Structural alterations in the transcription factor PEBP2/CBF linked to four different types of leukemia

Journal of Cancer Research and Clinical Oncology

Volumn 122, Issue 5, 1996, Pages 266-274

  Ito, Yoshiaki ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

ALL; AML; Heterodimer; inv(16); t(12; 21); t(3; 21); t(8; 21)

Indexed keywords

TRANSCRIPTION FACTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; CHROMOSOME INVERSION; CHROMOSOME TRANSLOCATION; HUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; DNA-BINDING PROTEINS; HUMANS; INVERSION, CHROMOSOME; LEUKEMIA; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 0029866537     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01261402     Document Type: Review

References (46)

1. Amati P (1985) Polyoma regulatory region: a potential probe for mouse cell differentiation. Cell 43:561-562
2. Asano M, Murakami Y, Furukawa K, Yamaguchi-Iwai Y, Satake M, Ito Y (1990) A polyomavirus enhancer-binding protein, PEBP5, responsive to 12-O-tetradecanoylphorbol-13-acetate but distinct from AP-1. J Virol 64:5927-5938
3. Bae SC, Yamaguchi-Iwai Y, Ogawa E, Maruyama M, Inuzuka M, Kagoshima K, Shigesada K, Satake M, Ito Y (1993) Isolation of PEBP2αB cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1. Oncogene 8:809-814
4. Bae SC, Ogawa E, Maruyama M, Oka M, Satake M, Shigesada K, Jenkins NA, Gilbert DJ, Copeland NG, Ito Y (1994) PEBP2αB/ mouse AML1 consists of multiple isoforms that possess differential transactivation potentials. Mol Cell Biol 14:3242-3252
5. Bae SC, Takahashi E, Zhang YW, Ogawa E, Shigesada K, Namba Y, Satake M, Ito Y (1995) Cloning, mapping and expression of PEBP2αC, a third gene encoding the mammalian Runt domain. Gene 159:245-248
6. Daga A, Tighe JE, Calabi F (1992) Leukaemia/Drosophila homology. Nature 356:484
7. Erickson P, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley J, Drabkin H (1992) Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood 80: 1825-1831
8. Giese K, Kingsley C, Kirshner JR, Grosschedl R (1995) Assembly and function of a TCRα enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev 9:995-1008
9. Golub TR, Barker GF, Lovett M, Gilliland DG (1994) Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77:307-316
10. Golub T, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD, Gilliland DG (1995) Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA 92:4917-4921
11. Hajra A, Liu PP, Wang Q, Kelley CA, Stacy T, Adelstein RS, Speck NA, Collins FS (1995) The leukemic core binding factor β-smooth muscle myosin heavy chain (CBFβ-SMMHC) chimeric protein requires both CBFβ and myosin heavy chain domains for transformation of NIH 3T3 cells. Proc Natl Acad Sci USA 92:1926-1930
12. Kagoshima H, Shigesada K, Satake M, Ito Y, Miyoshi H, Ohki M, Pepling M, Gergen P (1993) The Runt-domain identifies a new family of heteromeric DNA-binding transcriptional regulatory proteins. Trends Genet 9:338-341
13. Kamachi Y, Ogawa E, Asano M, Ishida S, Murakami Y, Satake M, Ito Y, Shigesada K (1990) Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer. J Virol 64:4808-4819
14. Kania MA, Bonner AS, Duffy JB, Gergen JP (1990) The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system. Genes Dev 4:1701-1713
15. Levanon D, Negreanu V, Bernstein, Y, Bar-Am I, Avivi L, Groner Y (1994) AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. Genomics 23:425-432
16. Liu P, Tarlé SA, Hajra A, Claxton DF, Marlton P, Freedman M, Siciliano MJ, Collins FS (1993) Fusion between transcription factor CBFβ/PEBP2β and a myosin heavy chain in acute myeloid leukemia. Science 261:1041-1044
17. Liu PP, Hajra A, Wijmenga C, Collins FS (1995) Molecular pathogenesis of the chromosome 16 inversion in the M4Eo subtype of acute myeloid leukemia. Blood 85:2289-2302
18. Lu J, Maruyama M, Satake M, Bae SC, Ogawa E, Kagoshima H, Shigesada K, Ito Y (1995) Subcellular localization of the a and β subunits of acute myeloid leukemia-linked transcription factor PEBP2. Mol Cell Biol 15:1651-1661
19. Melnikova I, Crute BE, Wang S, Speck NA (1993) Sequence specificity of the core-binding factor. J Virol 67:2408-2411
20. Meyers S, Downing JR, Hiebert SW (1993) Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. Mol Cell Biol 13:6336-6345.
21. Meyers S, Lenny N, Hiebert SW (1995) The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Mol Cell Biol 15:1974-1982
