The cellular and mediator basis of asthma in relation to natural history

Lancet

Volumn 350, Issue SUPPL.2, 1997, Pages 5-9

  Holgate, Stephen T ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; BRONCHODILATING AGENT; CORTICOSTEROID; CROMOGLYCATE DISODIUM; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT;

ASTHMA; CLINICAL FEATURE; ENVIRONMENTAL FACTOR; EOSINOPHIL; GENETIC SUSCEPTIBILITY; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MAST CELL; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; REVIEW; TISSUE REPAIR;

EID: 0030863032     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0140-6736(97)90029-5     Document Type: Article

References (56)

1. Holgate ST. Asthma genetics: waiting to exhale. Nat Genet 1997; 15: 227-29.
2. Daniels SE, Bhattacharrya S, James A, et al. A genome-wide search for quantitative trait loci underlying asthma. Nature 1996; 383: 247-50.
3. Burastero SE, Crimi E, Balbo A, et al. Oligoclonality of lung T lymphocytes following exposure to allergen in asthma. J Immunol 1995; 155: 5836-46.
4. Warner JA, Jones AC, Miles EA, Colwell BM, Warner JA. Maternofetal interaction and allergy. Allergy 1996; 51: 447-51.
5. Stevenson E, Turner G, Heaney LG, et al. Bronchoalveolar lavage findings suggest two different forms of childhood asthma. Clin Exp Allergy (in press).
6. Warner JA, Miles EA, Jones AC, Quint DJ, Colwell BM, Warner JA. Is deficiency of interferon gamma production by allergen triggered cord blood T cells a predictor of atopic eczema? Clin Exp Allergy 1994; 24: 223-30.
7. Tang MLK, Kemp AS, Thorburn J, Hill DJ. Reduced interferon-γ and subsequent atopy. Lancet 1994; 344: 983-85.
8. Miles EA, Warner JA, Jones AC, Colwell BM, Bryant TM, Warner JO. Peripheral blood mononuclear cell proliferation responses in the first year of life in babies born of allergic parents. Clin Exp Allergy 1996; 26: 780-88.
9. Shaheen S. Discovering the causes of atopy: patterns of childhood infection and fetal growth may be implicated. BMJ 1997; 314: 987-88.
10. Holt PG, Sly PD. Allergic respiratory disease: strategic targets for primary prevention in childhood. Thorax 1997; 52: 1-4.
11. 1) and the development of asthma in childhood: a prospective study. N Engl J Mud 1990; 323: 502-07.
12. Cookson WOCM, Moffatt ME. Asthma: an epidemic in the absence of infection. Science 1997; 275: 41-42.
13. Shaheen SO, Aaby P, Hall AJ, et al. Measles and atopy in Guinea-Bissau. Lancet 1996; 347: 1792-96.
14. Strachan DP. Allergy and family size: a riddle worth solving. Clin Exp Allergy 1997; 27: 235-36.
15. Strachan D. Socioeconomic factors and the development of allergy. Toxcol Lett 1996; 86: 199-203.
16. Weichmann HE. Environment, lifestyle and allergy: the German answer. Allergy 1995; 4: 315-16.
17. Martinez FO. Role of viral infections in the inception of asthma and allergies during childhood: could they be "protective"? Thorax 1994; 49: 1189-91.
18. Shirakawa T, Enomoto T, Shimazu S-I, Hopkin JM. The inverse association between tuberculin responses and atopic disorder. Science 1997; 275: 77-79.
19. Hussell T, Spender LC, Georgiou A, O'Garra A, Openshaw PJM. Th1 and Th2 cytokine induction in pulmonary T cells during infection with respiratory syncytial virus: J Gen Virol 1996; 77: 2447-55.
20. Varney VA, Hamid QA, Gaga M, et al. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest 1993; 92: 644-51.
21. Castro JE, Listman JA, Jacobson BA, et al. Fas modulation of apoptosis during negative selection of thymocytes. Immunity 1996; 5: 617-27.
22. Wefel T, Morita A, Greve M, et al. Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis. J Invest Dermatol 1996; 107: 871-76.
23. Krug N, Madden J, Redington AE, et al. T-cell cytokine profile evaluated at the single cell level in subjects with allergic asthma and control subjects: comparison between peripheral blood and bronchoalveolar lavage fluid. Am J Respir Cell Mol Biol 1996; 14: 319-26.
24. Semper AE, Hartley JA. Dendritic cells in the lung: what is their relevance to asthma? Clin Exp Allergy 1996; 26: 485-90.
25. Hartley JA, Semper AE, Holgate ST. In vivo and in vitro expression of Fc∈ R1 in human peripheral blood (PB). Immunology 1996; 89 (suppl 1): 41.
26. O'Hehir RE, Garman RD, Greenstein JL, Lamb JR. The specificity and regulation ofT-cell responsiveness to allergens. Ann Rev Immunol 1991; 9: 67-95.
27. Robinson DS, Hamid Q, Ying S, et al. Predominant Th2-type bronchoalveolar lavage T-lymphocyte population in atopic asthma. N Engl J Med 1992; 326: 298-304.
