메뉴 건너뛰기




Volumn 17, Issue 2, 1999, Pages 269-278

Bone morphogenetic proteins: An update on basic biology and clinical relevance

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGY; CARTILAGE; CELLS; GROWTH KINETICS; PROTEINS;

EID: 0032955419     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.1100170217     Document Type: Review
Times cited : (278)

References (123)
  • 1
    • 0028582171 scopus 로고
    • Osteogenin (bone morphogenetic protein 3) inhibits proliferation and stimulates differentiation of osteoprogenitors in human bone marrow
    • Amedee J, Bareille R, Rouais E, Cunningham N, Reddi H, Harmand MF: Osteogenin (bone morphogenetic protein 3) inhibits proliferation and stimulates differentiation of osteoprogenitors in human bone marrow. Differentiation 58:157-164, 1994
    • (1994) Differentiation , vol.58 , pp. 157-164
    • Amedee, J.1    Bareille, R.2    Rouais, E.3    Cunningham, N.4    Reddi, H.5    Harmand, M.F.6
  • 2
    • 0030775109 scopus 로고    scopus 로고
    • From receptor to nucleus: The Smad pathway
    • Baker JC, Haland RM: From receptor to nucleus: the Smad pathway. Curr Opin Genet Dev 7:467-473, 1997
    • (1997) Curr Opin Genet Dev , vol.7 , pp. 467-473
    • Baker, J.C.1    Haland, R.M.2
  • 3
    • 33748208571 scopus 로고    scopus 로고
    • Bone growth enhancing substances for spinal fusion
    • Ed by SR Garfin and SR Vaccaro, Rosemont, Illinois, American Academy of Orthopaedic Surgeons
    • Boden SD: Bone growth enhancing substances for spinal fusion. In: Orthopaedic Knowledge Update. Spine, pp 63-70. Ed by SR Garfin and SR Vaccaro, Rosemont, Illinois, American Academy of Orthopaedic Surgeons, 1997
    • (1997) Orthopaedic Knowledge Update. Spine , pp. 63-70
    • Boden, S.D.1
  • 6
    • 0026395108 scopus 로고
    • Early histological and ultrastructural changes in medullary fracture callus
    • Brighton CT, Hunt RM: Early histological and ultrastructural changes in medullary fracture callus. J Bone Joint Surg [Am] 73:832-847, 1991
    • (1991) J Bone Joint Surg [Am] , vol.73 , pp. 832-847
    • Brighton, C.T.1    Hunt, R.M.2
  • 8
    • 0027973996 scopus 로고
    • Mesenchytnal stem cells in bone development, bone repair, and skeletal regeneration therapy
    • Bruder SP, Fink DJ, Caplan AI: Mesenchytnal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 56:283-294, 1994
    • (1994) J Cell Biochem , vol.56 , pp. 283-294
    • Bruder, S.P.1    Fink, D.J.2    Caplan, A.I.3
  • 9
    • 0032577276 scopus 로고    scopus 로고
    • Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
    • Brunet LJ, McMahon JA, McMahon AP, Harland RM: Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science 280:1455-1457, 1998
    • (1998) Science , vol.280 , pp. 1455-1457
    • Brunet, L.J.1    McMahon, J.A.2    McMahon, A.P.3    Harland, R.M.4
  • 10
    • 0026228558 scopus 로고
    • Mesenchymal stem cells
    • Caplan AI: Mesenchymal stem cells. J Orthop Res 9:641-650, 1991
    • (1991) J Orthop Res , vol.9 , pp. 641-650
    • Caplan, A.I.1
  • 11
    • 0028359376 scopus 로고
    • Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor β and activin
    • Carcamo J, Weis FM, Ventura E, Wieser R, Wrana J, Attisano L, Massagué J: Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor β and activin. Mol Cell Biol 14:3810-3821, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 3810-3821
    • Carcamo, J.1    Weis, F.M.2    Ventura, E.3    Wieser, R.4    Wrana, J.5    Attisano, L.6    Massagué, J.7
  • 12
    • 0025672641 scopus 로고
    • Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone
    • Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA, Wozney JM: Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. Proc Natl Acad Sci USA 87:9843-9847, 1990
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9843-9847
    • Celeste, A.J.1    Iannazzi, J.A.2    Taylor, R.C.3    Hewick, R.M.4    Rosen, V.5    Wang, E.A.6    Wozney, J.M.7
  • 15
    • 0029157432 scopus 로고
    • A WD-domain protein that is associated with and phosphorylated by the tvpe II TGF-β receptor
    • Chen RH, Miettinen PJ, Maruoka EM, Choy L, Derynck R: A WD-domain protein that is associated with and phosphorylated by the tvpe II TGF-β receptor. Nature 377:548-552, 1995
