Heat shock protein interactions with the glucocorticoid receptor

Pulmonary Pharmacology and Therapeutics

Volumn 11, Issue 1, 1998, Pages 7-12

  Bertorelli, G ^a   Bocchino, V ^b   Olivieri, D ^b  

^a Ospedale Rasori   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; PROTEIN P53;

APOPTOSIS; ENZYME ACTIVITY; GENE EXPRESSION; HOMEOSTASIS; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION;

EID: 0032004231     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1006/pupt.1998.0119     Document Type: Review

References (57)

1. 1. Ritossa F M. A new puffing pattern induced by a temperature shock and DNP in Drosophila. Experientia 1962; 18: 571-573.
2. 2. Chrousos G P, Gold P W. The concepts of stress and stress system disorders. J Am Med Assoc 1992; 267: 1244-1252.
3. 3. Chrousos G P. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 1995; 332: 1351-1362.
4. 4. Evans R M. The steroid and thyroid hormone receptor superfamily. Science 1988; 240: 889-895.
5. 5. Mangelsdorf D J, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans R M. The nuclear receptor superfamily: the second decade. Cell 1995; 83: 835-839.
6. 6. Giguere V, Hollenberg S M, Rosenfeld M G, Evans R M. Functional domains of the human glucocorticoid receptor. Cell 1986; 46: 645-652.
7. 7. Hollenberg S M, Giguere V, Segui P, Evans R M. Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor. Cell 1987; 49: 39-46.
8. 8. Dahlman-Wright K, Almlof T, McEwan I J, Gustafsson J A, Wright A P H. Delineation of a small region within the major transactivation domain of the human glucocorticoid receptor that mediates transactivation of gene expression. Proc Natl Acad Sci USA 1994; 91: 1619-1623.
9. 9. Freedman L P, Luisi B F, Korszun Z R, Basavappa R, Sigler P B, Yamamoto K R. The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain. Nature 1988; 334: 543-546.
10. 10. Zilliacus J, Wright A P H, Carlstedt-Duke J, Gustafsson J-A. Structural determinants of DNA-binding specificity by steroid receptors. Mol Endocrinol 1995; 9: 389-400.
11. 11. Tsai S Y, Carlstedt-Duke J, Weigel N L, Dahlman K, Gustafsson J-A, Tsai M J, O'Malley B W. Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation. Cell 1988; 55: 361-369.
12. 12. Picard D, Yamamoto K R. Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J 1987; 6: 3333-3340.
13. 13. Lefstin J A, Thomas J R, Yamamoto K R. Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions. Genes Dev 1994; 8: 2842-2856.
14. 14. Warriar N, Yu C, Govindan M V. Hormone binding domain of the human glucocorticoid receptor. J Biol Chem 1994; 269: 29010-29015.
15. 15. Dalman F C, Scherrer L C, Taylor L P, Akil H, Pratt W B. Localization of the 90-kDa heat shock protein binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition. J Biol Chem 1991; 266: 3482-3490.
16. 16. Hutchison K A, Scherrer L C, Czar M J, Stancato L F, Chow Y H, Jove R, Pratt W B. Regulation of glucocorticoid receptor function through assembly of a receptor-heat shock protein complex. Ann NY Acad Sci 1993; 684: 35-48.
17. 17. Pratt W B. The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor. J Biol Chem 1993; 268: 21455-21458.
18. 18. Dahlman-Wright K, Wright A P H, Gustafsson J-A. Determinants of high-affinity DNA binding by the glucocorticoid receptor: evaluation of receptor domains outside the DNA-binding domain. Biochemistry 1992; 31: 9040-9044.
19. 19. Hollenberg S, Evans R M. Multiple and cooperative transactivation domains in the human glucocorticoid receptor. Cell 1988; 55: 899-906.
