메뉴 건너뛰기




Volumn 13, Issue 8, 1999, Pages 1188-1199

Effects of TGF-β on the immune system: Implications for cancer immunotherapy

Author keywords

Cancer immunotherapy; Immunosuppression; Leukemia; TGF

Indexed keywords

ALPHA 2 MACROGLOBULIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 1; INTERLEUKIN 2; RETINOIC ACID; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032868805     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401477     Document Type: Review
Times cited : (146)

References (152)
  • 1
    • 0028180315 scopus 로고
    • The TGF-β superfamily: New members, new receptors, and new genetic tests of function in different organisms
    • Kingsley DM. The TGF-β superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev 1994; 8: 133-146.
    • (1994) Genes Dev , vol.8 , pp. 133-146
    • Kingsley, D.M.1
  • 2
    • 0030849889 scopus 로고    scopus 로고
    • Transforming growth factor-β: The breaking open of a black box
    • Alevizopoulos A, Mermod N. Transforming growth factor-β: the breaking open of a black box. Bio Essays 1997; 19: 581-591.
    • (1997) Bio Essays , vol.19 , pp. 581-591
    • Alevizopoulos, A.1    Mermod, N.2
  • 5
    • 0027165486 scopus 로고
    • Differential growth factor production, secretion, and response by high and low metastatic variants of B16BL6 melanoma
    • Blanckaert VD, Schelling ME, Elstad CA, Meadows GG. Differential growth factor production, secretion, and response by high and low metastatic variants of B16BL6 melanoma. Cancer Res 1993; 53: 4075-4081.
    • (1993) Cancer Res , vol.53 , pp. 4075-4081
    • Blanckaert, V.D.1    Schelling, M.E.2    Elstad, C.A.3    Meadows, G.G.4
  • 6
    • 0031451835 scopus 로고    scopus 로고
    • Oncogene and cytokine expression of human colorectal tumors responding to immunotherapy
    • Doran T, Stuhlmiller H, Kim JA, Martin EW Jr, Triozzi PL. Oncogene and cytokine expression of human colorectal tumors responding to immunotherapy. J Immunother 1997; 20: 372-376.
    • (1997) J Immunother , vol.20 , pp. 372-376
    • Doran, T.1    Stuhlmiller, H.2    Kim, J.A.3    Martin E.W., Jr.4    Triozzi, P.L.5
  • 7
    • 0030874596 scopus 로고    scopus 로고
    • Critical stages of tumor growth regulation in transgenic mice harboring a hepatocellular carcinoma revealed by distinct patterns of tumor necrosis factor-β and transforming growth factor-β mRNA production
    • Romieu R, Lacabanne V, Kayibanda M, Antoine B, Bennoun M, Chouaib S, Guillet JG, Viguier M. Critical stages of tumor growth regulation in transgenic mice harboring a hepatocellular carcinoma revealed by distinct patterns of tumor necrosis factor-β and transforming growth factor-β mRNA production. Int Immunol 1997; 9: 1405-1413.
    • (1997) Int Immunol , vol.9 , pp. 1405-1413
    • Romieu, R.1    Lacabanne, V.2    Kayibanda, M.3    Antoine, B.4    Bennoun, M.5    Chouaib, S.6    Guillet, J.G.7    Viguier, M.8
  • 8
    • 0031058008 scopus 로고    scopus 로고
    • Human ex vivo carcinoma cells produce transforming growth factor beta and thereby can inhibit lymphocyte functions in vitro
    • Vánky F, Nagy N, Hising C, Sjovall K, Larson B, Klein E. Human ex vivo carcinoma cells produce transforming growth factor beta and thereby can inhibit lymphocyte functions in vitro. Cancer Immunol Immunother 1997; 42: 317-323.
    • (1997) Cancer Immunol Immunother , vol.42 , pp. 317-323
    • Vánky, F.1    Nagy, N.2    Hising, C.3    Sjovall, K.4    Larson, B.5    Klein, E.6
  • 9
    • 0031948084 scopus 로고    scopus 로고
    • A subset of metastatic human colon cancers expresses elevated levels of transforming growth factor betal
    • Picon A, Gold LI, Wang J, Cohen A, Friedman E. A subset of metastatic human colon cancers expresses elevated levels of transforming growth factor betal. Cancer Epidemiol Biomarkers Prev 1998; 7: 497-504.
    • (1998) Cancer Epidemiol Biomarkers Prev , vol.7 , pp. 497-504
    • Picon, A.1    Gold, L.I.2    Wang, J.3    Cohen, A.4    Friedman, E.5
  • 10
    • 0031928528 scopus 로고    scopus 로고
    • Transforming growth factor betal is associated with angiogenesis, metastasis, and poor clinical outcome in protstate cancer
    • Wikström P, Stattin P, Franck-Lissbrant I, Damber JE, Bergh A. Transforming growth factor betal is associated with angiogenesis, metastasis, and poor clinical outcome in protstate cancer. Prostate 1998; 37: 19-29.
    • (1998) Prostate , vol.37 , pp. 19-29
    • Wikström, P.1    Stattin, P.2    Franck-Lissbrant, I.3    Damber, J.E.4    Bergh, A.5
  • 11
    • 0030974902 scopus 로고    scopus 로고
    • Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta
    • Nunes I, Gleizes PE, Metz CN, Rifkin DB. Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta. J Cell Biol 1997; 136: 1151-1163.
    • (1997) J Cell Biol , vol.136 , pp. 1151-1163
    • Nunes, I.1    Gleizes, P.E.2    Metz, C.N.3    Rifkin, D.B.4
  • 12
    • 0030908028 scopus 로고    scopus 로고
    • Latent transforming growth factor-beta: Structural features and mechanisms of activation
    • Munger JS, Harpel JG, Gleizes PE, Mazzieri R, Nunes I, Rifkin DB. Latent transforming growth factor-beta: structural features and mechanisms of activation. Kidney Int 1997; 51: 1376-1382.
    • (1997) Kidney Int , vol.51 , pp. 1376-1382
    • Munger, J.S.1    Harpel, J.G.2    Gleizes, P.E.3    Mazzieri, R.4    Nunes, I.5    Rifkin, D.B.6
  • 13
    • 0025785601 scopus 로고
    • Cytokine binding and clearance properties of proteinase-activated α2-macroglobulins
    • LaMarre J, Wollenberg GK, Gonias SL, Hayes MA. Cytokine binding and clearance properties of proteinase-activated α2-macroglobulins. Lab Invest 1991; 65: 3-14.
    • (1991) Lab Invest , vol.65 , pp. 3-14
    • LaMarre, J.1    Wollenberg, G.K.2    Gonias, S.L.3    Hayes, M.A.4
  • 14
    • 0031240004 scopus 로고    scopus 로고
    • TGF-β: A critical modulator of immune cell function
    • Letterio JJ, Roberts AB. TGF-β: a critical modulator of immune cell function. Clin Immunol Immunopathol 1997; 84: 251-259.
    • (1997) Clin Immunol Immunopathol , vol.84 , pp. 251-259
    • Letterio, J.J.1    Roberts, A.B.2
  • 16
    • 0027967771 scopus 로고
    • Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in chemically defined system
    • Schultz-Cherry S, Ribeiro S, Gentry L, Murphy-Ullrich JE. Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in chemically defined system. J Biol Chem 1994; 269: 26775-26782.
