Dietary supplementation with eicosapentaenoic and docosahexaenoic acid inhibits growth of Morris hepatocarcinoma 3924A in rats: Effects on proliferation and apoptosis

International Journal of Cancer

Volumn 75, Issue 5, 1998, Pages 699-705

  Calviello, Gabriella ^a   Palozza, Paola ^a   Piccioni, Elisabetta ^a   Maggiano, Nicola ^a   Frattucci, Andrea ^a   Franceschelli, Piergiorgio ^a   Bartoli, Gianna M ^a,b  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; LINOLEIC ACID; OMEGA 3 FATTY ACID; POLYUNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; FAT INTAKE; FOOD COMPOSITION; LIVER CELL CARCINOMA; MALE; MORRIS HEPATOMA; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CELL DIVISION; DIETARY FATS; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MEMBRANE LIPIDS; NEOPLASM TRANSPLANTATION; PHOSPHOLIPIDS; RATS; RATS, INBRED ACI;

EID: 0032473553     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980302)75:5<699::AID-IJC7>3.0.CO;2-U     Document Type: Article

References (31)

1. ABOU-EL-ELA, S.H., PRASSE, K.W., FARREL, R.L., CARROL, R.W., WADE, A.E. and BUNCE, O.R., 2-difluoromethylornitine and indomethacin on mammary-tumor promotion in rats fed high n-3 and n-6 fat diets. Cancer Res., 49, 1434-1440 (1989).
2. ANTI, M. and 12 OTHERS, Effect of w-3 fatty acids on rectal mucosa-cell proliferation in subject at risk for colon cancer. Gastroenterology, 103, 883-891 (1992).
3. BLIGH, E.G. and DYER, W.J., A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol., 37, 911-917 (1959).
4. BROWN, E.R. and SUBBAIAH, P.V., Differential effect of eicosapentaenoic acid and docosahexaenoic acid on human skin fibroblast. Lipids, 29, 825-829 (1994).
5. CALVIELLO, G., PALOZZA, P., MAGGIANO, N., FRANCESCHELLI, P., FRATTUCCI, A. and BARTOLI, G.M., EPA but not DHA inhibits cell proliferation in rat colon mucosa and liver. Gastroenterology, 108, 453 (1995).
6. CARLSON, S.E., WERKMAN, S.H. and TOLLEY, E.A., Effect of long-chain n-3-fatty-acid supplementation on visual acuity and growth of pre-term infants with and without bronchopulmonary dysplasia. Amer. J. clin. Nutr., 63, 687-697 (1996).
7. CAVE, W.T., JR., Dietary n-3 (ω-3) polyunsaturated fatty effects on animal tumorigenesis. FASEB J., 5, 2160-2166 (1994).
8. CHAPKIN, R.S., GAO, J., LEE, D.K. and LUPTON, J.R., Effect of dietary fiber and fat on rat colon protein-kinase-C activity: correlation to cell proliferation. J. Nutr., 123, 649-655 (1993).
9. COHEN, L.A., CHEN-BACKLUND, J.Y., SEPKOVIC, D.W. and SUGIE, S., Effect of varying proportion of dietary menhaden oil on experimental rat mammary tumor promotion. Lipids, 28, 449-456 (1993).
10. COREY, R.J., SHIH, C. and CASHMAN, J.R., Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis. Proc. nat. Acad. Sci. (Wash.), 80, 3581-3584 (1983).
11. DREVON, C.A., Marine oils and their effects. Nutr. Rev., 50, 38-45 (1992).
12. FERNANDES, G., CHANDRASEKAR, B., LUAN, X. and TROYER, D.A., Modulation of anti-oxidant enzymes and programmed cell death by n-3 fatty acids. Lipids, 31, S91-S96 (1996).
13. GAVRIELY, Y., SHERMAN, Y. and SASSON, S.A., Identification of programmed cell death in situ via specific labeling DNA fragmentation. J. Cell Biol., 119, 493-501 (1992).
14. GONZALES, M.J., SHEMMEL, R.A., DUGAN, L., GRAY, J.I. and WELSH, C.W., Dietary fish oil inhibits human breast-carcinoma growth: a function of increased lipid peroxidation. Lipids, 28, 827-832 (1993).
