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Volumn 94, Issue 3, 1999, Pages 1070-1076

V(H) gene analysis of IgM-secreting myeloma indicates an origin from a memory cell undergoing isotype switch events

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN M;

EID: 0033178663     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.3.1070.415k25_1070_1076     Document Type: Article
Times cited : (38)

References (56)
  • 2
    • 0026844401 scopus 로고
    • The development of B cells and the B cell repertoire in the microenvironment of the germinal centre
    • Berek C: The development of B cells and the B cell repertoire in the microenvironment of the germinal centre. Immunol Rev 126:5, 1992
    • (1992) Immunol Rev , vol.126 , pp. 5
    • Berek, C.1
  • 3
    • 0031942845 scopus 로고    scopus 로고
    • Insight into the origin and clonal history of B-cell tumours as revealed by analysis of immunoglobulin variable region genes
    • Stevenson F, Sahota S, Zhu D, Ottensmeier C, Chapman C, Oscier D, Hamblin T: Insight into the origin and clonal history of B-cell tumours as revealed by analysis of immunoglobulin variable region genes. Immunol Rev 162:247, 1998
    • (1998) Immunol Rev , vol.162 , pp. 247
    • Stevenson, F.1    Sahota, S.2    Zhu, D.3    Ottensmeier, C.4    Chapman, C.5    Oscier, D.6    Hamblin, T.7
  • 5
    • 0029979577 scopus 로고    scopus 로고
    • H 4-21) encoded antibodies is determined by both VH framework region 1 and the complimentarity determining region 3
    • H 4-21) encoded antibodies is determined by both VH framework region 1 and the complimentarity determining region 3. J Mol Biol 256:577, 1996
    • (1996) J Mol Biol , vol.256 , pp. 577
    • Li, Y.1    Spellerberg, M.B.2    Stevenson, F.K.3    Capra, J.D.4    Potter, K.5
  • 7
    • 0030905707 scopus 로고    scopus 로고
    • Differential rates of somatic hypermutation in VH genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities
    • Oscier DG, Thompsett A, Zhu D, Stevenson FK: Differential rates of somatic hypermutation in VH genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities. Blood 89:4153, 1997
    • (1997) Blood , vol.89 , pp. 4153
    • Oscier, D.G.1    Thompsett, A.2    Zhu, D.3    Stevenson, F.K.4
  • 8
    • 0026636759 scopus 로고
    • Clonal evolution of a follicular lymphoma: Evidence for antigen selection
    • Bahler DW, Levy R: Clonal evolution of a follicular lymphoma: Evidence for antigen selection. Proc Natl Acad Sci USA 89:6770, 1992
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6770
    • Bahler, D.W.1    Levy, R.2
  • 9
    • 0025957456 scopus 로고
    • Histologic transformation of follicular lymphoma to diffuse lymphoma represents tumour progression by a single malignant cell
    • Zelenetz AD, Chen TT, Levy R: Histologic transformation of follicular lymphoma to diffuse lymphoma represents tumour progression by a single malignant cell. J Exp Med 173:197, 1991
    • (1991) J Exp Med , vol.173 , pp. 197
    • Zelenetz, A.D.1    Chen, T.T.2    Levy, R.3
  • 10
    • 0028341604 scopus 로고
    • Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes
    • Zhu D, Hawkins RE, Hamblin TJ, Stevenson FK: Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes. Br J Haematol 86:505, 1994
    • (1994) Br J Haematol , vol.86 , pp. 505
    • Zhu, D.1    Hawkins, R.E.2    Hamblin, T.J.3    Stevenson, F.K.4
  • 11
    • 1842405428 scopus 로고    scopus 로고
    • Evidence for a large compartment of IgM-expressing memory B cells in humans
    • Klein U, Kuppers R, Rajewsky K: Evidence for a large compartment of IgM-expressing memory B cells in humans. Blood 89:1288, 1997
    • (1997) Blood , vol.89 , pp. 1288
    • Klein, U.1    Kuppers, R.2    Rajewsky, K.3
  • 14
    • 0030209983 scopus 로고    scopus 로고
    • Cellular and molecular factors that regulate the differentiation and apoptosis of germinal center B cells
    • Choe J, Kim H-S, Zhang X, Armitage RJ, Choi YS: Cellular and molecular factors that regulate the differentiation and apoptosis of germinal center B cells. J Immunol 157:1006, 1996