    • (1994) J Biol Chem , vol.269 , pp. 26775-26782
    • Schultz-Cherry, S.1    Ribeiro, S.2    Gentry, L.3    Murphy-Ullrich, J.E.4
  • 17
    • 0026699253 scopus 로고
    • Particular types of tumour cells have the capacity to convert transforming growth factor β from a latent to an active form
    • Takiuchi H, Tada T, Li XF, Ogata M, Ikeda T, Fujimoto S, Fujiwara H, Hamaoka T. Particular types of tumour cells have the capacity to convert transforming growth factor β from a latent to an active form. Cancer Res 1992; 52: 5641-5646.
    • (1992) Cancer Res , vol.52 , pp. 5641-5646
    • Takiuchi, H.1    Tada, T.2    Li, X.F.3    Ogata, M.4    Ikeda, T.5    Fujimoto, S.6    Fujiwara, H.7    Hamaoka, T.8
  • 18
    • 0029097036 scopus 로고
    • Identification of a transforming growth factor beta-1 activator derived from a human gastric cancer cell line
    • Horimoto M, Kato J, Takimoto R, Terui T, Mogi Y, Niitsu Y. Identification of a transforming growth factor beta-1 activator derived from a human gastric cancer cell line. Br J Cancer 1995; 72: 676-682.
    • (1995) Br J Cancer , vol.72 , pp. 676-682
    • Horimoto, M.1    Kato, J.2    Takimoto, R.3    Terui, T.4    Mogi, Y.5    Niitsu, Y.6
  • 19
    • 0028845062 scopus 로고
    • Signaling by the transforming growth factor-β receptors
    • Yingling JM, Wang XF, Bassing CH. Signaling by the transforming growth factor-β receptors. Biochim Biophys Acta 1995; 1242: 115-136.
    • (1995) Biochim Biophys Acta , vol.1242 , pp. 115-136
    • Yingling, J.M.1    Wang, X.F.2    Bassing, C.H.3
  • 21
    • 0031438047 scopus 로고    scopus 로고
    • TGF-β signalling from cell membrane to nucleus through SMAD proteins
    • Heldin CH, Myazono K, ten Dijke P. TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 1997; 390: 465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Myazono, K.2    Ten Dijke, P.3
  • 22
    • 0032528041 scopus 로고    scopus 로고
    • Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors
    • Kawabata M, Inoue H, Hanyu A, Imamura T, Miyazono K. Smad proteins exist as monomers in vivo and undergo homo-and hetero-oligomerization upon activation by serine/threonine kinase receptors. EMBO J 1998; 17: 4056-4065.
    • (1998) EMBO J , vol.17 , pp. 4056-4065
    • Kawabata, M.1    Inoue, H.2    Hanyu, A.3    Imamura, T.4    Miyazono, K.5
  • 23
    • 0032572723 scopus 로고    scopus 로고
    • Smad3 and smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
    • Zhang Y, Feng X-H, Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription. Nature 1998; 394:909-913.
    • (1998) Nature , vol.394 , pp. 909-913
    • Zhang, Y.1    Feng, X.-H.2    Derynck, R.3
  • 25
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways
    • Lagna G, Hata A, Hemmati-Brivanlou A, Massague J. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature 1996; 383: 832-836.
    • (1996) Nature , vol.383 , pp. 832-836
    • Lagna, G.1    Hata, A.2    Hemmati-Brivanlou, A.3    Massague, J.4
  • 27
    • 0032521421 scopus 로고    scopus 로고
    • The Smad5 gene is involved in the intracellular signaling pathways that mediate the inhibitory effects of transforming growth factor-beta on human hematopoiesis
    • Bruno E, Horrigan SK, van den Berg D, Rozler E, Fitting PR, Moss ST, Westbrook C, Hoffman R. The Smad5 gene is involved in the intracellular signaling pathways that mediate the inhibitory effects of transforming growth factor-beta on human hematopoiesis. Blood 1998; 91: 1917-1923.
    • (1998) Blood , vol.91 , pp. 1917-1923
    • Bruno, E.1    Horrigan, S.K.2    Van Den Berg, D.3    Rozler, E.4    Fitting, P.R.5    Moss, S.T.6    Westbrook, C.7    Hoffman, R.8
  • 28
    • 0025326725 scopus 로고
    • Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation
    • Laiho M, DeCaprio JA, Ludlow JW, Livingston DM, Massagué J. Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation. Cell 1990; 62: 175-185.
    • (1990) Cell , vol.62 , pp. 175-185
    • Laiho, M.1    DeCaprio, J.A.2    Ludlow, J.W.3    Livingston, D.M.4    Massagué, J.5
  • 29
    • 0030657690 scopus 로고    scopus 로고
    • The restriction point and control of cell proliferation
    • Planas-Silva MD, Weinberg RA. The restriction point and control of cell proliferation. Curr Opin Cell Biol 1997; 9: 768-772.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 768-772
    • Planas-Silva, M.D.1    Weinberg, R.A.2
  • 30
    • 0028959644 scopus 로고
    • Cdk4 integrates growth stimulatory and inhibitory signals during G1 phase of hematopoietic cells
    • Ando K, Griffin JD. Cdk4 integrates growth stimulatory and inhibitory signals during G1 phase of hematopoietic cells. Oncogene 1995; 10: 751-755.
    • (1995) Oncogene , vol.10 , pp. 751-755
    • Ando, K.1    Griffin, J.D.2
  • 32
    • 0023691647 scopus 로고
    • Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor β
    • Coffey RJ, Bascom CC, Sipes NJ, Graves-Deal R, Weissman BE, Moses HL. Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor β. Mol Cell Biol 1988; 8: 3088-3093.
    • (1988) Mol Cell Biol , vol.8 , pp. 3088-3093
    • Coffey, R.J.1    Bascom, C.C.2    Sipes, N.J.3    Graves-Deal, R.4    Weissman, B.E.5    Moses, H.L.6
  • 33
    • 0023623241 scopus 로고
    • TGF-β inhibition of endothelial cell proliferation: Alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression
    • Takehara K, LeRoy EC, Grotendorst GR. TGF-β inhibition of endothelial cell proliferation: alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression. Cell 1987; 49: 415-422.
    • (1987) Cell , vol.49 , pp. 415-422
    • Takehara, K.1    LeRoy, E.C.2    Grotendorst, G.R.3
  • 34
    • 0028952955 scopus 로고
    • Transforming growth factor b1 inhibits expression of the gene products for steel factor and its receptor (c-kit)
    • Heinrich MC, Dooley DC, Keeble WW. Transforming growth factor b1 inhibits expression of the gene products for steel factor and its receptor (c-kit). Blood 1995; 85: 1769-1780.
    • (1995) Blood , vol.85 , pp. 1769-1780
    • Heinrich, M.C.1    Dooley, D.C.2    Keeble, W.W.3
  • 38
  • 39
    • 0023583780 scopus 로고
    • Inhibition of cytotoxic T cell development by transforming growth factor β and reversal by recombinant tumor necrosis factor α
    • Ranges GE, Figari IS, Espevik T, Palladino MA. Inhibition of cytotoxic T cell development by transforming growth factor β and reversal by recombinant tumor necrosis factor α. J Exp Med 1987; 166: 991-998.
    • (1987) J Exp Med , vol.166 , pp. 991-998
    • Ranges, G.E.1    Figari, I.S.2    Espevik, T.3    Palladino, M.A.4
  • 41
    • 0028348816 scopus 로고
    • Transfection of transforming growth factor-β producing tumor EMT6 with interleukin-2 elicits tumor rejection and tumor reactive cytotoxic T-lymphocytes
    • McAdam AJ, Felcher A, Woods ML, Pulaski BA, Hutter EK, Frelinger JG, Lord EM. Transfection of transforming growth factor-β producing tumor EMT6 with interleukin-2 elicits tumor rejection and tumor reactive cytotoxic T-lymphocytes. J Immunother 1994; 15: 155-164.
