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Volumn 160, Issue 6, 1998, Pages 2831-2841

Delineation of selective influences shaping the mutated expressed human Ig heavy chain repertoire

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

EID: 2642643710     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (48)

References (47)
  • 1
    • 0030483540 scopus 로고    scopus 로고
    • Receptor editing, immune diversification, and self-tolerance
    • Radic, M. Z., and M. Zouali. 1996. Receptor editing, immune diversification, and self-tolerance. Immunity 5:505.
    • (1996) Immunity , vol.5 , pp. 505
    • Radic, M.Z.1    Zouali, M.2
  • 2
    • 0029928877 scopus 로고    scopus 로고
    • Life and death in germinal centers (redux)
    • Kelsoe, G. 1996. Life and death in germinal centers (redux). Immunity 4:107.
    • (1996) Immunity , vol.4 , pp. 107
    • Kelsoe, G.1
  • 4
    • 0028794835 scopus 로고
    • Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process
    • Reynaud, C. A., C. Garcia, W. R. Hein, and J. C. Weill. 1995. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell 80:115.
    • (1995) Cell , vol.80 , pp. 115
    • Reynaud, C.A.1    Garcia, C.2    Hein, W.R.3    Weill, J.C.4
  • 5
    • 0029933460 scopus 로고    scopus 로고
    • Pathogenic autoantibodies are routinely generated during the response to foreign antigen: A paradigm for autoimmune disease
    • Ray, S. K., C. Putterman, and B. Diamond. 1996. Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease. Proc. Natl. Acad. Sci. USA 93:2019.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2019
    • Ray, S.K.1    Putterman, C.2    Diamond, B.3
  • 6
    • 0031039486 scopus 로고    scopus 로고
    • Differences in the mutational patterns between rheumatoid factors in health and disease are related to variable heavy chain family and germline gene usage
    • Borretzen, M., C. Chapman, J. B. Natvig, and K. M. Thompson. 1997. Differences in the mutational patterns between rheumatoid factors in health and disease are related to variable heavy chain family and germline gene usage. Eur. J Immunol. 27:735.
    • (1997) Eur. J Immunol. , vol.27 , pp. 735
    • Borretzen, M.1    Chapman, C.2    Natvig, J.B.3    Thompson, K.M.4
  • 8
    • 0029920268 scopus 로고    scopus 로고
    • The double edged sword of the immune response: Mutational analysis of a murine anti-pneumococcal, anti-DNA antibody
    • Putterman, C., W. Limpanasithikul, M. Edelman, and B. Diamond. 1996. The double edged sword of the immune response: mutational analysis of a murine anti-pneumococcal, anti-DNA antibody. J. Clin. Invest. 97:2251.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2251
    • Putterman, C.1    Limpanasithikul, W.2    Edelman, M.3    Diamond, B.4
  • 9
    • 0029063311 scopus 로고
    • Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction
    • Brezinschek, H.-P., R. I. Brezinschek, and P. E. Lipsky. 1995. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J. Immunol. 155:190.
    • (1995) J. Immunol. , vol.155 , pp. 190
    • Brezinschek, H.-P.1    Brezinschek, R.I.2    Lipsky, P.E.3
  • 12
    • 0027305024 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells
    • Jacob, J., J. Przylepa, C. Miller, and G. Kelsoe. 1993. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. J. Exp. Med. 178: 1293.
    • (1993) J. Exp. Med. , vol.178 , pp. 1293
    • Jacob, J.1    Przylepa, J.2    Miller, C.3    Kelsoe, G.4
  • 13
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunglobulin κ gene: Critical role for the intron enhancer/matrix attachment region
    • Betz, A. G., C. Milstein, A. Gonzalez-Fernandez, R. Pannell, T. Larsson, and M. S. Neuberger. 1994. Elements regulating somatic hypermutation of an immunglobulin κ gene: critical role for the intron enhancer/matrix attachment region. Cell 77:239.
