Effects of Integrelin, a platelet glycoprotein IIb/IIIa receptor antagonist, in unstable angina: A randomized multicenter trial

Circulation

Volumn 94, Issue 9, 1996, Pages 2083-2089

  Schulman, Steven P ^b   Goldschmidt Clermont, Pascal J ^c   Topol, Eric J ^c   Califf, Robert M ^c   Navetta, Frank I ^c   Willerson, James T ^c   Chandra, Nisha C ^c   Guerci, Alan D ^c   Ferguson, James J ^c   Harrington, Roben A ^c   Lincoff, A Michael ^c   Yakubov, Steven J ^c   Bray, Paul F ^c   Bahr, Raymond D ^c   Wolfe, Christopher L ^c   Yock, Paul G ^c   Vernon Anderson, H ^c   Nygaard, Thomas W ^c   Mason, Steven J ^c   Effron, Mark B ^c   Fatterpacker, Anil ^c   Raskin, Stephen ^c   Smith, Jack ^c   Brashears, Lori ^c   Gottdiener, Patricia ^c   Du Mee, Charles ^a   Kitt, Michael M ^a   Gerstenblith, Gary ^c   more..

^a COR Therapeutics ^*  (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

^c NONE

Author keywords

angina; integrins; ischemia; platelets

Indexed keywords

ACETYLSALICYLIC ACID; EPTIFIBATIDE; FIBRINOGEN RECEPTOR; HEPARIN;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG TOLERANCE; FEMALE; HOLTER MONITORING; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE AGGREGATION; UNSTABLE ANGINA PECTORIS;

EID: 10244253888     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.94.9.2083     Document Type: Article

References (35)