    • (1994) J Immunother , vol.15 , pp. 155-164
    • McAdam, A.J.1    Felcher, A.2    Woods, M.L.3    Pulaski, B.A.4    Hutter, E.K.5    Frelinger, J.G.6    Lord, E.M.7
  • 42
    • 0025858872 scopus 로고
    • Regulation of lymphockine-activated killer activity and pore-forming protein gene expression in human peripheral blood CD8+ T lymphocytes. Inhibition by transforming growth factor-β
    • Smyth MJ, Strobl SL, Young HA, Ortaldo JR, Ochoa AC. Regulation of lymphockine-activated killer activity and pore-forming protein gene expression in human peripheral blood CD8+ T lymphocytes. Inhibition by transforming growth factor-β. J Immunol 1991; 146: 3289-3297.
    • (1991) J Immunol , vol.146 , pp. 3289-3297
    • Smyth, M.J.1    Strobl, S.L.2    Young, H.A.3    Ortaldo, J.R.4    Ochoa, A.C.5
  • 43
    • 0029610610 scopus 로고
    • The failure of current immunotherapy for malignant glioma. Tumor-derived TGF-β, T-cell apoptosis, and the immune privilege of the brain
    • Weller M, Fontana A. The failure of current immunotherapy for malignant glioma. Tumor-derived TGF-β, T-cell apoptosis, and the immune privilege of the brain. Brain Res Rev 1995; 21: 128-151.
    • (1995) Brain Res Rev , vol.21 , pp. 128-151
    • Weller, M.1    Fontana, A.2
  • 44
    • 0033579820 scopus 로고    scopus 로고
    • Transforming growth factor β1 inhibits fas ligand expression and subsequent activation-induced cell death in T cels via downregulation of c-Myc
    • Genestier L, Kasibhatla S, Brunner T, Green DR. Transforming growth factor β1 inhibits fas ligand expression and subsequent activation-induced cell death in T cels via downregulation of c-Myc. J Exp Med 1999; 189: 231-239.
    • (1999) J Exp Med , vol.189 , pp. 231-239
    • Genestier, L.1    Kasibhatla, S.2    Brunner, T.3    Green, D.R.4
  • 45
    • 0027216817 scopus 로고
    • Differential activation of CD8+ T cells by transforming growth factor-beta 1
    • Lee HM, Rich S. Differential activation of CD8+ T cells by transforming growth factor-beta 1. J Immunother 1993; 151: 668-677.
    • (1993) J Immunother , vol.151 , pp. 668-677
    • Lee, H.M.1    Rich, S.2
  • 46
    • 0026581987 scopus 로고
    • Inhibition of tumor-specific cytotoxic T-lymphocyte responses by transforming growth factor b1
    • Inge TH, Hoover SK, Susskind BM, Barett SK, Bear HD. Inhibition of tumor-specific cytotoxic T-lymphocyte responses by transforming growth factor b1. Cancer Res 1992; 52: 1386-1392.
    • (1992) Cancer Res , vol.52 , pp. 1386-1392
    • Inge, T.H.1    Hoover, S.K.2    Susskind, B.M.3    Barett, S.K.4    Bear, H.D.5
  • 48
    • 0027241250 scopus 로고
    • Effect of transforming growth factor-β on early and late activation events in human T cells
    • Ahuja SS, Paliogianni F, Yamada H, Balow JE, Boumpas DT. Effect of transforming growth factor-β on early and late activation events in human T cells. J Immunol 1993; 150: 3109-3118.
    • (1993) J Immunol , vol.150 , pp. 3109-3118
    • Ahuja, S.S.1    Paliogianni, F.2    Yamada, H.3    Balow, J.E.4    Boumpas, D.T.5
  • 49
    • 0024440724 scopus 로고
    • Transforming growth factor beta slow down cell-cycle progression in a murine interleukin 2-dependent T-cell line
    • Stoeck M, Miescher S, MacDonald HR, von Fliedner V. Transforming growth factor beta slow down cell-cycle progression in a murine interleukin 2-dependent T-cell line. J Cell Physiol 1989; 141: 65-73.
    • (1989) J Cell Physiol , vol.141 , pp. 65-73
    • Stoeck, M.1    Miescher, S.2    MacDonald, H.R.3    Von Fliedner, V.4
  • 50
    • 0022478006 scopus 로고
    • BSC-1 growth inhibitor/type beta transforming growth factor is a strong inhibitor of thymocyte proliferation
    • Ristow HJ. BSC-1 growth inhibitor/type beta transforming growth factor is a strong inhibitor of thymocyte proliferation. Proc Natl Acad Sci USA 1986; 83: 5531-5533.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 5531-5533
    • Ristow, H.J.1
  • 51
    • 0028178471 scopus 로고
    • Transforming growth factor-β2 induces apoptosis of murine T cell clone without down-regulating bcl-2 mRNA expression
    • Weller M, Constam DB, Malipiero U, Fontana A. Transforming growth factor-β2 induces apoptosis of murine T cell clone without down-regulating bcl-2 mRNA expression. Eur J Immunol 1994; 24: 1293-1300.
    • (1994) Eur J Immunol , vol.24 , pp. 1293-1300
    • Weller, M.1    Constam, D.B.2    Malipiero, U.3    Fontana, A.4
  • 52
    • 0023694886 scopus 로고
    • Effects of transforming growth factor-β on human lymphokine-activated killer cell precursors. Autocrine inhibition of cellular proliferation and differentiation to immune killer cells
    • Kasid A, Bell GI, Director EP. Effects of transforming growth factor-β on human lymphokine-activated killer cell precursors. Autocrine inhibition of cellular proliferation and differentiation to immune killer cells. J Immunol 1988; 141: 690-698.
    • (1988) J Immunol , vol.141 , pp. 690-698
    • Kasid, A.1    Bell, G.I.2    Director, E.P.3
  • 53
    • 0033602101 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway
    • Ulloa L, Doody J, Massague J. Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway. Nature 1999; 397: 710-713.
    • (1999) Nature , vol.397 , pp. 710-713
    • Ulloa, L.1    Doody, J.2    Massague, J.3
  • 54
    • 0033104705 scopus 로고    scopus 로고
    • Downregulation of interleukin-12 responsiveness in human T cells by transforming growth factor-β: Relationship with IL-12 signaling
    • Pardoux C, Ma X, Gobert S, Pellegrini S, Mayeux P, Gay F, Trinchieri G, Chouaib S. Downregulation of interleukin-12 responsiveness in human T cells by transforming growth factor-β: relationship with IL-12 signaling. Blood 1999; 93: 1448-1455.
    • (1999) Blood , vol.93 , pp. 1448-1455
    • Pardoux, C.1    Ma, X.2    Gobert, S.3    Pellegrini, S.4    Mayeux, P.5    Gay, F.6    Trinchieri, G.7    Chouaib, S.8
  • 55
    • 0024988543 scopus 로고
    • Transforming growth factor b is a potent inhibitor of interleukin 1 (IL-1) receptor expression: Proposed mechanism of inhibition of IL-1 action
    • Dubois CM, Ruscetti FW, Palaszynski EW, Falk LA, Oppenheim JJ, Keller JR. Transforming growth factor b is a potent inhibitor of interleukin 1 (IL-1) receptor expression: Proposed mechanism of inhibition of IL-1 action. J Exp Med 1990; 172: 737-744.
