2 Fibrinogen Receptor Antagonists: Design and Clinical Applications

Progress in Medicinal Chemistry

Volumn 36, Issue C, 1999, Pages 29-90

  Eldred, Colin D ^a   Judkins, Brian D ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN RECEPTOR; FIBRINOLYTIC AGENT;

CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; FIBRINOLYTIC THERAPY; HUMAN; METHODOLOGY; REVIEW; STRUCTURE ACTIVITY RELATION; THROMBOSIS;

DRUG DESIGN; FIBRINOLYTIC AGENTS; HUMANS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOLYTIC THERAPY; THROMBOSIS;

EID: 0033289848     PISSN: 00796468     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6468(08)70045-6     Document Type: Article

References (210)

1. Packham M.A. Can. J. Physiol. Pharmacol. 72 (1994) 278-284
2. Coller B.S. Eur. Heart J. 16 Suppl. L (1995) 11-15
3. Frishman W.H., Burns B., Atac B., Alturk N., Altajar B., and Lerrick K. Am. Heart J. 130 (1995) 877-892
4. Lefkovits J., Plow E.F., and Topol E.J. N. Engl. J. Med. 332 (1995) 1553-1559
5. Harker L.A. Am. J. Cardiol. 60 (1987) 20-28B
6. Wu K.K. J. Intern. Med. 239 (1996) 17-34
7. Roth G.J. Blood 77 (1991) 5-19
8. Ruggeri Z.M., and Ware J. FASEB J. 7 (1993) 308-316
9. Bennett J.S. Hosp. Pract. 27 (1992) 124-138
10. Ruggeri Z.M. Circulation 86 Suppl. III (1992) 26-29
11. Mann K.G., Krishnaswamy S., and Lawson J.H. Semin. Hematol. 29 (1992) 213-226
12. Nemerson Y. Semin. Hematol. 29 (1992) 170-176
13. Manning D.R., and Brass L.F. Thromb. Haemostasis 66 (1991) 393-399
14. Faull R.J., and Ginsberg M.H. Stem Cells 13 (1995) 38-46
15. Eccleston D., and Topol E.J. Coron. Artery Dis. 6 (1995) 947-955
16. Coller B.S. N. Engl. J. Med. 322 (1990) 33-42
17. Scarborough R.M., Rose J.W., Hsu M.A., Phillips D.R., Fried V.A., Campbell A.M., Nannizzi L., and Charo I.F. J. Biol. Chem. 266 (1991) 9359-9362
18. Lazarus R.A., and McDowell R.S. Curr. Opin. Biotechnol. 4 (1993) 438-445
19. Bennett J.S., and Kolodziej M.A. DM, Dis.-Mon. 38 (1992) 577-631
20. Abrams C., and Shattil S.J. Adv. Mol. Cell Biol. 18 (1997) 67-108
21. Spriggs D., Gold H.K., Hashimoto Y., van Houtte E., Vermylen J., and Collen D. Thromb. Haemostasis 61 (1989) 93-96
22. Charo I.F., Kieffer N., and Phillips D.R. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. (1994), J.B. Lippincott, Philadelphia 489-507
23. D'Souza S.E., Ginsberg M.H., Burke T.A., and Plow E.F. Science (Washington, D.C.) 242 (1988) 91-93
24. Plow E.F., D'Souza S.E., and Ginsberg M.H. Semin. Thromb. Hemostasis 18 (1992) 324-332
25. Phillips D.R., Charo I.F., and Scarborough R.M. Cell 65 (1991) 359-362
26. Calvete J.J. Proc. Soc. Exp. Biol. Med. 208 (1995) 346-360
27. Albelda S.M., and Buck C.A. FASEB J. 4 (1990) 2868-2880
28. Schwartz M.A., Schaller M.D., and Ginsberg M.H. Ann. Rev. Cell Dev. Biol. 11 (1995) 549-599
29. Cox D., Aoki T., Seki J., Motoyama Y., and Yoshida K. Med. Res. Rev. 14 (1994) 195-228
30. Calvete J.J. Thromb. Haemostasis 72 (1994) 1-15
31. Jackson S.P., Yuan Y., Schoenwaelder S.M., and Mitchell C.A. Thromb. Res. 71 (1993) 159-168
32. Liu M.W., Roubin G.S., and King S.B. Circulation 79 (1989) 1374-1387
33. Foster M.R., Hornby E.J., Brown S., Hann M., Kitchin J., Pike N., and Ward P. Thromb. Res. 75 (1994) 269-284
34. Mousa S.A., and Cheresh D.A. Drug Discovery Today 2 (1997) 187-199
35. Mousa S.A., Forsythe M., Lorelli W., Bozarth J., Xue C.B., Wityak J., Sielecki T.M., Olson R.E., DeGrado W., Kapil R., Hussain M., Wexler R., Thoolen M.J., and Reilly T.M. Coron. Artery Dis. 7 (1996) 767-774
36. Alig L., Edenhofer A., Hadvary P., Hurzeler M., Knopp D., Muller M., Steiner B., Trzeciak A., and Weller T. J. Med. Chem. 35 (1992) 4393-4407
