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Volumn 22, Issue 6, 1998, Pages 591-603

Bone morphogenetic proteins: From basic studies to clinical approaches

Author keywords

Activin receptor (ActR); BMP receptor (BMPR); Bone morphogenetic protein (BMP); Chondro osteogenesis; Embryogenesis; Signaling mediators

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOGENIC PROTEIN 1; OSTEOGENIN; UNCLASSIFIED DRUG;

EID: 0032101214     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(98)00053-2     Document Type: Review
Times cited : (316)

References (180)
  • 2
    • 0027360838 scopus 로고
    • Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria
    • 2. Asahina, I., Sampath, T. K., Nishimura, I., and Hauscka, P. V. Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria. J Cell Biol 123:921-933; 1993.
    • (1993) J Cell Biol , vol.123 , pp. 921-933
    • Asahina, I.1    Sampath, T.K.2    Nishimura, I.3    Hauscka, P.V.4
  • 3
    • 0030056920 scopus 로고    scopus 로고
    • Human osteogenic protein-1 induces chondroblastic, osteoblastic and/or adipocytic differentiation of clonal murine target cells
    • 3. Asahina, I., Sampath, T. K., and Hauschka, P. V. Human osteogenic protein-1 induces chondroblastic, osteoblastic and/or adipocytic differentiation of clonal murine target cells. Exp Cell Res 222:38-47; 1996.
    • (1996) Exp Cell Res , vol.222 , pp. 38-47
    • Asahina, I.1    Sampath, T.K.2    Hauschka, P.V.3
  • 4
    • 0026527384 scopus 로고
    • Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors
    • 4. Attisano, L., Wrana, J. L., Cheifetz, S., and Massagué, J. Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors. Cell 68:97-108; 1992.
    • (1992) Cell , vol.68 , pp. 97-108
    • Attisano, L.1    Wrana, J.L.2    Cheifetz, S.3    Massagué, J.4
  • 5
    • 0030427867 scopus 로고    scopus 로고
    • Signal transduction by members of the transforming growth factor-β superfamily
    • 5. Attisano, L. and Wrana, J. L. Signal transduction by members of the transforming growth factor-β superfamily. Cytokine Growth Factor Rev 7:327-339; 1996.
    • (1996) Cytokine Growth Factor Rev , vol.7 , pp. 327-339
    • Attisano, L.1    Wrana, J.L.2
  • 7
    • 0029834634 scopus 로고    scopus 로고
    • Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of trangenic mice: Inhibitor or stimulation of proliferation depending on the pattern of transgene expression and formation of psoriatic lesions
    • 7. Blessing, M., Schirmacher, P., and Kaiser, S. Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of trangenic mice: Inhibitor or stimulation of proliferation depending on the pattern of transgene expression and formation of psoriatic lesions. J Cell Biol 135:227-239; 1996.
    • (1996) J Cell Biol , vol.135 , pp. 227-239
    • Blessing, M.1    Schirmacher, P.2    Kaiser, S.3
  • 9
    • 0028928743 scopus 로고
    • Expression of bone morphogenetic protein-6 messenger RNA in bovine growth plate chondrocytes of different size
    • 9. Carey, D. and Liu, X. Expression of bone morphogenetic protein-6 messenger RNA in bovine growth plate chondrocytes of different size. J Bone Miner Res 10:401-405; 1995.
    • (1995) J Bone Miner Res , vol.10 , pp. 401-405
    • Carey, D.1    Liu, X.2
  • 10
    • 0025672641 scopus 로고
    • Identification of transforming growth factor β family members present in bone-inductive protein purified from bovine bone
    • 10. Celeste, A. J., Iannazzi, J. A., Taylor, R. C., Hewick, R. M., Rosen, V., Wang, E. A., and Wozney, J. M. Identification of transforming growth factor β family members present in bone-inductive protein purified from bovine bone. Proc Natl Acad Sci USA 87:9843-9847; 1990.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9843-9847
    • Celeste, A.J.1    Iannazzi, J.A.2    Taylor, R.C.3    Hewick, R.M.4    Rosen, V.5    Wang, E.A.6    Wozney, J.M.7
  • 11
    • 0028126646 scopus 로고
    • Cartilage-derived morphogenetic protein. New members of the transforming growth factor-β superfamily predominantly express in long bones during human embryonic development
    • 11. Chang, S. C., Hoang, B., Thomas, J. T., Vukicevic, S., Luyten, F. P., Ryba, N. J. P., Kozak, C. A., Reddi, A. H., and Moos, M., Jr. Cartilage-derived morphogenetic protein. New members of the transforming growth factor-β superfamily predominantly express in long bones during human embryonic development. J Biol Chem 269:28227-28234; 1994.
    • (1994) J Biol Chem , vol.269 , pp. 28227-28234
    • Chang, S.C.1    Hoang, B.2    Thomas, J.T.3    Vukicevic, S.4    Luyten, F.P.5    Ryba, N.J.P.6    Kozak, C.A.7    Reddi, A.H.8    Moos M., Jr.9
  • 13
    • 0026319495 scopus 로고
    • Bone morphogenetic protein-2b stimulation of growth and osteogenic phenotypes in rat osteoblast-like cells: Comparison with TGF-β1
    • 13. Chen, T. L., Bates, R. L., Dudley, A., Hammonds, G., Jr., and Amento, E. Bone morphogenetic protein-2b stimulation of growth and osteogenic phenotypes in rat osteoblast-like cells: Comparison with TGF-β1. J Bone Miner Res 6:1387-1393; 1991.
    • (1991) J Bone Miner Res , vol.6 , pp. 1387-1393
    • Chen, T.L.1    Bates, R.L.2    Dudley, A.3    Hammonds, G.4    Amento, E.5
  • 14
    • 0029802485 scopus 로고    scopus 로고
    • A transcriptional partner for MAD proteins in TGF-β signaling
    • 14. Chen, X., Rubock, M. J., and Whiteman, M. A transcriptional partner for MAD proteins in TGF-β signaling. Nature 383:691-696; 1996.
    • (1996) Nature , vol.383 , pp. 691-696
    • Chen, X.1    Rubock, M.J.2    Whiteman, M.3
  • 15
    • 0028234952 scopus 로고
    • The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects
    • 15. Cook, S. D., Baffes, G. C., Wolfe, M. W., Sampath, T. K., Rueger, D. C., and Whitecloud, T. S., III. The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects. J Bone Jt Surg 76-A:827-838; 1994.
    • (1994) J Bone Jt Surg , vol.76 A , pp. 827-838
    • Cook, S.D.1    Baffes, G.C.2    Wolfe, M.W.3    Sampath, T.K.4    Rueger, D.C.5    Whitecloud T.S. III6
  • 16
    • 0028043934 scopus 로고
    • In vivo evaluation of recombinant human osteogenic protein-1 (rhOP-1) implants as a bone graft substitute for spinal fusions
    • 16. Cook, S. D., Dalton, J. E., Tan, M. E., Whitecloud, T. S., III, and Rueger, D. C. In vivo evaluation of recombinant human osteogenic protein-1 (rhOP-1) implants as a bone graft substitute for spinal fusions. Spine 19:1655-1663; 1994.
    • (1994) Spine , vol.19 , pp. 1655-1663
    • Cook, S.D.1    Dalton, J.E.2    Tan, M.E.3    Whitecloud, T.S.4    Rueger, D.C.5
  • 17
    • 0030070358 scopus 로고    scopus 로고
    • Osteogenic protein-1. Biology and application
    • 17. Cook, S. D. and Rueger, D. C. Osteogenic protein-1. Biology and application. Clin Orthop 324:29-38; 1996.
    • (1996) Clin Orthop , vol.324 , pp. 29-38
    • Cook, S.D.1    Rueger, D.C.2
  • 18
    • 0000708970 scopus 로고
    • Histological and ultrastructural comparison of the in vivo activities of rhBMP-2 and rhBMP-5
    • 18. Cox, K., Holtrop, M., D'Alessandro, J. S., Wang, E. A., Wozney, J. M., and Rosen, V. Histological and ultrastructural comparison of the in vivo activities of rhBMP-2 and rhBMP-5. J Bone Miner Res 6:S155; 1991.
