메뉴 건너뛰기




Volumn 185, Issue 1, 1998, Pages 61-70

Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism

Author keywords

linolenic; linolenic; Apoptosis; Arachidonic; Cell death; Cell lines; CFPAC; Cis parinaric; DNA fragmentation; Docosahexaenoic acids; Eicosapentaenoic; Erucic; HBL 100; HL 60; Linoleic; Lipid peroxidation; Mia Pa Ca 2; Morphology; Oleic; PANC 1 cells; Pancreatic cancer; Polyunsaturated fatty acids

Indexed keywords

ARACHIDONIC ACID; DNA FRAGMENT; DOCOSAHEXAENOIC ACID; ERUCIC ACID; GAMMA LINOLENIC ACID; ICOSAPENTAENOIC ACID; LINOLEIC ACID; LINOLENIC ACID; MALONALDEHYDE; MONOUNSATURATED FATTY ACID; OLEIC ACID; PARINARIC ACID; POLYUNSATURATED FATTY ACID;

EID: 0031800034     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199805)185:1<61::AID-PATH49>3.0.CO;2-8     Document Type: Article
Times cited : (140)

References (37)
  • 1
    • 2642619472 scopus 로고
    • Nutritional factors in disease
    • Edwards CRW, Boucher IAD, Haslett C, Chilvers, ER, eds. Edinburgh: Churchill Livingstone
    • Truswell AS. Nutritional factors in disease. In: Edwards CRW, Boucher IAD, Haslett C, Chilvers, ER, eds. Davidson's Principles and Practice of Medicine. 17th edn. Edinburgh: Churchill Livingstone, 1995; 550.
    • (1995) Davidson's Principles and Practice of Medicine. 17th Edn. , pp. 550
    • Truswell, A.S.1
  • 2
  • 3
    • 0002775088 scopus 로고
    • The eicosanoids: Prostaglandins, thromboxanes, leukotrienes and related compounds
    • Katzung BZ, ed. New York: Prentice Hall
    • Hecker M, Foegh ML, Ramwell PW. The eicosanoids: prostaglandins, thromboxanes, leukotrienes and related compounds. In: Katzung BZ, ed. Basic and Clinical Pharmacology. 6th edn. New York: Prentice Hall, 1995; 290-304.
    • (1995) Basic and Clinical Pharmacology. 6th Edn. , pp. 290-304
    • Hecker, M.1    Foegh, M.L.2    Ramwell, P.W.3
  • 4
    • 0028004342 scopus 로고
    • Dietary polyunsaturated fatty acids and composition of human aortic plaques
    • Felton CV, Crook D, Davies MJ, Oliver MF. Dietary polyunsaturated fatty acids and composition of human aortic plaques. Lancet 1994; 344: 1195-1196.
    • (1994) Lancet , vol.344 , pp. 1195-1196
    • Felton, C.V.1    Crook, D.2    Davies, M.J.3    Oliver, M.F.4
  • 5
    • 0029135389 scopus 로고
    • Enteral feeding a structured lipid emulsion containing fish oil prevents the fatty liver of septis
    • Lanza-Jacoby S, Phetterplace H, Tripp R. Enteral feeding a structured lipid emulsion containing fish oil prevents the fatty liver of septis. Lipids 1995; 30: 707-712.
    • (1995) Lipids , vol.30 , pp. 707-712
    • Lanza-Jacoby, S.1    Phetterplace, H.2    Tripp, R.3
  • 6
    • 0027320610 scopus 로고
    • Free radicals in inflammation: Second messengers and mediators of tissue destruction
    • Winrow VR, Winyard PG, Morris CJ, Blake DR. Free radicals in inflammation: second messengers and mediators of tissue destruction. Br Med Bull 1993; 49: 506-522.
    • (1993) Br Med Bull , vol.49 , pp. 506-522
    • Winrow, V.R.1    Winyard, P.G.2    Morris, C.J.3    Blake, D.R.4
  • 7
    • 0023941665 scopus 로고
    • Polyunsaturated fatty acid-induced cytotoxicity against tumour cells and its relationship to lipid peroxidation
    • Bégin ME, Ells G, Horrobin DF. Polyunsaturated fatty acid-induced cytotoxicity against tumour cells and its relationship to lipid peroxidation. J Natl Cancer Inst 1988; 80: 188-194.