28. Drazen JM, Arm JP, Austen KF. Sorting out the cytokines of asthma. J Exp Med 1996; 183: 1-5.
29. Keane-Myers A, Cause WC, Linsley PS, Chen S-J, Wills-Karp M. B7-CD28/CTLA-4 co-stimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens. J Immunol 1997; 158: 2042-49.
30. Palmer EM, Seventer GA. Human T cell differentiation is regulated by the combined action of cytokines and accessory cell-dependent costimulatory signals. J Immunol 1997; 158: 1654-62.
31. Jaffar Z, Djukanović R, Roberts K, Holgate S. Cytokine mRNA expression by lung biopsy tissue from asthmatic and normal subjects during culture. FASEB J 1996; 10: A1054.
32. Humbert M, Durham SR, Ying S, et al. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and non-atopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. Am J Respir Crit Care Med 1996; 154: 1497-504.
33. Humbert M, Grant JA, Taborda-Barata L, et al. High affinity IgE receptor (Fc∈R1)-bearing cells in bronchial biopsies from atopic and non-atopic asthma. Am J Respir Grit Care Med 1996; 153: 1931-37.
34. Yanagida M, Fukamachi H, Ohgami K, et al. Effects ofT helper 2-type cytokines, interleukin-3 (IL-3), IL-4, IL-5 and IL-6 on the survival of cultured human mast cells. Blood 1995; 86: 3705-14.
35. Denburg JA. Microenvironmental influences on inflammatory cell differentiation. Allergy 1995; 50 (suppl 25): 25-28.
36. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996; 383: 787-93.
37. Wilkinson J, Holgate ST. Evidence for and against chromosome 5q as a region of interest in asthma and atopy. Clin Exp Allergy 1996; 26: 861-64.
38. Bradding P, Walls AF, Church MK. Mast cells and basophils: their role in initiating and maintaining inflammatory responses. In: Holgate ST, ed. Immunopharmacology of the respiratory system. London: Academic Press, 1995: 53-84.
39. Church MK, Levi-Schaffer F. The human mast cell. J Allergy Clin Immunol 1997; 99: 155-60.
40. Springer TS. Adhesion receptors of the immune system. Nature 1990; 346: 425-34.
41. Casale TB, Costa JJ, Galli SJ. TNFα is important in human lung allergic reactions. Am J Respir Cell Mol Biol 1996; 15: 35-44.
42. 4-Integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep. J Clin Invest 1994; 93: 776-87.
43. Baggiolini M, Dahinden CA. CC chemokines in allergic inflammation. Immunol Today 1994; 15: 127-33.
44. Wilson JW, Li X, Pain MCF. The lack of distensibility of asthmatic airways. Am Rev Respir Dis 1993; 148: 806-09.
45. Montefort S, Djukanović R, Holgate ST, Roche WR. Ciliated cell damage in the bronchial epithelium of asthmatics and non-asthmatics. Clin Exp Allergy 1993; 23: 185-89.
46. Lackie PM, Baker JE, Günthert U, Holgate ST. Expression of CD44 isoforms is increased in the airway epithelium of asthmatic subjects. Am J Respir Cell Mol Biol 1997; 16: 14-22.
47. Raeburn D, Webber SE. Proinflammatory potential of the airway epithelium in bronchial asthma. Eur Respir J 1994; 7: 226-33.
48. Robinson C. The airway epithelium: the origin and target of inflammatory airways disease and injury. In: Holgate ST, ed. Immunopharmacology of the respiratory system. London: Academic Press, 1995: 187-207.
49. Pender SLF, Tickle SP, Docherty AJP, Howie D, Walter NC, McDonald TT. A major role for matrix metalloproteases in T cell injury in the gut. J Immunol 1997; 158: 1582-90.
50. Roche WR, Beasley R, Williams JH, Holgate ST. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1989; i: 520-23.
51. Holgate ST, Djukanović R, Howarth PH, Montefort S, Roche W. The T-cell and the airways fibrotic response in asthma. Chest 1993; 103: 125S-28S.
52. +T cells in atopic asthma. J Allergy Clin Immunol (in press).
53. Tomassini JE, Graham D, DeWitt CM, Lineberger DW, Rodkey JA, Colonno RJ. cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1. Proc Natl Acad Sci 1989; 86: 4907-11.
54. Johnston SL, Pattemore PK, Sanderson G, et al. Community study of role of viral infections in exacerbations of asthma in school children in the community. BMJ 1995; 310: 1225-29.
55. Fraenkel DJ, Bardin PG, Sanderson G, Lampe F, Johnston SL, Holgate ST. Lower airway inflammatory response during rhinovirus colds in normal and asthmatic subjects. Am J Respir Crit Care Med 1995; 151: 879-86.
56. König P, Shaffer J. The effect of drug therapy on long-term outcome of childhood asthma: a possible preview of the international guidelines. Allergy Clin Immunol 1996; 98: 1103-11.