Fish oil blocks azoxymethane-induced rat colon tumorigenesis by increasing cell differentiation and apoptosis rather than decreasing cell proliferation

Journal of Nutrition

Volumn 128, Issue 3, 1998, Pages 491-497

  Chang, Wen Chi L ^a   Chapkin, Robert S ^a   Lupton, Joanne R ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Apoptosis; Azoxymethane; Fish oil; Proliferation; Rats

Indexed keywords

AZOXYMETHANE; CORN OIL; FISH OIL;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; COLON TUMOR; DNA DETERMINATION; GENOME; MALE; NONHUMAN; PROTEIN BINDING; RAT;

ANIMALIA; DOLICHOS BIFLORUS; ZEA MAYS;

EID: 0031976795     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/128.3.491     Document Type: Article

References (39)

1. Bang, H. O., Dyerberg, J. & Hjorne, N. (1976) The composition of food consumed by Greenland Eskimos. Acta. Med. Scand. 200: 69-73.
2. Bartoli, G. M., Palozza, P., Marra, G., Armelao, F., Franceschelli, P., Luberto, C., Sgarlata, E., Piccioni, E. & Anti, M. (1993) N-3 PUFA and α-tocopherol control of tumor cell proliferation, Mol. Aspects Med. 14: 247-252.
3. 2 release in healthy subjects. Gastroenterology 105: 1317-1322.
4. Bedi, A., Pasricha, P. J., Akhtar, A. J., Barber, J. P., Bedi, G. C., Giardiello, F. M., Zehnbauer, B. A., Hamilton, S. R. & Jones, R. J. (1995) Inhibition of apoptosis during development of colorectal cancer. Cancer Res. 55: 1811-1816.
5. Blot, W. J., Lanier, A., Fraumeri, J. F. & Bender T. R. (1975) Cancer mortality among Alaska natives, 1960-69. J. Nat. Cancer Inst. 55: 547-554.
6. Boland, C. R., Montgomery, C. K. & Kim, Y. S. (1982) Alterations in colonic mucin structure occuring with cellular differentiation and malignant transformation. Proc. Natl. Acad. Sci. USA 79: 2051-2055.
7. Caygill, C.P.J., Chartert, A. & Hill, M. J. (1996) Fat, fish, fish oil and cancer. Br. J. Cancer 74: 159-164.
8. Chang, W.-C.L., Chapkin, R. S. & Lupton, J. R. (1997a) Luminal butyrate concentration is positively associated with colonocyte differentiation apoptosis and negatively associated with proliferation. FASEB J. 11: A566 (abs.).
9. Chang, W.-C.L., Chapkin, R. S. & Lupton, J. R. (1997b) Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis. Carcinogenesis 18: 721-730.
10. ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2. Oncogene 11: 1487-1498.
11. Deschner, E. E., Lytle, J. S., Wong, G., Ruperto, J. F. & Newmark, H. L. (1990) The effect of dietary omega-3 fatty acids (fish oil) on azoxymethanol-induced focal areas of dysplasia and colon tumor incidence. Cancer 66: 2350-2356.
12. Fearon, E. R. & Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell 61: 759-767.
13. Garewal, H., Bernstein, H., Bernstein, C., Sampliner, R. & Payne, C. (1996) Reduced bile acid-induced apoptosis in "normal" colorectal mucosa: a potential biological marker for cancer risk. Cancer Res. 56: 1480-1483.
14. Gavrieli, Y., Sherman, Y. & Ben-Sasson, S. A. (1992) Identification of programmed cell death in-situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119: 493-501.
15. Jiang, Y. H., Lupton, J. R., Chang, W.-C.L., Jolly, C. A., Aukema, H. M. & Chapkin, R. S. (1996) Dietary fat and fiber differentially alter intracellular second messengers during tumor development in rat colon. Carcinogenesis 17: 1227-1233.
16. Jiang, Y. H., Lupton, J. R. & Chapkin, R. S. (1997) Dietary fish oil blocks carcinogen-induced down-regulation of colonie protein kinase C isozymes. Carcinogenesis 18: 351-357.
17. Jiang, Y. H., Lupton, J. R. & Chapkin, R. S. (1995) Modulation of intermediate biomarkers of colon cancer by dietary fat, fiber and carcinogen in rat colonocytes. FASEB J. 9: A868 (abs.).
18. Kerr, J.F.K., Gobé, G. C., Winterford, C. M. & Harmon, B. V. (1995) Anatomical methods in cell death. Methods Cell Biol. 46: 1-27.