37. Allen D.G., Eldred C.D., Judkins B.D., Mitchell W.L., and Scopes D.I.C. PCT Int. Appl. (1998) 97-49698
38. Chem. Abstr. 128 (1997) 102084
39. Foster M.R., Hornby E.J., Brown S., Kitchin J., Hann M., and Ward P. Thromb. Res. 72 (1993) 231-245
40. Panzer-Knodle S., Taite B.B., Mehrotra D.V., Nicholson N.S., and Feigen L.P. J. Pharmacol. Toxicol. Methods 30 (1993) 47-53
41. Folts J. Circulation 83 IV Suppl.IV (1991) 3-14
42. Bush L.R., and Shebuski R.J. FASEB J. 4 (1990) 3087-3098
43. Schumacher W.A., Lee E.C., and Lucchesi B.R. J. Cardiovasc. Pharmacol. 7 (1985) 739-746
44. Romson J.L., Haack D.W., and Lucchesi B.R. Thromb. Res (1980) 841-853
45. Harker L.A., Kelly A.B., and Hanson S.R. Circulation 83 IV Suppl IV (1991) 41-55
46. Makkar R.R., Litvack F., Eigler N.L., Nakamura M., Ivey P.A., Forrester J.S., Shah P.K., Jordan R.E., and Kaul S. Circulation 95 (1997) 1015-1021
47. Hanson S.R., Pareti F.I., Ruggeri Z.M., Marzec U.M., Kunicki T.J., Montgomery R.R., Zimmerman T.S., and Harker L.A. J. Clin. Invest. 81 (1988) 149-158
48. Umemura K., Ishiye M., Araki S., and Nakashima M. Arch. Int. Pharmacodyn. Ther. 330 (1995) 13-24
49. Gold H.K., Yasuda T., Jang I.K., Guerrero J.L., Fallon J.T., Leinbach R.C., and Collen D. Circulation 83 IV Suppl. IV (1991) 26-40
50. Samanen J., Ali F., Romoff T., Calvo R., Sorenson E., Vasko J., Storer B., Berry D., Bennett D., Strohsacker M., Powers D., Stadel J., and Nichols A. J. Med. Chem. 34 (1991) 3114-3125
51. Hayashi Y., Sato Y., Katada J., Takiguchi Y., Ojima I., and Uno I. Bioorg. Med. Chem. Lett. 6 (1996) 1351-1356
52. Barker P.L., Bullens S., Bunting S., Burdick D.J., Chan K.S., Deisher T., Eigenbrot C., Gadek T.R., Gantzos R., Lipari M.T., Muir C.D., Napier M.A., Pitti R.M., Padua A., Quan C., Stanley M., Tom J.Y.K., and Burnier J.P. J. Med. Chem. 35 (1992) 2040-2048
53. Hann M.M., Carter B., Kitchin J., Ward P., Pipe A., Broomhead J., Hornby E., Foster M., and Perry C. Special Publication R. Soc. Chem. 111 (Molecular Recognition: Chemical and Biochemical Problems II) (1992) 145-159
54. Gartner T.K., and Bennett J.S. J. Biol. Chem. 260 (1985) 11891-11894
55. Plow E.E., Pierschbacher M.D., Ruoslahti E., and Marguerie G.A. Proc. Natl. Acad. Sci. U.S.A. 82 (1985) 8057-8061
56. Hawiger J., Kloczewiak M., Bednarek M.A., and Timmons S. Biochemistry 28 (1989) 2909-2914
57. Plow E.E., Pierschbacher M.D., Ruoslahti E., Marguerie G., and Ginsberg M.H. Blood 70 (1987) 110-115
58. Pfaff M., Tangemann K., Muller B., Gurrath M., Muller G., Kessler H., Timpl R., and Engel J. J. Biol. Chem. 269 (1994) 20233-20238
59. Ku T.W., Ali F.E., Barton L.S., Bean J.W., Bondinell W.E., Burgess J.L., Callahan J.E., Calvo R.R., Chen L., Eggleston D.S., Gleason J.G., Huffman W.F., Hwang S.M., Jakas D.R., Karash C.B., Keenan R.M., Kopple K.D., Miller W.H., Newlander K.A., Nichols A., Parker M.F., Peishoff C.E., Samanen J.M., Uzinskas I., and Venslavsky J.W. J. Am. Chem. Soc. 115 (1993) 8861-8862
60. Ali F.E., Bennett D.B., Calvo R.R., Elliott J.D., Hwang S.M., Ku T.W., Lago M.A., Nichols A.J., Romoff T.T., Shah D.H., Vasko J.A., Wong A.S., Yellin T.O., Yuan C.K., and Samanen J.M. J. Med. Chem. 37 (1994) 769-780
61. Bean J.W., Kopple K.D., and Peishoff C.E. J. Am. Chem. Soc. 114 (1992) 5328-5334
62. Ku T.W., Miller W.H., Bondinell W.E., Erhard K.F., Keenan R.M., Nichols A.J., Peishoff C.E., Samanen J.M., Wong A.S., and Huffman W.F. J. Med. Chem. 38 (1995) 9-12
63. Jackson S., DeGrado W., Dwivedi A., Parthasarathy A., Higley A., Krywko J., Rockwell A., Markwalder J., Wells G., Wexler R., Mousa S., and Harlow R. J. Am. Chem. Soc. 116 (1994) 3220-3230