    • (1995) Nature , vol.377 , pp. 548-552
    • Chen, R.H.1    Miettinen, P.J.2    Maruoka, E.M.3    Choy, L.4    Derynck, R.5
  • 16
    • 0029802485 scopus 로고    scopus 로고
    • A transcriptional partner for MAD proteins in TGF-β signalling
    • Chen X, Rubock MJ, Whitman M: A transcriptional partner for MAD proteins in TGF-β signalling. Nature 383:691-696, 1996
    • (1996) Nature , vol.383 , pp. 691-696
    • Chen, X.1    Rubock, M.J.2    Whitman, M.3
  • 18
    • 0028271621 scopus 로고
    • Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model
    • Cook SD, Baffes GC, Wolfe MW, Sampath TK, Rueger DC: Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model. Clin Orthop 301:302-312, 1994
    • (1994) Clin Orthop , vol.301 , pp. 302-312
    • Cook, S.D.1    Baffes, G.C.2    Wolfe, M.W.3    Sampath, T.K.4    Rueger, D.C.5
  • 20
    • 0028043934 scopus 로고
    • In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as a bone graft substitute for spinal fusions
    • Cook SD, Dalton JE, Tan EH, Whitecloud TS 3rd, Rueger DC: In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as a bone graft substitute for spinal fusions. Spine 19:1655-1663, 1994
    • (1994) Spine , vol.19 , pp. 1655-1663
    • Cook, S.D.1    Dalton, J.E.2    Tan, E.H.3    Whitecloud III, T.S.4    Rueger, D.C.5
  • 21
    • 0029440755 scopus 로고
    • Evaluation of recombinant human osteogenic protein (rhOP-1) placed with dental implants in fresh extraction sites
    • Cook SD, Salkeld SL, Rueger DC: Evaluation of recombinant human osteogenic protein (rhOP-1) placed with dental implants in fresh extraction sites. J Oral Implantai 21:281-289, 1995
    • (1995) J Oral Implantai , vol.21 , pp. 281-289
    • Cook, S.D.1    Salkeld, S.L.2    Rueger, D.C.3
  • 22
    • 0029018646 scopus 로고
    • Effect of recombinant human osteogenic protein-1 on healing of segmentai defects in non-human primates
    • Cook SD, Wolfe MW, Salkeld SL, Rueger DC: Effect of recombinant human osteogenic protein-1 on healing of segmentai defects in non-human primates. J Bone Joint Surg [Am] 77:734-750, 1995
    • (1995) J Bone Joint Surg [Am] , vol.77 , pp. 734-750
    • Cook, S.D.1    Wolfe, M.W.2    Salkeld, S.L.3    Rueger, D.C.4
  • 23
    • 0028927556 scopus 로고
    • Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene
    • Ducy P, Karsenty G: Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol Cell Biol 15:1858-1869, 1995
    • (1995) Mol Cell Biol , vol.15 , pp. 1858-1869
    • Ducy, P.1    Karsenty, G.2
  • 24
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfal: A transcriptional activator of osteoblast differentiation
    • Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G: Osf2/Cbfal: a transcriptional activator of osteoblast differentiation. Cell 89:747-754, 1997
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 25
    • 0028832707 scopus 로고
    • A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
    • Dudley AT, Lyons KM, Robertson EJ: A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev 9:2795-2807, 1995
    • (1995) Genes Dev , vol.9 , pp. 2795-2807
    • Dudley, A.T.1    Lyons, K.M.2    Robertson, E.J.3
  • 27
    • 0029417351 scopus 로고
    • A PEBP2α/AML-1-related factor increases osteocalcin promoter activity through its binding to a osteoblast-specific cis-acting element
    • Geoffroy V, Ducy P, Karsenty G: A PEBP2α/AML-1-related factor increases osteocalcin promoter activity through its binding to a osteoblast-specific cis-acting element. J Biol Chem 270:30973-30979, 1995
    • (1995) J Biol Chem , vol.270 , pp. 30973-30979
    • Geoffroy, V.1    Ducy, P.2    Karsenty, G.3
  • 30
    • 0031964859 scopus 로고    scopus 로고
    • Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
    • Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A: Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev 12:186-197, 1998
    • (1998) Genes Dev , vol.12 , pp. 186-197
    • Hata, A.1    Lagna, G.2    Massagué, J.3    Hemmati-Brivanlou, A.4
  • 31
    • 0031438047 scopus 로고    scopus 로고
    • TGF-β signalling from cell membrane to nucleus through SMAD proteins
    • Heldin CH, Miyazono K, ten Dijke P: TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390:465-471, 1997