22. Mitani K, Ogawa S, Tanaka T, Miyoshi H, Kurokawa M, Mano H, Yazaki Y, Ohki M, Hirai H (1994) Generation of the AML1-EVI-1 fusion gene in the t(3;21) (q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J 13:504-510
23. Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M (1991) t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene. AML1. Proc Natl Acad Sci USA 88:10431-10434
24. Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N, Ohki M (1993) The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J 12:2715-2721
25. Miyoshi H, Ohira M, Shimizu K, Mitani K, Hirai H, Imai T, Yokoyama K, Soeda E, Ohki M (1995) Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia. Nucleic Acids Res 23:2762-2769
26. Morishita K, Parker DS, Mucenski M L, Jenkins NA, Copeland, NG, Ihle JN (1988) Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell 54:831-840
27. Nucifora G, Rowley JD (1995) AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia. Blood 86: 1-14
28. Nucifora G, Birn DJ, Espinosa III R, Erickson P, LeBeau MM, Roulston D, McKeithan TW, Drabkin H. Rowley JD (1993a) Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in Chronic myeloid leukemia in blast crisis. Blood 81:2728-2734
29. Nucifora G, Begy CR, Erickson P, Drabkin HA, Rowley JD (1993b) The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1. Proc Natl Acad Sci USA 90: 7784-7788
30. Nucifora G, Begy CR, Kobayashi H, Roulston D, Claxton F, Pedersen-Bjergaard J, Parganas E, Ihle H, Rowley JD (1994) Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in the (3;21)(q26;q22) translocation. Proc Natl Acad Sci USA 91:4004-4008
31. Ogawa E, Maruyama M, Kagoshima H, Inuzuka M, Lu J, Satake M, Shigesada K, Ito Y (1993a) PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc Natl Acad Sci USA 90:6859-6863
32. Ogawa E, Inuzuka M, Maruyama M, Satake M, Naito-Fujimoto M, Ito Y, Shigesada K (1993b) Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α. Virology 194:314-331
33. Sakakura C, Yamaguchi-Iwai Y, Satake M, Bae SC, Takahashi A, Ogawa E, Hagiwara A, Takahashi T, Murakami A, Makino K, Nakagawa T, Kamada N, Ito Y (1994) Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukemia cells by the DNA-binding domain of PEBP2 and the AML1/ MTG8(ETO)-specific antisense oligonucleotide. Proc Natl Acad Sci USA 91:11 723-11 727
34. Satake M, Ibaraki T, Ito Y (1988) Modulation of polyomavirus enhancer binding proteins by Ha-ras oncogene. Oncogene 3:69-78
35. Satake M, Inuzuka M, Shigesada K, Oikawa T, Ito Y (1992) Differential expression of subspecies of polyomavirus and murine leukemia virus enhancer core binding protein, PEBP2, in various hematopoietic cells. Jpn J Cancer Res 83:714-722
36. Speck NA, Renjifo B, Golemis E, Fredrickson TN, Hartley JW, Hopkins N (1990) Mutation of the core or adjacent LVb elements of the Moloney murine leukemia virus enhancer alters disease specificity. Genes Dev 4:233-242
37. Sun W, Graves BJ, Speck NA (1995) Transactivation of the Moloney murine leukemia virus and T-Cell receptor β-chain enhancers by cbf and ets requires intact binding sites for both proteins, J Virol 69:4941-4949
38. Tanaka T, Mitani K, Kurokawa M, Ogawa S, Tanaka K, Nishida J, Yazaki Y, Shibata Y, Mirai H (1995) Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias. Mol Cell Biol 15:2383-2392
39. Tighe JE, Calabi F (1994) Alternative, out-of-frame runt/ MTG8 transcripts are encoded by the derivative(8) chromosome in the t(8;21) of acute myeloid leukemia m2. Blood 84: 2115-2121
40. Tighe JE, Daga A, Calabi F (1993) Translocation breakpoints are clustered on both chromosome 8 and chromosome 21 in the t(8;21) of acute myeloid leukemia. Blood 81:592-596
41. Wang S, Speck NA (1992) Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers. Mol Cell Biol 12:89-102
42. Wang S, Wang Q, Crute BE, Melnikova IN, Keller SR, Speck NA (1993) Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol 13:3324-3339
43. Weiher H, Zonig M, Gruss P (1983) Multiple point mutations affecting the simian virus 40 enhance. Science 219:626-631
44. Wijmenga C, Speck NA, Dracopoli NC, Hofker MH, Liu P, Collins FS (1995) Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter. Genomics 26:611-614
45. Wotton D, Ghysdael J, Wang S, Speck NA, Owen MJ (1994) Cooperative binding of Ets-1 and core binding factor to DNA. Mol Cell Biol 14:840-850
46. Yamaguchi Y, Satake M, Ito Y (1989) Two overlapping sequence motifs within the polyomavirus enhancer are independently the targets of stimulation by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the Ha-ras oncogene. J Virol 63:1040-1048