20. 20. Webster N J G, Green S, Jin J R, Chambon P. The hormone-binding domain of estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell 1988; 54: 199-207.
21. 21. Danielian P S, White R, Lees J A, Parker M G. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J 1992; 11: 1025-1033.
22. 22. Lanz R B, Rusconi S. A conserved carboxy-terminal subdomain is important for ligand interpretation and transactivation by nuclear receptors. Endocrinology 1994; 135: 2183-2195.
23. 23. Godowski P J, Rusconi S, Miesfeld R, Yamamoto K R. Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement. Nature 1987; 325: 365-368.
24. 24. Truss M, Beato M. Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocr Rev 1993; 14: 459-479.
25. 25. Tsai M-J, O'Malley B W. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 1994; 63: 451-486.
26. 26. Beato M, Herrlich P, Schutz G. Steroid hormone receptors: many actors in search of a plot. Cell 1995; 83: 851-857.
27. 27. Wright A P, Zilliacus J, McEwan I J, Dahlman-Wright K, Almlof T, Carlstedt-Duke J, Gustafsson J-A. Structure and function of the glucocorticoid receptor. J Steroid Biochem Mol Biol 1993; 47: 11-19.
28. 28. Smith D F, Toft D O. Steroid receptors and their associated proteins. Mol Endocrinol 1993; 7: 4-11.
29. 29. Czar M J, Owens-Grillo J K, Dittmar K D, Hutchison K A, Zacharel A M, Leach K L, Deibel M R J, Pratt W B. Characterization of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex. J Biol Chem 1994; 269: 11155-11161.
30. 30. Hutchison K A, Dittmar K D, Czar M J, Pratt W B. Proof that hsp70 is required for assembly of the glucocorticoid receptor into a heterocomplex with hsp90. J Biol Chem 1994; 269: 5043-5049.
31. 31. Hutchison K A, Dittmar K D, Pratt W B. All of the factors required for assembly of the glucocorticoid receptor into a functional heterocomplex with heat shock protein 90 are preassociated in a self-sufficient protein folding structure, a 'foldosome'. J Biol Chem 1994; 269: 27894-27899.
32. 32. Hu L-M, Bodwell J, Hu J-M, Orti E, Munck A. Glucocorticoid receptors in ATP-depleted cells. J Biol Chem 1994; 269: 6571-6577.
33. 33. Madan A P, DeFranco D B. Bidirectional transport of glucocorticoid receptors across the nuclear envelope. Proc Natl Acad Sci USA 1993; 90: 3588-3592.
34. 34. Czar M J, Owens-Grillo J K, Yem A W, Leach K, Deibel M R, Welsh M J, Pratt W B. The hsp56 immunophilin component untransformed steroid receptor complexes is localized both to microtubules in the cytoplasm and to the same non-random region within the nucleus as the steroid receptor. Mol Endocrinol 1994; 8: 1734-1741.
35. 35. Czar M J, Lyons R H, Welsh M J, Renoir J-M, Pratt W B. Evidence that the FK506-binding immunophilin heat shock protein 56 is required for trafficking of the glucocorticoid receptor from the cytoplasm to the nucleus. Mol Endocrinol 1995; 9: 1549-1560.
36. 36. Lukola A, Akerman K, Pseea T. Human lymphocyte glucocorticoid receptors reside mainly in the cytoplasm. Biochem Biophys Res Commun 1985; 131: 877.
37. 37. Cidlowski J A, Bellingham D L, Powell-Oliver F E, Lubahn D B, Sar M. Novel antipeptide antibodies to the human glucocorticoid receptor: recognition of multiple receptor forms in vitro and distinct localization of cytoplasmic and nuclear receptors. Mol Endocrinol 1990; 4: 1427-1437.