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    Ten Dijke, P.3
  • 32
    • 0030218004 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in development
    • Hogan BL: Bone morphogenetic proteins in development. Curr Opin Genet Dev 6:432-438, 1996
    • (1996) Curr Opin Genet Dev , vol.6 , pp. 432-438
    • Hogan, B.L.1
  • 33
    • 0030339606 scopus 로고    scopus 로고
    • The integrated processes of hard tissue regeneration with special emphasis on fracture healing
    • Hollinger J, Wong ME: The integrated processes of hard tissue regeneration with special emphasis on fracture healing. Oral Surg Oral Med Oral Path Oral Radiol Endodontics 82:594-606, 1996
    • (1996) Oral Surg Oral Med Oral Path Oral Radiol Endodontics , vol.82 , pp. 594-606
    • Hollinger, J.1    Wong, M.E.2
  • 34
    • 0027583414 scopus 로고
    • Factors for osseous repair and delivery. Part 1
    • Hollinger JO: Factors for osseous repair and delivery. Part 1. J Craniofac Surg 4:102-108, 1993
    • (1993) J Craniofac Surg , vol.4 , pp. 102-108
    • Hollinger, J.O.1
  • 35
    • 0030034285 scopus 로고    scopus 로고
    • Poly(alpha-hydroxy acids): Carriers for bone morphogenetic proteins
    • Hollinger JO, Leong K: Poly(alpha-hydroxy acids): carriers for bone morphogenetic proteins. Biomaterials 17:187-194, 1996
    • (1996) Biomaterials , vol.17 , pp. 187-194
    • Hollinger, J.O.1    Leong, K.2
  • 36
    • 0029890008 scopus 로고    scopus 로고
    • Poly(alpha-hydroxy acid) carrier for delivering recombinant human bone morphogenetic protein-2 for bone regeneration
    • Hollinger JO, Mayer M, Buck D, Zegzula HD, Ron E, Smith J, Lin L, Wozney J: Poly(alpha-hydroxy acid) carrier for delivering recombinant human bone morphogenetic protein-2 for bone regeneration. J Controlled Rel 39:287-304, 1996
    • (1996) J Controlled Rel , vol.39 , pp. 287-304
    • Hollinger, J.O.1    Mayer, M.2    Buck, D.3    Zegzula, H.D.4    Ron, E.5    Smith, J.6    Lin, L.7    Wozney, J.8
  • 40
    • 0032039482 scopus 로고    scopus 로고
    • The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities
    • Hsu DR, Economides AN, Wang X, Eimon PM, Harland RM: The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell 1:673-683, 1998
    • (1998) Mol Cell , vol.1 , pp. 673-683
    • Hsu, D.R.1    Economides, A.N.2    Wang, X.3    Eimon, P.M.4    Harland, R.M.5
  • 41
    • 0001774050 scopus 로고    scopus 로고
    • Fibroblast growth factor and vascular endothelial cell growth factor families
    • Ed by JP Bilezikian, LG Raisz, and GA Rodan. San Diego, Academic Press
    • Hurley M, Florkiewicz R: Fibroblast growth factor and vascular endothelial cell growth factor families. In: Principles of Bone Biology, pp 627-646. Ed by JP Bilezikian, LG Raisz, and GA Rodan. San Diego, Academic Press, 1996
    • (1996) Principles of Bone Biology , pp. 627-646
    • Hurley, M.1    Florkiewicz, R.2
  • 43
    • 0029866537 scopus 로고    scopus 로고
    • Structural alterations in the transcription factor PEBP2/Cbf linked to four different types of leukemia
    • Ito Y: Structural alterations in the transcription factor PEBP2/Cbf linked to four different types of leukemia. J Cancer Res Clin Oncol 122:266-274, 1996
    • (1996) J Cancer Res Clin Oncol , vol.122 , pp. 266-274
    • Ito, Y.1
  • 44
    • 0004809527 scopus 로고    scopus 로고
    • Human osteoblastic cells secrete paracrine factors which regulate differentiation of osteogenic precursors in marrow
    • Jaiswal N, Bruder SP: Human osteoblastic cells secrete paracrine factors which regulate differentiation of osteogenic precursors in marrow. Trans Orthop Res Soc 22:524, 1997
    • (1997) Trans Orthop Res Soc , vol.22 , pp. 524
    • Jaiswal, N.1    Bruder, S.P.2
  • 45
    • 0025047508 scopus 로고
    • The Drosophila segementation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system
    • Kania MA, Bonner AS, Duffy JB, Gergen JP: The Drosophila segementation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system. Genes Dev 4:1701-1713, 1990
    • (1990) Genes Dev , vol.4 , pp. 1701-1713
    • Kania, M.A.1    Bonner, A.S.2    Duffy, J.B.3    Gergen, J.P.4
  • 46
    • 0025307333 scopus 로고
    • Fibrodysplasia ossificans progressive: A clue from the fly?
