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Volumn 1, Issue 3, 1999, Pages 316-322

The application of ribozymes to HIV infection

Author keywords

[No Author keywords available]

Indexed keywords

RIBOZYME;

EID: 0032993464     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (39)

References (66)
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    • Preclinical characterization of an anti-tat ribozyme for therapeutic application
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    • Wang, L.1    Witherington, C.2    King, A.3    Gerlach, W.L.4    Carr, A.5    Penny, R.6    Cooper, D.7    Symonds, G.8    Sun, L.Q.9
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    • A controlled, phase 1 clinical trial to evaluate the safety and effects in HIV-1 Infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA
    • Wong-Staal F, Poeschla EM, Looney DJ: A controlled, phase 1 clinical trial to evaluate the safety and effects in HIV-1 Infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA. Hum Gene Ther (1998) 9(16):2407-2425. •• Autologous gene-altered T-cells were infused into asymptomatic HIV-1 seropositive individuals in a phase I human gene therapy trial. The objectives of this trial were to test the safety, feasibility and potential efficacy of T-cell ribozyme gene therapy for the treatment of HIV-1 infection. Autologous CDB-depleted mononuclear cells were transduced with ribozyme expressing or a control murine retroviral vector. The transduced cells were expanded ex vivo in the presence of a anti-HIV-1 drug. The cells were subsequently infused into patients. In addition to the safety aspects of this trial, in vivo survival of control and ribozyme-transduced cells was carefully followed by PCR analyses. Preliminary results from this trial have indicated that transduced cells can persist for long intervals in HIV-infected subjects and ribozyme-transduced cells may possess a survival advantage in vivo.
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