    • (1988) J Natl Cancer Inst , vol.80 , pp. 188-194
    • Bégin, M.E.1    Ells, G.2    Horrobin, D.F.3
  • 8
    • 0028203340 scopus 로고
    • Effect of eicosapentenoic acid and other fatty acids on the growth in vitro of human pancreatic cancer cell lines
    • Falconer JS, Ross JA, Fearon KCH, Hawkins RA, O'Riordain MG, Carter DC. Effect of eicosapentenoic acid and other fatty acids on the growth in vitro of human pancreatic cancer cell lines. Br J Cancer 1994; 69: 826-832.
    • (1994) Br J Cancer , vol.69 , pp. 826-832
    • Falconer, J.S.1    Ross, J.A.2    Fearon, K.C.H.3    Hawkins, R.A.4    O'Riordain, M.G.5    Carter, D.C.6
  • 10
    • 0026023962 scopus 로고
    • Effect of diets high in ω-3 and ω-6 fatty acids on initiation and post-initiation stages of colon carcinogenesis
    • Reddy BS, Burill C, Rigotty J. Effect of diets high in ω-3 and ω-6 fatty acids on initiation and post-initiation stages of colon carcinogenesis. Cancer Res 1991; 51: 487-491.
    • (1991) Cancer Res , vol.51 , pp. 487-491
    • Reddy, B.S.1    Burill, C.2    Rigotty, J.3
  • 11
    • 84970850321 scopus 로고
    • Hopeful newspaper article was justified
    • Hawkes N. Hopeful newspaper article was justified. Br Med J 1994; 309: 543-544.
    • (1994) Br Med J , vol.309 , pp. 543-544
    • Hawkes, N.1
  • 12
    • 0029936742 scopus 로고    scopus 로고
    • The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer
    • Wigmore SJ, Ross JA, Falconer S, et al. The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. Nutrition 1996; 12: s27-s30.
    • (1996) Nutrition , vol.12
    • Wigmore, S.J.1    Ross, J.A.2    Falconer, S.3
  • 13
    • 0011049272 scopus 로고
    • Weight loss and nutritional abnormalities in cancer patients: Incidence, severity and significance
    • Calman KC, Fearon KCH, eds. London: Balliere Tindal
    • De Wys WD. Weight loss and nutritional abnormalities in cancer patients: incidence, severity and significance. In: Calman KC, Fearon KCH, eds. Nutritional Support for the Cancer Patient. London: Balliere Tindal, 1986; 251-256.
    • (1986) Nutritional Support for the Cancer Patient , pp. 251-256
    • De Wys, W.D.1
  • 15
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide ranging implications in tissue kinetics
    • Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-257.
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.R.1    Wyllie, A.H.2    Currie, A.R.3
  • 16
  • 17
    • 0025932984 scopus 로고
    • Apoptosis: Mechanisms and roles in pathology
    • Arenas MJ, Wyllie AH. Apoptosis: mechanisms and roles in pathology. Int Rev Exp Pathol 1991; 32: 223-254.
    • (1991) Int Rev Exp Pathol , vol.32 , pp. 223-254
    • Arenas, M.J.1    Wyllie, A.H.2
  • 18
    • 0003100740 scopus 로고
    • Apoptosis: Molecular aspects and pathological perspective
    • Crocker J, ed. Chichester: John Wiley
    • Arends MJ, Harrison DJ. Apoptosis: molecular aspects and pathological perspective. In: Crocker J, ed. Molecular Biology in Histopathology. Chichester: John Wiley, 1994; 151-170.
    • (1994) Molecular Biology in Histopathology , pp. 151-170
    • Arends, M.J.1    Harrison, D.J.2
  • 19
    • 0027515642 scopus 로고
    • Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability
    • Arends MJ, McGregor AH, Toft NJ, Brown EJH, Wyllie AH. Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability. Br J Cancer 1993; 68: 1127-1133.
