메뉴 건너뛰기




Volumn 4, Issue 8, 1997, Pages 861-867

Inhibition of HIV-1 replication by retroviral vectors expressing monomeric and multimeric hammerhead ribozymes

Author keywords

Gene therapy; Hammerhead ribozymes; HIV 1; Retroviral vector

Indexed keywords

CD4 ANTIGEN; RIBOZYME; VIRUS DNA; VIRUS VECTOR;

EID: 0030775529     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300474     Document Type: Article
Times cited : (23)

References (43)
  • 1
    • 0029113184 scopus 로고
    • Genetic therapies for HIV infections: Promise for the future
    • Pomerantz RJ, Trono D. Genetic therapies for HIV infections: promise for the future AIDS 1995; 9: 985-993.
    • (1995) AIDS , vol.9 , pp. 985-993
    • Pomerantz, R.J.1    Trono, D.2
  • 2
    • 0026523627 scopus 로고
    • Ribozymes as anti-HIV-1 therapeutic agents, principles, applications and problems
    • Rossi JJ, Elkin D, Zaia JA, Sullivan S. Ribozymes as anti-HIV-1 therapeutic agents, principles, applications and problems AIDS Res Hum Retrovir 1992; 8: 183-189.
    • (1992) AIDS Res Hum Retrovir , vol.8 , pp. 183-189
    • Rossi, J.J.1    Elkin, D.2    Zaia, J.A.3    Sullivan, S.4
  • 3
    • 0028932258 scopus 로고
    • Gene therapeutic agents: The use of ribozymes, antisense, and RNA decoys for HIV-1 infection
    • Smythe JA, Symonds G. Gene therapeutic agents: the use of ribozymes, antisense, and RNA decoys for HIV-1 infection. Inflamm Res 1995; 44: 11-15.
    • (1995) Inflamm Res , vol.44 , pp. 11-15
    • Smythe, J.A.1    Symonds, G.2
  • 4
    • 0026515136 scopus 로고
    • Functional characterization of a U5 ribozyme: Intracellular suppression of HIV-1 expression
    • Dropulic B, Lin HN, Martin MA, Jeang KT. Functional characterization of a U5 ribozyme: intracellular suppression of HIV-1 expression. J Virol 1992; 66: 1432-1441.
    • (1992) J Virol , vol.66 , pp. 1432-1441
    • Dropulic, B.1    Lin, H.N.2    Martin, M.A.3    Jeang, K.T.4
  • 5
    • 0026055747 scopus 로고
    • - lymphocyte-derived cell lines using retroviral vectors expressing an HIV-1 RNA specific ribozyme
    • - lymphocyte-derived cell lines using retroviral vectors expressing an HIV-1 RNA specific ribozyme. J Virol 1991; 65: 5531-5534.
    • (1991) J Virol , vol.65 , pp. 5531-5534
    • Weerasinghe, M.1
  • 7
    • 0028558654 scopus 로고
    • Intracellular susceptibility to ribozymes in a tethered substrate-ribozyme provirus model is not predicted by secondary structures of HIV-1 RNAs in vitro
    • Dropulic B, Jeang KT. Intracellular susceptibility to ribozymes in a tethered substrate-ribozyme provirus model is not predicted by secondary structures of HIV-1 RNAs in vitro. Antisense Res Devel 1994; 4: 217-221.
    • (1994) Antisense Res Devel , vol.4 , pp. 217-221
    • Dropulic, B.1    Jeang, K.T.2
  • 8
    • 0028170723 scopus 로고
    • Ribozyme-mediated suppression of MoMuLV and HIV-1 replication in permissive cell lines
    • Sun L-Q et al. Ribozyme-mediated suppression of MoMuLV and HIV-1 replication in permissive cell lines Proc Natl Acad Sci USA 1994; 91: 9715-9719.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9715-9719
    • Sun, L.-Q.1
  • 9
    • 0029812227 scopus 로고    scopus 로고
    • Comparative analysis of five highly conserved target sites within the HIV-1 RNA for their susceptibility to hammerhead ribozyme-mediated cleavage in vitro and in vivo
    • Ramezani A, Joshi S. Comparative analysis of five highly conserved target sites within the HIV-1 RNA for their susceptibility to hammerhead ribozyme-mediated cleavage in vitro and in vivo. Antisense Nucl Acid Drug Dev 1996; 6: 229-235.
    • (1996) Antisense Nucl Acid Drug Dev , vol.6 , pp. 229-235
    • Ramezani, A.1    Joshi, S.2
  • 10
    • 0025363891 scopus 로고
    • Ribozymes as potential HIV-1 therapeutic agents
    • Sarver N et al. Ribozymes as potential HIV-1 therapeutic agents. Science 1990; 247: 1222-1225.