    • (1990) J Exp Med , vol.172 , pp. 737-744
    • Dubois, C.M.1    Ruscetti, F.W.2    Palaszynski, E.W.3    Falk, L.A.4    Oppenheim, J.J.5    Keller, J.R.6
  • 56
    • 0030988396 scopus 로고    scopus 로고
    • C-kit receptors in childhood malignant lymphoblastic cells
    • Sykora KW, Tomeczkowski J, Reiter A. C-kit receptors in childhood malignant lymphoblastic cells. Leuk Lymphoma 1997; 25: 201-216.
    • (1997) Leuk Lymphoma , vol.25 , pp. 201-216
    • Sykora, K.W.1    Tomeczkowski, J.2    Reiter, A.3
  • 57
    • 0031854560 scopus 로고    scopus 로고
    • Expression and regulation of c-kit receptor and response to stem cell factor in childhood malignant T-lymphoblastic cells
    • Tomeczkowski J, Frick D, Schwinzer B, Wittner M, Ludwig WD, Reiter A, Weite K, Sykora KW. Expression and regulation of c-kit receptor and response to stem cell factor in childhood malignant T-lymphoblastic cells. Leukemia 1998; 12: 1221-1229.
    • (1998) Leukemia , vol.12 , pp. 1221-1229
    • Tomeczkowski, J.1    Frick, D.2    Schwinzer, B.3    Wittner, M.4    Ludwig, W.D.5    Reiter, A.6    Weite, K.7    Sykora, K.W.8
  • 58
    • 0028177911 scopus 로고
    • Transforming growth factor-b regulates c-kit message stability and cell surface protein expression in hematopoietic progenitors
    • Dubois CM, Ruscetti FW, Stankova J, Keller JR. Transforming growth factor-b regulates c-kit message stability and cell surface protein expression in hematopoietic progenitors. Blood 1994; 83: 3138-3145.
    • (1994) Blood , vol.83 , pp. 3138-3145
    • Dubois, C.M.1    Ruscetti, F.W.2    Stankova, J.3    Keller, J.R.4
  • 59
    • 0033105768 scopus 로고    scopus 로고
    • Resolving conflicting signals: Cross inhibition of cytokine signaling pathways
    • Begley CG, Nicola NA. Resolving conflicting signals: cross inhibition of cytokine signaling pathways. Blood 1999; 93: 1443-1447.
    • (1999) Blood , vol.93 , pp. 1443-1447
    • Begley, C.G.1    Nicola, N.A.2
  • 61
    • 0029120245 scopus 로고
    • CD28 and CTLA4 have opposing effects on the response of T cells to stimulation
    • Krummel M, Allison J. CD28 and CTLA4 have opposing effects on the response of T cells to stimulation. J Exp Med 1995; 182: 459-465.
    • (1995) J Exp Med , vol.182 , pp. 459-465
    • Krummel, M.1    Allison, J.2
  • 62
    • 0032538819 scopus 로고    scopus 로고
    • Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor b (TGF-b) production by murine CD4+ T cells
    • Chen W, Jin W, Wahl SM. Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor b (TGF-b) production by murine CD4+ T cells. J Exp Med 1998; 188: 1849-1857.
    • (1998) J Exp Med , vol.188 , pp. 1849-1857
    • Chen, W.1    Jin, W.2    Wahl, S.M.3
  • 63
    • 0023904805 scopus 로고
    • Transforming growth factor-β1 (TGF-β1) and recombinant human tumor necrosis factor-α reciprocally regulate the generation of lymphokine-activated killer cell activity: Comparison between natural porcine platelet-derived TGF-β1, and TGF-β2, and recombinant human TGF-β1
    • Espevik T, Figari IS, Ranges GE, Palladino MA. Transforming growth factor-β1 (TGF-β1) and recombinant human tumor necrosis factor-α reciprocally regulate the generation of lymphokine-activated killer cell activity: comparison between natural porcine platelet-derived TGF-β1, and TGF-β2, and recombinant human TGF-β1. J Immunol 1988; 140: 2312-2316.
    • (1988) J Immunol , vol.140 , pp. 2312-2316
    • Espevik, T.1    Figari, I.S.2    Ranges, G.E.3    Palladino, M.A.4
  • 64
    • 0028972556 scopus 로고
    • TGF-β enhances macrophage ability to produce IL-10 in normal and tumor-bearing mice
    • Maeda H, Kuwahara H, Ichimura Y, Ohtsuki M, Kurakata S, Shiraishi A. TGF-β enhances macrophage ability to produce IL-10 in normal and tumor-bearing mice. J Immunol 1995; 155: 4926-4932.
    • (1995) J Immunol , vol.155 , pp. 4926-4932
    • Maeda, H.1    Kuwahara, H.2    Ichimura, Y.3    Ohtsuki, M.4    Kurakata, S.5    Shiraishi, A.6
  • 65
    • 0030456368 scopus 로고    scopus 로고
    • A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: The skin of transforming growth factor beta 1 null mice is devoid of epidermal langerhans cells
    • Borkowski TA, Letterio JJ, Farr AG, Udey MC. A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells. J Exp Med 1996; 184: 2417-2422.
    • (1996) J Exp Med , vol.184 , pp. 2417-2422
    • Borkowski, T.A.1    Letterio, J.J.2    Farr, A.G.3    Udey, M.C.4
  • 67
    • 0031279952 scopus 로고    scopus 로고
    • Effect of TGF-β1 on cell-cycle regulatory proteins in LPS-stimulated normal mouse B lymphocytes
    • Bouchard C, Frikman WH, Sautès C. Effect of TGF-β1 on cell-cycle regulatory proteins in LPS-stimulated normal mouse B lymphocytes. J Immunol 1997; 159: 4155-4164.
    • (1997) J Immunol , vol.159 , pp. 4155-4164
    • Bouchard, C.1    Frikman, W.H.2    Sautès, C.3
  • 68
    • 0028248079 scopus 로고
    • Induction of B cell IgA secretion by the culture supernatants of lipopolysaccharide-stimulated peritoneal macrophages
    • Shieh JJ, Tseng J. Induction of B cell IgA secretion by the culture supernatants of lipopolysaccharide-stimulated peritoneal macrophages. Proc Natl Acad Sci Council, Republic of China-Part B, Life Sciences 1994; 18: 17-23.
    • (1994) Proc Natl Acad Sci Council, Republic of China-part B, Life Sciences , vol.18 , pp. 17-23
    • Shieh, J.J.1    Tseng, J.2
  • 69
    • 0032573581 scopus 로고    scopus 로고
    • Regulation of the proinflammatory effects of Fas Ligand (CD95L)
    • Chen J-J, Sun Y, Nabel CJ. Regulation of the proinflammatory effects of Fas Ligand (CD95L). Science 1998; 282: 1714-1717.
    • (1998) Science , vol.282 , pp. 1714-1717
    • Chen, J.-J.1    Sun, Y.2    Nabel, C.J.3
  • 70
    • 0023746462 scopus 로고
    • Transforming growth factor-β1 modulates the expression of class II histocompatibility antigens on human cells
    • Czarniecki CW, Chiu HH, Wong GHW, McCabe SM, Palladino MA. Transforming growth factor-β1 modulates the expression of class II histocompatibility antigens on human cells. J Immunol 1988: 140: 4217-4223.
    • (1988) J Immunol , vol.140 , pp. 4217-4223
    • Czarniecki, C.W.1    Chiu, H.H.2    Wong, G.H.W.3    McCabe, S.M.4    Palladino, M.A.5
  • 71
    • 0023794509 scopus 로고
    • Transforming growth factor β1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent myeloid leukemia cell lines
    • Keller JR, Mantel C, Sing GK, Ellingsworth LR, Ruscetti SK, Ruscetti FW. Transforming growth factor β1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent myeloid leukemia cell lines. J Exp Med 1988; 168: 737-750.