    • (1991) J Bone Miner Res , vol.6
    • Cox, K.1    Holtrop, M.2    D'Alessandro, J.S.3    Wang, E.A.4    Wozney, J.M.5    Rosen, V.6
  • 19
    • 0027074882 scopus 로고
    • Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor β1 mRNA expression
    • 19. Cunningham, N. S., Paralkar, V., and Reddi, A. H. Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor β1 mRNA expression. Proc Natl Acad Sci USA 89:11740-11744; 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11740-11744
    • Cunningham, N.S.1    Paralkar, V.2    Reddi, A.H.3
  • 20
    • 0029119066 scopus 로고
    • Growth/differentiation factor-10: A new member of the transforming growth factor-β superfamily related to bone morphogenetic protein-3
    • 20. Cunningham, N. S., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Reddi, A. H., and Lee, S.-J. Growth/differentiation factor-10: A new member of the transforming growth factor-β superfamily related to bone morphogenetic protein-3. Growth Factors 12:99-109; 1995.
    • (1995) Growth Factors , vol.12 , pp. 99-109
    • Cunningham, N.S.1    Jenkins, N.A.2    Gilbert, D.J.3    Copeland, N.G.4    Reddi, A.H.5    Lee, S.-J.6
  • 21
    • 0026717301 scopus 로고
    • Bone morphogenetic protein 4: A ventralizing factor in early Xenopus development
    • 21. Dale, L., Howes, G., Price, B. M., and Smith, J. C. Bone morphogenetic protein 4: A ventralizing factor in early Xenopus development. Development 115:573-585; 1992.
    • (1992) Development , vol.115 , pp. 573-585
    • Dale, L.1    Howes, G.2    Price, B.M.3    Smith, J.C.4
  • 23
    • 0029664488 scopus 로고    scopus 로고
    • Common plan for dorsoventral pattering in Bilateria
    • 23. De Robertis, E. M. and Sasai, Y. A. Common plan for dorsoventral pattering in Bilateria. Nature 380:37-40; 1996.
    • (1996) Nature , vol.380 , pp. 37-40
    • De Robertis, E.M.1    Sasai, Y.A.2
  • 24
    • 0028173316 scopus 로고
    • TGF-β-receptor-mediated signaling
    • 24. Derynck, R. TGF-β-receptor-mediated signaling. Trends Biochem Sci 19: 548-553; 1994.
    • (1994) Trends Biochem Sci , vol.19 , pp. 548-553
    • Derynck, R.1
  • 25
    • 0030265714 scopus 로고    scopus 로고
    • Intracellular signaling: The Mad way to do it
    • 25. Derynck, R. and Zhang, Y. Intracellular signaling: The Mad way to do it. Curr Biol 6:1226-1229; 1996.
    • (1996) Curr Biol , vol.6 , pp. 1226-1229
    • Derynck, R.1    Zhang, Y.2
  • 27
    • 0028284846 scopus 로고
    • Opposite effects of osteogenetic protein and transforming growth factor-β on chondrogenesis in cultured long bone rudiments
    • 27. Dieudonné, S. C., Semeis, C. M., Goel, S. W., Vukicevic, S., Nulend, J. K., Sampath, T. K., Heldler, M., and Burger, E. H. Opposite effects of osteogenetic protein and transforming growth factor-β on chondrogenesis in cultured long bone rudiments. J Bone Miner Res 9:771-780; 1994.
    • (1994) J Bone Miner Res , vol.9 , pp. 771-780
    • Dieudonné, S.C.1    Semeis, C.M.2    Goel, S.W.3    Vukicevic, S.4    Nulend, J.K.5    Sampath, T.K.6    Heldler, M.7    Burger, E.H.8
  • 28
    • 0029861824 scopus 로고    scopus 로고
    • Growth differentiation factor-9 is required during early ovarian folliculogenesis
    • 28. Dong, J., Albertini, D. F., Nishimori, K., Kumar, T. R., Lu, N., and Matzuk, M. M. Growth differentiation factor-9 is required during early ovarian folliculogenesis. Nature 383:531-535; 1996.
    • (1996) Nature , vol.383 , pp. 531-535
    • Dong, J.1    Albertini, D.F.2    Nishimori, K.3    Kumar, T.R.4    Lu, N.5    Matzuk, M.M.6
  • 29
    • 0028832707 scopus 로고
    • A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
    • 29. Dudley, A. T., Lyons, K. M., and Robertson, E. J. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev 9:2795-2807; 1995.
    • (1995) Genes Dev , vol.9 , pp. 2795-2807
    • Dudley, A.T.1    Lyons, K.M.2    Robertson, E.J.3
  • 32
    • 0027332995 scopus 로고
    • Cloning of a TGF-β type I receptor that forms a heteromeric complex with the TGF-β type II receptor
    • 32. Franzén, P., ten Dijke, P., Ichijo, H., Yamashita, H., Schulz, P., Heldin, C.-H., and Miyazono, K. Cloning of a TGF-β type I receptor that forms a heteromeric complex with the TGF-β type II receptor. Cell 75:681-692; 1993.
    • (1993) Cell , vol.75 , pp. 681-692
    • Franzén, P.1    Ten Dijke, P.2    Ichijo, H.3    Yamashita, H.4    Schulz, P.5    Heldin, C.-H.6    Miyazono, K.7
  • 33
    • 0027965225 scopus 로고
    • Recombinant Vgr-1/BMP-6 expressing tumors induce fibrosis and enchondral bone formation in vivo
    • 33. Gitelman, S. E., Kobrin, M. S., Ye, J. Q., Lopez, A. R., Lee, A., and Derynck, R. Recombinant Vgr-1/BMP-6 expressing tumors induce fibrosis and enchondral bone formation in vivo. J Cell Biol 126:1595-1609; 1994.
    • (1994) J Cell Biol , vol.126 , pp. 1595-1609
    • Gitelman, S.E.1    Kobrin, M.S.2    Ye, J.Q.3    Lopez, A.R.4    Lee, A.5    Derynck, R.6
  • 34
    • 0029065505 scopus 로고
    • Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells
    • 34. Gitelman, S. E., Kirk, M., Ye, J.-Q., Filvaroff, E. H., Kahn, A. J., and Derynck, R. Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells. Cell Growth Diff 6:827-836; 1995.
    • (1995) Cell Growth Diff , vol.6 , pp. 827-836
    • Gitelman, S.E.1    Kirk, M.2    Ye, J.-Q.3    Filvaroff, E.H.4    Kahn, A.J.5    Derynck, R.6
  • 35
    • 0030953118 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1α effects on proteoglycan synthesis and content
    • 35. Glansbeek, H., van Beuningen, H. M., Vitters, E. L., Morris, E. A., van der Kraan, P. M., and van den Berg, W. B. Bone morphogenetic protein 2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1α effects on proteoglycan synthesis and content. Arthritis Rheum 40:1020-1028; 1997.
    • (1997) Arthritis Rheum , vol.40 , pp. 1020-1028
    • Glansbeek, H.1    Van Beuningen, H.M.2    Vitters, E.L.3    Morris, E.A.4    Van Der Kraan, P.M.5    Van Den Berg, W.B.6
  • 36
    • 0029940972 scopus 로고    scopus 로고
    • Xenopus mad proteins transduce distinct subsets of signals for the TGF-β superfamily
    • 36. Graff, J. M., Bansal, A., and Melton, D. A. Xenopus mad proteins transduce distinct subsets of signals for the TGF-β superfamily. Cell 85:479-487; 1996.
    • (1996) Cell , vol.85 , pp. 479-487
    • Graff, J.M.1    Bansal, A.2    Melton, D.A.3
  • 37
    • 0030273439 scopus 로고    scopus 로고
    • Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells
    • 37. Gross, R. E., Mehler, M. F., Mabie, P. C., Zang, Z., Santschi, L., and Kessler, J. A. Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells. Neuron 17:595-606; 1996.
    • (1996) Neuron , vol.17 , pp. 595-606
    • Gross, R.E.1    Mehler, M.F.2    Mabie, P.C.3    Zang, Z.4    Santschi, L.5    Kessler, J.A.6
  • 42
    • 0029028648 scopus 로고
    • Efficient expression of a heterodimer of bone morphogenetic protein subunits using a baculovirus expression system
    • 42. Hazama, M., Aono, A., Ueno, N., and Fujisawa, Y. Efficient expression of a heterodimer of bone morphogenetic protein subunits using a baculovirus expression system. Biochem Biophys Res Commun 209:859-866; 1995.
    • (1995) Biochem Biophys Res Commun , vol.209 , pp. 859-866
    • Hazama, M.1    Aono, A.2    Ueno, N.3    Fujisawa, Y.4
  • 44
    • 0026325169 scopus 로고
    • Bone morphogenetic protein (BMP-2 and BMP-3) promote growth and expression of the differentiated phenotype of rabbit chondrocytes and osteoblastic MC3T3-E1 cells in vitro
    • 44. Hiraki, Y., Inoue, H., Shigeno, C., Sanma, Y., Benty, H., Rosen, D. M., Asada, A., and Suzuki, F. Bone morphogenetic protein (BMP-2 and BMP-3) promote growth and expression of the differentiated phenotype of rabbit chondrocytes and osteoblastic MC3T3-E1 cells in vitro. J Bone Miner Res 6:1373-1384; 1991.