64. Bach A.C., Eyermann C.J., Gross J.D., Bower M.J., Harlow R.L., Weber P.C., and DeGrado W.F. J. Am. Chem. Soc. 116 (1994) 3207-3219
65. Mcdowell R.S., and Gadek T.R. J. Am. Chem. Soc. 114 (1992) 9245-9253
66. Scarborough R.M., Naughton M.A., Teng W., Rose J.W., Phillips D.R., Nannizzi L., Arfsten A., Campbell A.M., and Charo I.F. J. Biol. Chem. 268 (1993) 1066-1073
67. Wityak J., and Sielecki T.M. Exp. Opin. Ther. Pat. 6 (1996) 1175-1194
68. Scarborough R.M. Drugs Future 23 (1998) 585-590
69. Cheng S., Craig W.S., Mullen D., Tschopp J.E., Dixon D., and Pierschbacher M.D. J. Med. Chem. 37 (1994) 1-8
70. Cheng S., Craig W.S., and Tschopp J.F. Drugs Future 19 (1994) 1098-1100
71. Wagner G., Horn H., Richter P., Vieweg H., Lischke I., and Kazmirowski H.G. Pharmazie 36 (1981) 597-603
72. Zablocki J.A., Miyano M., Rao S.N., Panzer-Knodle S., Nicholson N., and Feigen L. J. Med. Chem. 35 (1992) 4914-4917
73. Zablocki J.A., Miyano M., Garland R.B., Pireh D., Schretzman L., Rao S.N., Lindmark R.J., Panzer-Knodle S.G., Nicholson N.S., Taite B.B., Salyers A.K., King L.W., Campion J.C., and Feigen L.P. J. Med. Chem. 36 (1993) 1811-1819
74. Zablocki J.A., Rico J.G., Garland R.B., Rogers T.E., Williams K., Schretzman L.A., Rao S.A., Bovy P.R., Tjoeng F.S., Lindmark R.J., Toth M.V., Zupec M.E., McMackins D.E., Adams S.P., Miyano M., Markos C.S., Milton M.N., Paulson S., Herin M., Jacqmin P., Nicholson N.S., Panzer-Knodle S.G., Haas N.F., Page J.D., Szalony J.A., Taite B.B., Salyers A.K., King L.W., Campion J.G., and Feigen L.P. J. Med. Chem. 38 (1995) 2378-2394
75. Bondinell W.E., Keenan R.M., Miller W.H., Ali F.E., Allen A.C., and DeBrosse C.W. Bioorg. Med. Chem. 2 (1994) 897-908
76. McDowell R.S., Gadek T.R., Barker P.L., Burdick D.J., Chan K.S., and Quan C.L. J. Am. Chem. Soc. 116 (1994) 5069-5076
77. McDowell R.S., Blackburn B.K., Gadek T.R., McGee L.R., Rawson T., and Reynolds M.E. J. Am. Chem. Soc. 116 (1994) 5077-5083
78. Wityak J., Sielecki T.M., Pinto D.J., Emmett G., Sze J.Y., Liu J., Tobin A.E., Wang S.A., Jiang B., Ma P., Mousa S.A., Wexler R.R., and Olson R.E. J. Med. Chem. 40 (1997) 50-60
79. Xue C.B., Rafalski M., Roderick J., Eyermann C.J., Mousa S., Olson R.E., and DeGrado W.F. Bioorg. Med. Chem. Lett. 6 (1996) 339-344
80. Xue C.B., Wityak J., Sielecki T.M., Pinto D.J., Batt D.G., Cain G.A., Sworin M., Rockwell A.L., Roderick J.J., Wang S., Orwat M.J., Frietze W.E., Bostrom L.L., Liu J., Higley C.A., Rankin F.W., Tobin E., Emmett G., Lalka G.K., Sze J.Y., Di Meo S.V., Mousa S.A., Thoolan M.J., Racanelli A.L., Hausner E.A., Reilly T.M., DeGrado W.F., Wexler R.R., and Olson R.E. J. Med. Chem. 40 (1997) 2064-2084
81. Fisher M.J., Gunn B., Harms C.S., Kline A.D., Mullaney J.T., and Nunes A. J. Med. Chem. 40 (1997) 2085-2101
82. Sall D.J., Arfsten A.E., Berry D.R., Denney M.L., Harms C.S., McCowan J.R., Ray J.K., Scarborough R.M., Um S.L., Utterback B.G., and Jakubowski J.A. Bioorg. Med. Chem. Lett. 6 (1996) 81-86
83. Sall D.J., Arfsten A.E., Bastian J.A., Denney M.L., Harms C.S., McCowan J.R., Morin Jr. J.M., Rose J.W., Scarborough R.M., Smyth M.S., Um S.L., Utterback B.G., Vasileff R.T., Wikel J.H., Wyss V.L., and Jakubowski J.A. J. Med. Chem. 40 (1997) 2843-2857
84. Himmelsbach F., Austel V., Guth B., Linz G., Muller T.H., Piper H., Seewaldt Becker E., and Weisenberger H. Eur. J. Med. Chem. 30 (1995) 243s-254s
85. J. Kitchin, J. Broomhead, B. Carter, A.J. Crame, M. Foster, M. Hann, E. Hornby, S. Hindley, C. Perry, A.J. Pipe, N.R. Taylor, P. Ward, Innovation Perspect. Solid Phase Synth. Comb. Libr., Collect. Pap., Int. Symp., 4th Meeting Date 1995, 1996, R. Epton (Ed.), Mayflower Scientific, Birmingham, UK, 449-454.