    • (1990) Science , vol.247 , pp. 1222-1225
    • Sarver, N.1
  • 11
    • 0026779558 scopus 로고
    • Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 Env RNA regions inhibits HIV-1 replication-potential effectiveness against most presently sequenced HIV-1 isolates
    • Chen CJ et al. Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 Env RNA regions inhibits HIV-1 replication-potential effectiveness against most presently sequenced HIV-1 isolates. Nucleic Acids Res 1992; 20: 4581-4589.
    • (1992) Nucleic Acids Res , vol.20 , pp. 4581-4589
    • Chen, C.J.1
  • 12
    • 0027445682 scopus 로고
    • Inhibition of HIV replication by ribozymes that show poor activity in vitro
    • Crissell P, Thompson S, James W. Inhibition of HIV replication by ribozymes that show poor activity in vitro. Nucleic Acids Res 1993; 21: 5251-5255.
    • (1993) Nucleic Acids Res , vol.21 , pp. 5251-5255
    • Crissell, P.1    Thompson, S.2    James, W.3
  • 13
    • 0029160885 scopus 로고
    • Resistance to HIV-1 infection conferred by transduction of PBLs with ribozymes, antisense, or polymeric trans-activation response element constructs
    • Sun LQ et al. Resistance to HIV-1 infection conferred by transduction of PBLs with ribozymes, antisense, or polymeric trans-activation response element constructs. Proc Natl Acad Sci USA 1995; 92: 7272-7276.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7272-7276
    • Sun, L.Q.1
  • 14
    • 0027973382 scopus 로고
    • Inhibition of HIV-1 in human T lymphocytes by retrovirally transduced anti-tat and rev hammerhead ribozymes
    • Zhou C et al. Inhibition of HIV-1 in human T lymphocytes by retrovirally transduced anti-tat and rev hammerhead ribozymes. Gene 1994; 149: 33-39.
    • (1994) Gene , vol.149 , pp. 33-39
    • Zhou, C.1
  • 15
    • 0026785305 scopus 로고
    • Inhibition of replication of HIV-1 by retroviral vectors expressing tat-antisense and anti-tat ribozyme RNA
    • Lo KM et al. Inhibition of replication of HIV-1 by retroviral vectors expressing tat-antisense and anti-tat ribozyme RNA. Virology 1992; 190: 176-183.
    • (1992) Virology , vol.190 , pp. 176-183
    • Lo, K.M.1
  • 16
    • 0029120442 scopus 로고
    • Target sequence-specific inhibition of HIV-1 replication by ribozymes directed to tat RNA
    • Sun LQ, Wang L, Gerlach WL, Symonds G. Target sequence-specific inhibition of HIV-1 replication by ribozymes directed to tat RNA. Nucleic Acids Res 1995; 23: 2909-2913.
    • (1995) Nucleic Acids Res , vol.23 , pp. 2909-2913
    • Sun, L.Q.1    Wang, L.2    Gerlach, W.L.3    Symonds, G.4
  • 17
    • 0029937091 scopus 로고    scopus 로고
    • A novel ribozyme target site located in the HIV-1 nef open reading frame
    • Larsson S et al. A novel ribozyme target site located in the HIV-1 nef open reading frame. Virology 1996; 219: 161-169.
    • (1996) Virology , vol.219 , pp. 161-169
    • Larsson, S.1
  • 19
    • 0027264877 scopus 로고
    • A hairpin ribozyme inhibits expression of diverse strains of HIV-1
    • Yu M et al. A hairpin ribozyme inhibits expression of diverse strains of HIV-1. Proc Natl Acad Sci USA 1993; 90: 6340-6344.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6340-6344
    • Yu, M.1
  • 20
    • 0028051280 scopus 로고
    • Intracellular immunization of human T cells with a hairpin ribozyme against HIV-1
    • Yamada O et al. Intracellular immunization of human T cells with a hairpin ribozyme against HIV-1. Gene Therapy 1994; 1: 38-45.
    • (1994) Gene Therapy , vol.1 , pp. 38-45
    • Yamada, O.1
  • 21
    • 0028033248 scopus 로고
    • Activity and cleavage site specificity of an anti-HIV-1 hairpin ribozyme in human T cells
    • Yamada O et al. Activity and cleavage site specificity of an anti-HIV-1 hairpin ribozyme in human T cells. Virology 1994; 205: 121-126.
    • (1994) Virology , vol.205 , pp. 121-126
    • Yamada, O.1
  • 22