    • (1993) Br J Cancer , vol.68 , pp. 1127-1133
    • Arends, M.J.1    McGregor, A.H.2    Toft, N.J.3    Brown, E.J.H.4    Wyllie, A.H.5
  • 20
    • 0028231893 scopus 로고
    • Apoptosis is inversely related to necrosis and determines net growth in tumours bearing constitutively expressed myc, ras and HPV oncogenes
    • Arends MJ, McGregor AH, Wyllie AH. Apoptosis is inversely related to necrosis and determines net growth in tumours bearing constitutively expressed myc, ras and HPV oncogenes. Am J Pathol 1994; 114: 1045-1057.
    • (1994) Am J Pathol , vol.114 , pp. 1045-1057
    • Arends, M.J.1    McGregor, A.H.2    Wyllie, A.H.3
  • 21
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 22
    • 0000457381 scopus 로고
    • Preparation of genomic DNA from mammalian tissue
    • Strauss WM. Preparation of genomic DNA from mammalian tissue. Curr Protocols Mol Biol 1987; Suppl. 13: 2.2.1-2.2.3.
    • (1987) Curr Protocols Mol Biol , Issue.13 SUPPL. , pp. 221-223
    • Strauss, W.M.1
  • 23
    • 0028323164 scopus 로고
    • A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry
    • Gong J, Traganos F, Darzynkiewicz Z. A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal Biochem 1993; 218: 314-319.
    • (1993) Anal Biochem , vol.218 , pp. 314-319
    • Gong, J.1    Traganos, F.2    Darzynkiewicz, Z.3
  • 24
    • 0029143540 scopus 로고
    • Growth arrest vs. direct cytotoxicity and the importance of molecular structure for the in vitro anti-tumour activity of ether lipids
    • Lohmeyer M, Workman P. Growth arrest vs. direct cytotoxicity and the importance of molecular structure for the in vitro anti-tumour activity of ether lipids. Br J Cancer 1995; 72: 277-286.
    • (1995) Br J Cancer , vol.72 , pp. 277-286
    • Lohmeyer, M.1    Workman, P.2
  • 25
    • 0027217084 scopus 로고
    • Apoptotic death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation
    • Oberhammer F, Wilson JWW, Dive C, et al. Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 1993; 12: 3679-3684.
    • (1993) EMBO J , vol.12 , pp. 3679-3684
    • Oberhammer, F.1    Wilson, J.W.W.2    Dive, C.3
  • 26
    • 0029063863 scopus 로고
    • Induction of apoptosis by anti-cancer drugs with disparate modes of action: Kinetics of cell death and changes in c-myc expression
    • Wood AC, Elvin P, Hickman JA. Induction of apoptosis by anti-cancer drugs with disparate modes of action: kinetics of cell death and changes in c-myc expression. Br J Cancer 1995; 71: 937-941.
    • (1995) Br J Cancer , vol.71 , pp. 937-941
    • Wood, A.C.1    Elvin, P.2    Hickman, J.A.3
  • 27
    • 0026788002 scopus 로고
    • Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation
    • Cohen GM, Sun X-M, Snowden RT, Dinsdale D, Skilleter DN. Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochem J 1992; 286: 331-334.
    • (1992) Biochem J , vol.286 , pp. 331-334
    • Cohen, G.M.1    Sun, X.-M.2    Snowden, R.T.3    Dinsdale, D.4    Skilleter, D.N.5
  • 28
    • 0026548817 scopus 로고
    • Effect of ω3 and ω6 fatty acids on transformation of cultured cells by irradiation and transfection
    • Takahashi M, Przetakiewicz M, Ong A, Borek C, Lowenstein JM. Effect of ω3 and ω6 fatty acids on transformation of cultured cells by irradiation and transfection. Cancer Res 1992; 52: 154-162.
    • (1992) Cancer Res , vol.52 , pp. 154-162