    • Kaplan FS, Tabas JA, Zasloff MA: Fibrodysplasia ossificans progressive: a clue from the fly? Calcif Tissue Int 47:117-125, 1990
    • (1990) Calcif Tissue Int , vol.47 , pp. 117-125
    • Kaplan, F.S.1    Tabas, J.A.2    Zasloff, M.A.3
  • 47
    • 0030872367 scopus 로고    scopus 로고
    • Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
    • Kim J, Johnson K, Chen HJ, Carroll S, Laughon A: Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388:304-308, 1997
    • (1997) Nature , vol.388 , pp. 304-308
    • Kim, J.1    Johnson, K.2    Chen, H.J.3    Carroll, S.4    Laughon, A.5
  • 48
    • 0027976891 scopus 로고
    • What do BMPs do in mammals? Clues from the mouse short-ear mutation
    • Kingsley D: What do BMPs do in mammals? Clues from the mouse short-ear mutation. Trends Genet 10:16-21, 1994
    • (1994) Trends Genet , vol.10 , pp. 16-21
    • Kingsley, D.1
  • 49
    • 0026440993 scopus 로고
    • The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF-beta superfamily
    • Kingsley DM, Bland AE, Grubber JM, Marker PC, Russell LB, Copeland NG, Jenkins NA: The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF-beta superfamily. Cell 71:399-410, 1992
    • (1992) Cell , vol.71 , pp. 399-410
    • Kingsley, D.M.1    Bland, A.E.2    Grubber, J.M.3    Marker, P.C.4    Russell, L.B.5    Copeland, N.G.6    Jenkins, N.A.7
  • 50
    • 0028180315 scopus 로고
    • The TGF-beta superfamily: New members, new receptors, and new genetic tests of function in different organisms
    • Kingsley DM: The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev 8:133-146, 1994
    • (1994) Genes Dev , vol.8 , pp. 133-146
    • Kingsley, D.M.1
  • 52
    • 0030911104 scopus 로고    scopus 로고
    • The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase
    • Kretzschmar M, Liu E, Hata A, Doody J, Massagué J: The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev 11:984-995, 1997
    • (1997) Genes Dev , vol.11 , pp. 984-995
    • Kretzschmar, M.1    Liu, E.2    Hata, A.3    Doody, J.4    Massagué, J.5
  • 53
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DCP4 and SMAD proteins in TGF-β signalling pathways
    • Lagna G, Hata A, Hemmati-Brivanlou A, Massagué J: Partnership between DCP4 and SMAD proteins in TGF-β signalling pathways. Nature 383:832-836, 1996
    • (1996) Nature , vol.383 , pp. 832-836
    • Lagna, G.1    Hata, A.2    Hemmati-Brivanlou, A.3    Massagué, J.4
  • 54
    • 0029008597 scopus 로고
    • Human type II receptor for bone morphogenetic proteins (BMPs): Extension of the two-kinase receptor model to the BMPs
    • Liu F, Ventura F, Doody J, Massagué J: Human type II receptor for bone morphogenetic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol Cell Biol 15:3479-3486, 1995
    • (1995) Mol Cell Biol , vol.15 , pp. 3479-3486
    • Liu, F.1    Ventura, F.2    Doody, J.3    Massagué, J.4
  • 56
    • 0032481351 scopus 로고    scopus 로고
    • The L3 loop: A structural motif determining specific interactions between SMAD proteins and TGF-β receptors
    • Lo RS, Chen YG, Shi Y, Pavletich NP, Massagué J: The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-β receptors. EMBO J 17:996-1005, 1998
    • (1998) EMBO J , vol.17 , pp. 996-1005
    • Lo, R.S.1    Chen, Y.G.2    Shi, Y.3    Pavletich, N.P.4    Massagué, J.5
  • 57
    • 0028821341 scopus 로고
    • Regulation of human bone marrow-derived osteoprogenitor cells by osteogenic growth factors
    • Long MW, Robinson JA, Ashcraft EA, Mann KG: Regulation of human bone marrow-derived osteoprogenitor cells by osteogenic growth factors. J Clin Invest 95:881-887, 1995
    • (1995) J Clin Invest , vol.95 , pp. 881-887
    • Long, M.W.1    Robinson, J.A.2    Ashcraft, E.A.3    Mann, K.G.4
  • 58
    • 0028882261 scopus 로고
    • BMP-7 is an inducer of neprogenesis, and is also required for eye development and skeletal patterning
    • Luo G, Hofmann C, Bronckers AL, Sohocki M, Bradley A, Karsenty G: BMP-7 is an inducer of neprogenesis, and is also required for eye development and skeletal patterning. Genes Dev 9:2808-2820, 1995
    • (1995) Genes Dev , vol.9 , pp. 2808-2820
    • Luo, G.1    Hofmann, C.2    Bronckers, A.L.3    Sohocki, M.4    Bradley, A.5    Karsenty, G.6
  • 59
    • 0028518484 scopus 로고
    • Recombinant human bone morphogenetic protein-2 is superior to demineralized bone matrix in repairing craniotomy defects in rat