    • (1996) J Immunol , vol.157 , pp. 1006
    • Choe, J.1    Kim, H.-S.2    Zhang, X.3    Armitage, R.J.4    Choi, Y.S.5
  • 15
    • 0030017254 scopus 로고    scopus 로고
    • IgM-producing chronic lymphocytic leukemia cells undergo immunoglobulin isotype-switching without acquiring somatic mutations
    • Efremov DG, Ivanovski M, Batista FD, Pozzato G, Burrone O: IgM-producing chronic lymphocytic leukemia cells undergo immunoglobulin isotype-switching without acquiring somatic mutations. J Clin Invest 98:290, 1996
    • (1996) J Clin Invest , vol.98 , pp. 290
    • Efremov, D.G.1    Ivanovski, M.2    Batista, F.D.3    Pozzato, G.4    Burrone, O.5
  • 16
    • 0030071237 scopus 로고    scopus 로고
    • B-chronic lymphocytic leukemias can undergo isotype switching in vivo and can be induced to differentiate and switch in vitro
    • Malison F, Fluckiger A-C, Ho S, Guret C, Banchereau J, Martinez-Valdez H: B-chronic lymphocytic leukemias can undergo isotype switching in vivo and can be induced to differentiate and switch in vitro. Blood 87:717, 1996
    • (1996) Blood , vol.87 , pp. 717
    • Malison, F.1    Fluckiger, A.-C.2    Ho, S.3    Guret, C.4    Banchereau, J.5    Martinez-Valdez, H.6
  • 17
    • 0032081314 scopus 로고    scopus 로고
    • H genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression
    • H genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression. Blood 91:4292, 1998
    • (1998) Blood , vol.91 , pp. 4292
    • Ottensmeier, C.H.1    Thompsett, A.R.2    Zhu, D.3    Wilkins, B.S.4    Sweetenham, J.W.5    Stevenson, F.K.6
  • 18
    • 0026786675 scopus 로고
    • Evidence that multiple myeloma Ig heavy-chain VDJ genes contain somatic mutations but show no intraclonal variation
    • Bakkus MHC, Heirman C, van Riet I, van Camp B, Thielemans K: Evidence that multiple myeloma Ig heavy-chain VDJ genes contain somatic mutations but show no intraclonal variation. Blood 80:2326, 1992
    • (1992) Blood , vol.80 , pp. 2326
    • Bakkus, M.H.C.1    Heirman, C.2    Van Riet, I.3    Van Camp, B.4    Thielemans, K.5
  • 19
    • 0027991864 scopus 로고
    • Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma
    • Sahota S, Hamblin T, Oscier DG, Stevenson FK: Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma. Leukemia 8:1285, 1994
    • (1994) Leukemia , vol.8 , pp. 1285
    • Sahota, S.1    Hamblin, T.2    Oscier, D.G.3    Stevenson, F.K.4
  • 22
    • 0029797359 scopus 로고    scopus 로고
    • Comparable gene structure of the immunoglobulin heavy chain variable region between multiple myeloma and normal bone marrow lymphocytes
    • Kiyoi H, Naito K, Ohno R, Naoe T: Comparable gene structure of the immunoglobulin heavy chain variable region between multiple myeloma and normal bone marrow lymphocytes. Leukemia 10:1804, 1996
    • (1996) Leukemia , vol.10 , pp. 1804
    • Kiyoi, H.1    Naito, K.2    Ohno, R.3    Naoe, T.4
  • 23
    • 0030614775 scopus 로고    scopus 로고
    • H gene sequences reveal a complementary imprint of antigen selection in tumor cells
    • H gene sequences reveal a complementary imprint of antigen selection in tumor cells. Blood 89:219, 1997
    • (1997) Blood , vol.89 , pp. 219
    • Sahota, S.S.1    Leo, R.2    Hamblin, T.J.3    Stevenson, F.K.4
  • 24
    • 0027232455 scopus 로고
    • Advancement of multiple myeloma from diagnosis through plateau phase to progression does not involve a new B-cell clone: Evidence from the Ig heavy chain gene
    • Ralph QM, Brisco MJ, Joshua DE, Brown R, Gibson J, Morley AA: Advancement of multiple myeloma from diagnosis through plateau phase to progression does not involve a new B-cell clone: Evidence from the Ig heavy chain gene. Blood 82:202, 1993
    • (1993) Blood , vol.82 , pp. 202
    • Ralph, Q.M.1    Brisco, M.J.2    Joshua, D.E.3    Brown, R.4    Gibson, J.5    Morley, A.A.6
  • 25
    • 0027257608 scopus 로고
    • The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cells
    • Billadeau D, Ahmann G, Greip P, van Ness B: The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cells. J Exp med 178:1023, 1993
