Beta-amino acid derivatives as orally active non-peptide fibrinogen receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 6, 1997, Pages 727-732

  Kottirsch, Georg ^a   Zerwes, Hans Günther ^a   Cook, Nigel S ^a   Tapparelli, Carlo ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BETA AMINO ACID; FIBRINOGEN RECEPTOR; FIBRINOGEN RECEPTOR ANTAGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; NONHUMAN; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0031576887     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00095-4     Document Type: Article

References (27)

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23. 8 platelets/ml, incubated with inhibitor or solvent (control) and fibrinogen (0.1 mg/ml) and aggregation was initiated by adding 10 μM ADP. The ability of the platelets to aggregate in the presence or absence of inhibitor was quantified using an aggregometer.
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