    • (1991) J Bone Miner Res , vol.6 , pp. 1373-1384
    • Hiraki, Y.1    Inoue, H.2    Shigeno, C.3    Sanma, Y.4    Benty, H.5    Rosen, D.M.6    Asada, A.7    Suzuki, F.8
  • 45
    • 0029737070 scopus 로고    scopus 로고
    • Bone morphogenetic protein: Multifunctional regulators of vertebrate development
    • 45. Hogan, B. L. M. Bone morphogenetic protein: Multifunctional regulators of vertebrate development. Genes Dev 10:1580-1594; 1996.
    • (1996) Genes Dev , vol.10 , pp. 1580-1594
    • Hogan, B.L.M.1
  • 46
    • 0029077979 scopus 로고
    • A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin
    • 46. Holley, S. A., Jackson, P. D., Sasai, Y., Lu, B., De Robertis, E. M., Hoffmann, F. M., and Ferguson, E. L. A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin. Nature 376:249-253; 1995.
    • (1995) Nature , vol.376 , pp. 249-253
    • Holley, S.A.1    Jackson, P.D.2    Sasai, Y.3    Lu, B.4    De Robertis, E.M.5    Hoffmann, F.M.6    Ferguson, E.L.7
  • 47
    • 0030598871 scopus 로고    scopus 로고
    • The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor
    • 47. Holley, S. A., Neul, J. L., Attisano, L., Wrana, J. L., Sasai, Y., O'Conner, M. B., De Robertis, E. M., and Ferguson, E. L. The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor. Cell 86:607-617; 1996.
    • (1996) Cell , vol.86 , pp. 607-617
    • Holley, S.A.1    Neul, J.L.2    Attisano, L.3    Wrana, J.L.4    Sasai, Y.5    O'Conner, M.B.6    De Robertis, E.M.7    Ferguson, E.L.8
  • 49
    • 0030823929 scopus 로고    scopus 로고
    • Fibroblasts of spinal ligaments pathologically differentiate into chondrocytes induced by recombinant human bone morphogenetic protein-2: Morphological examinations for ossification of spinal ligaments
    • 49. Hoshi, K., Amizuka, N., Sakou, T., Kurokawa, T., and Ozawa, H. Fibroblasts of spinal ligaments pathologically differentiate into chondrocytes induced by recombinant human bone morphogenetic protein-2: Morphological examinations for ossification of spinal ligaments. Bone 21:155-162; 1997.
    • (1997) Bone , vol.21 , pp. 155-162
    • Hoshi, K.1    Amizuka, N.2    Sakou, T.3    Kurokawa, T.4    Ozawa, H.5
  • 51
    • 0026673314 scopus 로고
    • Differential chemotactic responses of different populations of fetal rat calvaria cells to platelet-derived growth factor and transforming growth factor beta
    • 51. Hughes, F. J., Aubin, J. E., and Heersche, J. N. Differential chemotactic responses of different populations of fetal rat calvaria cells to platelet-derived growth factor and transforming growth factor beta. Bone Miner 19:63-74; 1992.
    • (1992) Bone Miner , vol.19 , pp. 63-74
    • Hughes, F.J.1    Aubin, J.E.2    Heersche, J.N.3
  • 53
    • 0030585355 scopus 로고    scopus 로고
    • Bone morphogenetic protein-12 and -13 inhibit terminal differentiation of myoblasts, but do not induce their differentiation into osteoblasts
    • 53. Inada, M., Katagiri, T., Akiyama, S., Namiki, M., Komaki, M., Yamaguchi, A., Kamoi, K., Rosen, V., and Suda T. Bone morphogenetic protein-12 and -13 inhibit terminal differentiation of myoblasts, but do not induce their differentiation into osteoblasts. Biochem Biophys Res Commun 222:317-322; 1996.
    • (1996) Biochem Biophys Res Commun , vol.222 , pp. 317-322
    • Inada, M.1    Katagiri, T.2    Akiyama, S.3    Namiki, M.4    Komaki, M.5    Yamaguchi, A.6    Kamoi, K.7    Rosen, V.8    Suda, T.9
  • 55
    • 0029862206 scopus 로고    scopus 로고
    • Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo
    • 55. Israel, D. I., Nove, J., Kerns, K. M., Kaufman, R. J., Rosen, V., Cox, K. A., and Wozney, J. M. Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo. Growth Factors 13:291-300; 1996.
    • (1996) Growth Factors , vol.13 , pp. 291-300
    • Israel, D.I.1    Nove, J.2    Kerns, K.M.3    Kaufman, R.J.4    Rosen, V.5    Cox, K.A.6    Wozney, J.M.7
  • 56
    • 0023906710 scopus 로고
    • Bone morphogenetic protein augmentation grafting of resistant femoral nonunions: A preliminary report
    • 56. Johnson, E. E., Urist, M. R., and Finerman, G. A. M. Bone morphogenetic protein augmentation grafting of resistant femoral nonunions: A preliminary report. Clin Orthop 230:257-265; 1988.
    • (1988) Clin Orthop , vol.230 , pp. 257-265
    • Johnson, E.E.1    Urist, M.R.2    Finerman, G.A.M.3
  • 57
    • 0023716334 scopus 로고
    • Repair of segmental defects of the tibia with cancellous bone grafts augmented with human bone morphogenetic protein. A preliminary report
    • 57. Johnson, E. E., Urist, M. R., and Finerman, G. A. M. Repair of segmental defects of the tibia with cancellous bone grafts augmented with human bone morphogenetic protein. A preliminary report. Clin Orthop 236:249-257; 1988.
    • (1988) Clin Orthop , vol.236 , pp. 249-257
    • Johnson, E.E.1    Urist, M.R.2    Finerman, G.A.M.3
  • 58
    • 0025023612 scopus 로고
    • Distal metaphyseal tibial nonunion. Deformity and bone loss treated by open reduction, internal fixation, and human bone morphogenetic protein (hBMP)
    • 58. Johnson, E. E., Urist, M. R., and Finerman, G. A. M. Distal metaphyseal tibial nonunion. Deformity and bone loss treated by open reduction, internal fixation, and human bone morphogenetic protein (hBMP). Clin Orthop 250: 234-240; 1990.
    • (1990) Clin Orthop , vol.250 , pp. 234-240
    • Johnson, E.E.1    Urist, M.R.2    Finerman, G.A.M.3
  • 59
    • 0026680530 scopus 로고
    • DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction
    • 59. Jones, C. M., Lyons, K. M., Lapan, P. M., Wright, C. V., and Hogan, B. L. M. DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. Development 115:639-647; 1992.
    • (1992) Development , vol.115 , pp. 639-647
    • Jones, C.M.1    Lyons, K.M.2    Lapan, P.M.3    Wright, C.V.4    Hogan, B.L.M.5
  • 60
    • 0028819919 scopus 로고
    • Stimulatory effect of bone morphogenetic protein-2 on osteoclast-like cell formation and bone-resorbing activity
    • 60. Kanatani, M., Sugimoto, T., Kaji, H., Kobayashi, T., Nishiyama, K., Fukase, M., Kumegawa, M., and Chihara, K. Stimulatory effect of bone morphogenetic protein-2 on osteoclast-like cell formation and bone-resorbing activity. J Bone Miner Res 10:1681-1690; 1995.
    • (1995) J Bone Miner Res , vol.10 , pp. 1681-1690
    • Kanatani, M.1    Sugimoto, T.2    Kaji, H.3    Kobayashi, T.4    Nishiyama, K.5    Fukase, M.6    Kumegawa, M.7    Chihara, K.8
  • 61
    • 0025307333 scopus 로고
    • Fibrodysplasia ossificans progressiva: A clue from the fly?
    • 61. Kaplan, F. S., Tabas, J. A., and Zasloff, M. A. Fibrodysplasia ossificans progressiva: A clue from the fly? Calcif Tissue Int 47:117-125; 1990.
    • (1990) Calcif Tissue Int , vol.47 , pp. 117-125
    • Kaplan, F.S.1    Tabas, J.A.2    Zasloff, M.A.3
  • 63
    • 0031080176 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 inhibits terminal differentiation of myogenic cells by suppressing the transcriptional activity of MyoD and myogen
    • 63. Katagiri, T., Akiyama, S., Namiki, M., Komaki, M., Yamaguchi, A., Rosen, V., Wozney, J. M., Fijisawa-Sehara, A., and Suda T. Bone morphogenetic protein-2 inhibits terminal differentiation of myogenic cells by suppressing the transcriptional activity of MyoD and myogen. Exp Cell Res 230:342-351; 1997.