1. Graves EJ. Detailed diagnoses and procedures: National Hospital Discharge Survey, 1990. National Center for Health Statistics. Vital Health Stat [13]. 1992;113.
2. Clinical Practice Guideline, Unstable Angina: Diagnosis and Management. Washington, DC: US Department of Health and Human Services; AHCPR publication No. 94-0603;1994.
3. Gazes PC, Mobley EM, Paris HM, Duncan RC, Humphries GB. Preinfarctional (unstable) angina: a prospective study: ten year follow-up: prognostic significance of electrocardiographic changes. Circulation. 1973;48:331-337.
4. Ouyang P, Brinker JA, Mellits ED, Weisfeldt ML, Gerstenblith G. Variables predictive of successful medical therapy in patients with unstable angina: selection by multivariate analysis from clinical, electrocardiographic, and angiographic evaluations. Circulation. 1984;70:367-376.
5. Chierchia S, Brunelli C, Simonetti I, Lazzari M, Maseri A. Sequence of events in angina at rest: primary reduction in coronary flow. Circulation. 1980;61:759-768.
6. Ambrose JA, Winters SL, Stern A, Eng A, Teichholz LE, Gorlin R, Fuster V. Angiographic morphology und the pathogenesis of unstable angina pectoris. J Am Coll Cardiol. 1985;5:609-616.
7. Fitzgerald DJ, Roy L, Catella F, Fitzgerald GA. Platelet activation in unstable coronary disease. N Engl J Med. 1986;315:913-919.
8. Falk E. Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death: autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion. Circulation. 1985;71:699-708.
9. Hirsh PD, Hillis LD, Campbell WB, Firth BG, Willerson JT. Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease. N Engl J Med. 1981;304:685-691.
10. Willerson JT, Golino P, Eidt J, Campbell WB, Buja LM. Specific platelet mediators and unstable coronary artery lesions; experimental evidence and potential clinical implications. Circulation. 1989;80: 198-205.
11. Eichorn EJ, Grayburn PA, Willard JE, Anderson HV, Bedotto JB, Carry M, Kahn JK, Willerson JT. Spontaneous alterations in coronary blood flow velocity before and after coronary angioplasty in patients with severe angina. J Am Coll Cardiol. 1991;17:43-52.
12. Theroux P, Ouimet H, McCans J, Latour J-G, Joly P, Levy G, Pelletier E, Juneau M, Stasiak J, deGuise P, Pelletier GB, Rinzler D, Waters DD. Aspirin, heparin, or both to treat acute unstable angina, N Engl J Med. 1988;319:1105-1111.
13. Lewis HD, Davis JW, Archibald DG, Steinke WE, Smitherman TC, Doherty JE III, Schnaper HW, LeWinter MM, Linares E, Pouget JM, Sabharwal SC, Chesler E, DeMots H. Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina: results of a Veterans Administration Cooperative Study, N Engl J Med. 1983;309:396-403.
14. The RISC Group. Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease. Lancet. 1990;336:827-830.
15. Theroux P, Waters D, Lam J, Juneau M, McCans J. Reactivation of unstable angina after the discontinuation of heparin. N Engl J Med. 1992;327:141-145.
16. The TIMI IIIB Investigators. Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies' in unstable angina and non-Q-wave myocardial infarction: results of the TIMI IIIB trial. Circulation. 1994;89:1545-1556.
17. Simmoons ML, de Boer MJ, van den Brand MJBM, van Miltenburg AJM, Hoorntje JCA, Heyndrickx GR, van der Wieden LR, De Bono D, Rutsch W, Schaible TF, Weisman HF, Klootwijk P, Nijssen KM, Stibbe J, de Feyter PJ, and the European Cooperative Study Group. Randomized trial of a GPIIb/IIIa platelet receptor blocker in refractory unstable angina. Circulation. 1994;89:596-603.
18. Topol EJ, Fuster V, Harrington RA, Califf RM, Kleiman NS, Dereiakes DJ, Cohen M, Chapekis A, Gold HK, Tannenbaum MA, Rao AK, Debowey D, Schwartz D, Henis M, Chesebro J, Recombinant hirudin for unstable angina pectoris: a multicenter, randomized, angiographie trial. Circulation. 1994;89:1557-1566.
19. Coller BS. Platelets and thrombolytic therapy. N Engl J Med. 1990;322:33-42.
20. Phillips DR, Charo IF, Scarborough RM. GPIIb-IIIa: the responsive integrin. Cell. 1991;65:359-362.
21. Tcheng JE, Harrington RA, Kottke-Marchant K, Kleiman NS, Ellis SG, Kereiakes DJ, Mick MJ, Navetta FI, Smith JE, Worley SJ, Miller JA, Joseph DM, Sigmon KN, Kitt MM, du Mee CP, Califf RM, Topol EJ, for the IMPACT Investigators. Multicenter, randomized, double-blind, placebo controlled trial of the platelet integrin glycoprotein IIb/IIIa blocker Integrelin in elective coronary intervention. Circulation. 1995;91:2151-2157.
22. Gottlieb SO, Weisfeldt ML, Ouyang P, Mellits ED, Gerstenblith G. Silent ischemia as a marker for early unfavorable outcomes in patients with unstable angina. N Engl J Med. 1986;314:1214-1219.
23. SAS/STAT User's Guide: Version 6. 4th ed. Cary, NC: SAS Institute; 1989.
24. Theroux P, Latour JG, Keger-Gauthier C, De Lara J. Fibrinopeptide A and platelet factor levels in unstable angina pectoris. Circulation. 1987;75:156-162.
25. Mizuno K, Satomura K, Miyamoto A, Arakawa K, Shibuya T, Arai T, Kurita A, Nakamura H, Ambrose JA, Angioscopic evaluation of coronary-artery thrombi in acute coronary syndromes. N Engl J Med. 1992;326:287-291.
26. Patrono C. Aspirin as an antiplatelet drug. N Engl J Med. 1994;330:1287-1294.
27. 3 (platelet GPIIb-IIIa). Cell. 1991;65:409-416.
28. Theroux P, White H, David D, Van de Werf F, Nienaber CA, Charbonnier B, Erhardt L, Gill J, Hillis WS, Jennings G, Tan LB, Deschenes N, Fitzpatrick V, Sax FL. A heparin-controlled study of MK-383 in unstable angina. Circulation. 1994;90(suppl I):I-231. Abstract.
29. The EPIC Investigators. Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. N Engl J Med. 1994;330:956-961.
30. Elveback LR, Connolly DC, Melton LJ III. Coronary heart disease in residents of Rochester, Minnesota: incidence, 1950 through 1982. Mayo Clin Proc. 1986;61:896-900.
31. Becker RC, Terrin M, Ross R, Knatterud GL, Desvigne-Nickens P, Gore JM, Braunwald E, and the Thrombolysis in Myocardial Infarction Investigators. Comparison of clinical outcomes for women and men after acute myocardial infarction. Ann Intern Med. 1994;120:638-645.
32. Lerner DJ, Kannel WB. Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J. 1986;111:383-390.
33. Greenland P, Reicher-Reiss H, Goldbourt U, Behar S, and the Israeli SPRINT Investigators. In-hospital and 1-year mortality in 1,524 women after myocardial infarction: comparison with 4,315 men. Circulation. 1991;83:484-491.
34. Roberts JW, Goldschmidt-Clermont PJ, Bray P, Addo JB, Grigoryev D, Becker D, Becker L. Effect of gender on thrombogenic factors in asymptomatic people at high risk for coronary artery disease. Circulation. 1994;90(suppl I):I-283. Abstract.
35. Gottlieb SO, Weisfeldt ML, Ouyang P, Mellits ED, Gerstenblith G. Silent ischemia predicts infarction and death during 2 year follow-up of unstable angina. J Am Coll Cardiol. 1987;10:756-760.