    • 0028852546 scopus 로고
    • In vitro and in vivo characterization of a second functional hairpin ribozyme against HIV-1
    • Yu M et al. In vitro and in vivo characterization of a second functional hairpin ribozyme against HIV-1. Virology 1995; 206: 381-386.
    • (1995) Virology , vol.206 , pp. 381-386
    • Yu, M.1
  • 23
    • 0028561948 scopus 로고
    • Transfer of an anti-HIV-1 ribozyme gene into primary human lymphocytes
    • Leavitt MC et al. Transfer of an anti-HIV-1 ribozyme gene into primary human lymphocytes. Hum Gene Ther 1994; 5: 1115-1120.
    • (1994) Hum Gene Ther , vol.5 , pp. 1115-1120
    • Leavitt, M.C.1
  • 24
    • 0028876680 scopus 로고
    • Intracellular immunization of human fetal cord blood stem/progenitor cells with a ribozyme against HIV-1
    • Yu M et al. Intracellular immunization of human fetal cord blood stem/progenitor cells with a ribozyme against HIV-1. Proc Natl Acad Sci USA 1995; 92: 699-703.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 699-703
    • Yu, M.1
  • 25
    • 0027022327 scopus 로고
    • Activities of HIV RNA targeted ribozymes transcribed from a 'shot-gun' type ribozymetrimming plasmid
    • Ohkawa J, Yuyama N, Taira K. Activities of HIV RNA targeted ribozymes transcribed from a 'shot-gun' type ribozymetrimming plasmid. Nucleic Acids Symp Series 1992; 27: 15-16.
    • (1992) Nucleic Acids Symp Series , vol.27 , pp. 15-16
    • Ohkawa, J.1    Yuyama, N.2    Taira, K.3
  • 26
    • 0027435063 scopus 로고
    • Importance of independence in ribozyme reactions: Kinetic behavior of trimmed and of simply connected multiple ribozymes with potential activity against HIV
    • Ohkawa J et al. Importance of independence in ribozyme reactions: kinetic behavior of trimmed and of simply connected multiple ribozymes with potential activity against HIV. Proc Natl Acad Sci USA 1993; 90: 11302-11306.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11302-11306
    • Ohkawa, J.1
  • 27
    • 0344168886 scopus 로고
    • A retroviral vector to allow constitutive and Tat-inducible gene expression for anti-HIV-1 gene therapy
    • Joshi S, Davison L, Van Brunschot A, Van der Elst I. A retroviral vector to allow constitutive and Tat-inducible gene expression for anti-HIV-1 gene therapy. Mol Biol Life Sci Adv 1993; 12: 135-189
    • (1993) Mol Biol Life Sci Adv , vol.12 , pp. 135-189
    • Joshi, S.1    Davison, L.2    Van Brunschot, A.3    Van der Elst, I.4
  • 28
    • 8544266442 scopus 로고
    • Rapid complementation assays measuring replicative potential of HIV-1 envelope glycoprotein mutants
    • Heleseth E et al. Rapid complementation assays measuring replicative potential of HIV-1 envelope glycoprotein mutants. J Virol 1990; 64: 2415-2420.
    • (1990) J Virol , vol.64 , pp. 2415-2420
    • Heleseth, E.1
  • 29
    • 0026688887 scopus 로고
    • Viral DNA carried by HIV-1 virions
    • Lori F et al. Viral DNA carried by HIV-1 virions. J Virol 1992; 66: 5067-5074.
    • (1992) J Virol , vol.66 , pp. 5067-5074
    • Lori, F.1
  • 30
    • 0028205977 scopus 로고
    • Mature RT (p66/p51) is responsible for low level of viral DNA found in HIV-1
    • Arts EJ, Mak J, Kleiman L, Wainberg MA. Mature RT (p66/p51) is responsible for low level of viral DNA found in HIV-1. Leukemia 1994; 8 (Suppl. 1): S175-S178.
    • (1994) Leukemia , vol.8 , Issue.1 SUPPL.
    • Arts, E.J.1    Mak, J.2    Kleiman, L.3    Wainberg, M.A.4
  • 31
    • 0024999452 scopus 로고
    • Retroviral RT: Syntheses, structure and function
    • Goff SP. Retroviral RT: syntheses, structure and function. J AIDS 1990; 3: 817-831.
    • (1990) J AIDS , vol.3 , pp. 817-831
    • Goff, S.P.1
  • 32
    • 0030047819 scopus 로고    scopus 로고
    • HIV-1 reverse transcriptase and early events in reverse transcription
    • Arts EJ, Wainberg MA. HIV-1 reverse transcriptase and early events in reverse transcription. Adv Virus Res 1996; 46: 97-163.