    • (1997) Exp Cell Res , vol.230 , pp. 342-351
    • Katagiri, T.1    Akiyama, S.2    Namiki, M.3    Komaki, M.4    Yamaguchi, A.5    Rosen, V.6    Wozney, J.M.7    Fijisawa-Sehara, A.8    Suda, T.9
  • 64
    • 0026538115 scopus 로고
    • Immunohistochemical demonstration of bone morphogenetic protein-2 and transforming growth factor-β in the ossification of the posterior longitudinal ligament of the cervical spine
    • 64. Kawaguchi, H., Kurokawa, T., Hoshino, Y., Kawahara, H., Ogata, E., and Matsumoto, T. Immunohistochemical demonstration of bone morphogenetic protein-2 and transforming growth factor-β in the ossification of the posterior longitudinal ligament of the cervical spine. Spine 17:33-36; 1992.
    • (1992) Spine , vol.17 , pp. 33-36
    • Kawaguchi, H.1    Kurokawa, T.2    Hoshino, Y.3    Kawahara, H.4    Ogata, E.5    Matsumoto, T.6
  • 65
    • 0030593032 scopus 로고    scopus 로고
    • Bone morphogenetic protein-1: The type I procollagen C-proteinase
    • 65. Kessler, E., Takahara, K., Biniaminov, L., Brusel, M., and Greenspan, D. S. Bone morphogenetic protein-1: The type I procollagen C-proteinase. Science 271:360-362; 1996.
    • (1996) Science , vol.271 , pp. 360-362
    • Kessler, E.1    Takahara, K.2    Biniaminov, L.3    Brusel, M.4    Greenspan, D.S.5
  • 66
    • 0029762378 scopus 로고    scopus 로고
    • The role of BMPs and GDFs in development of region-specific skeletal structures
    • 66. King, J. A., Storm, E. E., Marker, P. C., Dileone, R. J., and Kingsley, D. M. The role of BMPs and GDFs in development of region-specific skeletal structures. Ann NY Acad Sci 785:70-79; 1996.
    • (1996) Ann NY Acad Sci , vol.785 , pp. 70-79
    • King, J.A.1    Storm, E.E.2    Marker, P.C.3    Dileone, R.J.4    Kingsley, D.M.5
  • 67
    • 0026440993 scopus 로고
    • The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily
    • 67. Kingsley, D. M., Bland, A. E., Grubber, J. M., Marker, P. C., Russell, L. B., Copeland, N. G., and Jenkins, N. A. The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Cell 71:339-410; 1992.
    • (1992) Cell , vol.71 , pp. 339-410
    • Kingsley, D.M.1    Bland, A.E.2    Grubber, J.M.3    Marker, P.C.4    Russell, L.B.5    Copeland, N.G.6    Jenkins, N.A.7
  • 68
    • 0028180315 scopus 로고
    • The TGF-β superfamily: New members, new receptors, and new genetic tests of function in different organisms
    • 68. Kingsley, D. M. The TGF-β superfamily: New members, new receptors, and new genetic tests of function in different organisms. Genes Dev 8:133-146; 1994.
    • (1994) Genes Dev , vol.8 , pp. 133-146
    • Kingsley, D.M.1
  • 70
    • 0030042313 scopus 로고    scopus 로고
    • Restriction fragment polymorphism of gene of α2(XI) collagen, bone morphogenetic protein-2, alkaline phosphatase and tumor necrosis factor α among ossification of posterior longitudinal ligament patients and control Japanese population
    • 70. Koga, H., Hayashi, K., Taketomi, E., Matsunaga, S., Yashiki, S., Fujiyoshi, T., Sonoda, S., and Sakou, T. Restriction fragment polymorphism of gene of α2(XI) collagen, bone morphogenetic protein-2, alkaline phosphatase and tumor necrosis factor α among ossification of posterior longitudinal ligament patients and control Japanese population. Spine 21:469-473; 1996.
    • (1996) Spine , vol.21 , pp. 469-473
    • Koga, H.1    Hayashi, K.2    Taketomi, E.3    Matsunaga, S.4    Yashiki, S.5    Fujiyoshi, T.6    Sonoda, S.7    Sakou, T.8
  • 72
    • 0030773834 scopus 로고    scopus 로고
    • Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
    • 72. Kretzschmar, M., Doody, J., and Massagué, J. Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1. Nature 389:618-622; 1997.
    • (1997) Nature , vol.389 , pp. 618-622
    • Kretzschmar, M.1    Doody, J.2    Massagué, J.3
  • 73
    • 0030911104 scopus 로고    scopus 로고
    • The TGF-β family mediator smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase
    • 73. Kretzschmar, M., Liu, F., Hata, A., Doody, J., and Massagué, J. The TGF-β family mediator smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev 11:984-995; 1997.
    • (1997) Genes Dev , vol.11 , pp. 984-995
    • Kretzschmar, M.1    Liu, F.2    Hata, A.3    Doody, J.4    Massagué, J.5
  • 74
    • 0028860775 scopus 로고
    • Trophic and protective effects of growth/differentiation factor 5, a member of the transforming growth factor-β superfamily, on midbrain dopaminergic neurons
    • 74. Kriegestein, K., Suter-Crazzolara, C., Hötten, G., Pohl, J., and Unsicker, K. Trophic and protective effects of growth/differentiation factor 5, a member of the transforming growth factor-β superfamily, on midbrain dopaminergic neurons. J Neurosci Res 42:724-732; 1995.
    • (1995) J Neurosci Res , vol.42 , pp. 724-732
    • Kriegestein, K.1    Suter-Crazzolara, C.2    Hötten, G.3    Pohl, J.4    Unsicker, K.5
  • 75
    • 0023180330 scopus 로고
    • Current approaches to experimental bone grafting
    • 75. Lane, J. M. and Sandhu, H. S. Current approaches to experimental bone grafting. Orthop Clin North Am 18:213-225; 1987.
    • (1987) Orthop Clin North Am , vol.18 , pp. 213-225
    • Lane, J.M.1    Sandhu, H.S.2
  • 77
    • 0029082799 scopus 로고
    • Osteogenic protein-1 induces dendritic growth in rat sympathetic neurons
    • 77. Lein, P., Johnson, M., Guo, X., Rurger, D., and Higgins, D. Osteogenic protein-1 induces dendritic growth in rat sympathetic neurons. Neuron 15: 597-605; 1995.
    • (1995) Neuron , vol.15 , pp. 597-605
    • Lein, P.1    Johnson, M.2    Guo, X.3    Rurger, D.4    Higgins, D.5
  • 78
    • 0030049816 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 but both bone morphogenetic protein-4 and -6 stimulates chemotactic migration of human osteoblasts, human marrow osteoblasts, and U2-OS cells
    • 78. Lido, M., Eriksen, E. F., and Bünger, C. Bone morphogenetic protein-2 but both bone morphogenetic protein-4 and -6 stimulates chemotactic migration of human osteoblasts, human marrow osteoblasts, and U2-OS cells. Bone 18:53-57; 1996.
    • (1996) Bone , vol.18 , pp. 53-57
    • Lido, M.1    Eriksen, E.F.2    Bünger, C.3
  • 79
    • 0010339704 scopus 로고
    • Receptors for the TGF-β superfamily
    • 79. Lin, H. Y. and Lodish, H. F. Receptors for the TGF-β superfamily. Trends Cell Biol 11:972-978; 1993.
    • (1993) Trends Cell Biol , vol.11 , pp. 972-978
    • Lin, H.Y.1    Lodish, H.F.2
  • 81
    • 0029008597 scopus 로고
    • Human type II receptor for bone morphogenetic proteins (BMPs): Expression of the two-kinase receptor model to the BMPs
    • 81. Liu, F., Ventura, F., Doody, J., and Massagué, J. Human type II receptor for bone morphogenetic proteins (BMPs): Expression of the two-kinase receptor model to the BMPs. Mol Cell Biol 15:3479-3486; 1995.
    • (1995) Mol Cell Biol , vol.15 , pp. 3479-3486
    • Liu, F.1    Ventura, F.2    Doody, J.3    Massagué, J.4
  • 82
    • 0029931509 scopus 로고    scopus 로고
    • A human Mad protein acting as a BMP-regulated transcriptional activator
    • 82. Liu, F., Hata, A., Baker, J. C., Doody, J., Cárcano, J., Harland, R. M., and Massagué, J. A human Mad protein acting as a BMP-regulated transcriptional activator. Nature 381:620-623; 1996.