    • Marden LJ, Hollinger JO, Chaudhari A, Turek T, Schaub RG, Ron E: Recombinant human bone morphogenetic protein-2 is superior to demineralized bone matrix in repairing craniotomy defects in rat. J Biomed Mater Res 28:1127-1138, 1994
    • (1994) J Biomed Mater Res , vol.28 , pp. 1127-1138
    • Marden, L.J.1    Hollinger, J.O.2    Chaudhari, A.3    Turek, T.4    Schaub, R.G.5    Ron, E.6
  • 60
    • 0025222517 scopus 로고
    • The transforming growth factor-beta family
    • Massagué J: The transforming growth factor-beta family. Annu Rev Cell Biol 6:597-641, 1990
    • (1990) Annu Rev Cell Biol , vol.6 , pp. 597-641
    • Massagué, J.1
  • 62
    • 0030604542 scopus 로고    scopus 로고
    • TGFβ signaling: Receptors, transducers, and Mad proteins
    • Massagué J: TGFβ signaling: receptors, transducers, and Mad proteins. Cell 85:947-950, 1996
    • (1996) Cell , vol.85 , pp. 947-950
    • Massagué, J.1
  • 63
    • 0029891982 scopus 로고    scopus 로고
    • Repair of alveolar clefts in dogs with recombinant bone morphogenetic protein and poly(α-hydroxy acid)
    • Mayer MH, Hollinger JO, Ron E, Wozney J: Repair of alveolar clefts in dogs with recombinant bone morphogenetic protein and poly(α-hydroxy acid). Plast Reconstr Surg 98:247-259, 1996
    • (1996) Plast Reconstr Surg , vol.98 , pp. 247-259
    • Mayer, M.H.1    Hollinger, J.O.2    Ron, E.3    Wozney, J.4
  • 64
    • 0029561282 scopus 로고
    • Indirect and direct disruption of transcriptional regulation in cancer: E2F and AML-1
    • Meyers S, Hiebert SW: Indirect and direct disruption of transcriptional regulation in cancer: E2F and AML-1. Crit Rev Eukary Gene Express 5:365-383, 1995
    • (1995) Crit Rev Eukary Gene Express , vol.5 , pp. 365-383
    • Meyers, S.1    Hiebert, S.W.2
  • 65
    • 6244256053 scopus 로고
    • Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
    • Mishina Y, Suzuki A, Ueno N, Behringer RR: Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev 9:3027-3037, 1995
    • (1995) Genes Dev , vol.9 , pp. 3027-3037
    • Mishina, Y.1    Suzuki, A.2    Ueno, N.3    Behringer, R.R.4
  • 66
    • 0029893734 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-β1 on gene expression
    • Mucsi I, Skorecki K, Goldberg HJ: Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-β1 on gene expression. J Biol Chem 271:16567-16572, 1996
    • (1996) J Biol Chem , vol.271 , pp. 16567-16572
    • Mucsi, I.1    Skorecki, K.2    Goldberg, H.J.3
  • 69
    • 0030018425 scopus 로고    scopus 로고
    • Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells
    • Newfeld SJ, Chartoff EH, Graff JM, Melton DA, Gelbart WM: Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells. Development 122:2099-2108, 1996
    • (1996) Development , vol.122 , pp. 2099-2108
    • Newfeld, S.J.1    Chartoff, E.H.2    Graff, J.M.3    Melton, D.A.4    Gelbart, W.M.5
  • 70
    • 0031939744 scopus 로고    scopus 로고
    • Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12
    • Nishimura R, Kato Y, Chen D, Harris SE, Mundy GR, Yoneda T: Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J Biol Chem 273:1872-1879, 1998
    • (1998) J Biol Chem , vol.273 , pp. 1872-1879
    • Nishimura, R.1    Kato, Y.2    Chen, D.3    Harris, S.E.4    Mundy, G.R.5    Yoneda, T.6
  • 72
    • 0029153741 scopus 로고
    • Identification of a human type II receptor for bone morphogenetic protine-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors
    • Nohno T, Ishikawa T, Saito T, Hosokawa K, Noji S, Wolsing DH, Rosenbaum JS: Identification of a human type II receptor for bone morphogenetic protine-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors. J Biol Chem 270:22522-22526, 1995
    • (1995) J Biol Chem , vol.270 , pp. 22522-22526
    • Nohno, T.1    Ishikawa, T.2    Saito, T.3    Hosokawa, K.4    Noji, S.5    Wolsing, D.H.6    Rosenbaum, J.S.7
  • 73
    • 0027184229 scopus 로고
    • Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α
    • Ogawa E, Inuzuka M, Maruyama M, Satake M, Naito-Fujimoto M, Ito Y, Shigesada K: Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α. Virology 194:314-331, 1993
    • (1993) Virology , vol.194 , pp. 314-331
    • Ogawa, E.1    Inuzuka, M.2    Maruyama, M.3    Satake, M.4    Naito-Fujimoto, M.5    Ito, Y.6    Shigesada, K.7
  • 74
    • 0027220003 scopus 로고
    • PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