    • (1988) J Exp Med , vol.168 , pp. 737-750
    • Keller, J.R.1    Mantel, C.2    Sing, G.K.3    Ellingsworth, L.R.4    Ruscetti, S.K.5    Ruscetti, F.W.6
  • 72
    • 0029948374 scopus 로고    scopus 로고
    • Transforming growth factor β1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells
    • Sitnicka E, Ruscetti FW, Priestley GV, Wolf NS, Bartelmez SH. Transforming growth factor β1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells. Blood 1996; 88: 82-88.
    • (1996) Blood , vol.88 , pp. 82-88
    • Sitnicka, E.1    Ruscetti, F.W.2    Priestley, G.V.3    Wolf, N.S.4    Bartelmez, S.H.5
  • 73
    • 0024315377 scopus 로고
    • Inhibition of early murine hematopoietic progenitor cell proliferation after in vivo locoregional administration of transforming growth factor-β1
    • Goey H, Keller JR, Back T, Longo DL, Ruscetti FW, Wiltrout RH. Inhibition of early murine hematopoietic progenitor cell proliferation after in vivo locoregional administration of transforming growth factor-β1. J Immunol 1989; 143: 877-880.
    • (1989) J Immunol , vol.143 , pp. 877-880
    • Goey, H.1    Keller, J.R.2    Back, T.3    Longo, D.L.4    Ruscetti, F.W.5    Wiltrout, R.H.6
  • 74
    • 0025232370 scopus 로고
    • The production of transforming growth factor-b in acute megakaryoblastic leukemia and its possible implications in myelofibrosis
    • Terui T, Niitsu Y, Mahara K, Fujisaki Y, Urushizaki Y, Mogi Y, Kohgo Y, Watanabe N, Ogura M, Saito H. The production of transforming growth factor-b in acute megakaryoblastic leukemia and its possible implications in myelofibrosis. Blood 1990; 7: 1540-1548.
    • (1990) Blood , vol.7 , pp. 1540-1548
    • Terui, T.1    Niitsu, Y.2    Mahara, K.3    Fujisaki, Y.4    Urushizaki, Y.5    Mogi, Y.6    Kohgo, Y.7    Watanabe, N.8    Ogura, M.9    Saito, H.10
  • 75
    • 0028031971 scopus 로고
    • Transforming growth factor b as endogenous growth inhibitor of chronic lymphocytic leukemia B cells
    • Lotz M, Ranheim E, Kipps TJ. Transforming growth factor b as endogenous growth inhibitor of chronic lymphocytic leukemia B cells. J Exp Med 1994; 179: 999-1004.
    • (1994) J Exp Med , vol.179 , pp. 999-1004
    • Lotz, M.1    Ranheim, E.2    Kipps, T.J.3
  • 76
    • 0030940853 scopus 로고    scopus 로고
    • Loss of functional cell surface transforming growth factor β (TGF-β) type 1 receptor correlates with insensitivity to TGF-β in chronic lymphocytic leukemia
    • DeCoteau JF, Knaus PI, Yankelev H, Reis MD, Lowsky R, Lodish HF, Kadin ME. Loss of functional cell surface transforming growth factor β (TGF-β) type 1 receptor correlates with insensitivity to TGF-β in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 1997; 94: 5877-5881.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 5877-5881
    • Decoteau, J.F.1    Knaus, P.I.2    Yankelev, H.3    Reis, M.D.4    Lowsky, R.5    Lodish, H.F.6    Kadin, M.E.7
  • 77
    • 0023749277 scopus 로고
    • Transforming growth factor b inhibits the proliferation of the blast cells of acute myeloblastic leukemia
    • Tessier N, Hoang T. Transforming growth factor b inhibits the proliferation of the blast cells of acute myeloblastic leukemia. Blood 1988; 72: 159-164.
    • (1988) Blood , vol.72 , pp. 159-164
    • Tessier, N.1    Hoang, T.2
  • 78
    • 0027265286 scopus 로고
    • Effects of transforming growth factor β1 on growth and apoptosis of human acute myelogenous leukemia cells
    • Taetle R, Payne C, Dod Santos B, Russell M, Segarini P. Effects of transforming growth factor β1 on growth and apoptosis of human acute myelogenous leukemia cells. Cancer Res 1993; 53: 3386-3393.
    • (1993) Cancer Res , vol.53 , pp. 3386-3393
    • Taetle, R.1    Payne, C.2    Dod Santos, B.3    Russell, M.4    Segarini, P.5
  • 79
    • 0030986972 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells are resistant to the apoptotic effects of transforming growth factor-β
    • Douglas RS, Capocasale RJ, Lamb RJ, Nowell PC, Moore JS. Chronic lymphocytic leukemia B cells are resistant to the apoptotic effects of transforming growth factor-β. Blood 1997; 89: 941-947.
    • (1997) Blood , vol.89 , pp. 941-947
    • Douglas, R.S.1    Capocasale, R.J.2    Lamb, R.J.3    Nowell, P.C.4    Moore, J.S.5
  • 81
    • 0031035406 scopus 로고    scopus 로고
    • Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia
    • Batova A, Diccianni MB, Yu JC, Nobori T, Link MP, Pullen J, Yu AL. Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia. Cancer Res 1997; 57: 832-836.
    • (1997) Cancer Res , vol.57 , pp. 832-836
    • Batova, A.1    Diccianni, M.B.2    Yu, J.C.3    Nobori, T.4    Link, M.P.5    Pullen, J.6    Yu, A.L.7
  • 83
    • 0032190067 scopus 로고    scopus 로고
    • MCP-1, not MIP-1a, is the endogenous chemokine that cooperates with TGF-β to inhibit the cycling of primitive normal but not leukemic (CML) progenitors in long-term human marrow cultures
    • Cashman JD, Eaves CJ, Sarris AH, Eaves AC. MCP-1, not MIP-1a, is the endogenous chemokine that cooperates with TGF-β to inhibit the cycling of primitive normal but not leukemic (CML) progenitors in long-term human marrow cultures. Blood 1998; 92: 2338-2344.
    • (1998) Blood , vol.92 , pp. 2338-2344
    • Cashman, J.D.1    Eaves, C.J.2    Sarris, A.H.3    Eaves, A.C.4
  • 85
    • 0031824917 scopus 로고    scopus 로고
    • Mutational analysis of the tumor suppressor Smad2 in acute lymphoid and myeloid leukemia
    • Wieser R, Gruber B, Rieder H, Fonatsch C. Mutational analysis of the tumor suppressor Smad2 in acute lymphoid and myeloid leukemia. Leukemia 1998; 12: 1114-1118.
    • (1998) Leukemia , vol.12 , pp. 1114-1118
    • Wieser, R.1    Gruber, B.2    Rieder, H.3    Fonatsch, C.4
  • 86
    • 0033104503 scopus 로고    scopus 로고
    • Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β
    • Yang X, Letterio JJ, Lechleider RJ, Chen L, Hayman R, Gu H, Roberts AB, Deng C. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β. EMBO J 1999; 18: 1280-1291.
    • (1999) EMBO J , vol.18 , pp. 1280-1291
    • Yang, X.1    Letterio, J.J.2    Lechleider, R.J.3    Chen, L.4    Hayman, R.5    Gu, H.6    Roberts, A.B.7    Deng, C.8
  • 87
    • 0033014867 scopus 로고    scopus 로고
    • MDS1/EVI1 enhances TFG-β1 signaling and strengthens its growth-inhibitory effect, but the leukemia-associated fusion protein AML1/MDS1/EVI1, product of the t(3;21), abrogates growth-inhibition in response to TGF-β1
    • Sood R, Talwar-Trikha A, Chakrabarti SR, Nucifora G. MDS1/EVI1 enhances TFG-β1 signaling and strengthens its growth-inhibitory effect, but the leukemia-associated fusion protein AML1/MDS1/EVI1, product of the t(3;21), abrogates growth-inhibition in response to TGF-β1. Leukemia 1999; 13: 348-357.
