Nonpeptide GPIIb/IIIa inhibitors. 16. Thieno[2,3-b]thiophene α-sulfonamides are potent inhibitors of platelet aggregation

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 7, 1997, Pages 865-870

  Prugh, John D ^a   Gould, Robert J ^a   Lynch, Robert J ^a   Zhang, Guixiang ^a   Cook, Jacquelynn J ^a   Holahan, Marie A ^a   Stranieri, Maria T ^a   Sitko, Gary R ^a   Gaul, S Lee ^a   Bednar, Rodney A ^a   Bednar, Bohumil ^a   Hartman, George D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBOCYTIC AGENT; N [2 [N [5 (2 PIPERIDINOETHYL)THIENO[2,3 B]THIEN 2 YLCARBONYL]AMINO] 1 CARBOXYETHYL]BENZENESULFONAMIDE; SULFONAMIDE; THIENO[2,3 B]THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; ORAL DRUG ADMINISTRATION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION;

EID: 0030901982     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00120-0     Document Type: Article

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16. Full discussion of this important compound will appear in a subsequent paper.
17. All compounds were characterized by NMR; TLC; HPLC; C,H,N analysis and/or HRMS.