    • Ogawa E, Maruyama M, Kagoshima H, Inuzuka M, Lu J, Satake M, Shigesada K, Ito Y: PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc Natl Acad Sci USA 90:6859-6863, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6859-6863
    • Ogawa, E.1    Maruyama, M.2    Kagoshima, H.3    Inuzuka, M.4    Lu, J.5    Satake, M.6    Shigesada, K.7    Ito, Y.8
  • 75
    • 0032100625 scopus 로고    scopus 로고
    • Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a bmp type II receptor during fracture healing in rats
    • Onishi T, Ishidou Y, Nagamine T, Yone K, Imamura T, Kato M, Sampath TK, ten Dijke P, Sakou T: Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a bmp type II receptor during fracture healing in rats. Bone 22:605-612, 1998
    • (1998) Bone , vol.22 , pp. 605-612
    • Onishi, T.1    Ishidou, Y.2    Nagamine, T.3    Yone, K.4    Imamura, T.5    Kato, M.6    Sampath, T.K.7    Ten Dijke, P.8    Sakou, T.9
  • 77
    • 0019309291 scopus 로고
    • The origin of bone cells in the postnatal organism
    • Owen M: The origin of bone cells in the postnatal organism. Arthritis Rheum 23:1073-1080, 1980
    • (1980) Arthritis Rheum , vol.23 , pp. 1073-1080
    • Owen, M.1
  • 80
    • 0026459795 scopus 로고
    • Osteogenic protein-2: A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis
    • Özkaynak E, Schnegelsberg PN, Jin DF, Clifford GM, Warren ED, Drier EA, Oppermann H: Osteogenic protein-2: a new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. J Biol Chem 267:25220-25227, 1992
    • (1992) J Biol Chem , vol.267 , pp. 25220-25227
    • Özkaynak, E.1    Schnegelsberg, P.N.2    Jin, D.F.3    Clifford, G.M.4    Warren, E.D.5    Drier, E.A.6    Oppermann, H.7
  • 81
    • 0026563955 scopus 로고
    • The gene for bone morphogenetic protein 2A (BMP2A) is localized to human chromosome 20p12 by radioactive and nonradioactive in situ hybridization
    • Rao VV, Loffler C, Wozney JM, Hansmann I: The gene for bone morphogenetic protein 2A (BMP2A) is localized to human chromosome 20p12 by radioactive and nonradioactive in situ hybridization. Hum Genet 90:299-302, 1992
    • (1992) Hum Genet , vol.90 , pp. 299-302
    • Rao, V.V.1    Loffler, C.2    Wozney, J.M.3    Hansmann, I.4
  • 82
    • 0024242060 scopus 로고
    • Induction and maintenance of new bone formation by growth and differentiation factors
    • Reddi AH, Ma SS, Cunningham NS: Induction and maintenance of new bone formation by growth and differentiation factors. Ann Chir Gynaecol 77:189-192, 1988
    • (1988) Ann Chir Gynaecol , vol.77 , pp. 189-192
    • Reddi, A.H.1    Ma, S.S.2    Cunningham, N.S.3
  • 83
    • 0026453628 scopus 로고
    • Regulation of cartilage and bone differentiation by bone morphogenetic proteins
    • Reddi AH: Regulation of cartilage and bone differentiation by bone morphogenetic proteins. Curr Opin Cell Biol 4:850-855, 1992
    • (1992) Curr Opin Cell Biol , vol.4 , pp. 850-855
    • Reddi, A.H.1
  • 84
    • 0028097108 scopus 로고
    • Bone and cartilage differentiation
    • Reddi AH: Bone and cartilage differentiation. Curr Opin Genet Dev 4:737-744, 1994
    • (1994) Curr Opin Genet Dev , vol.4 , pp. 737-744
    • Reddi, A.H.1
  • 85
    • 0028097108 scopus 로고
    • Bone and cartilage morphogenesis: Cell biology to clinical applications
    • Reddi AH: Bone and cartilage morphogenesis: cell biology to clinical applications. Curr Opin Genet Dev 4:737-744, 1994
    • (1994) Curr Opin Genet Dev , vol.4 , pp. 737-744
    • Reddi, A.H.1
  • 86
    • 0028117413 scopus 로고
    • Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2
    • Rickard DJ, Sullivan TA, Shenker BJ, LeBoy PS, Kazhdan I: Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev Biol 161:218-228, 1994
    • (1994) Dev Biol , vol.161 , pp. 218-228
    • Rickard, D.J.1    Sullivan, T.A.2    Shenker, B.J.3    LeBoy, P.S.4    Kazhdan, I.5
  • 87
    • 0029911896 scopus 로고    scopus 로고
    • Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7)
    • Ripamonti U, van den Heever B, Sampath TK, Tucker MM, Rueger DC, Reddi AH: Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7). Growth Factors 13:273-289, 1996
    • (1996) Growth Factors , vol.13 , pp. 273-289
    • Ripamonti, U.1    Van Den Heever, B.2    Sampath, T.K.3    Tucker, M.M.4    Rueger, D.C.5    Reddi, A.H.6
  • 88
    • 0028920686 scopus 로고
    • Osteogenic growth peptide regulates proliferation and osteogenic maturation of human and rabbit bone marrow stromal cells