    • (1999) Leukemia , vol.13 , pp. 348-357
    • Sood, R.1    Talwar-Trikha, A.2    Chakrabarti, S.R.3    Nucifora, G.4
  • 89
    • 0025759209 scopus 로고
    • Induction of transforming growth factor-b1 (TGF-b1) receptor expression and TGF-β1 protein production in retinoic acid-treated HL-60 cells: Possible TGF-β1-mediated autocrine inhibition
    • Falk LA, De Benedetti F, Lohrey N, Birchenall-Roberts MC, Ellingsworth LW, Faltynek CR, Ruscetti FW. Induction of transforming growth factor-b1 (TGF-b1) receptor expression and TGF-β1 protein production in retinoic acid-treated HL-60 cells: possible TGF-β1-mediated autocrine inhibition. Blood 1991; 77: 1248-1255.
    • (1991) Blood , vol.77 , pp. 1248-1255
    • Falk, L.A.1    De Benedetti, F.2    Lohrey, N.3    Birchenall-Roberts, M.C.4    Ellingsworth, L.W.5    Faltynek, C.R.6    Ruscetti, F.W.7
  • 91
    • 0029885562 scopus 로고    scopus 로고
    • The graft-versus-leukemia effect
    • Barrett, Malkovska V. The graft-versus-leukemia effect. Curr Opin Oncol 1996; 8: 89-95.
    • (1996) Curr Opin Oncol , vol.8 , pp. 89-95
    • Barrett1    Malkovska, V.2
  • 92
    • 0030986821 scopus 로고    scopus 로고
    • Adoptive immunotherapy with donor lymphocyte transfusions
    • Kolb HF, Holler E. Adoptive immunotherapy with donor lymphocyte transfusions. Curr Opin Oncol 1997; 9: 139-145.
    • (1997) Curr Opin Oncol , vol.9 , pp. 139-145
    • Kolb, H.F.1    Holler, E.2
  • 93
    • 0031931827 scopus 로고    scopus 로고
    • Infusion of donor peripheral blood mono-nuclear cells to treat relapse after transplantation for chronic myelogenous leukemia
    • Porter DL, Antin JH. Infusion of donor peripheral blood mono-nuclear cells to treat relapse after transplantation for chronic myelogenous leukemia. Hematol Oncol Clin N Am 1998; 12: 123-150.
    • (1998) Hematol Oncol Clin N Am , vol.12 , pp. 123-150
    • Porter, D.L.1    Antin, J.H.2
  • 94
    • 0030738037 scopus 로고    scopus 로고
    • Induction of graft-versus-host disease as immunotherapy of leukemia relapsing after allogeneic transplantation: Single-center experience of 32 adult patients
    • Mehta J, Powles R, Kulkarni S, Treleaven J, Singhal S. Induction of graft-versus-host disease as immunotherapy of leukemia relapsing after allogeneic transplantation: single-center experience of 32 adult patients. Bone Marrow Transplant 1997; 20: 129-135.
    • (1997) Bone Marrow Transplant , vol.20 , pp. 129-135
    • Mehta, J.1    Powles, R.2    Kulkarni, S.3    Treleaven, J.4    Singhal, S.5
  • 96
    • 0032127430 scopus 로고    scopus 로고
    • Antileukemic HLA-restricted T-cell clones generated with naturally processed peptides eluted from acute myeloblastic leukemia blasts
    • Ostankovitch M, Buzyn A, Bonhomme D, Connan F, Bouscary D, Heshmati F, Dreyfus F, Choppin J, Guillet JG. Antileukemic HLA-restricted T-cell clones generated with naturally processed peptides eluted from acute myeloblastic leukemia blasts. Blood 1998; 92: 19-24.
    • (1998) Blood , vol.92 , pp. 19-24
    • Ostankovitch, M.1    Buzyn, A.2    Bonhomme, D.3    Connan, F.4    Bouscary, D.5    Heshmati, F.6    Dreyfus, F.7    Choppin, J.8    Guillet, J.G.9
  • 97
    • 0031965021 scopus 로고    scopus 로고
    • Gene immunotherapy in murine acute myeloid leukemia: Granulocyte-macrophage colony-stimulating factor tumor cell vaccines elicit more potent antitumor immunity compared with B7 family and other cytokine vaccines
    • Dunussi-Joannopoulos D, Dranoff G, Weinstein HJ, Ferrara JL, Bierer EE, Croop JM. Gene immunotherapy in murine acute myeloid leukemia: granulocyte-macrophage colony-stimulating factor tumor cell vaccines elicit more potent antitumor immunity compared with B7 family and other cytokine vaccines. Blood 1998; 91: 222-230.
    • (1998) Blood , vol.91 , pp. 222-230
    • Dunussi-Joannopoulos, D.1    Dranoff, G.2    Weinstein, H.J.3    Ferrara, J.L.4    Bierer, E.E.5    Croop, J.M.6
  • 99
    • 0031672556 scopus 로고    scopus 로고
    • Active immunization against cancer cells: Impediments and advances
    • Velders MP, Schreiber H, Kast WM. Active immunization against cancer cells: impediments and advances. Semin Oncol 1998; 25: 697-706.
    • (1998) Semin Oncol , vol.25 , pp. 697-706
    • Velders, M.P.1    Schreiber, H.2    Kast, W.M.3
  • 101
    • 0030798673 scopus 로고    scopus 로고
    • Overexpression of autocrine TGF-β1 suppresses the growth of spindle epithelial cells in vitro and in vivo in the rat 4NQO model of oral carcinogenesis
    • Davies M, Prime SS, Stone AM, Heung YLM, Huntley SP, Matthews JB, Eveson JW, Paterson IC. Overexpression of autocrine TGF-β1 suppresses the growth of spindle epithelial cells in vitro and in vivo in the rat 4NQO model of oral carcinogenesis. Int J Cancer 1997; 73: 68-74.
    • (1997) Int J Cancer , vol.73 , pp. 68-74
    • Davies, M.1    Prime, S.S.2    Stone, A.M.3    Heung, Y.L.M.4    Huntley, S.P.5    Matthews, J.B.6    Eveson, J.W.7    Paterson, I.C.8
  • 103
    • 0031776562 scopus 로고    scopus 로고
    • Loss of expression of transforming growth factor-beta receptors is associated with poor prognosis in prostate cancer patients
    • Kim IY, Ahn HJ, Lang S, Oefelein MG, Oyasu R, Kozlowski JM, Lee C. Loss of expression of transforming growth factor-beta receptors is associated with poor prognosis in prostate cancer patients. Clin Cancer Res 1998; 4: 1625-1630.
    • (1998) Clin Cancer Res , vol.4 , pp. 1625-1630
    • Kim, I.Y.1    Ahn, H.J.2    Lang, S.3    Oefelein, M.G.4    Oyasu, R.5    Kozlowski, J.M.6    Lee, C.7
  • 104
    • 0029063595 scopus 로고
    • Transforming growth factor β: A cytokine with multiple actions in oncology and potential clinical applications
    • Kekow J, Wiedemann G. Transforming growth factor β: a cytokine with multiple actions in oncology and potential clinical applications. Int J Oncol 1995; 7: 177-182.