    • (1993) J Exp Med , vol.178 , pp. 1023
    • Billadeau, D.1    Ahmann, G.2    Greip, P.3    Van Ness, B.4
  • 26
    • 0027296754 scopus 로고
    • Evidence for a bone marrow B cell transcribing malignant plasma cell VDJ joined to a Cμ sequence in IgG- and IgA-secreting multiple myelomas
    • Corradini P, Boccadoro M, Voena C, Pileri A: Evidence for a bone marrow B cell transcribing malignant plasma cell VDJ joined to a Cμ sequence in IgG- and IgA-secreting multiple myelomas. J Exp Med 178:1091, 1993
    • (1993) J Exp Med , vol.178 , pp. 1091
    • Corradini, P.1    Boccadoro, M.2    Voena, C.3    Pileri, A.4
  • 27
    • 0028246112 scopus 로고
    • Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell
    • Bakkus MHC, van Riet I, van Camp B, Thielemans K: Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell. Br J Haematol 87:68, 1994
    • (1994) Br J Haematol , vol.87 , pp. 68
    • Bakkus, M.H.C.1    Van Riet, I.2    Van Camp, B.3    Thielemans, K.4
  • 32
    • 0029664365 scopus 로고    scopus 로고
    • H gene mutational patterns indicate different tumor cell status in human myeloma and monoclonal gammopathy of undetermined significance
    • H gene mutational patterns indicate different tumor cell status in human myeloma and monoclonal gammopathy of undetermined significance. Blood 87:746, 1996
    • (1996) Blood , vol.87 , pp. 746
    • Sahota, S.S.1    Leo, R.2    Hamblin, T.J.3    Stevenson, F.K.4
  • 33
    • 0028986982 scopus 로고
    • The human immunoglobulin repertoire
    • Cook GP, Tomlinson IM: The human immunoglobulin repertoire. Immunol Today 16:237, 1995
    • (1995) Immunol Today , vol.16 , pp. 237
    • Cook, G.P.1    Tomlinson, I.M.2
  • 34
    • 0028364706 scopus 로고
    • Idiotypic vaccination against human B-cell lymphoma. Rescue of variable region gene sequences from biopsy material for assembly as single-chain Fv personal vaccines
    • Hawkins RE, Zhu D, Ovecka M, Winter G, Hamblin TJ, Long A, Stevenson FK: Idiotypic vaccination against human B-cell lymphoma. Rescue of variable region gene sequences from biopsy material for assembly as single-chain Fv personal vaccines. Blood 83:3279, 1994
    • (1994) Blood , vol.83 , pp. 3279
    • Hawkins, R.E.1    Zhu, D.2    Ovecka, M.3    Winter, G.4    Hamblin, T.J.5    Long, A.6    Stevenson, F.K.7
  • 35
    • 0029063311 scopus 로고
    • Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction
    • Brezinschek H-P, Brezinschek RI, Lippsky PE: Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J Immunol 155:190, 1995
    • (1995) J Immunol , vol.155 , pp. 190
    • Brezinschek, H.-P.1    Brezinschek, R.I.2    Lippsky, P.E.3
  • 36
    • 0031586221 scopus 로고    scopus 로고
    • Sequence of the human immunoglobulin diversity (D) segment locus: A systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination
    • Corbett SJ, Tomlinson IM, Sonnhammer ELL, Buck D, Winter G: Sequence of the human immunoglobulin diversity (D) segment locus: A systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination. J Mol Biol 270:587, 1997
    • (1997) J Mol Biol , vol.270 , pp. 587
    • Corbett, S.J.1    Tomlinson, I.M.2    Sonnhammer, E.L.L.3    Buck, D.4    Winter, G.5
  • 37
    • 0027932998 scopus 로고
    • H genes are inherently susceptible to amino acid replacement
    • H genes are inherently susceptible to amino acid replacement. Immunol Today 15:367, 1994
    • (1994) Immunol Today , vol.15 , pp. 367
    • Chang, B.1    Casali, P.2
  • 38
    • 0031569118 scopus 로고    scopus 로고
    • Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes
    • Dorner T, Brezinschek H-P, Brezinschek RI, Foster SJ, DomiatiSaad R, Lipsky PE: Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes. J Immunol 158:2779, 1997
    • (1997) J Immunol , vol.158 , pp. 2779
    • Dorner, T.1    Brezinschek, H.-P.2    Brezinschek, R.I.3    Foster, S.J.4    Domiatisaad, R.5    Lipsky, P.E.6
  • 39
    • 0027227311 scopus 로고
    • Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes
    • Betz AG, Neuberger MS, Milstein C: Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol Today 14:405, 1993
