VH gene usage in multiple myeloma: Complete absence of the VH4.21 (VH4-34) gene

Blood

Volumn 87, Issue 7, 1996, Pages 2846-2852

  Rettig, Matthew B ^a   Vescio, Robert A ^b   Cao, Jin ^b   Wu, Chun H ^b   Lee, Jong C ^b   Han, Eugene ^b   DerDanielian, Melina ^b   Newman, Roland ^b   Hong, Charlie ^b   Lichtenstein, Alan K ^b   Berenson, James R ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENE DELETION; GENE REARRANGEMENT; GENETICS; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOLOGY; MOLECULAR GENETICS; MULTIPLE MYELOMA; NUCLEOTIDE SEQUENCE; CONTROLLED STUDY; GENE FREQUENCY; GENE MUTATION; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BASE SEQUENCE; GENE DELETION; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; HUMANS; MOLECULAR SEQUENCE DATA; MULTIPLE MYELOMA;

COMPLEMENTARY DNA; IMMUNOGLOBULIN HEAVY CHAIN;

EID: 0029664523     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.7.2846.bloodjournal8772846     Document Type: Article

References (50)

1. Tonegawa S: Somatic generation of antibody diversity. Nature 302:575, 1983
2. Honjo T, Habu S: Origin of immune diversity: genetic variation and selection. Annu Rev Biochem 54:903, 1985
3. Seidman JG, Leder A, Nau M, Norman B, Leder P: Antibody diversity. Science 202:11, 1978
4. Seidman JG, Leder P: The arrangement and rearrangement of antibody genes. Nature 276:790, 1978
5. Sanz I: Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions. J Immunol 147:1720, 1991
6. Yamada M, Wasserman R, Reichard BA, Shane S, Caton AJ, Rovera F: Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral B lymphocytes. J Exp Med 173:395, 1991
7. Wasserman R, Galili N, Ito Y, Reichard BA, Shane S, Rovera F: Predominance of fetal type DJH joining in young children with B precursor lymphoblastic leukemia as evidence for an in utero transforming event. J Exp Med 176:1577, 1992
8. Lafaille JJ, Decloux A, Bonneville M, Takagaki Y, Tonegawa S: Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of VDJ Joining. Cell 50:859, 1989
9. MacCormack WT, Tjoilker LW, Carlson LM, Petryniak B, Barth CF, Humphries EH, Thompson CB: Chicken IgL chain rearrangement involves deletion of a circular episome and addition of single non random nucleotides to both coding region segments. Cell 56:785, 1989
10. Meek K: Analysis of junctional diversity during B lymphocyte development. Science 250:820, 1990
11. Ichihara Y, Matsuoka H, Kurosawa Y: Organization of human immunoglobulin heavy chain diversity gene loci. EMBO J 7:4141, 1988
12. Berman JE, Mellis SJ, Pollock R, Smith CL, Suh H, Heinke B, Kowal C, Surti U, Chess L, Cantor CR: Content and organization of the human Ig VH locus: Definition of three new VH families and linkage to the Ig CH locus. EMBO J 7:727, 1988
13. Siebenlist U, Ravelch JV, Korsmeyer S, Waldmann T, Leder P: Human immunoglobulin D segments encoded in tandem multigenic families. Nature 294:631, 1981
14. Kirsch IR, Morton CC, Nakahara K, Leder P: Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes. Science 216:301, 1982
15. Ravetch JV, Siebenlist U, Korsmeyer S, Waldmann T, Leder P: Structure of the human immunoglobulin mu locus: Characterization of embryonic and rearranged J and D genes. Cell 27:583, 1981
16. H locus completed by analysis of the telomeric region of chromosome 14q. Nature Genet 7:162, 1994
17. H gene families display remarkably little polymorphism. EMBO J 8:3741, 1989
18. K repertoire revealed by in situ hybridization. Mol Immunol 27:935, 1990
19. Brezinschek, HP, Brezinschek RI, Lipsky PE: Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J Immunol 155:190, 1995
20. H segment encodes autoantibodies. J Autoimmun 2:203, 1989 (suppl)
21. L) expressed in early fetal bone marrow. New Biol 2:689, 1990
22. H gene-family utilization in human peripheral B cells by in situ hybridization. J Immunol 146:2855, 1991