86. Eldred C.D., Evans B., Hindley S., Judkins B.D., Kelly H.A., Kitchin J., and Lumley P. J. Med. Chem. 37 (1994) 3882-3885
87. Eldred, CD., D.A. Allen, Y.W. Cheung, T.A. Cook, B.D. Judkins, Kelly. H.A., P. Lumley, B. Porter, (1994) XIIIth International Symposium on Medicinal Chemistry, Paris, France, poster no. P4.
88. Harada T., Katada J., Tachiki A., Asari T., Iijima K., Uno I., Ojima I., and Hayashi Y. Bioorg. Med. Chem. Lett. 7 (1997) 209-212
89. Asari T., Ishikawa S., Sasaki T., Katada J., Hayashi Y., Harada T., Yano M., Yasuda E., Uno I., and Ojima I. Bioorg. Med. Chem. Lett. 7 (1997) 2099-2104
90. Kottirsch G., Tapparelli C., and Zerwes H.G. Bioorg. Med. Chem. Lett. 3 (1993) 1675-1680
91. Kottirsch G., Zerwes H.G., Cook N.S., and Tapparelli C. Bioorg. Med. Chem. Lett. 7 (1997) 727-732
92. Badorc A., Bordes M.F., de Cointet P., Savi P., Bernat A., Lale A., Petitou M., Maffrand J.P., and Herbert J.M. J. Med. Chem. 40 (1997) 3393-3401
93. Tanaka A., Sakai H., Ishikawa T., Aoki T., Moroyama Y., and Takasugi H. Bioorg. Med. Chem. Lett. 7 (1997) 521-526
94. Tanaka A., Sakai H., Ishikawa T., Nakanishi I., Ohkubo M., Aoki T., Motoyama Y., and Takasugi H. Bioorg. Med. Chem. Lett. 6 (1996) 1443-1448
95. Sugihara H., Fukushi H., Miyawaki T., Imai Y., Terashita Z., Kawamura M., Fujisawa Y., and Kita S. J. Med. Chem. 41 (1998) 489-502
96. Klein S.I., Czekaj M., Molino B.F., and Chu V. Bioorg. Med. Chem. Lett. 7 (1997) 1773-1778
97. Hartman G.D., Egbertson M.S., Halczenko W., Laswell W.L., Duggan M.E., Smith R.L., Naylor A.M., Manno P.D., Lynch R.J., Zhang G., Chang C.T.-C., and Gould R.J. J. Med. Chem. 35 (1992) 4640-4642
98. Naylor A.M., Egbertson M.S., Vassallo L.M., Birchenough L.A., Zhang G.X., Gould R.J., and Hartman G.D. Bioorg. Med. Chem. Lett. 4 (1994) 1841-1846
99. Egbertson M.S., Naylor A.M., Hartman G.D., Cook J.J., Gould R.J., Holahan M.A., Lynch Jr. J.J., Lynch R.J., Stanieri M.T., and Vassallo L.M. Bioorg. Med. Chem. Lett. 4 (1994) 1835-1840
100. Duggan M.E., Naylor A.M., Olsen J.J., Perkins P.S., Anderson C.T., Chang C., Cook J.J., Gould R.J., Ihle N.C., Hartman G.D., Lynch J.J., Lynch R.J., Manno P.D., Schaffer L.W., and Smith R.L. J. Med. Chem. 38 (1995) 3332-3341
101. Askew B.C., Mclntyre C.J., Hunt C.A., Claremon D.A., Gould R.J., Lynch R.J., and Armstrong D.J. Bioorg. Med. Chem. Lett. 5 (1995) 475-480
102. Egbertson M.S., Bednar B., Bednar R.A., Hartman G.D., Gould R.J., Lynch R.J., Vassallo L.M., and Young S.D. Bioorg. Med. Chem. Lett. 6 (1996) 1415-1420
103. Egbertson M.S., Hartman G.D., Gould R.J., Bednar B., Bednar R.A., Cook J.J., Gaul S.L., Holahan M.A., Libby L.A., Lynch J.J., Lynch R.J., Sitko G.R., Stranieri M.T., and Vasallo L.M. Bioorg. Med. Chem. Lett. 6 (1996) 2519-2524
104. Halczenko W., Cook J.J., Holahan M.A., Sitko G.R., Stranieri M.T., Zhang G., Lynch R.J., Lynch Jr. J.J., Gould R.J., and Hartman G.D. Bioorg. Med. Chem. Lett. 6 (1996) 2771-2776
