Ig VH gene mutational patterns indicate different tumor cell status in human myeloma and monoclonal gammopathy of undetermined significance

Blood

Volumn 87, Issue 2, 1996, Pages 746-755

  Sahota, Surinder S ^b   Leo, Regine ^b   Hamblin, Terry J ^b   Stevenson, Freda K ^a  

^a UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CLINICAL ARTICLE; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; PLASMA CELL; PLASMACYTOMA; PRIORITY JOURNAL; AMINO ACID SEQUENCE; CELL CLONE; CELL LINEAGE; COMPARATIVE STUDY; GENE REARRANGEMENT; GENETICS; GERMINAL CENTER; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PARAPROTEINEMIA; PHYSIOLOGY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

IMMUNOGLOBULIN HEAVY CHAIN; PARAPROTEIN;

ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINEAGE; CLONE CELLS; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN; GERMINAL CENTER; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MULTIPLE MYELOMA; MYELOMA PROTEINS; PARAPROTEINEMIAS; PLASMA CELLS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0029664365     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.2.746.bloodjournal872746     Document Type: Article

References (24)

1. Boccadoro M, Pileri A: Standard chemotherapy for myelomatosis: An area of great controversy. Hematol Oncol Clin North Am 6:371, 1992
2. Jagannath S, Vesole DH, Glenn L, Crowley J, Barlogie B: Low-risk intensive therapy for multiple myeloma with combined autologous bone marrow and blood stem cell support. Blood 80:1666, 1992
3. Kyle RA, Lust JA: The monoclonal gammopathies (paraproteins). Adv Clin Chem 28:145, 1990
4. Paladini G, Fogher M, Mazzanti G, Parma A, Fabiani MG, Sala PG, Santini P, Torre R, Bravini D: Gammopatia monoclonale idiopatica. Studio a lungo termine di 313 casi. Recenti Prog Med 80:123, 1989
5. Saleun JP, Vicariot M, Deroff P, Morin JF: Monoclonal gammopathies in the adult population of Finistère, France. J Clin Pathol 35:63, 1982
6. Baliler DW, Levy R: Clonal evolution of a follicular lymphoma: Evidence for antigen selection. Proc Natl Acad Sci USA 89:6770, 1992
7. Zhu D, Hawkins RE, Hamblin TJ, Stevenson FK: Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes. Br J Haematol 86:505, 1994
8. Berek C. The development of B cells and the B cell repertoire in the microenvironment of the germinal centre. Immunol Rev 126:5, 1992
9. Bakkus MHC, Heirman C, van Riet I, van Camp B, Thielemans K: Evidence that multiple myeloma Ig heavy-chain VDJ genes contain somatic mutations but show no intraclonal variation. Blood 80:2326, 1992
10. Sahota S, Hamblin T, Oscier DG, Stevenson FK: Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma. Leukemia 8:1285, 1994
11. Durie BGM, Salmon SE: A clinical staging system for multiple myeloma. Correlation of measured myeloma mass with present clinical features, response to treatment and survival. Cancer 36:842, 1975
12. Leo R, Boeker M, Peest D, Hein R, Bartl R, Gessner JE, Selbach J, Wacker G, Deicher H: Multiparameter analyses of normal and malignant human plasma cells: CD38++, CD56+, CD54+, cIg is the common phenotype of myeloma cells. Ann Hematol 64:132, 1992
13. H repertoire. Immunol Today 16:237, 1995
14. Shlomchik MJ, Aucoin AH, Pisetsky DS, Weigert MG: Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci USA 84:9150, 1987
15. Sanz I: Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions. J Immunol 147:1720, 1991
16. Kirkham PM, Schroeder HW Jr: Antibody structure and the evolution of immunoglobulin V gene segments. Semin Immunol 6:347, 1994
17. Levy R, Levy S, Cleary HL, Carroll W, Kon S, Bird J, Sklar J: Somatic mutation in human B-cell tumors. Immunol Rev 96:43, 1987
18. H genes utilized by neoplastic B cells in endemic Burkitt's lymphoma reveals somatic hypermutation and intraclonal heterogeneity. Blood 85:2176, 1995
19. Liu Y-J, Joshua DE, Williams GT, Smith CA, Gordon J, MacLennan ICM: Mechanisms of antigen-driven selection in germinal centre. Nature 342:929, 1989
20. Vescio RA, Hong CH, Cao J, Kim A, Schiller GJ, Lichtenstein AK, Berenson RJ, Berenson JR: The haematopoietic stem cell antigen CD34, is not expressed on the malignant cells in multiple myeloma. Blood 84:3283, 1994
21. Ralph QM, Brisco MJ, Joshua DE, Brown R, Gibson J, Morley A: Advancement of multiple myeloma from diagnosis through plateau phase to progression does not involve a new B-cell clone: evidence from the Ig heavy-chain gene. Blood 82:202, 1993
22. Corradini P, Boccadoro M, Voena C, Pileri A: Evidence for a bone marrow B cell transcribing malignant plasma cell VDJ joined to Cμ sequence in IgG and IgA secreting multiple myelomas. J Exp Med 178:1091, 1993
23. Billadeau D, Ahmann G, Greipp P, van Ness B: The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell. J Exp Med 178:1023, 1993
24. Ffrench M, Ffrench P, Remy F, Chabuis-Cellier C, Wolowiec D, Ville D, Bryan PA: Plasma cell proliferation in monoclonal gammopathy: Relations with other biologic variables - Diagnostic and prognostic significance. Am J Med 98:60, 1995