The p21RAS farnesyltransferase α subunit in TGF-β and activin signaling

Science

Volumn 271, Issue 5252, 1996, Pages 1120-1122

  Wang, Tongwen ^a   Danielson, Paul D ^a   Li, Bi Yu ^a   Shah, Paresh C ^a   Kim, Stephen D ^a   Donahoe, Patricia K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN FARNESYLTRANSFERASE; PROTEIN SUBUNIT; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ACTIVIN RECEPTORS; ACTIVIN RECEPTORS, TYPE I; ACTIVINS; ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; HUMANS; INHIBINS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSFERASES; TRANSFORMING GROWTH FACTOR BETA;

EID: 0029670049     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.271.5252.1120     Document Type: Article

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38. We are grateful to J. Goldstein and G. James fo FNTA and FNTB antibodies and many helpful suggestions, A. Roberts and R. Lechleider for R4 anti serum, and R. Brent for LexA antiserum and all the yeast strains and plasmids of the yeast protein trap system. The human fetal brain library and the Dro sophila imaginai disc library were gifts from R Brent at Harvard. The 15-O-desmethyl-FK520 infrom Sandoz (a gift from H. Fliri). We also thank S Rockwell and Y. Wang for technical assistance This work is supported by a National Institute o Child Health and Human Development Reproduc tive Sciences Training Grant (T.W.), by fellowships from Gynecological Oncology, Massachusetts General Hospital (MGH) (B.-y L.), the Departmen of Surgery, MGH, and the Surdna Foundatior (P.C S.), and the Department of Surgery, University of Rochester (P.D.D.), and by NIH National Institute of Child Health and Human Development grants R01HD3081 and R01HD32112 and a Reproductive Sciences Center grant (HD28138) from the Child Health Institute (P K.D.).