105. Hutchinson J.H., Cook J.J., Brashear K.M., Breslin M.J., Glass J.D., Gould R.J., Halczenko W., Holahan M.A., Lynch R.J., Sitko G.R., Stranieri M.T., and Hartman G.D. J. Med. Chem. 39 (1996) 4583-4591
106. Prugh J.D., Gould R.J., Lynch R.J., Zhang G.X., Cook J.J., Holahan M.A., Stranieri M.T., Sitko G.R., Gaul S.L., Bednar R.A., Bednar B., and Hartman G.D. Bioorg. Med. Chem. Lett. 7 (1997) 865-870
107. Brashear K.M., Cook J.J., Bednar B., Bednar R.A., Gould R.J., Halczenko W., Holahan M.A., Lynch R.J., Hartman G.D., and Hutchinson J.H. Bioorg. Med. Chem. Lett. 7 (1997) 2793-2798
108. Askew B.C., Bednar R.A., Bednar B., Claremon D.A., Cook J.J., Mclntyre C.J., Hunt C.A., Gould R.J., Lynch R.J., Lynch J.J., Gaul S.L., Stranieri M.T., Sitko G.R., Holahan M.A., Glass J.D., Hamill T., Gorham L.M., Prueksaritanont T., Baldwin J.J., and Hartman G.D. J. Med. Chem. 40 (1997) 1779-1788
109. Askew B.C., Mclntyre C.J., Hunt C.A., Claremon D.A., Baldwin J.J., Anderson P.S., Gould R.J., Lynch R.J., Chang C.C.T., Cook J.J., Lynch J.J., Holahan M.A., Sitko G.R., and Stranieri M.T. Bioorg. Med. Chem. Lett. 7 (1997) 1531-1536
110. Miller W.H., AH F.E., Bondinell W.E., Callahan J.F., Calvo R.R., Eggleston D.S., Haltiwanger R.C., Huffman W.F., Hwang S.M., Jakas D.R., Keenan R.M., Koster P.F., Ku T.W., Kwon C., Newlander K.A., Nichols A.J., Parker M.F., Samanen J.M., Southall L.S., Takata D.T., Uzsinskas I.N., Valocik R.E., Vasko-Moser J.A., Wong A.S., Yellin T.O., and Yuan C.C.K. Bioorg. Med. Chem. Lett. 6 (1996) 2481-2486
111. Samanen J.M., Ali F.E., Barton L.S., Bondinell W.E., Burgess J.L., Callahan J.F., Calvo R.R., Chen W.T., Chen L.C., Erhard K., Feuerstein G., Heys R., Hwang S.M., Jakas D.R., Keenan R.M., Ku T.W., Kwon C., Lee C.P., Miller W.H., Newlander K.A., Nichols A., Parker M., Peishoff C.E., Rhodes G., Ross S., Shu A., Simpson R., Takata D., Yellin T.O., Uzsinskas I., Venslavsky J.W., Yuan C.K., and Huffman W.F. J. Med. Chem. 39 (1996) 4867-4870
112. Klein S.I., Molino B.F., Czekaj M., Dener J.S., Leadley R.J., Sabatino R., Dunwiddie C.T., and Chu V. Bioorg. Med. Chem. Lett. 6 (1996) 1403-1408
113. Allen D.G., Eldred C.D., Judkins B.D., and Mitchell W.L. PCT Int Appl 97 (1998) 49699
114. Chem. Abstr. 128 (1997) 102085
115. Allen D.G., Eldred C.D., and Mitchell W.L. PCT Int. Appl. 96 (1996) 20192
116. Chem. Abstr. 125 (1996) 167980
117. Judkins B.D. PCT Int. Appl. 96 (1996) 41803
118. Chem. Abstr. 126 (1996) 131454
119. Hoekstra W.J., Beavers M.P., Andrade-Gordon P., Evangelisto M.F., Keane P.M., Press J.B., Tomko K.A., Fan F., Kloczewiaik M., Mayo K.H., Durkin K.A., and Liotta D.C. J. Med. Chem. 38 (1995) 1582-1592
120. Hoekstra W.J., Maryanoff B.E., Andrade-Gordon P., Cohen J.H., Costanzo M.J., Damiano B.P., Haertlein B.J., Harris B.D., Kauffman J.A., Keane P.M., McComsey D.F., Villani F.J., and Yabut S.C. Bioorg. Med. Chem. Lett. 6 (1996) 2371-2376