23. H gene in the expressed human B cell repertoire. J Exp Med 177:409, 1993
24. Klein U, Küppers R, Rajewsky: Variable region gene analysis of B cell subsets derived from a 4-year-old child: Somatically mutated memory B cells accumulate in the peripheral blood already at young age. J Exp Med 180:1383, 1994
25. H gene segments in the human adult antibody repertoire. J Immunol 154:3902, 1995
26. H4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire. J Immunol 154:6406, 1995
27. Stevenson FK, Spellerberg MB, Treasure J, Shapman CJ, Silberstein LE, Hamblin TJ, Jones DB: Differential usage of an Ig heavy chain variable region gene by human B-cell tumors. Blood 82:224, 1993
28. H gene segment overrepresented in the autoimmune repertoire. Arth and Rheum 35:11, 1992
29. H gene expression in chronic lymphocytic leukemia. Int Immunol 1:362, 1989
30. H4-21 variable region gene-associated epitope. Scand J Immunol 34:509, 1991
31. H4 gene usage in B lymphoid leukaemias. Br J Haematol 84:242, 1993
32. Logtenberg T, Schutte MEM, Ebeling SB, Gmelig-Meyling FHJ, van Es JH: Molecular approaches to the study of human B-cell and (auto)antibody repertoire generation and selection. Immunol Rev 128:23, 1992
33. Pritsch O, Magnac C, Dumas G, Egile C, Dighiero G: V gene usage by seven hybrids derived from CD5+ B-cell chronic lymphocytec leukemia and displaying autoantibody activity. Blood 82:3103, 1993
34. Bahler DW, Levy R: Clonal evolution of a follicular lymphoma: Evidence for antigen selection. Proc Natl Acad Sci USA 86:6770, 1992
35. H4-21 gene during pre-B acute lymphoblastic leukemia. Leuk Lymphoma 17:435, 1995
36. H4 immunoglobulin gene family by diffuse large cell lymphoma. Blood 86:3072, 1995
37. Sahota S, Hamblin, T, Oscier DG, Stevenson FK: Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma. Leukemia 8:1285, 1994
38. Cogné M, Guglielme P: Exon skipping without splice site mutation accounting for abnormal immunoglobulin chains in nonsecretory human myeloma. Eur J Immunol 23:1289, 1993
39. Bakkus MHC, Heirman C, Van Riet I, Van Camp B, Thielemans K: Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation. Blood 8:2326, 1992
40. Vescio RA, Cao, Hong CH, Lee JC, Wu CH, Wu V, Newman R, Lichtenstein AK, Berenson JR: The heavy chain variable region in multiple myeloma shows evidence of prior somatic mutation and antigenic selection but the lack of intraclonal diversity or clonal progression. J Immunol 155:2487, 1995
41. Chomezynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Ann Biochem 162:156, 1987
42. Campbell MJ, Zelentetz AD, Levy S, Levy R: Use of family specific leader region primers for PCR amplification of the human heavy chain variable region gene repertoire. Mol Immunol 29:193, 1992
43. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual (2nd ed). Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1989, p 7.39
44. H gene family usage in multiple myeloma. Proc Am Ass Can Res 32:271a, 1991
45. Centola M, Lin K, Berenson JR, Kunkel LA, Rosen L, Hahn BH, Robinson RR: Production of anti-erythrocyte antibodies by leukemic and nonleukemic B cells in chronic lymphocytic leukemia patients. Leuk Lymphoma (in press)
46. Kipps TJ, Carson DA: Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases. Blood 81:2475, 1993
47. H4-21 gene segment is required to encode anti-i and anti-I specificities. J Immunol 149:2337, 1992
48. Pascual V, Victor K, Lelsz D, Spellerberg MB, Hamblin TJ, Thompson KM, Ramden I, Natvig J, Capra JD, Stevenson FK: Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. J Immunol 146:4385, 1991
49. Silberstein LE, Jeffries LC, Goldman J, Friedman D, Moore JS, Nowell PC, Roelcke D, Pruzanski W, Roudier J, Silverman GJ: Variable region gene analysis of pathologic human autoantibodies to the related I and I red blood cell antigens. Blood 78:2372, 1991
50. H segments with different hypervariable loops. J Mol Biol 227:776, 1992