    • (1993) Immunol Today , vol.14 , pp. 405
    • Betz, A.G.1    Neuberger, M.S.2    Milstein, C.3
  • 42
    • 0028686184 scopus 로고
    • Antibody structure and the evolution of immunoglobulin V gene segments
    • Kirkham PM, Schroeder HW Jr: Antibody structure and the evolution of immunoglobulin V gene segments. Semin Immunol 6:347, 1994
    • (1994) Semin Immunol , vol.6 , pp. 347
    • Kirkham, P.M.1    Schroeder H.W., Jr.2
  • 44
    • 0028178499 scopus 로고
    • Similar patterns of VK gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenstrom's macroglobulinemia, and myeloma
    • Wagner SD, Martinelli V, Luzzato L: Similar patterns of VK gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenstrom's macroglobulinemia, and myeloma. Blood 83:3647, 1994
    • (1994) Blood , vol.83 , pp. 3647
    • Wagner, S.D.1    Martinelli, V.2    Luzzato, L.3
  • 45
    • 0028966630 scopus 로고
    • H segments of Ig gene in Waldenstrom's macroglobulinemia and chronic lymphocytic leukemia (CLL) with Richter's syndrome but not in common CLL
    • H segments of Ig gene in Waldenstrom's macroglobulinemia and chronic lymphocytic leukemia (CLL) with Richter's syndrome but not in common CLL. Blood 85:1913, 1995
    • (1995) Blood , vol.85 , pp. 1913
    • Aoki, H.1    Takishita, M.2    Kosaka, M.3    Saito, S.4
  • 47
    • 0031594647 scopus 로고    scopus 로고
    • H gene analysis of clonally related IgM and IgG from human lymphoplasmacytoid B-cell tumors with chronic lymphocytic leukemia features and high serum monoclonal IgG
    • H gene analysis of clonally related IgM and IgG from human lymphoplasmacytoid B-cell tumors with chronic lymphocytic leukemia features and high serum monoclonal IgG. Blood 91:238, 1998
    • (1998) Blood , vol.91 , pp. 238
    • Sahota, S.S.1    Garand, R.2    Bataille, R.3    Smith, A.J.4    Stevenson, F.K.5
  • 48
    • 0345671747 scopus 로고
    • Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG-secreting B-cell blasts
    • Radbruch A, Muller W, Rajewsky K: Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG-secreting B-cell blasts. Proc Natl Acad Sci USA 83:3954, 1986
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 3954
    • Radbruch, A.1    Muller, W.2    Rajewsky, K.3
  • 50
    • 0025828378 scopus 로고
    • Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene
    • Shimizu A, Nussenzweig MC, Han H, Sanchez M, Honjo T: Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene. J Exp Med 173:1385, 1991
    • (1991) J Exp Med , vol.173 , pp. 1385
    • Shimizu, A.1    Nussenzweig, M.C.2    Han, H.3    Sanchez, M.4    Honjo, T.5
  • 51
    • 0031985198 scopus 로고    scopus 로고
    • Multiple myeloma: Increasing evidence for a multistep transformation process
    • Hallek M, Bergsagel PL, Anderson KC: Multiple myeloma: Increasing evidence for a multistep transformation process. Blood 91:3, 1998
    • (1998) Blood , vol.91 , pp. 3
    • Hallek, M.1    Bergsagel, P.L.2    Anderson, K.C.3
  • 52
    • 0031031695 scopus 로고    scopus 로고
    • Memory B lymphocytes migrate to bone marrow in humans
    • Paramithiotis E, Cooper MD: Memory B lymphocytes migrate to bone marrow in humans. Proc Natl Acad Sci USA 94:208, 1997
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 208
    • Paramithiotis, E.1    Cooper, M.D.2
  • 54
    • 0021327134 scopus 로고
    • Antibody synthesis by bone marrow cells in vitro following primary and booster tetanus toxoid immunization in humans
    • Kodo H, Gale RP, Saxon A: Antibody synthesis by bone marrow cells in vitro following primary and booster tetanus toxoid immunization in humans. J Clin Invest 73:1377, 1984
    • (1984) J Clin Invest , vol.73 , pp. 1377
    • Kodo, H.1    Gale, R.P.2    Saxon, A.3
  • 56
    • 0025618890 scopus 로고
    • The monoclonal gammopathies (paraproteins)
    • Kyle RA, Lust JA: The monoclonal gammopathies (paraproteins). Adv Clin Chem 28:145, 1990
    • (1990) Adv Clin Chem , vol.28 , pp. 145
    • Kyle, R.A.1    Lust, J.A.2


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