121. Katano K., Shitara E., Shimizu M., Sasaki K., Miura T., Isomura Y., Kawaguchi M., Ohuchi S., and Tsuruoka T. Bioorg. Med. Chem. Lett. 6 (1996) 2601-2606
122. Wayne M.G., Smithers M.J., Rayner J.W., Faull A.W., Pearce R.J., Brewster A.G., Shute R.E., Mills S.D., and Caulkett P.W.R. PCT Int. Appl. 94 (1995) 22835
123. Chem. Abstr. 123 (1994) 169654
124. Wayne M.G., Smithers M.J., Rayner J.W., Faull A.W., Pearce R.J., Brewster A.G., Shute R.E., Mills S.D., and Caulkett P.W.R. PCT Int. Appl. 94 (1995) 22834
125. Chem. Abstr. 123 (1994) 227994
126. Raddatz P., and Gante J. Exp. Opin. Ther. Pat. 5 (1995) 1165-1183
127. Bhattacharya S., Jordan R., Machin S., Senior R., Mackie I., Smith C.R., Schaible T.F., Weisman H.F., and Lahiri A. Cardiovasc. Drugs Ther. 9 (1995) 665-675
128. Barrett J.S., Murphy G., Peerlinck K., Lepeleire I.D., Gould R.J., Panebianco D., Hand E., Deckmyn H., Vermylen J., and Arnout J. Clin. Pharmacol Ther 56 (1994) 377-388
129. Nichols A.J., Vasko J.A., Koster P.F., Valocik R.E., Rhodes G.R., Miller-Stein C., Boppana V., and Samanen J.M. J. Pharmacol. Exp. Ther. 270 (1994) 614-621
130. Barrett J.S., Gould R.J., Ellis J.D., Holahan M.M., Stranieri M.T., Lynch Jr. J.J., Hartman G.D., Ihle N., Duggan M., Moreno O.A., and Theoharides A.D. Pharm. Res. 11 (1994) 426-431
131. Prueksaritanont T., Gorham L.M., Naue J.A., Hamill T.G., Askew B.C., and Vyas K.P. Drug Metab. Disp. 25 (1997) 355-361
132. Refino C.J., Modi N.B., Bullens S., Pater C., Lipari M.T., Robarge K., Blackburn B., Beresini M., Weller T., Steiner B., and Bunting S. Thromb. Haemostasis 79 (1998) 169-176
133. Nicholson N.S., Panzer-Knodle S.G., Salyers A.K., Taite B.B., Szalony J.A., Haas N.F., King L.W., Zablocki J.A., Keller B.T., Broschat K., Engleman V.W., Herin M., Jacqmin P., and Feigen L.P. Circulation 91 (1995) 403-410
134. Crenshaw B.S., Harrington R.A., and Tcheng J.E. Exp. Opin. Invest. Drugs 4 (1995) 1033-1044
135. Gibaldi M. Biopharmaceutics and Clinical Pharmacokinetics. 4th ed. (1991), Lea and Febiger 200
136. Takada S., Kurokawa T., Miyazaki K., Iwasa S., and Ogawa Y. Pharm. Res. 14 (1997) 1146-1150
137. Graul A., Martel A.M., and Castaner J. Drugs Future 22 (1997) 508-517
138. Stilz H.U., Beck G., Jablonka B., and Just M. Bull. Soc. Chim. Belg. 105 (1996) 711-719
139. Stilz H.U., Jablonka B., Just M., Knolle J., Paulus E.F., and Zoller G. J. Med. Chem. 39 (1996) 2118-2122
140. Prueksaritanont T., Gorham L.M., Breslin M.J., Hutchinson J.H., Hartman G.D., Vyas K.P., and Baillie T.A. Drug Metab. Dispos. 25 (1997) 978-984
141. Weller T., Alig L., Beresini M., Blackburn B., Bunting S., and Hadvary P. J. Med. Chem. 39 (1996) 3139-3147
142. Constantinides P.P., Scalart J.P., Lancaster C., Marcello J., Marks G., and Ellens H. Pharm. Res. 11 (1994) 1385-1390
143. B.J. Aungst, H. Saitoh, D.L. Burcham, S.M. Huang, S.A. Mousa, M.A. Hussain, (1996) J. Controlled Release 41 (1,2, Fifth International Symposium on Delivery and Targeting of Pesticides, Proteins and Genes, 1995), 19-31.
