Y.1    Piper, P.J.2
  • 72
    • 0023269394 scopus 로고
    • Oral nafazatrom in man: Effect on inhaled antigen challenge
    • Fuller RW, Maltby N, Richmond R, et al. Oral nafazatrom in man: effect on inhaled antigen challenge. Br J Clin Pharmacol 1987;23:677-81.
    • (1987) Br J Clin Pharmacol , vol.23 , pp. 677-681
    • Fuller, R.W.1    Maltby, N.2    Richmond, R.3
  • 73
    • 0022548106 scopus 로고
    • Effect of piriprost (U-60,257) a novel leukotriene inhibitor on allergen- And exercise-induced asthma
    • Mann JS, Holgate ST. Effect of piriprost (U-60,257) a novel leukotriene inhibitor on allergen- and exercise-induced asthma. Thorax 1986;41:746-52.
    • (1986) Thorax , vol.41 , pp. 746-752
    • Mann, J.S.1    Holgate, S.T.2
  • 74
    • 0023024261 scopus 로고
    • Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects
    • Fujimura M, Sasaki F, Nakatsumi Y, et al. Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects. Thorax 1986; 41:955-65.
    • (1986) Thorax , vol.41 , pp. 955-965
    • Fujimura, M.1    Sasaki, F.2    Nakatsumi, Y.3
  • 76
    • 0026078163 scopus 로고
    • Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients
    • Hui KP, Taylor IK, Taylor GW, et al. Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients. Thorax 1991;46:184-9.
    • (1991) Thorax , vol.46 , pp. 184-189
    • Hui, K.P.1    Taylor, I.K.2    Taylor, G.W.3
  • 77
    • 0025647031 scopus 로고
    • The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air
    • Israel E, Demarkarian R, Rosenberg M, et al. The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air. N Engl J Med 1990;323:1740-4.
    • (1990) N Engl J Med , vol.323 , pp. 1740-1744
    • Israel, E.1    Demarkarian, R.2    Rosenberg, M.3
  • 78
    • 0027762572 scopus 로고
    • The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin
    • Israel E, Fischer AR, Rosenberg MA, et al. The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin. Am Rev Respir Dis 1993;148: 1447-51.
    • (1993) Am Rev Respir Dis , vol.148 , pp. 1447-1451
    • Israel, E.1    Fischer, A.R.2    Rosenberg, M.A.3
  • 79
    • 0027369276 scopus 로고
    • The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate asthma
    • Israel E, Rubin P, Kemp JP, et al. The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate asthma. Ann Intern Med 1993;119:1059-66.
    • (1993) Ann Intern Med , vol.119 , pp. 1059-1066
    • Israel, E.1    Rubin, P.2    Kemp, J.P.3
  • 80
    • 0013562459 scopus 로고
    • The comparative effects of zileuton, a 5-lipoxygenase inhibitor, vs. theophylline in patients with moderate asthma: Results from a 13-week, multicenter trial
    • Zileuton Study Group.
    • Schwartz HJ, Petty T, Reed R, Dube LM, Swanson LJ, Zileuton Study Group. The comparative effects of zileuton, a 5-lipoxygenase inhibitor, vs. theophylline in patients with moderate asthma: results from a 13-week, multicenter trial [abstract]. Am J Respir Crit Care Med 1995;151:A376.
    • (1995) Am J Respir Crit Care Med , vol.151
    • Schwartz, H.J.1    Petty, T.2    Reed, R.3    Dube, L.M.4    Swanson, L.J.5
  • 81
    • 2642680620 scopus 로고
    • Effects of zileuton, a 5-lipoxygenase inhibitor, in moderate asthma: Results of a 6-month double-blind placebo-controlled trial
    • Zileuton Study Group.
    • Liu M, Cohn J, Zileuton Study Group. Effects of zileuton, a 5-lipoxygenase inhibitor, in moderate asthma: results of a 6-month double-blind placebo-controlled trial [abstract]. Eur Respir J 1994;7:282s.
    • (1994) Eur Respir J , vol.7
    • Liu, M.1    Cohn, J.2
  • 82
    • 1842807848 scopus 로고
    • Chronic 5-lipoxygenase (5-LO) inhibition by zileuton significantly decreases the requirement for acute steroid treatment of asthma
    • Zileuton Study Group.
    • Israel E, Cohn J, Dube L, Drazen J, Zileuton Study Group. Chronic 5-lipoxygenase (5-LO) inhibition by zileuton significantly decreases the requirement for acute steroid treatment of asthma [abstract]. Am J Respir Crit Care Med 1995;151:A678.
    • (1995) Am J Respir Crit Care Med , vol.151
    • Israel, E.1    Cohn, J.2    Dube, L.3    Drazen, J.4
  • 83
    • 85030271933 scopus 로고
    • The effect of a 5-lipoxygenase (5-LO) inhibitor ABT-761 on inhaled house dust mite early asthmatic response
    • Presented at February 24-March 1, New York, NY
    • Rosenberg MA, Torres MJ, Valencia A, et al. The effect of a 5-lipoxygenase (5-LO) inhibitor ABT-761 on inhaled house dust mite early asthmatic response. Presented at American Academy of Allergy and Immunology Annual Conference; February 24-March 1, 1995; New York, NY.
    • (1995) American Academy of Allergy and Immunology Annual Conference
    • Rosenberg, M.A.1    Torres, M.J.2    Valencia, A.3
  • 84
    • 15844419802 scopus 로고
    • Effect of the 5-lipoxygenase inhibitor, ZD2138, on cold-air-induced bronchoconstriction in patients with asthma
    • Strek ME, Solway J, Saller L, Kowash K, Miller CJ, Israel E. Effect of the 5-lipoxygenase inhibitor, ZD2138, on cold-air-induced bronchoconstriction in patients with asthma [abstract]. Am J Respir Crit Care Med 1995;151: A377.
    • (1995) Am J Respir Crit Care Med , vol.151
    • Strek, M.E.1    Solway, J.2    Saller, L.3    Kowash, K.4    Miller, C.J.5    Israel, E.6
  • 86
    • 0027458882 scopus 로고
    • Oral leukotriene inhibitor (MK-886) blocks allergen-induced airway responses
    • Friedman BS, Bel EH, Buntinx A, et al. Oral leukotriene inhibitor (MK-886) blocks allergen-induced airway responses. Am Rev Respir Dis 1993;147:839-44.
    • (1993) Am Rev Respir Dis , vol.147 , pp. 839-844
    • Friedman, B.S.1    Bel, E.H.2    Buntinx, A.3
  • 87
    • 0028821025 scopus 로고
    • The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo
    • Diamant Z, Timmers MC, Van der Veen H, et al. The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo. J Allergy Clin Immunol 1995;95:42-51.
    • (1995) J Allergy Clin Immunol , vol.95 , pp. 42-51
    • Diamant, Z.1    Timmers, M.C.2    Van Der Veen, H.3
  • 89
    • 0000981709 scopus 로고
    • Multicenter trial of Bay x1005, a new 5-lipoxygenase activating protein inhibitor in the treatment of chronic asthma
    • Virchow JC, Noller PS, Wiessman KJ, et al. Multicenter trial of Bay x1005, a new 5-lipoxygenase activating protein inhibitor in the treatment of chronic asthma [abstract]. Am J Respir Crit Care Med 1995;151:A377.
    • (1995) Am J Respir Crit Care Med , vol.151
    • Virchow, J.C.1    Noller, P.S.2    Wiessman, K.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.