    • (1994) Cell , vol.77 , pp. 239
    • Betz, A.G.1    Milstein, C.2    Gonzalez-Fernandez, A.3    Pannell, R.4    Larsson, T.5    Neuberger, M.S.6
  • 15
    • 0023462643 scopus 로고
    • Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse
    • Shlomchik, M. J., A. H. Aucoin, D. S. Pisetsky, and M. G. Weigert. 1987. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc. Natl. Acad. Sci. USA 84:9150.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 9150
    • Shlomchik, M.J.1    Aucoin, A.H.2    Pisetsky, D.S.3    Weigert, M.G.4
  • 16
    • 0028832881 scopus 로고
    • Somatic hypermutation in low-grade mucosa-associated lymphoid tissue-type B-cell lymphoma
    • Quin, Y., A. Greiner, M. J. F. Trunk, B. Schmausser, M. M. Ott, and H. K. Müller-Härmelink. 1995. Somatic hypermutation in low-grade mucosa-associated lymphoid tissue-type B-cell lymphoma. Blood 86:3528.
    • (1995) Blood , vol.86 , pp. 3528
    • Quin, Y.1    Greiner, A.2    Trunk, M.J.F.3    Schmausser, B.4    Ott, M.M.5    Müller-Härmelink, H.K.6
  • 17
    • 0029661825 scopus 로고    scopus 로고
    • L gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection
    • L gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection. Blood 88:3562.
    • (1996) Blood , vol.88 , pp. 3562
    • Chapman, C.1    Zhou, J.X.2    Gregory, C.3    Rickinson, A.B.4    Stevenson, F.K.5
  • 18
    • 0026443954 scopus 로고
    • Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis
    • Rogozin, I. B., and N. A. Kolchanov. 1992. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim. Biophys. Acta 1171:11.
    • (1992) Biochim. Biophys. Acta , vol.1171 , pp. 11
    • Rogozin, I.B.1    Kolchanov, N.A.2
  • 21
    • 0026786650 scopus 로고
    • High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire
    • van Es, J. H., F. H. J. Gmelig Meyling, and T. Logtenberg. 1992. High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire. Eur. J. Immunol. 22:2761.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 2761
    • Van Es, J.H.1    Gmelig Meyling, F.H.J.2    Logtenberg, T.3
  • 22
    • 0023278330 scopus 로고
    • Canonical structures for the hypervariable regions on immunoglobulins
    • Chothia, C., and A. M. Lesk. 1987. Canonical structures for the hypervariable regions on immunoglobulins. J. Mol. Biol. 196:901.
    • (1987) J. Mol. Biol. , vol.196 , pp. 901
    • Chothia, C.1    Lesk, A.M.2
  • 23
    • 0028577994 scopus 로고
    • Somatic mutation of immunoglobulin λ chains: A segment of the major intron hypermutates as much as the complementarity-determining regions
    • Gonzalez-Fernandez, A., S. K. Gupta, R. Pannell, M. S. Neuberger, and C. Milstein. 1994. Somatic mutation of immunoglobulin λ chains: a segment of the major intron hypermutates as much as the complementarity-determining regions. Proc. Natl. Acad. Sci. USA 91:12614.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12614
    • Gonzalez-Fernandez, A.1    Gupta, S.K.2    Pannell, R.3    Neuberger, M.S.4    Milstein, C.5
  • 24
    • 0027227311 scopus 로고
    • Discriminating intrinsic and antigen-selected mutational hot spots in immunoglobulin V genes
    • Betz, A. G., M. S. Neuberger, and C. Milstein. 1993. Discriminating intrinsic and antigen-selected mutational hot spots in immunoglobulin V genes. Immunol. Today 14:405.
    • (1993) Immunol. Today , vol.14 , pp. 405
    • Betz, A.G.1    Neuberger, M.S.2    Milstein, C.3
  • 28
    • 0028818503 scopus 로고
    • Somatic hypermutation: How many mechanisms diversify V region sequences?
    • Maizels, N. 1995. Somatic hypermutation: how many mechanisms diversify V region sequences? Cell 83:9.
    • (1995) Cell , vol.83 , pp. 9
    • Maizels, N.1
  • 30