144. Hussain M.A., Aungst B.J., Kapil R., and Mousa S.A. J. Pharm. Sci. 86 (1997) 1358-1360
145. Baxter A. PCT Int. Appl. 97 (1997) 49382
146. Hussain M.A., and Repta A.J. PCT Int. Appl. 97 (1997) 48395
147. Coller B.S., Folts J.D., Scudder L.E., and Smith S.R. Blood 68 (1986) 783-786
148. Coller B.S., Folts J.D., Smith S.R., Scudder L.E., and Jordan R. Circulation 80 (1989) 1766-1774
149. Mickelson J.K., Simpson P.J., and Lucchesi B.R. J. Mol. Cell Cardiol. 21 (1989) 393-405
150. Rote W.E., Nedelman M.A., Mu D.X., Manley P.J., Weisman H., Cunningham M.R., and Lucchesi B.R. Stroke 25 (1994) 1223-1233
151. Shetler T.J., Crowe V.G., Bailey B.D., and Jackson C.V. Circulation 94 (1996) 1719-1725
152. Lynch Jr. J.J., Cook J.J., Sitko G.R., Holahan M.A., Ramjit D.R., Mellott M.J., Stranieri M.T., Stabilito I.I., Zhang G., Lynch R.J., Manno P.D., Chang C.T.C., Egbertson M.S., Halczenko W., Duggan M.E., Laswell W.L., Vassallo L.M., Shafer J.A., Anderson P.S., Friedman P.A., Hartman G.D., and Gould R.J. J. Pharmacol. Exp. Ther. 272 (1995) 20-32
153. Roux S., Carteaux J.P., Hess P., Falivene L., and Clozel J.P. Thromb. Haemostasis 71 (1994) 252-256
154. Guth B.D., Seewaldt-Becker E., Himmelsbach F., Weisenberger H., and Muller T.H. J. Cardiov. Pharmacol. 30 (1997) 261-272
155. Szalony J.A., Haas N.F., Salyers A.K., Taite B.B., Nicholson N.S., and Mehrotra D.V. Circulation 91 (1995) 411-416
156. Frederick L.G., Suleymanov O.D., King L.W., Salyers A.K., Nicholson N.S., and Feigen L.P. Circulation 93 (1996) 129-134
157. Cook J.J., Glass J.D., Sitko G.R., Holahan M.A., Stupienski R.F., Wallace A.A., Stump G.L., Hand E.L., Askew B.C., Hartman G.D., Gould R.J., and Lynch J.J. Circulation 96 (1997) 949-958
158. Cook J.J., Sitko G.R., Holahan M.A., Stranieri M.T., Glass J.D., Askew B.C., Mclntyre C.J., Claremon D.A., Baldwin J.J., Hartman G.D., Gould R.J., and Lynch J.J. J. Pharmacol. Exp. Ther. 281 (1997) 677-689
159. Just M., Hropot M., Jablonka B., Konig W., and Stilz H.U. Thromb. Haemostasis 73 (1995) 1444
160. Gold H.K., Coller B.S., Yasuda T., Saito T., Fallon J.T., Guerrero J.L., Leinbach R.C., Ziskind A.A., and Collen D. Circulation 77 (1988) 670-677
161. Yasuda T., Gold H.K., Fallon J.T., Leinbach R.C., Guerrero J.L., Scudder L.E., Kranke M., Shealy D., Ross M.J., Collen D., and Coller B.S. J. Clin. Invest. 81 (1988) 1284-1291
162. Kohmura C., Gold H.K., Yasuda T., Holt R., Nedelman M.A., Guerrero J.L., Weisman H.F., and Collen D. Arterioscler. Thromb. 13 (1993) 1837-1842
163. Yasuda T., Gold H.K., Yaoita H., Leinbach R.C., Guerrero J.L., Jang I.K., Holt R., Fallon J.T., and Collen D. J. Am. Coll. Cardiol. 16 (1990) 714-722
164. Mickelson J.K., Simpson P.J., Cronin M., Homeister J.W., Laywell E., Kitzen J., and Lucchesi B.R. Circulation 81 (1990) 617-627
165. Rote W.E., Mu D.X., Bates E.R., Nedelman M.A., and Lucchesi B.R. J. Cardiovasc. Pharmacol. 23 (1994) 194-202
166. Sudo Y., Kilgore K.S., and Lucchesi B.R. J. Cardiovasc. Pharmacol. 26 (1995) 241-250
167. Nicolini F.A., Lee P., Rios G., Kottke-Marchant K., and Topol E.J. Circulation 89 (1994) 1802-1809
168. Umemura K., Nishiyama H., Kikuchi S., Kondo K., and Nakashima M. Thromb. Haemostasis 76 (1996) 799-806
169. Hiramatsu Y., Gikakis N., Anderson I.H.L., Gorman I.J.H., Marcinkiewicz C., Gould R.J., Niewiarowski S., and Edmunds Jr. L.H. J. Thorac. Cardiovasc. Surg. 113 (1997) 182-193
170. Uthoff K., Zehr K.J., Geerling R., Herskowitz A., Cameron D.E., and Reitz B.A. Circulation 90 (part 2) II (1994) 269-274
171. Candinas D., Lesnikoski B.A., Hancock W.W., Otsu I., Koyamada N., Dalmasso A.P., Robson S.C., and Bach F.H. Transplantation 62 (1996) 1-5
172. Lister-James J., Knight L.C., Maurer A.H., Bush L.R., Moyer B.R., and Dean R.T. J. Nucl. Med. 37 (1996) 775-781
173. Barrett J.A., Damphousse D.J., Heminway S.J., Liu S., Edwards D.S., Looby R.J., and Carroll T.R. Bioconjug. Chem. 7 (1996) 203-208