    • Robinson D, Bab I, Nevo Z: Osteogenic growth peptide regulates proliferation and osteogenic maturation of human and rabbit bone marrow stromal cells. J Bone Miner Res 10:690-696, 1995
    • (1995) J Bone Miner Res , vol.10 , pp. 690-696
    • Robinson, D.1    Bab, I.2    Nevo, Z.3
  • 89
    • 0030690556 scopus 로고    scopus 로고
    • The missing bone
    • Rodan GA, Harada S: The missing bone. Cell 89:677-680, 1997
    • (1997) Cell , vol.89 , pp. 677-680
    • Rodan, G.A.1    Harada, S.2
  • 91
    • 0032101214 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: From basic studies to clinical approaches
    • Sakou T: Bone morphogenetic proteins: from basic studies to clinical approaches. Bone 22:591-603, 1998
    • (1998) Bone , vol.22 , pp. 591-603
    • Sakou, T.1
  • 92
    • 0030058914 scopus 로고    scopus 로고
    • Caenorhabditis elegans genes sma-2, sma-3, sma-4 define a conserved family of transforming growth factor beta pathway components
    • Savage C, Das P, Finelli AL, Townsend SR, Sun CY, Baird SE, Padgett RW: Caenorhabditis elegans genes sma-2, sma-3, sma-4 define a conserved family of transforming growth factor beta pathway components. Proc Natl Acad Sci USA 93:790-794, 1996
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 790-794
    • Savage, C.1    Das, P.2    Finelli, A.L.3    Townsend, S.R.4    Sun, C.Y.5    Baird, S.E.6    Padgett, R.W.7
  • 93
    • 0028940853 scopus 로고
    • Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster
    • Sekelsky JJ, Newfeld SJ, Raftery LA, Chartoff EH, Gelbart WM: Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139:1347-1358, 1995
    • (1995) Genetics , vol.139 , pp. 1347-1358
    • Sekelsky, J.J.1    Newfeld, S.J.2    Raftery, L.A.3    Chartoff, E.H.4    Gelbart, W.M.5
  • 95
    • 0029583960 scopus 로고
    • A new transcription factor family associated with human leukemias
    • Speck NA, Terryl S: A new transcription factor family associated with human leukemias. Crit Rev Eukary Gene Express 5:337-364, 1995
    • (1995) Crit Rev Eukary Gene Express , vol.5 , pp. 337-364
    • Speck, N.A.1    Terryl, S.2
  • 97
    • 0019983146 scopus 로고
    • The reaction of the dura to bone morphogenetic protein (BMP) in repair of skull defects
    • Takagi K, Urist MR: The reaction of the dura to bone morphogenetic protein (BMP) in repair of skull defects. Ann Surg 196:100-109, 1982
    • (1982) Ann Surg , vol.196 , pp. 100-109
    • Takagi, K.1    Urist, M.R.2
  • 98
    • 0025950741 scopus 로고
    • Mandibular reconstruction with a recombinant bone-inducing factor: Functional, histologic, and biomechanical evaluation
    • Toriumi DM, Kotler HS, Luxenberg DP, Holtrop ME, Wang EA: Mandibular reconstruction with a recombinant bone-inducing factor: functional, histologic, and biomechanical evaluation. Arch Otolaryngol Head Neck Surg 117:1101-1112, 1991
    • (1991) Arch Otolaryngol Head Neck Surg , vol.117 , pp. 1101-1112
    • Toriumi, D.M.1    Kotler, H.S.2    Luxenberg, D.P.3    Holtrop, M.E.4    Wang, E.A.5
  • 99
    • 0028286048 scopus 로고
    • Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs
    • Towler DA, Bennette CD, Rodan GA: Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs. Mol Endocrinol 8:614-624, 1994
    • (1994) Mol Endocrinol , vol.8 , pp. 614-624
    • Towler, D.A.1    Bennette, C.D.2    Rodan, G.A.3
  • 100
    • 34250019537 scopus 로고
    • Bone: Formation by autoinduction
    • Urist MR: Bone: formation by autoinduction. Science 150:893-899, 1965
    • (1965) Science , vol.150 , pp. 893-899
    • Urist, M.R.1
  • 101
    • 0015155737 scopus 로고
    • Bone morphogenetic protein
    • Urist MR, Strates BS: Bone morphogenetic protein. J Dent Res 50:1392-1406, 1971
    • (1971) J Dent Res , vol.50 , pp. 1392-1406
    • Urist, M.R.1    Strates, B.S.2
  • 102
    • 17644419891 scopus 로고
    • Bone morphogenetic protein induced bone formation in experimental animals and patients with large bone defects
    • Ed by D Evered and S Harnett. Chichester. Wiley
    • Urist MR: Bone morphogenetic protein induced bone formation in experimental animals and patients with large bone defects. In: Cell and Molecular Biology of Vertebrate Hard Tissue, pp 281 -284. Ed by D Evered and S Harnett. Chichester. Wiley, 1988
    • (1988) Cell and Molecular Biology of Vertebrate Hard Tissue , pp. 281-284
