Virion encapsidation of tRNA3(Lys)-Ribozyme chimeric RNAs inhibits HIV infection

Antisense and Nucleic Acid Drug Development

Volumn 8, Issue 3, 1998, Pages 185-197

  Westaway, Shawn K ^a   Cagnon, Laurence ^a   Chang, Zongli ^a,b   Li, Shirley ^a   Li, Haitang ^a   Larson, Garry P ^a   Zaia, John A ^a   Rossi, John J ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYSINE TRANSFER RNA; RIBOZYME;

ARTICLE; CHIMERA; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LENTIVIRINAE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; VIRION; VIRUS CAPSID; VIRUS INFECTIVITY;

EID: 0031824423     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1998.8.185     Document Type: Article

References (10)

1. ADACHI, A., GENDELMAN, H.E., KOENIG, S., FOLKS, T., WILLEY, R., RABSON, A., and MARTIN, M.A. (1986). Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 59, 284-291.
2. Lys. Nucleic Acids Res. 19, 751-757.
3. BARAT, C., LULLIEN, V., SCHATZ, O., KEITH, G., NUGEYRE, M.T., GRÜNINGER-LEITCH, F., BARRÉ-SINOUSSI, F., LEGRICE, S.F.J., and DARLIX, J.L. (1989). HIV-1 reverse transcriptase specifically interacts with the anticodon domain of its cognate primer tRNA. EMBO J. 8, 3279-3285.
4. BERTRAND, E., CASTANOTTO, D., ZHOU, C., CARBONNELLE, C., LEE, N.-S., GOOD, P., CHATTERJEE, S., GRANGE, T., PICTET, R., KOHN, D., ENGELKE, D., and ROSSI, J.J. (1997). The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization. RNA 3, 75-88.
5. CAMPBELL, F.E., JR., and SETZER, D.R. (1992). Transcription termination by RNA polymerase III: Uncoupling of polymerase release from termination signal recognition. Mol. Cell. Biol. 12, 2260-2272.
6. COZZARELLI, N.R., GERRARD, S.P., SCHLISSEL, M., BROWN, D.D., and BOGENHAGEN, D.R (1983). Purified RNA polymerase III accurately and efficiently terminates transcription of 5S RNA genes. Cell 34, 829-835.
7. CRAIG, L.C., WANG, L.P., LEE, M.M., PIRTLE, I.L., and PIRTLE, R.M. (1989). A human tRNA gene cluster encoding the major and minor valine tRNAs and a lysine tRNA. DNA 8, 457-471.
8. WAIN-HOBSON, S., SONIGO, P., DANOS, O., and ALISON, M. (1985). Nucleotide sequence of the AIDS virus LAV. Cell 40, 9-17.
9. Lys3-ribozyme inhibits HIV replication following virion assembly. Nucleic Acids Symp. Ser. 33, 194-199.
10. Lys-3 complexes. J. Biol. Chem. 268, 13617-13624.