    • 0031041632 scopus 로고    scopus 로고
    • The transcriptional promoter regulates hypermutation of the antibody heavy chain locus
    • Tumas-Brundage, K., and T. Manser. 1997. The transcriptional promoter regulates hypermutation of the antibody heavy chain locus. J. Exp. Med. 185:239.
    • (1997) J. Exp. Med. , vol.185 , pp. 239
    • Tumas-Brundage, K.1    Manser, T.2
  • 31
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • Peters, A., and U. Storb. 1996. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4:57.
    • (1996) Immunity , vol.4 , pp. 57
    • Peters, A.1    Storb, U.2
  • 32
    • 0027932998 scopus 로고
    • H genes are inherently susceptible to amino acid replacement
    • H genes are inherently susceptible to amino acid replacement. Immunol. Today 15:367.
    • (1994) Immunol. Today , vol.15 , pp. 367
    • Chang, B.1    Casali, P.2
  • 33
    • 0025630537 scopus 로고
    • Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′boundary is near the promoter, and 3′boundary is approximately 1kb from V(D)J gene
    • Lebecque, S. G., and P. J. Gearhart. 1990. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′boundary is near the promoter, and 3′boundary is approximately 1kb from V(D)J gene. J. Exp. Med. 172:1717.
    • (1990) J. Exp. Med. , vol.172 , pp. 1717
    • Lebecque, S.G.1    Gearhart, P.J.2
  • 35
    • 0014019617 scopus 로고
    • Origin of antibody variation
    • Brenner, S., and C. Milstein. 1966. Origin of antibody variation. Nature 211:242.
    • (1966) Nature , vol.211 , pp. 242
    • Brenner, S.1    Milstein, C.2
  • 38
    • 0030450401 scopus 로고    scopus 로고
    • Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation
    • Goyonechea, B., and C. Milstein. 1996. Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation. Proc. Natl. Acad. Sci. USA 93:13979.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13979
    • Goyonechea, B.1    Milstein, C.2
  • 39
    • 0030821164 scopus 로고    scopus 로고
    • Structural insights into the evolution of an antibody combining site
    • Wedetmayer, G. J., P. A. Patten, L. H. Wang, P. G. Schultz, and R. C. Stevens. 1997. Structural insights into the evolution of an antibody combining site. Science 276:1665.
    • (1997) Science , vol.276 , pp. 1665
    • Wedetmayer, G.J.1    Patten, P.A.2    Wang, L.H.3    Schultz, P.G.4    Stevens, R.C.5
  • 40
    • 0023718496 scopus 로고
    • V region sequences of anti-DNA and anti-RNA autoantibodies from NZB/NZW F1 mice
    • Eilat, D., D. M. Webster, and A. R. Rees. 1988. V region sequences of anti-DNA and anti-RNA autoantibodies from NZB/NZW F1 mice. J. Immunol. 141:1745.
    • (1988) J. Immunol. , vol.141 , pp. 1745
    • Eilat, D.1    Webster, D.M.2    Rees, A.R.3
  • 42
    • 0342740028 scopus 로고
    • Somatic mulation of the T15 heavy chain gives rise to an antibody with autoantibody specificity
    • Diamond, B., and M. D. Scharff. 1984. Somatic mulation of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc. Natl. Acad. Sci. USA 81:5811.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 5811
    • Diamond, B.1    Scharff, M.D.2
  • 44
    • 0023510298 scopus 로고
    • Evolutionary and somatic selection of the antibody repertoire in the mouse
    • Rajewski, K., I. Förster, and A. Cumano. 1987. Evolutionary and somatic selection of the antibody repertoire in the mouse. Science 238:1088.
    • (1987) Science , vol.238 , pp. 1088
    • Rajewski, K.1    Förster, I.2    Cumano, A.3
  • 47
    • 0027260343 scopus 로고
    • The maturation of the immune response
    • Berek, C., and M. Ziegner. 1993. The maturation of the immune response. Immunol. Today 14:400.
    • (1993) Immunol. Today , vol.14 , pp. 400
    • Berek, C.1    Ziegner, M.2


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