    • (1996) Nature , vol.381 , pp. 620-623
    • Liu, F.1    Hata, A.2    Baker, J.C.3    Doody, J.4    Cárcano, J.5    Harland, R.M.6    Massagué, J.7
  • 83
    • 0028882261 scopus 로고
    • BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning
    • 83. Luo, G., Hofmann, C., Bronckers, A. L. J. J., Sohocki, M., Bradley, A., and Karsently, G. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev 9:2808-2820; 1995.
    • (1995) Genes Dev , vol.9 , pp. 2808-2820
    • Luo, G.1    Hofmann, C.2    Bronckers, A.L.J.J.3    Sohocki, M.4    Bradley, A.5    Karsently, G.6
  • 85
    • 0026709638 scopus 로고
    • Natural bovine osteogenin and recombinant human bone morphogenetic protein-2B are equipotent in the maintenance of proteoglycans in bovine articular cartilage explant cultures
    • 85. Luyten, F. P., Yu, Y. M., Yanagishita, M., Vukicevic, S., Hammonds, R. G., and Reddi, A. H. Natural bovine osteogenin and recombinant human bone morphogenetic protein-2B are equipotent in the maintenance of proteoglycans in bovine articular cartilage explant cultures. J Biol Chem 267:3691-3695; 1992.
    • (1992) J Biol Chem , vol.267 , pp. 3691-3695
    • Luyten, F.P.1    Yu, Y.M.2    Yanagishita, M.3    Vukicevic, S.4    Hammonds, R.G.5    Reddi, A.H.6
  • 86
    • 0024761677 scopus 로고
    • Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-β-like genes coordinately regulate aspects of embryonic development
    • 86. Lyons, K. M., Pelton, R. W., and Hogan, B. L. M. Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-β-like genes coordinately regulate aspects of embryonic development. Genes Dev 3:1657-1668; 1989.
    • (1989) Genes Dev , vol.3 , pp. 1657-1668
    • Lyons, K.M.1    Pelton, R.W.2    Hogan, B.L.M.3
  • 87
    • 0030300115 scopus 로고    scopus 로고
    • MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and signaling
    • 87. Macías-Silva, M., Abdollah, S., Hoodless, P. A., Pirone, R., Attisano, L., and Wrana, J. L. MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87:1215-1224; 1996.
    • (1996) Cell , vol.87 , pp. 1215-1224
    • Macías-Silva, M.1    Abdollah, S.2    Hoodless, P.A.3    Pirone, R.4    Attisano, L.5    Wrana, J.L.6
  • 88
    • 0028574322 scopus 로고
    • Osteogenic protein-1 (BMP-7) inhibits cell proliferation and stimulates the expression of markers characteristic of osteoblast phenotype in rat osteosarcoma (17/2.8) cells
    • 88. Maliakal, J. C., Asahina, I., Hauscka, P. V., and Sampath, T. K. Osteogenic protein-1 (BMP-7) inhibits cell proliferation and stimulates the expression of markers characteristic of osteoblast phenotype in rat osteosarcoma (17/2.8) cells. Growth Factors 11:227-234; 1994.
    • (1994) Growth Factors , vol.11 , pp. 227-234
    • Maliakal, J.C.1    Asahina, I.2    Hauscka, P.V.3    Sampath, T.K.4
  • 89
    • 0030604542 scopus 로고    scopus 로고
    • TGF-β signaling: Receptors, transducers, and mad proteins
    • 89. Massagué, J. TGF-β signaling: Receptors, transducers, and mad proteins. Cell 85:947-950; 1996.
    • (1996) Cell , vol.85 , pp. 947-950
    • Massagué, J.1
  • 90
    • 0029904671 scopus 로고    scopus 로고
    • Serine/threonine kinase receptors: Mediators of transforming growth factor β signals
    • 90. Massagué, J. and Weis-Gracia, F. Serine/threonine kinase receptors: Mediators of transforming growth factor β signals. Cancer Surv 27:41-64; 1996.
    • (1996) Cancer Surv , vol.27 , pp. 41-64
    • Massagué, J.1    Weis-Gracia, F.2
  • 91
    • 0025905181 scopus 로고
    • Expression cloning of an activin receptor, a predicted transmembrane serine kinase
    • 91. Mathews, L. S. and Vale, W. W. Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell 65:973-982; 1991.
    • (1991) Cell , vol.65 , pp. 973-982
    • Mathews, L.S.1    Vale, W.W.2
  • 92
    • 0031010050 scopus 로고    scopus 로고
    • Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member
    • 92. McPherron, A. C., Lawler, A. M., and Lee, S. J. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 387:83-90; 1997.
    • (1997) Nature , vol.387 , pp. 83-90
    • McPherron, A.C.1    Lawler, A.M.2    Lee, S.J.3
  • 94
    • 6244256053 scopus 로고
    • Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
    • 94. Mishina, Y., Suzuki, A., Ueno, N., and Behringer, R. R. Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev 9:3027-3037; 1995.
    • (1995) Genes Dev , vol.9 , pp. 3027-3037
    • Mishina, Y.1    Suzuki, A.2    Ueno, N.3    Behringer, R.R.4
  • 98
  • 99
    • 0031034589 scopus 로고    scopus 로고
    • Identification of Smad, a human Mad-related protein in the transforming growth factor beta signaling pathway
    • 99. Nakao, A., Roijer, E., Imamura, T., Souchelnytskyi, S., Stenman, G., Heldin, C.-H., and ten Dijke, P. Identification of Smad, a human Mad-related protein in the transforming growth factor beta signaling pathway. J Biol Chem 272:2896-2900; 1997.
    • (1997) J Biol Chem , vol.272 , pp. 2896-2900
    • Nakao, A.1    Roijer, E.2    Imamura, T.3    Souchelnytskyi, S.4    Stenman, G.5    Heldin, C.-H.6    Ten Dijke, P.7
  • 101
    • 0030018425 scopus 로고    scopus 로고
    • Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells
    • 101. Newfeld, S. J., Chartoff, E. H., Graff, J. M., Melton, D. A., and Gilbert, W. M. Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells. Development 122:2099-2108; 1996.
    • (1996) Development , vol.122 , pp. 2099-2108
    • Newfeld, S.J.1    Chartoff, E.H.2    Graff, J.M.3    Melton, D.A.4    Gilbert, W.M.5
  • 102
    • 0027410497 scopus 로고
    • The MAP kinase cascade is essential for diverse signal transduction pathways
    • 102. Nishida, E. and Gotoh, Y. The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci 18:128-131; 1993.
    • (1993) Trends Biochem Sci , vol.18 , pp. 128-131
    • Nishida, E.1    Gotoh, Y.2
  • 104
    • 0029153741 scopus 로고
    • Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors
    • 104. Nohno, T., Ishikawa, T., Hosokawa, K., Noji, S., Wolsing, D. H., and Rosenbaum, J. S. Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors. J Biol Chem 270:22522-22526; 1995.
    • (1995) J Biol Chem , vol.270 , pp. 22522-22526
    • Nohno, T.1    Ishikawa, T.2    Hosokawa, K.3    Noji, S.4    Wolsing, D.H.5    Rosenbaum, J.S.6
  • 105
    • 85120517929 scopus 로고    scopus 로고
    • Orthotopic ossification of the spinal ligaments in Zucker fatty rats: A possible animal model for human ossification of the posterior longitudinal ligament
    • In press
    • 105. Okano, T., Ishidou, Y., Kato, M., Imamura, T., Yonemori, K., Origuchi, N., Matsunaga, S., Yoshida, H., ten Dijke, P., and Sakou, T. Orthotopic ossification of the spinal ligaments in Zucker fatty rats: A possible animal model for human ossification of the posterior longitudinal ligament. J Orthop Res. In press.
    • J Orthop Res.
    • Okano, T.1    Ishidou, Y.2    Kato, M.3    Imamura, T.4    Yonemori, K.5    Origuchi, N.6    Matsunaga, S.7    Yoshida, H.8    Ten Dijke, P.A.9    Sakou, T.10
  • 106
    • 0010417871 scopus 로고    scopus 로고
    • Distinct and overlapping patterns of localization of BMP family members and a BMP type II receptor during fracture healing in rats
    • In press
    • 106. Onishi, T., Ishidou, Y., Nagamine, T., Yone, K., Imamura, T., Kato, M., Sampath, T. K., ten Dijke, P., and Sakou, T. Distinct and overlapping patterns of localization of BMP family members and a BMP type II receptor during fracture healing in rats. Bone. In press.