19. Klurfeld, D. M., Weber, M. M. & Kritchevsky, D. (1987) Inhibition of chemically induced mammary and colon tumor promotion by caloric restriction in rats fed increased dietary fat. Cancer Res. 47: 2759-2762.
20. Laurenz, J. C., Gunn, J. M., Jolly, C. A. & Chapkin, R. S. (1996) Alteration of glycerolipid and sphingolipid-derived second messenger kinetics in ras transformed 3T3 cells. Biochim. Biophys. Acta. 1299: 146-154.
21. Lee, D. Y., Chapkin, R. S. & Lupton, J. R. (1993a) Dietary fat and fiber modulate colonic cell proliferation in an interactive site-specific manner. Nutr. Cancer 20: 107-118.
22. Lee, D. Y., Lupton, J. R., Aukema, H. M. & Chapkin, R. S. (1993b) Dietary fat and fiber alter rat colonie mucosal lipid mediators and cell proliferation. J. Nutr. 123: 1808-1817.
23. Maciorowski, K. G., Turner, N. D., Lupton, J. R., Chapkin, R. S., Shermer, C. L., Ha, S. D. & Ricke, S. C. (1997) Diet and carcinogen alter the fecal microbial populations of rats. J. Nutr. 127: 449-457.
24. Maher, J., Colonna, F., Baker, D., Luzzatto, L. & Roberts, I. (1994) Retroviral-mediated gene transfer of a mutant H-ras gene into normal human bone marrow alters myeloid cell proliferation and differentiation. Exp. Hematol. 22: 8-12.
25. Paganelli, G. M., Biasco, G., Santucci, R., Brandi, G., Lalli, A. A., Miglioli, M. & Barbara, L. (1991) Rectal cell proliferation and colorectal cancer risk level in patients with non-familial adenomatous polyps of the large bowel. Cancer 68: 2451-2454.
26. Preston-Martin, S., Pike, M. C., Ross, R. K., Jones, P. A. & Henderson, B. E. (1990) Increased cell division as a cause of human cancer. Cancer Res. 50: 7415-7421.
27. Rao, C. V. & Reddy, B. S. (1993) Modulating effect of amount and types of dietary fat on ornithine decarboxylase, tyrosine protein kinase and prostaglandins production during colon carcinogenesis in male F344 rats. Carcinogenesis 14: 1327-1333.
28. Reddy, B. S., Burill, C. & Rigotty, J. (1991) Effect of diets high in ω-3 and ω-6 fatty acids on initiation and postinitiation stages of colon carcinogenesis. Cancer Res. 51: 487-491.
29. Rusnak, J.M. & Lazo, J. S. (1996) Downregulation of protein kinase C suppresses induction of apoptosis in human prostatic carcinoma cells. Exp. Cell Res. 224: 189-199.
30. SAS Institute Inc. (1985) SAS User's Guide. SAS Institute, Cary, NC.
31. Schreinemachers, D. M. & Everson, R. B. (1994) Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology 5: 138-146.
32. Sniff, S. J., Qiao, L., Tsai, L. L. & Rigas, B. (1995) Sulindac sulfide, an aspirin-like compound, inhibits proliferation, cause cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells. J. Clin. Invest. 96: 491-503.
33. Singh, J., Hamid, R. & Reddy, B. S. (1997) Dietary fat and colon cancer: modulating effect of types and amount of dietary fat on ras-p21 function during promotion and progression stages of colon cancer. Cancer Res. 57: 253-258.
34. Thun, M. J., Namboodiri, M. M. & Heath, C. W., Jr. (1991) Aspirin use and reduced risk of fatal colon cancer. N. Engl. J. Med. 325: 1593-1596.
35. Tomlinson, I. P. & Bodmer, W. F. (1995) Failure of programmed cell death and differentiation as causes of tumors: some mathematical models. Proc. Natl. Acad. Sci. USA 92: 11130-11134.
36. Tsujii, M. & DuBois, R. N. (1995) Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83: 493-501.
37. Tsujitani, S., Shirai, H., Tatebe, S., Sugamura, K., Ohfuji, S., Gomyo, Y., Maeta, M., Ito, H. & Kaibara, N. (1996) Apoptotic cell death and its relationship to carcinogenesis in colorectal carcinoma. Cancer 77: 1711-1716.
38. US Public Health Service (1991) National Health Promotion and Disease Prevention Objectives. US Department of Health and Human Services, Publication PHS 91-50212. Washington, D.C.
39. Willett, W. C., Stampfer, M. J., Colditz, G. A., Rosner, B. A. & Speizer, F. E. (1990) Relation of meat, fat and fiber intake to the risk of colon cancer in a prospective study among women. N. Engl. J. Med. 323: 1664-1672.