174. Matsuno H., Kozawa O., Niwa M., Kaida T., Hayashi H., and Uematsu T. Br. J. Pharmacol. 122 (1997) 1099-1104
175. Winkelmann B.R., Zahn R., and Stilz H.U. Exp. Opin. Invest. Drugs 6 (1997) 1623-1642
176. Topol E.J. Am. Heart J. 130 (1995) 666-672
177. Tcheng J.E. Am. J. Cardiol. 78 Suppl. 3A (1996) 35-40
178. Topol E.J., Ferguson J.J., Weisman H.F., Tcheng J.E., Ellis S.G., Kleiman N.S., Ivanhoe R.J., Wang A.L., Miller D.P., Anderson K.M., and Califf R.M. JAMA 278 (1997) 479-484
179. The Epilog Investigators, Topol E.J., et al. N. Engl. J. Med. 336 (1997) 1689-1696
180. Muhlestein J.B., Karagounis L.A., Treehan S., and Anderson J.L. J. Am. Coll. Cardiol. 30 (1997) 1729-1734
181. Tcheng J.E. Am. J. Cardiol. 80 4A (1997) B21-B28
182. Phillips D.R., and Scarborough R.M. Am. J. Cardiol. 80 4A (1997) B11-B20
183. Phillips D.R., Teng W., Arfsten A., Nannizzialaimo L., White M.M., Longhurst C., Shattil S.J., Randolph A., Jakubowski J.A., Jennings L.K., and Scarborough R.M. Circulation 96 (1997) 1488-1494
184. Harrington R.A., Kleiman N.S., Kottke-Marchant K., Lincoff A.M., Tcheng J.E., Sigmon K.N., Joseph D., Rios G., Trainor K., Rose D., Greenberg C.S., Kitt M.M., Topol E.J., and Califf R.M. Am. J. Cardiol. 76 (1995) 1222-1227
185. The RESTORE Investigators, Hanrath P., et al. Circulation 96 (1997) 1445-1453
186. Schulman S.P., Goldschmidt-Clermont P.J., Topol E.J., Califf R.M., Navetta F.I., Willerson J.T., Chandra N.C., Guerci A.D., Ferguson J.J., Harrington R.A., Lincoff A.M., Yakubov S.J., Bray P.F., Bahr R.D., Wolfe C.L., Yock P.G., Anderson H.V., Nygaard T.W., Mason S.J., Effron M.B., Fatterpacker A., Raskin S., Smith J., Brashears L., Gottdiener P., du Mee C., Kitt M.M., and Gerstenblith G. Circulation 94 (1996) 2083-2089
187. Harrington R.A. Am. J. Cardiol. 80 4A (1997) B34-B38
188. Scrip, PJB Publications, 24th March 1997.
189. Theroux P., Kouz S., Roy L., Knudtson M.L., Diodati J.G., Marquis J.F., Nasmkh J., Fung A.Y., Boudreault J.R., Delage F., Dupuis R., Kells C., Bokslag M., Steiner B., and Rapold H.J. Circulation 94 (1996) 899-905
190. Scrip, PJB Publications, 14th November 1997.
191. Kumar A., and Herrmann H.C. Exp. Opin. Invest. Drugs 6 (1997) 1257-1267
192. Scrip, PJB Publications, 20th November 1997.
193. Lefkovits J., and Topol E.J. Prog. Cardiovasc. Dis. 40 (1997) 141-158
194. Le Breton H., Plow E.F., and Topol E.J. J. Am. Coll. Cardiol. 28 (1996) 1643-1651
195. Ferguson J.J. J. Interventional Cardiol. 10 (1997) 155-159
196. Schultz R.D., Heuser R.R., Hatler C., and Frey D. Cathet. Cardiovasc. Diagn. 39 (1996) 143-148
197. Pharmaprojects, PJB Publications, record for Tc-99m-P280, updated on 3rd December 1997.
198. Scrip, PJB Publications, 19th November 1997.
199. Simpfendorfer C., Kottke-Marchant K., Lowrie M., Anders R.J., Burns D.M., Cove C.S., DeFranco A.C., Ellis S.G., Moliterno D.J., Raymond R.E., Sutton J.M., and Topol E.J. Circulation 96 (1997) 76-81
200. Kereiakes D.J., Kleiman N., Ferguson J.J., Runyon J.P., Broderick T.M., Higby N.A., Martin L.H., Hantsbarger G., Mcdonald S., and Anders R.J. Circulation 96 (1997) 1117-1121
201. Scrip, PJB Publications, 4th September 1997.
202. Kereiakes D.J., Runyon J.P., Kleiman N.S., Higby N.A., Anderson L.C., Hantsbarger G., McDonald S., and Anders R.J. Circulation 94 (1996) 906-910
203. Pharmaprojects, PJB Publications, record for sibrafiban, updated on 5th December 1997.
204. Cannon C.P., Mccabe C.H., Borzak S., Henry T.D., Tischler M.D., Mueller H.S., Feldman R., Palmeri S.T., Ault K., Hamilton S.A., Rothman J.M., Novotny W.F., and Braunwald E. Circulation 97 (1998) 340-349
205. Muller T.H., Weisenberger H., Brickl R., Narjes H., Himmelsbach F., and Krause J. Circulation 96 (1997) 1130-1138
206. Kleiman N.S. Am. J. Cardiol. 80 4A (1997) B29-B33
207. Adgey A.A. Haemostasis 26 (1996) 237-246
208. Lincoff A.M. J. Invasive Cardiol. 8 Suppl. B (1996) B15-B20
209. Tcheng J.E. Am. Heart J. 130 (1995) 673-679
210. Armstrong P.W., and Mant M.J. Eur. Heart J. 16 Suppl. L. (1995) 75-80