    • Bone
    • Onishi, T.1    Ishidou, Y.2    Nagamine, T.3    Yone, K.4    Imamura, T.5    Kato, M.6    Sampath, T.K.7    Ten Dijke, P.A.8    Sakou, T.9
  • 109
    • 0023233755 scopus 로고
    • A transcript from a Drosophila pattern gene predict a protein homologous to the transforming growth factor-β family
    • 109. Padgett, R. W., St. Johnston, D., and Gelbalt, W. M. A transcript from a Drosophila pattern gene predict a protein homologous to the transforming growth factor-β family. Nature 325:81-84; 1993.
    • (1993) Nature , vol.325 , pp. 81-84
    • Padgett, R.W.1    St. Johnston, D.2    Gelbalt, W.M.3
  • 110
    • 0027403003 scopus 로고
    • Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo
    • 110. Padgett, R. W., Wozney, J. M., and Gelbert, W. M. Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo. Proc Natl Acad Sci USA 90:2905-2909; 1993.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2905-2909
    • Padgett, R.W.1    Wozney, J.M.2    Gelbert, W.M.3
  • 112
    • 0026563955 scopus 로고
    • The gene for BMP2A is localized to human chromosome 20p12 by radioactive and non-radioactive in situ hybridization
    • 112. Rao, V. V. N. G., Löffler, C., Wozney, J. M., and Hansmann, I. The gene for BMP2A is localized to human chromosome 20p12 by radioactive and non-radioactive in situ hybridization. Human Genet 90:299; 1992.
    • (1992) Human Genet , vol.90 , pp. 299
    • Rao, V.V.N.G.1    Löffler, C.2    Wozney, J.M.3    Hansmann, I.4
  • 113
    • 0026453628 scopus 로고
    • Regulation of cartilage and bone differentiation by bone morphogenetic protein
    • 113. Reddi, A. H. Regulation of cartilage and bone differentiation by bone morphogenetic protein. Curr Opin Cell Biol 4:850-855; 1992.
    • (1992) Curr Opin Cell Biol , vol.4 , pp. 850-855
    • Reddi, A.H.1
  • 114
    • 0028097108 scopus 로고
    • Bone and cartilage differentiation
    • 114. Reddi, A. H. Bone and cartilage differentiation. Curr Opin Genet Develop 4:737-744; 1994.
    • (1994) Curr Opin Genet Develop , vol.4 , pp. 737-744
    • Reddi, A.H.1
  • 115
    • 0031105160 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: An unconventional approach to isolation of first mammalian morphogens
    • 115. Reddi, A. H. Bone morphogenetic proteins: An unconventional approach to isolation of first mammalian morphogens. Cytokine Growth Factor Rev 8:11-20; 1997.
    • (1997) Cytokine Growth Factor Rev , vol.8 , pp. 11-20
    • Reddi, A.H.1
  • 116
    • 0018135520 scopus 로고
    • Association of diffuse idiopathic skeletal hyperostosis (DISH) and calcification and ossification of the posterior longitudinal ligament
    • 116. Resnick, D., Guerra, J., Robinson, C. A., and Vint, V. C. Association of diffuse idiopathic skeletal hyperostosis (DISH) and calcification and ossification of the posterior longitudinal ligament. Am J Roentgenol 131:1049-1053; 1978.
    • (1978) Am J Roentgenol , vol.131 , pp. 1049-1053
    • Resnick, D.1    Guerra, J.2    Robinson, C.A.3    Vint, V.C.4
  • 119
    • 0029911896 scopus 로고    scopus 로고
    • Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7)
    • 119. Ripamont, U., Heever, B. D., Sampath, T. K., Tucker, M. M., Ruegwer, D. C., and Reddi, A. H. Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7). Growth Factors 123:273-289; 1996.
    • (1996) Growth Factors , vol.123 , pp. 273-289
    • Ripamont, U.1    Heever, B.D.2    Sampath, T.K.3    Tucker, M.M.4    Ruegwer, D.C.5    Reddi, A.H.6
  • 120
    • 0029744589 scopus 로고    scopus 로고
    • Signaling pathways in skeletal formation: A role for BMP receptors
    • 120. Rosen, V., Thies, R. S., and Lyons, K. Signaling pathways in skeletal formation: A role for BMP receptors. Ann NY Acad Sci 785:59-69; 1996.
    • (1996) Ann NY Acad Sci , vol.785 , pp. 59-69
    • Rosen, V.1    Thies, R.S.2    Lyons, K.3
  • 123
    • 0025997676 scopus 로고
    • Genetic study of ossification of the posterior longitudinal ligament in the cervical spine with human leukocyte antigen haplotype
    • 123. Sakou, T., Taketomi, E., Matsunaga, S., Yamaguchi, M., Sonoda, S., and Yashiki, S. Genetic study of ossification of the posterior longitudinal ligament in the cervical spine with human leukocyte antigen haplotype. Spine 6:1249-1252; 1991.
    • (1991) Spine , vol.6 , pp. 1249-1252
    • Sakou, T.1    Taketomi, E.2    Matsunaga, S.3    Yamaguchi, M.4    Sonoda, S.5    Yashiki, S.6
  • 124
    • 0023429111 scopus 로고
    • Isolation of osteogenin, an extracellular matrix-associated, bone-inductive protein, by heparin affinity chromatography
    • 124. Sampath, T. K., Muthukumaran, N., and Reddi, A. H. Isolation of osteogenin, an extracellular matrix-associated, bone-inductive protein, by heparin affinity chromatography. Proc Natl Acad Sci USA 84:7109-7113; 1987.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7109-7113
    • Sampath, T.K.1    Muthukumaran, N.2    Reddi, A.H.3
  • 125
    • 0025323376 scopus 로고
    • Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-β superfamily
    • 125. Sampath, T. K., Coughlin, J. E., Whetstone, R. M., Banach, D., Corbett, C., Ridge, R. J., Özkaynak, E., Oppermann, H., and Rueger, D. C. Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-β superfamily. J Biol Chem 265: 13198-13250; 1990.
    • (1990) J Biol Chem , vol.265 , pp. 13198-13250
    • Sampath, T.K.1    Coughlin, J.E.2    Whetstone, R.M.3    Banach, D.4    Corbett, C.5    Ridge, R.J.6    Özkaynak, E.7    Oppermann, H.8    Rueger, D.C.9
  • 126
    • 0026739256 scopus 로고
    • Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro
    • 126. Sampath, T. K., Maniacal, J. C., Hauschka, P. V., Jones, W. K., Sasak, H., Tucker, R. F., White, K. H., Coughlin, J. E., Tucker, M. M., Pang, R. H. L., Corbett, C., Özkaynak, E., Oppermann, H., and Rueger, D. C. Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J Biol Chem 267:20352-20362; 1992.
    • (1992) J Biol Chem , vol.267 , pp. 20352-20362
    • Sampath, T.K.1    Maniacal, J.C.2    Hauschka, P.V.3    Jones, W.K.4    Sasak, H.5    Tucker, R.F.6    White, K.H.7    Coughlin, J.E.8    Tucker, M.M.9    Pang, R.H.L.10    Corbett, C.11    Özkaynak, E.12    Oppermann, H.13    Rueger, D.C.14
  • 127
    • 0027161383 scopus 로고
    • Drosophila TGF-β superfamily proteins induce endochondral bone formation in mammals
    • 127. Sampath, T. K., Rashka, K. E., Doctor, J. S., Tucker, R. F., and Hoffmann, F. M. Drosophila TGF-β superfamily proteins induce endochondral bone formation in mammals. Proc Natl Acad Sci USA 90:6004-6008; 1993.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6004-6008
    • Sampath, T.K.1    Rashka, K.E.2    Doctor, J.S.3    Tucker, R.F.4    Hoffmann, F.M.5
  • 128
    • 0000209736 scopus 로고
    • Structure, function, and orthopedic application of osteogenic protein-1 (OP-1)
    • 128. Sampath, T. K. and Rueger, D. C. Structure, function, and orthopedic application of osteogenic protein-1 (OP-1). Compli Orthop Winter: 101-107; 1994.
    • (1994) Compli Orthop Winter , pp. 101-107
    • Sampath, T.K.1    Rueger, D.C.2
  • 129
    • 0030058914 scopus 로고    scopus 로고
    • Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a novel conserved family of transforming growth factor β pathway components
    • 129. Savage, C., Das, P., Finelli, A., Townsend, S., Sun, C., Bairrd, S., and Padgett, R. Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a novel conserved family of transforming growth factor β pathway components. Proc Natl Acad Sci USA 93:790-794; 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 790-794
    • Savage, C.1    Das, P.2    Finelli, A.3    Townsend, S.4    Sun, C.5    Bairrd, S.6    Padgett, R.7
  • 131
    • 0029897371 scopus 로고    scopus 로고
    • Alternative neural crest cell fates are instructively promoted by TGFβ superfamily members
    • 131. Shah, N. M., Groves, A. K., and Anderson, D. J. Alternative neural crest cell fates are instructively promoted by TGFβ superfamily members. Cell 85:331-343; 1996.