15. HIBBELN, J.R. and SALEM, R., Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy. Amer. J. clin. Nutr., 62, 1-9 (1995).
16. IIGO, M., NAGAKAWA, T., ISHIKAWA, C., IWAHORI, Y., ASAMOTO, M., YAZAWA, K., ARAKI, E. and TSUDA, H., Inhibitory effect of docosahexaenoic acid on colon-carcinoma-26 metastasis to the lung. Brit. J. Cancer, 75, 650-655 (1997).
17. KARMALI, R.A., Eicosanoids in neoplasia. Prev. Med., 16, 493-502 (1987).
18. KINSELLA, J.E. and BLACK, J.M., Effect of polyunsaturated fatty acids on the efficacy of anti-neoplastic agents toward L5178 lymphoma cells. Biochem. Pharmacol., 9, 1881-1887 (1993).
19. KROKAN, H.E., RUDRA, P.K., SCHONBERG, S., SLETTAHJELL, W., SOLUM, K., MOLLERUP, S., EILERTSEN, E., MAELE, L. and HAUGEN, A., In: C.A. Drevon, I. Baksaas and H.E. Krokan (eds.), Omega-3 fatty acids: metabolism and biological effects, pp. 327-341, Birkhauser, Basel (1993).
20. LAI, P.B.S., ROSS, J.A., FEARON, K.C.H., ANDERSON, J.D. and CARTER, D.C., Cell-cycle arrest and induction of apoptosis in pancreatic-cancer cells exposed to eicosapentaenoic acid in vitro. Brit. J. Cancer, 74, 1375-1383 (1996).
21. LEIBOVITZ, B.E., HU, M.L. and TAPPEL, A.L., Lipid peroxidation in rat tissue slices: effect of dietary vitamin E, corn, oil-lard and menhaden oil. Lipids, 25, 125-129 (1990).
22. MINAMI, M. and NOGUCHI, M., Effect of low-dose eicosapentaenoic acid, docosahexaenoic acid and dietary fat on the incidence, growth and cell kinetics of mammary carcinomas in rats. Oncology, 53, 398-405 (1996).
23. NOGUCHI, M., MINAMI, M., YAGASAKI, R., KINOSHITA, K., EARASHI, M., KITAGAWA, H., TANIYA, T. and MIYAZAKI, I., Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. Brit. J. Cancer, 75, 348-353 (1997).
24. Δ716 knockout mice. Carcinogenesis, 16, 2605-2607 (1995).
25. PALOZZA, P., SGARLATA, E., LUBERTO, C., PICCIONI, E., ANTI, M., MARRA, G., ARMELAO, F., FRANCESCHELLI, P. and BARTOLI, G.M., n-3 fatty acids induce oxidative modifications in human erythrocytes, depending on dose and duration of dietary supplementation. Amer. J. clin. Nutr., 64, 297-304 (1996).
26. REDDY, B.S. and MARUYAMA, H., Effect of dietary fish oil on azoxymethane-induced colon carcinogenesis in male F344 rats. Cancer Res., 46, 3367-3370 (1986).
27. ROSE, D.P., CONNOLLY, J.M. and COLEMAN, M., Effect of omega-3 fatty acids on the progression of metastases after the surgical excision of human breast-cancer-cell solid tumors growing in nude mice. Clin. Cancer Res., 2, 1751-1756 (1996).
28. ROSE, D.P., CONNOLLY, J.M., RAYBURN, J. and COLEMAN, M., Influence of diets containing eicosapentaenoic acid and docosahexaenoic acid on growth and metastasis of breast-cancer cells in nude mice. J. nat. Cancer Inst., 87, 587-592 (1995).
29. SHIINA, T., TERANO, T., SAITO, J., TAMURA, Y. and YOSHIDA, S., Eicosapentaenoic acid and docosahexaenoic acid suppress the proliferation of vascular smooth-muscle cells. Atherosclerosis, 104, 95-103 (1993).
30. SWANN, P.G., PARENT, C.A., CROSET, M., FONLUPT, P., LAGARD, M., VENTON, D.L., Enrichment of platelet phospholipids with eicosapentaenoic acid and docosahexaenoic acid inhibits tromboxane A2/prostaglandine H2 receptor binding and function. J. biol. Chem., 265, 21692-21697 (1990).
31. WILLUMSEN, N., VAAGENES, H., LIE, O., RUSTAN, A.C. and BERGE, R.K., Eicosapentaenoic acid, but not docosahexaenoic acid, increases mitochondrial fatty acid oxidation and up-regulates 2,4-dienoyl-coa-reductase gene expression. Lipids, 31, 579-592 (1996).