    • (1995) Int J Oncol , vol.7 , pp. 177-182
    • Kekow, J.1    Wiedemann, G.2
  • 106
    • 0032545222 scopus 로고    scopus 로고
    • p53-independent role of MDM2 in TGF-β1 resistance
    • Sun P, Dong P, Dai K, Hannon GJ, Beach D. p53-independent role of MDM2 in TGF-β1 resistance. Science 1998; 282: 2270-2272.
    • (1998) Science , vol.282 , pp. 2270-2272
    • Sun, P.1    Dong, P.2    Dai, K.3    Hannon, G.J.4    Beach, D.5
  • 107
    • 0026712153 scopus 로고
    • Excessive production of transforming growth-factor β1 can play an important role in the development of tumorigenesis by its action for angiogenesis: Validity of neutralizing antibodies to block tumor growth
    • Ueki N, Nakazato M, Ohkawa T, Ikeda T, Amuro Y, Hada T, Higashino K. Excessive production of transforming growth-factor β1 can play an important role in the development of tumorigenesis by its action for angiogenesis: validity of neutralizing antibodies to block tumor growth. Biochim Biophys Acta 1992; 1137: 189-196.
    • (1992) Biochim Biophys Acta , vol.1137 , pp. 189-196
    • Ueki, N.1    Nakazato, M.2    Ohkawa, T.3    Ikeda, T.4    Amuro, Y.5    Hada, T.6    Higashino, K.7
  • 108
    • 0031855882 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 inhibits generation of angiostatin by human pancreatic cancer cells
    • O'Mahony CA, Albo D, Tuszynski GP, Berger DH. Transforming growth factor-beta 1 inhibits generation of angiostatin by human pancreatic cancer cells. Surgery 1998; 124: 388-393.
    • (1998) Surgery , vol.124 , pp. 388-393
    • O'Mahony, C.A.1    Albo, D.2    Tuszynski, G.P.3    Berger, D.H.4
  • 109
    • 0024448588 scopus 로고
    • Regulation of endothelial cell growth, architecture, and matrix synthesis by TGF-beta
    • Roberts AB, Sporn MB. Regulation of endothelial cell growth, architecture, and matrix synthesis by TGF-beta. Am Rev Resp Dis 1989; 140: 1126-1128.
    • (1989) Am Rev Resp Dis , vol.140 , pp. 1126-1128
    • Roberts, A.B.1    Sporn, M.B.2
  • 110
    • 0031278373 scopus 로고    scopus 로고
    • Transforming growth factor-β, other growth factors, and the extracellular matrix
    • Haralson MA. Transforming growth factor-β, other growth factors, and the extracellular matrix. J Lab Clin Med 1997; 130: 455-458.
    • (1997) J Lab Clin Med , vol.130 , pp. 455-458
    • Haralson, M.A.1
  • 113
    • 0031708258 scopus 로고    scopus 로고
    • Increased transforming growth factor betal plasma level in patients with renal cell carcinoma: A tumor-specific marker?
    • Wunderlich H, Steiner T, Kosmehl H, Junker U, Reinhold D, Reichelt O, Zermann DH, Schubert J. Increased transforming growth factor betal plasma level in patients with renal cell carcinoma: a tumor-specific marker? Urol Int 1998; 60: 205-207.
    • (1998) Urol Int , vol.60 , pp. 205-207
    • Wunderlich, H.1    Steiner, T.2    Kosmehl, H.3    Junker, U.4    Reinhold, D.5    Reichelt, O.6    Zermann, D.H.7    Schubert, J.8
  • 114
    • 0026541255 scopus 로고
    • Differential expression of transforming growth factor-β1, β2 and β3 by glioblastoma cells, astrocytes and microglia
    • Constam DB, Philipp J, Malipiero UV, Ten Dijke P, Schachner M, Fontana A. Differential expression of transforming growth factor-β1, β2 and β3 by glioblastoma cells, astrocytes and microglia. J Immunol 1992; 148: 1404-1410.
    • (1992) J Immunol , vol.148 , pp. 1404-1410
    • Constam, D.B.1    Philipp, J.2    Malipiero, U.V.3    Ten Dijke, P.4    Schachner, M.5    Fontana, A.6
  • 115
    • 0027223428 scopus 로고
    • The effect of transforming growth factor-β2-specific phosphorothioate-antisense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma
    • Jachimczak P, Bogdahn U, Schneider J, Behl C, Meixensberger J, Apfel R, Dörries R, Schlingensiepen KH, Brysch W. The effect of transforming growth factor-β2-specific phosphorothioate-antisense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma. J Neurosurg 1993; 78: 944-951.
    • (1993) J Neurosurg , vol.78 , pp. 944-951
    • Jachimczak, P.1    Bogdahn, U.2    Schneider, J.3    Behl, C.4    Meixensberger, J.5    Apfel, R.6    Dörries, R.7    Schlingensiepen, K.H.8    Brysch, W.9
  • 116
  • 118
    • 0025974603 scopus 로고
    • Long-term follow-up of patients with recurrent malignant gliomas treated with adjuvant adoptive immunotherapy
    • Lillehei KO, Mitchell DH, Johnson SP, McCleary EL, Kruse CA. Long-term follow-up of patients with recurrent malignant gliomas treated with adjuvant adoptive immunotherapy. Neurosurgery 1991; 28: 16-23.
    • (1991) Neurosurgery , vol.28 , pp. 16-23
    • Lillehei, K.O.1    Mitchell, D.H.2    Johnson, S.P.3    McCleary, E.L.4    Kruse, C.A.5
  • 119
    • 0025745414 scopus 로고
    • Modulation of T-cell function by gliomas
    • Roszman T, Elliott L, Brooks W. Modulation of T-cell function by gliomas. Immunol Today 1991; 12: 370-374.
    • (1991) Immunol Today , vol.12 , pp. 370-374
    • Roszman, T.1    Elliott, L.2    Brooks, W.3
  • 120
    • 0023223190 scopus 로고
    • Role of interleukin-2 (IL-2) and IL-2 receptor expression in the proliferative defect observed in mitogen-stimulated lymphocytes from patients with gliomas
    • Elliott CH, Brooks W, Roszman T. Role of interleukin-2 (IL-2) and IL-2 receptor expression in the proliferative defect observed in mitogen-stimulated lymphocytes from patients with gliomas. J Natl Cancer Inst 1987; 78: 919-922.
    • (1987) J Natl Cancer Inst , vol.78 , pp. 919-922
    • Elliott, C.H.1    Brooks, W.2    Roszman, T.3
  • 121
    • 0031435653 scopus 로고    scopus 로고
    • Reversal of tumor-induced immunosuppression: A new approach to cancer therapy
    • Wojtowicz-Praga S. Reversal of tumor-induced immunosuppression: a new approach to cancer therapy. J Immunother 1997; 20: 165-177.
    • (1997) J Immunother , vol.20 , pp. 165-177
    • Wojtowicz-Praga, S.1
  • 122
    • 0026536584 scopus 로고
    • Protease inhibitors interfere with the transforming growth factor-beta-dependent but not the transforming growth factor-beta-independent pathway of tumor cell-mediated immunosuppression
    • Huber D, Philipp J, Fontana A. Protease inhibitors interfere with the transforming growth factor-beta-dependent but not the transforming growth factor-beta-independent pathway of tumor cell-mediated immunosuppression. J Immunol 1992; 148: 277-284.
    • (1992) J Immunol , vol.148 , pp. 277-284
    • Huber, D.1    Philipp, J.2    Fontana, A.3
  • 130
    • 0030587855 scopus 로고    scopus 로고
    • DNA vaccination primes MHC class I-restricted, simian virus 40 large tumor antigen-specific CTL in H-2d mice that reject syngeneic tumors
    • Schirmbeck R, Böhm W, Reimann J. DNA vaccination primes MHC class I-restricted, simian virus 40 large tumor antigen-specific CTL in H-2d mice that reject syngeneic tumors. J Immunol 1996; 157: 3550-3558.