    • Takahashi, M.1    Przetakiewicz, M.2    Ong, A.3    Borek, C.4    Lowenstein, J.M.5
  • 29
    • 0028017856 scopus 로고
    • n-3 and n-6 fatty acid processing and growth effects in neoplastic and non-cancerous human mammary epithelial cell lines
    • Grammatikos SI, Subbaiah PV, Victor TA, Miller WM. n-3 and n-6 fatty acid processing and growth effects in neoplastic and non-cancerous human mammary epithelial cell lines. Br J Cancer 1994; 70: 219-227.
    • (1994) Br J Cancer , vol.70 , pp. 219-227
    • Grammatikos, S.I.1    Subbaiah, P.V.2    Victor, T.A.3    Miller, W.M.4
  • 31
    • 0027455786 scopus 로고
    • Induction of apoptosis in human leukemic cells by the ether lipid 1-octadecyl-2-methyl-RAC-glycero-3-phosphocholine. A possible basis for its selective action
    • Diomede L, Colotta F, Piovani B, Re F, Modest EJ, Salmona M. Induction of apoptosis in human leukemic cells by the ether lipid 1-octadecyl-2-methyl-RAC-glycero-3-phosphocholine. A possible basis for its selective action. Int J Cancer 1993; 53: 124-130.
    • (1993) Int J Cancer , vol.53 , pp. 124-130
    • Diomede, L.1    Colotta, F.2    Piovani, B.3    Re, F.4    Modest, E.J.5    Salmona, M.6
  • 32
    • 0026329025 scopus 로고
    • Cytotoxic effect of cis-parinaric acid in cultured malignant cells
    • Cornelius AS, Yerram NR, Kratz DA, Spector AA. Cytotoxic effect of cis-parinaric acid in cultured malignant cells. Cancer Res 1991; 51: 6025-6030.
    • (1991) Cancer Res , vol.51 , pp. 6025-6030
    • Cornelius, A.S.1    Yerram, N.R.2    Kratz, D.A.3    Spector, A.A.4
  • 33
    • 0027406896 scopus 로고
    • The relationship between fatty acid peroxidation and α-tocopherol consumption in isolated normal and transformed hepatocytcs
    • Cogrel P, Morel I, Lescoat G, et al. The relationship between fatty acid peroxidation and α-tocopherol consumption in isolated normal and transformed hepatocytcs. Lipids 1993; 28: 115-119.
    • (1993) Lipids , vol.28 , pp. 115-119
    • Cogrel, P.1    Morel, I.2    Lescoat, G.3
  • 34
    • 0028089905 scopus 로고
    • Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in Ehrlich mouse ascites cells at different proliferation stages
    • Grune T, Siems WG, Zollner H, Esterbauer H. Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in Ehrlich mouse ascites cells at different proliferation stages. Cancer Res 1994; 54: 5231-5235.
    • (1994) Cancer Res , vol.54 , pp. 5231-5235
    • Grune, T.1    Siems, W.G.2    Zollner, H.3    Esterbauer, H.4
  • 35
    • 0028545415 scopus 로고
    • Newer aspects of micronutrients in at risk groups. New metabolic roles for selenium
    • Arthur JR, Beckett GJ. Newer aspects of micronutrients in at risk groups. New metabolic roles for selenium. Proc Nutrition Soc 1994; 53: 615-624.
    • (1994) Proc Nutrition Soc , vol.53 , pp. 615-624
    • Arthur, J.R.1    Beckett, G.J.2
  • 36
    • 0027416872 scopus 로고
    • Effect of polyunsaturated fatty acids on the drug sensitivity of human tumour cell lines resistant to either cis-platin or doxorubicin
    • Plumb JA, Luo W, Kerr DJ. Effect of polyunsaturated fatty acids on the drug sensitivity of human tumour cell lines resistant to either cis-platin or doxorubicin. Br J Cancer 1993; 67: 728-733.
    • (1993) Br J Cancer , vol.67 , pp. 728-733
    • Plumb, J.A.1    Luo, W.2    Kerr, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.