    • (1996) Adv Virus Res , vol.46 , pp. 97-163
    • Arts, E.J.1    Wainberg, M.A.2
  • 33
    • 0029931402 scopus 로고    scopus 로고
    • Fusion with an RNA binding domain to confer target RNA specificity to an RNase: Design and engineering of Tat-RNase H that specifically recognizes and cleaves HIV-1 RNA in vitro
    • Melekhovets YF, Joshi S. Fusion with an RNA binding domain to confer target RNA specificity to an RNase: design and engineering of Tat-RNase H that specifically recognizes and cleaves HIV-1 RNA in vitro. Nucleic Acids Res 1996; 24: 1908-1912.
    • (1996) Nucleic Acids Res , vol.24 , pp. 1908-1912
    • Melekhovets, Y.F.1    Joshi, S.2
  • 34
    • 0020582124 scopus 로고
    • Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus
    • Mann R, Mulligan RC, Baltimore D. Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell 1983; 33: 153-159.
    • (1983) Cell , vol.33 , pp. 153-159
    • Mann, R.1    Mulligan, R.C.2    Baltimore, D.3
  • 35
    • 0025291646 scopus 로고
    • Efficient replication, integration and packaging of retroviral vectors modified LTR containing the packaging signal
    • Joshi S, Van Brunschot A, Robson I, Bernstein A. Efficient replication, integration and packaging of retroviral vectors modified LTR containing the packaging signal. Nucleic Acids Res 1990; 18: 4223-4226.
    • (1990) Nucleic Acids Res , vol.18 , pp. 4223-4226
    • Joshi, S.1    Van Brunschot, A.2    Robson, I.3    Bernstein, A.4
  • 36
    • 0022767368 scopus 로고
    • Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production
    • Miller AD, Buttimore C. Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol 1986; 6: 2895-2902.
    • (1986) Mol Cell Biol , vol.6 , pp. 2895-2902
    • Miller, A.D.1    Buttimore, C.2
  • 37
    • 0024508058 scopus 로고
    • HIV with reduced sensitivity to AZT isolated during prolonged therapy
    • Larder BA, Darby G, Richman DD. HIV with reduced sensitivity to AZT isolated during prolonged therapy. Science 1989; 243: 1731-1734.
    • (1989) Science , vol.243 , pp. 1731-1734
    • Larder, B.A.1    Darby, G.2    Richman, D.D.3
  • 38
    • 0023277417 scopus 로고
    • Sensitive and rapid assay on MT4 cells for detection of antiviral compounds against the AIDS virus
    • Pauwels R et al. Sensitive and rapid assay on MT4 cells for detection of antiviral compounds against the AIDS virus. J Virol Meth 1987; 16: 171-185.
    • (1987) J Virol Meth , vol.16 , pp. 171-185
    • Pauwels, R.1
  • 39
    • 0027965847 scopus 로고
    • + lymphocytic cell line expressing antisense and sense RNA molecules containing HIV-1 packaging signal and Rev response element(s)
    • + lymphocytic cell line expressing antisense and sense RNA molecules containing HIV-1 packaging signal and Rev response element(s). Antisense Res Dev 1994; 4: 19-26.
    • (1994) Antisense Res Dev , vol.4 , pp. 19-26
    • Cohli, H.1
  • 40
    • 0027721156 scopus 로고
    • The development and testing of retroviral vectors expressing trans-dominant mutants of HIV-1 proteins to confer anti-HIV-1 resistance
    • Liem SE, Ramezani A, Li X, Joshi S. The development and testing of retroviral vectors expressing trans-dominant mutants of HIV-1 proteins to confer anti-HIV-1 resistance. Hum Gene Ther 1993; 4: 625-634.
    • (1993) Hum Gene Ther , vol.4 , pp. 625-634
    • Liem, S.E.1    Ramezani, A.2    Li, X.3    Joshi, S.4
  • 41
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 43
    • 0022495870 scopus 로고
    • Production of AIDS associated retrovirus in human and non-human cells transfected with an infectious molecular clone
    • Adachi A et al. Production of AIDS associated retrovirus in human and non-human cells transfected with an infectious molecular clone. J Virol 1986; 59: 284-291.
    • (1986) J Virol , vol.59 , pp. 284-291
    • Adachi, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.