38. 38. Brink M, Humbel B M, De Kloet E R, Van Driel R. The unliganded glucocorticoid receptor is localized in the nucleus, not in the cytoplasm. Endocrinology 1992; 130: 3575-3581.
39. 39. Akner G, Wikstrom A C, Mossberg K, Sundqvist K G, Gustafsson J-A. Morphometric studies of the localization of the glucocorticoid receptor in mammalian cells and of glucocorticoid hormone-induced effects. J Histochem Cytochem 1994; 42: 645-657.
40. 40. Rossini G P, Malaguti C. Nanomolar concentrations of untransformed glucocorticoid receptor in nuclei of intact cells. J Steroid Biochem Mol Biol 1994; 51: 291-298.
41. 41. Akner G, Wikstrom A-C, Gustafsson J-A. Subcellular distribution of the glucocorticoid receptor and evidence for its association with microtubules. J Steroid Biochem Mol Biol 1995; 52: 1-16.
42. 42. Bresnick E H, Dalman F C, Sanchez E R, Pratt W B. Evidence that the 90-kDa heat shock protein is necessary for the steroid binding conformation of the L cell glucocorticoid receptor. J Biol Chem 1989; 264: 4992-4997.
43. 43. Nathan D F, Lindquist S. Mutational analysis of hsp90 function: interactions with a steroid receptor and a protein kinase. Mol Cell Biol 1995; 15: 3917-3925.
44. 44. Orti E, Bodwell J E, Munck A. Phosphorylation of steroid hormone receptors. Endocr Rev 1992; 13: 105-128.
45. 45. Bodwell J E, Hu L-M, Hu J-M, Orti E, Munck A. Glucocorticoid receptors: ATP-dependent cycling and hormone-dependent hyperphosphorylation. J Steroid Biochem Mol Biol 1993; 47: 31-38.
46. 46. Pratt W B. Transformation of glucocorticoid and progesterone receptors to the DNA-binding state. J Cell Biochem 1987; 35: 51-68.
47. 47. De Franco D B, Madan A P, Tang Y, Chandran U R, Xiao N, Yang J. Nucleocytoplasmic shuttling of steroid receptors. Vit. Horm 1995; 51: 315-338.
48. 48. Dalman F C, Scherrer L C, Taylor L P, Akil H, Pratt W B. Localization of the 90-kDa heat shock protein-binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition. J Biol Chem 1991; 266: 3482-3490.
49. 49. Bresnick E H, Dalman F C, Sanchez E R, Pratt W B. Evidence that the 90-kDa heat shock protein is necessary for the steroid binding conformation of the L cell glucocorticoid receptor. J Biol Chem 1989; 264: 4992-4997.
50. 50. Meshinchi S, Sanchez E R, Martell K J, Pratt W B. Elimination and reconstitution of the requirement for hormone in promoting temperature-dependent transformation of cytosolic glucocorticoid receptors to the DNA-binding state. J Biol Chem 1990; 265: 4863-4870.
51. 51. Hutchison K A, Czar M J, Scherrer L C, Pratt W B. Monovalent selectivity for ATP-dependent association of the glucocorticoid receptor with hsp70 and hsp90. J Biol Chem 1992; 267: 14047-14053.
52. 52. Whitesell L, Cook P. Stable and specific binding of hsp90 by geldanamycin disrupts glucocorticoid receptor function in intact cells. Mol Endocrinol 1995; 9: 670-678.
53. 53. Schulte T W, An W G, Neckers L M. Geldanamycin-induced destabilization of RAF-1 involves the proteasome. Biochem Biophys Res Commun 1997; 239: 655-659.
54. 54. Dasgupta G, Momand J. Geldanamycin prevents nuclear translocation of mutant p53. Exp Cell Res 1997; 237: 29-37.
55. 55. Pratt W B, Toft D O. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocrinol Rev 1997; 18: 306-360.
56. 56. Jacob U, Meyer I, Bugl H, Andre S, Bardwell J C A, Buchner J. Structural organization of prokaryotic and eukaryotic hsp90. J Biol Chem 1995; 270: 14412-14419.
57. 57. Gupta R S, Golding B. The origin of the eukaryotic cell. Trends Biochem Sci 1996; 21: 166-171.