    • Urist, M.R.1
  • 104
    • 0003139148 scopus 로고    scopus 로고
    • Osteoclast function: Biology and mechanisms
    • Ed by JP Bilezikian, LG Raisz, and GA Rodan. San Diego, Academic Press
    • Vaananen K: Osteoclast function: biology and mechanisms. In: Principles of Bone Biology, pp 103-113. Ed by JP Bilezikian, LG Raisz, and GA Rodan. San Diego, Academic Press, 1996
    • (1996) Principles of Bone Biology , pp. 103-113
    • Vaananen, K.1
  • 106
    • 0027657692 scopus 로고
    • Bone morphogenetic proteins (BMPs): Therapeutic potential in healing bony defects
    • Wang EA: Bone morphogenetic proteins (BMPs): therapeutic potential in healing bony defects. Trends Biotech 11:379-383, 1993
    • (1993) Trends Biotech , vol.11 , pp. 379-383
    • Wang, E.A.1
  • 107
    • 0029670049 scopus 로고    scopus 로고
    • The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling
    • Wang T, Danielson PD, Li BY, Shah PC, Kim SD, Donahoe PK: The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling. Science 271:1120-1122, 1996
    • (1996) Science , vol.271 , pp. 1120-1122
    • Wang, T.1    Danielson, P.D.2    Li, B.Y.3    Shah, P.C.4    Kim, S.D.5    Donahoe, P.K.6
  • 110
    • 0030037438 scopus 로고    scopus 로고
    • Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye
    • Wiersdorff V, Lecuit T, Cohen SM, Mlodzik M: Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. Development 122:2153-2162, 1996
    • (1996) Development , vol.122 , pp. 2153-2162
    • Wiersdorff, V.1    Lecuit, T.2    Cohen, S.M.3    Mlodzik, M.4
  • 111
    • 0032482163 scopus 로고    scopus 로고
    • Sustained release emphasizing recombinant human bone morphogenetic protein-2
    • Winn SR, Uludag H, Hollinger JO: Sustained release emphasizing recombinant human bone morphogenetic protein-2. Adv Drug Deliv Rev 31:303-318, 1998
    • (1998) Adv Drug Deliv Rev , vol.31 , pp. 303-318
    • Winn, S.R.1    Uludag, H.2    Hollinger, J.O.3
  • 113
    • 0029149656 scopus 로고
    • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    • Winnier G, Blessing M, Labosky PA, Hogan BL: Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 9:2105-2116, 1995
    • (1995) Genes Dev , vol.9 , pp. 2105-2116
    • Winnier, G.1    Blessing, M.2    Labosky, P.A.3    Hogan, B.L.4
  • 115
    • 0002598756 scopus 로고
    • Bone morphogenetic proteins and their expression
    • Ed by M Noda. San Francisco, Academic Press
    • Wozney JM: Bone morphogenetic proteins and their expression. In: Cellular and Molecular Biology of Bone, pp 131-165. Ed by M Noda. San Francisco, Academic Press, 1993
    • (1993) Cellular and Molecular Biology of Bone , pp. 131-165
    • Wozney, J.M.1
  • 118
    • 0031577571 scopus 로고    scopus 로고
    • Smad1 and Smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts
    • Yamamoto N, Akiyama S, Katagiri T, Namiki M, Kurokawa T, Suda T: Smad1 and Smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts. Biochem Biophys Res Commun 238:574-580, 1997
    • (1997) Biochem Biophys Res Commun , vol.238 , pp. 574-580
    • Yamamoto, N.1    Akiyama, S.2    Katagiri, T.3    Namiki, M.4    Kurokawa, T.5    Suda, T.6
  • 120
    • 0026757708 scopus 로고
    • The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2): A radiographie, histological, and biomechanical study in rats
    • Yasko AW, Lane JM, Fellinger EJ, Rosen V, Wozney JM, Wang EA: The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2): a radiographie, histological, and biomechanical study in rats. J Bone Joint Surg [Am] 74:659-670, 1992
    • (1992) J Bone Joint Surg [Am] , vol.74 , pp. 659-670
    • Yasko, A.W.1    Lane, J.M.2    Fellinger, E.J.3    Rosen, V.4    Wozney, J.M.5    Wang, E.A.6
  • 122
    • 0029850112 scopus 로고
    • Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
    • Zhang H, Bradley A: Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development 122:2977-2986, 1994
    • (1994) Development , vol.122 , pp. 2977-2986
    • Zhang, H.1    Bradley, A.2
  • 123
    • 0030598829 scopus 로고    scopus 로고
    • The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
    • Zimmerman LB, De Jesus-Escobar JM, Harland RM: The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86:599-606, 1996
    • (1996) Cell , vol.86 , pp. 599-606
    • Zimmerman, L.B.1    De Jesus-Escobar, J.M.2    Harland, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.