Heterogeneous point mutations in the BRCA1 breast cancer susceptibility gene occur in high frequency at the site of homonucleotide tracts, short repeats and methylatable CpG/CpNpG motifs

Oncogene

Volumn 12, Issue 12, 1996, Pages 2623-2629

  Rodenhiser, David ^a,b   Chakraborty, Pranesh ^a,b   Andrews, Joseph ^a   Ainsworth, Peter ^a,b,c   Mancini, Debora ^a,b   Lopes, Eve ^a,c   Singh, Shiva ^a,b  

^a CHILDREN S HOSPITAL OF WESTERN ONTARIO   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

BRCA1; CpG; Homonucleotides; Mutagenesis; Mutation; Repeats

Indexed keywords

DNA; REPETITIVE DNA; BRCA1 PROTEIN; MICROSATELLITE DNA; OLIGODEOXYRIBONUCLEOTIDE; TRANSCRIPTION FACTOR; TUMOR PROTEIN;

ARTICLE; BREAST CANCER; CANCER GENETICS; CANCER SUSCEPTIBILITY; DNA METHYLATION; DNA SEQUENCE; GENE DELETION; GENE INSERTION; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; NUCLEIC ACID BASE SUBSTITUTION; POINT MUTATION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; BREAST TUMOR; CPG ISLAND; DNA BASE COMPOSITION; FEMALE; GENETIC PREDISPOSITION; GENETICS; METABOLISM; METHYLATION; MOLECULAR GENETICS; MUTAGENESIS; MUTATION; NUCLEOTIDE SEQUENCE; TRANSPOSON; TRINUCLEOTIDE REPEAT;

BASE COMPOSITION; BASE SEQUENCE; BRCA1 PROTEIN; BREAST NEOPLASMS; CPG ISLANDS; DNA TRANSPOSABLE ELEMENTS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; METHYLATION; MICROSATELLITE REPEATS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; NEOPLASM PROTEINS; OLIGODEOXYRIBONUCLEOTIDES; POINT MUTATION; SEQUENCE DELETION; TRANSCRIPTION FACTORS; TRINUCLEOTIDE REPEATS;

EID: 0029666432     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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