    • (1996) Cell , vol.85 , pp. 331-343
    • Shah, N.M.1    Groves, A.K.2    Anderson, D.J.3
  • 132
    • 0028940853 scopus 로고
    • Genetic characterization and cloning of mothers against dpp, a gene required for decapentalegic function in Drosophila melanogaster
    • 132. Sekelsky, J. J., Newfeld, S. J., Raftery, L. A., Chartoff, E. H., and Gelbart, W. M. Genetic characterization and cloning of Mothers against dpp, a gene required for decapentalegic function in Drosophila melanogaster. Genetics 139:1347-1358; 1995.
    • (1995) Genetics , vol.139 , pp. 1347-1358
    • Sekelsky, J.J.1    Newfeld, S.J.2    Raftery, L.A.3    Chartoff, E.H.4    Gelbart, W.M.5
  • 133
    • 0026646326 scopus 로고
    • Expression cloning of noggin, a new dorsalizing factor localized to the spemann organizer in Xenopus embryos
    • 133. Smith, W. C. and Harland, R. M. Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Cell 70:829-840; 1992.
    • (1992) Cell , vol.70 , pp. 829-840
    • Smith, W.C.1    Harland, R.M.2
  • 134
    • 0029121286 scopus 로고
    • Bone morphogenetic protein-9 binds to liver cells stimulates proliferation
    • 134. Song, J. J., Celeste, A. J., Kong, F.-M., Jirtle, R. L., Rosen, V., and Thies, R. S. Bone morphogenetic protein-9 binds to liver cells stimulates proliferation. Endocrinology 136:4293-4297; 1995.
    • (1995) Endocrinology , vol.136 , pp. 4293-4297
    • Song, J.J.1    Celeste, A.J.2    Kong, F.-M.3    Jirtle, R.L.4    Rosen, V.5    Thies, R.S.6
  • 135
    • 0028232724 scopus 로고
    • Limb alterations in brachypodism mice due to mutations in a new member of the TGF-β superfamily
    • 135. Storm, E. E., Huynh, T. V., Copeland, N. G., Jenkins, N. A., Kingsley, D. M., and Lee, S.-J. Limb alterations in brachypodism mice due to mutations in a new member of the TGF-β superfamily. Nature 368:639-643; 1994.
    • (1994) Nature , vol.368 , pp. 639-643
    • Storm, E.E.1    Huynh, T.V.2    Copeland, N.G.3    Jenkins, N.A.4    Kingsley, D.M.5    Lee, S.-J.6
  • 136
    • 0030481707 scopus 로고    scopus 로고
    • Joint pattering defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family
    • 136. Storm, E. E. and Kingsley, D. M. Joint pattering defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family. Development 122:3969-3979; 1996.
    • (1996) Development , vol.122 , pp. 3969-3979
    • Storm, E.E.1    Kingsley, D.M.2
  • 140
    • 0026068646 scopus 로고
    • Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1
    • 140. Takuwa, Y., Ohse, C., Wang, E. A., Wozney, J. M., and Yamashita, K. Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1. Biochem Biophys Res Commun 174:96-101; 1991.
    • (1991) Biochem Biophys Res Commun , vol.174 , pp. 96-101
    • Takuwa, Y.1    Ohse, C.2    Wang, E.A.3    Wozney, J.M.4    Yamashita, K.5
  • 142
    • 0029944441 scopus 로고    scopus 로고
    • Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors
    • 142. ten Dijke, P., Miyazono, K., and Heldin, C.-H. Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. Curr Opin Cell Biol 8:139-145; 1996.
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 139-145
    • Ten Dijke, P.1    Miyazono, K.2    Heldin, C.-H.3
  • 143
    • 0026603456 scopus 로고
    • Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells
    • 143. Thies, R. S., Bauduy, M., Ashton, B. A., Kurtzberg, L., Wozney, J. M., and Rosen, V. Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinology 130:1318-1324; 1992.
    • (1992) Endocrinology , vol.130 , pp. 1318-1324
    • Thies, R.S.1    Bauduy, M.2    Ashton, B.A.3    Kurtzberg, L.4    Wozney, J.M.5    Rosen, V.6
  • 144
  • 145
    • 0029834231 scopus 로고    scopus 로고
    • Xenopus mothers against decapentalgic is an embryonic ventralizing agent that acts downstream of BMP-2/-4 receptor
    • 145. Thomsen, G. H. Xenopus mothers against decapentalgic is an embryonic ventralizing agent that acts downstream of BMP-2/-4 receptor. Development 122:2359-2366; 1996.
    • (1996) Development , vol.122 , pp. 2359-2366
    • Thomsen, G.H.1
  • 146
    • 0025950741 scopus 로고
    • Mandibular reconstruction with a recombinant bone-inducing factor. Functional, histologic, and biomechanical evaluation
    • 146. Toriumi, D. M., Kotler, H. S., Luxenberg, D. P., Holtrop, M. E., and Wang, E. A. Mandibular reconstruction with a recombinant bone-inducing factor. Functional, histologic, and biomechanical evaluation. Arch Otolaryngol Head Neck Surg 117:1101-1112; 1991.
    • (1991) Arch Otolaryngol Head Neck Surg , vol.117 , pp. 1101-1112
    • Toriumi, D.M.1    Kotler, H.S.2    Luxenberg, D.P.3    Holtrop, M.E.4    Wang, E.A.5
  • 147
    • 0025864713 scopus 로고
    • Platelet-derived growth factor B chain homodimer enhances chemotaxis and DNA synthesis in normal osteoblast-like cells (MC3T3-E1)
    • 147. Tsukamoto, T., Matsui, T., Fukase, M., and Fujita, T. Platelet-derived growth factor B chain homodimer enhances chemotaxis and DNA synthesis in normal osteoblast-like cells (MC3T3-E1). Biochem Biophys Res Commun 175:745-751; 1991.
    • (1991) Biochem Biophys Res Commun , vol.175 , pp. 745-751
    • Tsukamoto, T.1    Matsui, T.2    Fukase, M.3    Fujita, T.4
  • 148
    • 34250019537 scopus 로고
    • Bone formation by autoinduction
    • 148. Urist, M. R. Bone formation by autoinduction. Science 150:893-899; 1965.
    • (1965) Science , vol.150 , pp. 893-899
    • Urist, M.R.1
  • 149
    • 0001817964 scopus 로고
    • Practical application of basic research on bone graft physiology
    • 149. Urist, M. R. Practical application of basic research on bone graft physiology. AAOS Instr Course Lee 25:1-26; 1976.
    • (1976) AAOS Instr Course Lee , vol.25 , pp. 1-26
    • Urist, M.R.1
  • 150
    • 0019434265 scopus 로고
    • Intertransverse process fusion with the aid of chemosterized autolyzed antigen-extracted allogenic (AAA) bone
    • 150. Urist, M. R. and Dawson, E. Intertransverse process fusion with the aid of chemosterized autolyzed antigen-extracted allogenic (AAA) bone. Clin Orthop 154:97-113; 1981.
    • (1981) Clin Orthop , vol.154 , pp. 97-113
    • Urist, M.R.1    Dawson, E.2
  • 152
    • 0024389202 scopus 로고
    • Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin
    • 152. Vukicevic, S., Luyten, F. P., and Reddi, A. H. Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin. Proc Natl Acad Sci USA 86:8793-8797; 1989.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 8793-8797
    • Vukicevic, S.1    Luyten, F.P.2    Reddi, A.H.3
  • 153
    • 0028306248 scopus 로고
    • Localization of osteogenic protein-1 (bone morphogenetic protein-7) during human embryonic development: High affinity binding to basement membranes
    • 153. Vukicevic, S., Latin, V., Chen, P., Batorsky, R., Reddi, A. H., and Sampath, T. K. Localization of osteogenic protein-1 (bone morphogenetic protein-7) during human embryonic development: High affinity binding to basement membranes. Biochem Biophys Res Commun 198:693-700; 1994.
    • (1994) Biochem Biophys Res Commun , vol.198 , pp. 693-700
    • Vukicevic, S.1    Latin, V.2    Chen, P.3    Batorsky, R.4    Reddi, A.H.5    Sampath, T.K.6
  • 154
    • 0027404155 scopus 로고
    • Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6)
    • 154. Wall, N. A., Blessing, M., Wright, C. V. E., and Hogan, B. L. M. Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). J Cell Biol 120:493-502; 1993.
