Discovery of potent isoxazoline glycoprotein IIb/IIIa receptor antagonists

Journal of Medicinal Chemistry

Volumn 40, Issue 1, 1997, Pages 50-60

  Wityak, John ^a   Sielecki, Thais M ^a   Pinto, Donald J ^a   Emmett, George ^a   Sze, Jean Y ^a   Liu, Jie ^a   Tobin, A Ewa ^a   Wang, Shuaige ^a   Jiang, Biao ^a   Ma, Philip ^a   Mousa, Shaker A ^a   Wexler, Ruth R ^a   Olson, Richard E ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 [2 [3 (4 FORMAMIDINOPHENYL) 2 ISOXAZOLIN 5 YL]ACETAMIDO]PROPIONIC ACID; 2 AMINO 3 [2 [3 (4 FORMAMIDINOPHENYL) 2 ISOXAZOLIN 5 YL]ACETAMIDO]PROPIONIC ACID ETHYL ESTER; FIBRINOGEN RECEPTOR; FIBRINOGEN RECEPTOR ANTAGONIST; ISOXAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DOG; DOSE RESPONSE; DRUG POTENCY; DRUG RECEPTOR BINDING; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; STEREOCHEMISTRY; THROMBOCYTE AGGREGATION INHIBITION;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DOGS; ISOXAZOLES; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN CONFORMATION;

EID: 8044236449     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960626t     Document Type: Article

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