    • (1993) J Cell Biol , vol.120 , pp. 493-502
    • Wall, N.A.1    Blessing, M.2    Wright, C.V.E.3    Hogan, B.L.M.4
  • 157
    • 0027185702 scopus 로고
    • Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells
    • 157. Wang, E. A., Israel, D., Kelly, S., and Luxenburg, D. P. Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells. Growth Factors 19:57-71; 1993.
    • (1993) Growth Factors , vol.19 , pp. 57-71
    • Wang, E.A.1    Israel, D.2    Kelly, S.3    Luxenburg, D.P.4
  • 158
    • 0027367937 scopus 로고
    • Signaling activity of TGF-β type II receptors lacking specific domains in the cytoplasmic regions
    • 158. Wieser, R., Attisano, L., Wrana, J. L., and Massagué, J. Signaling activity of TGF-β type II receptors lacking specific domains in the cytoplasmic regions. Mol Cell Biol 13:7239-7247; 1993.
    • (1993) Mol Cell Biol , vol.13 , pp. 7239-7247
    • Wieser, R.1    Attisano, L.2    Wrana, J.L.3    Massagué, J.4
  • 159
    • 0029022221 scopus 로고
    • GS domain mutations that constitutively activate TβR-I, the downstream signaling component in the TGF-β receptor complex
    • 159. Wieser, R., Wrana, J. L., and Massagué, J. GS domain mutations that constitutively activate TβR-I, the downstream signaling component in the TGF-β receptor complex. Eur Mol Biol Org J 14:2199-2208; 1995.
    • (1995) Eur Mol Biol Org J , vol.14 , pp. 2199-2208
    • Wieser, R.1    Wrana, J.L.2    Massagué, J.3
  • 160
    • 0029149656 scopus 로고
    • Bone morphogenetic protein-4 is required for mesodermal formation and patterning in the mouse
    • 160. Winner, G., Blessing, M., Labosky, P. A., and Hogan, B. L. M. Bone morphogenetic protein-4 is required for mesodermal formation and patterning in the mouse. Genes Dev 9:2105-2116; 1995.
    • (1995) Genes Dev , vol.9 , pp. 2105-2116
    • Winner, G.1    Blessing, M.2    Labosky, P.A.3    Hogan, B.L.M.4
  • 163
    • 0002598756 scopus 로고
    • Bone morphogenetic proteins and their gene expression
    • Noda, M., Eds. San Diego: Academic
    • 163. Wozney, J. M. Bone morphogenetic proteins and their gene expression. In: Noda, M., Eds. Cellular and Molecular Biology of Bone. San Diego: Academic; 1993; 131-167.
    • (1993) Cellular and Molecular Biology of Bone , pp. 131-167
    • Wozney, J.M.1
  • 165
    • 0025857671 scopus 로고
    • Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro
    • 165. Yamaguchi, A., Katagiri, T., Ikeda, T., Wozney, J. M., Rosen, V., Wang, E. A., Kahn, A. J., Suda, T., and Yoshiki, S. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J Cell Biol 113:681-687; 1991.
    • (1991) J Cell Biol , vol.113 , pp. 681-687
    • Yamaguchi, A.1    Katagiri, T.2    Ikeda, T.3    Wozney, J.M.4    Rosen, V.5    Wang, E.A.6    Kahn, A.J.7    Suda, T.8    Yoshiki, S.9
  • 166
    • 0029317997 scopus 로고
    • Relation of differentiation pathway of skeletal mesenchymal cell in cell lines by transforming growth factor-β superfamily
    • 166. Yamaguchi, A. Relation of differentiation pathway of skeletal mesenchymal cell in cell lines by transforming growth factor-β superfamily. J Cell Biol 6:165-173; 1995.
    • (1995) J Cell Biol , vol.6 , pp. 165-173
    • Yamaguchi, A.1
  • 167
    • 0027930903 scopus 로고
    • Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-β
    • 167. Yamashita, H., ten Dijke, P., Franzén, P., Miyazono, K., and Heldin, C. H. Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-β. J Biol Chem 269:20172-20178; 1994.
    • (1994) J Biol Chem , vol.269 , pp. 20172-20178
    • Yamashita, H.1    Ten Dijke, P.2    Franzén, P.3    Miyazono, K.4    Heldin, C.H.5
  • 171
    • 0026757708 scopus 로고
    • The healing of segmental defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats
    • 171. Yasko, A. W., Lane, J. M., Fellinger, E. F., Rosen, V., Wozney, J. M., and Wang, E. A. The healing of segmental defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats. J Bone Jt Surg 74-A:659-670; 1992.
    • (1992) J Bone Jt Surg , vol.74 A , pp. 659-670
    • Yasko, A.W.1    Lane, J.M.2    Fellinger, E.F.3    Rosen, V.4    Wozney, J.M.5    Wang, E.A.6
  • 173
    • 0030895267 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissue of patients with ossification of the posterior longitudinal ligament
    • 173. Yonemori, K., Imamura, T., Ishidou, Y., Okano, T., Matsunaga, S., Yoshida, H., Kato, M., Sampath, T. K., Miyazono, K., ten Dijke, P., and Sakou, T. Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissue of patients with ossification of the posterior longitudinal ligament. Am J Pathol 150:1335-1347; 1997.
    • (1997) Am J Pathol , vol.150 , pp. 1335-1347
    • Yonemori, K.1    Imamura, T.2    Ishidou, Y.3    Okano, T.4    Matsunaga, S.5    Yoshida, H.6    Kato, M.7    Sampath, T.K.8    Miyazono, K.9    Ten Dijke, P.A.10    Sakou, T.11
  • 174
    • 0029850112 scopus 로고    scopus 로고
    • Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
    • 174. Zhang, H. and Bradley, A. Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development 122:2977-2986; 1996.
    • (1996) Development , vol.122 , pp. 2977-2986
    • Zhang, H.1    Bradley, A.2
  • 175
    • 0029775560 scopus 로고    scopus 로고
    • The gene encoding bone morphogenetic protein 8b is required for the initiation and maintenance of spermatogenesis in the mouse
    • 175. Zhao, G. O., Deng, K., Labosky, P. A., Liaw, L., and Hogan, B. L. M. The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. Genes Dev 10:1657-1669; 1996.
    • (1996) Genes Dev , vol.10 , pp. 1657-1669
    • Zhao, G.O.1    Deng, K.2    Labosky, P.A.3    Liaw, L.4    Hogan, B.L.M.5
  • 176
    • 0030598829 scopus 로고    scopus 로고
    • The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
    • 176. Zimmerman, L. B., De Jesus-Escobar, J. M., and Harland, R. M. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86:599-606; 1996.
    • (1996) Cell , vol.86 , pp. 599-606
    • Zimmerman, L.B.1    De Jesus-Escobar, J.M.2    Harland, R.M.3
  • 177
    • 0029876835 scopus 로고    scopus 로고
    • Requirement for BMP signaling in interdigital apoptosis and scale formation
    • 177. Zou, H. and Niswander, L. Requirement for BMP signaling in interdigital apoptosis and scale formation. Science 272:738-741; 1996.
    • (1996) Science , vol.272 , pp. 738-741
    • Zou, H.1    Niswander, L.2
  • 178
    • 0030955344 scopus 로고    scopus 로고
    • Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage
    • 178. Zou, H., Wieser, R., Massague, J., and Niswander, L. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev 11:2191-2203; 1997.
    • (1997) Genes Dev , vol.11 , pp. 2191-2203
    • Zou, H.1    Wieser, R.2    Massague, J.3    Niswander, L.4
  • 179
    • 77957216320 scopus 로고
    • Fatty, a new mutation in the rat
    • 179. Zucker, L. M. and Zucker, T. Fatty, a new mutation in the rat. J Hered 52:275-278; 1961.
    • (1961) J Hered , vol.52 , pp. 275-278
    • Zucker, L.M.1    Zucker, T.2
  • 180
    • 0023789143 scopus 로고
    • Short gastrulation, a mutation causing delays in stage-specific cell shape changes during gastrulation in Drosophila melanogaster
    • 180. Zusman, S. B., Sweeton, D., and Wieschaus, E. F. Short gastrulation, a mutation causing delays in stage-specific cell shape changes during gastrulation in Drosophila melanogaster. Dev Biol 129:417-427; 1988.
    • (1988) Dev Biol , vol.129 , pp. 417-427
    • Zusman, S.B.1    Sweeton, D.2    Wieschaus, E.F.3


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