    • (1996) J Immunol , vol.157 , pp. 3550-3558
    • Schirmbeck, R.1    Böhm, W.2    Reimann, J.3
  • 131
    • 0028350530 scopus 로고
    • In vivo regulation of transforming growth factor β1 transcription by immunotherapy: Interleukin-2 impairs interferon-α-stimulated increase in steady-state mRNA levels of transforming growth factor β1
    • Jahn B, Brieger J, Fenchel K, Mitrou S, Berhamnn L. In vivo regulation of transforming growth factor β1 transcription by immunotherapy: interleukin-2 impairs interferon-α-stimulated increase in steady-state mRNA levels of transforming growth factor β1. Cancer Immunol Immunother 1994; 38: 304-310.
    • (1994) Cancer Immunol Immunother , vol.38 , pp. 304-310
    • Jahn, B.1    Brieger, J.2    Fenchel, K.3    Mitrou, S.4    Berhamnn, L.5
  • 132
    • 0028820153 scopus 로고
    • Transforming growth factor β1 (TGF-β1) is an autocrine positive regulator of colon carcinoma U9 cells in vivo as shown by transfection of a TGF-β1 antisense expression plasmid
    • Huang F, Newman E, Theodorescu D, Kerbel RS, Friedman E. Transforming growth factor β1 (TGF-β1) is an autocrine positive regulator of colon carcinoma U9 cells in vivo as shown by transfection of a TGF-β1 antisense expression plasmid. Cell Growth Differ 1995; 6: 1635-1642.
    • (1995) Cell Growth Differ , vol.6 , pp. 1635-1642
    • Huang, F.1    Newman, E.2    Theodorescu, D.3    Kerbel, R.S.4    Friedman, E.5
  • 133
    • 0030802978 scopus 로고    scopus 로고
    • Antisense oligonucleotides specific for transforming growth factor beta2 inhibit the growth of malignant mesothelioma both in vitro and in vivo
    • Marzo AL, Fitzpatrick DR, Robinson BW, Scott B. Antisense oligonucleotides specific for transforming growth factor beta2 inhibit the growth of malignant mesothelioma both in vitro and in vivo. Cancer Res 1997; 57: 3200-3207.
    • (1997) Cancer Res , vol.57 , pp. 3200-3207
    • Marzo, A.L.1    Fitzpatrick, D.R.2    Robinson, B.W.3    Scott, B.4
  • 134
    • 0027548803 scopus 로고
    • Repression of autocrine transforming growth factor β1 and β2 in quiescent CBS colon carcinoma cells leads to progression of tumorigenic properties
    • Wu SP, Sun LZ, Willson JKV, Humphrey L, Kerbel R, Brattain MG. Repression of autocrine transforming growth factor β1 and β2 in quiescent CBS colon carcinoma cells leads to progression of tumorigenic properties. Cell Growth Differ 1993; 4: 115-123.
    • (1993) Cell Growth Differ , vol.4 , pp. 115-123
    • Wu, S.P.1    Sun, L.Z.2    Willson, J.K.V.3    Humphrey, L.4    Kerbel, R.5    Brattain, M.G.6
  • 135
    • 0029623185 scopus 로고
    • Restoration of interleukin-2 production in tumor-bearing rats through reducing tumor-derived transforming growth factor beta by treatment with bleomycin
    • Yuan L, Kuramitsu Y, Li Y, Kobayashi M, Hosokawa M. Restoration of interleukin-2 production in tumor-bearing rats through reducing tumor-derived transforming growth factor beta by treatment with bleomycin. Cancer Immunol Immunother 1995; 41: 355-362.
    • (1995) Cancer Immunol Immunother , vol.41 , pp. 355-362
    • Yuan, L.1    Kuramitsu, Y.2    Li, Y.3    Kobayashi, M.4    Hosokawa, M.5
  • 136
    • 0027137485 scopus 로고
    • Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity: Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression
    • Arteaga CL, Hurd SD, Winnier AR, Johnson MD, Fendly BM, Forbes JT. Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity: implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression. J Clin Invest 1993; 92: 2569-2576.
    • (1993) J Clin Invest , vol.92 , pp. 2569-2576
    • Arteaga, C.L.1    Hurd, S.D.2    Winnier, A.R.3    Johnson, M.D.4    Fendly, B.M.5    Forbes, J.T.6
  • 137
    • 0027569092 scopus 로고
    • Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice
    • Arteaga CL, Carty-Dugger T, Moses H, Hurd S, Pietenpol J. Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice. Cell Growth Differ 1993; 4: 193-201.
    • (1993) Cell Growth Differ , vol.4 , pp. 193-201
    • Arteaga, C.L.1    Carty-Dugger, T.2    Moses, H.3    Hurd, S.4    Pietenpol, J.5
  • 138
    • 0029615462 scopus 로고
    • Anti-(transforming growth factor-beta) antibodies with predefined specificity inhibit metastasis of higher tumorigenic human xenotransplants in nu/nu mice
    • Hoefer M, Anderer FA. Anti-(transforming growth factor-beta) antibodies with predefined specificity inhibit metastasis of higher tumorigenic human xenotransplants in nu/nu mice. Cancer Immunol Immunother 1995; 41: 302-308.
    • (1995) Cancer Immunol Immunother , vol.41 , pp. 302-308
    • Hoefer, M.1    Anderer, F.A.2
  • 139
    • 0030036344 scopus 로고    scopus 로고
    • Modulation of B16 melanoma growth and metastasis by anti-transforming growth factor β antibody and interleukin-2
    • Wojtowicz-Praga S, Verma UM, Wakefield L, Esteban JM, Hartmann D, Mazumber A. Modulation of B16 melanoma growth and metastasis by anti-transforming growth factor β antibody and interleukin-2. J Immunother 1996; 19: 169-175.
    • (1996) J Immunother , vol.19 , pp. 169-175
    • Wojtowicz-Praga, S.1    Verma, U.M.2    Wakefield, L.3    Esteban, J.M.4    Hartmann, D.5    Mazumber, A.6
  • 140
    • 0021029449 scopus 로고
    • Conformation and protease binding-activity of binary and ternary human α2-macroglobulin-protease complexes
    • Gonas SL, Pizzo SV. Conformation and protease binding-activity of binary and ternary human α2-macroglobulin-protease complexes. J Biol Chem 1983; 258: 14682-14685.
    • (1983) J Biol Chem , vol.258 , pp. 14682-14685
    • Gonas, S.L.1    Pizzo, S.V.2
  • 141
    • 0024333351 scopus 로고
    • α-Macroglobulins, structure, shape and mechanism of proteinase complex formation
    • Sottrup-Jensen L. α-Macroglobulins, structure, shape and mechanism of proteinase complex formation. J Biol Chem 1989; 264: 11539-11542.
    • (1989) J Biol Chem , vol.264 , pp. 11539-11542
    • Sottrup-Jensen, L.1
  • 142
    • 0026090471 scopus 로고
    • An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice
    • LaMarre J, Hayes MA, Wollenberg GK, Hussaini I, Hall SW, Gonias SL. An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice. J Clin Invest 1991; 87: 39-44.
    • (1991) J Clin Invest , vol.87 , pp. 39-44
    • Lamarre, J.1    Hayes, M.A.2    Wollenberg, G.K.3    Hussaini, I.4    Hall, S.W.5    Gonias, S.L.6
  • 144
    • 0028174633 scopus 로고
    • Transforming growth factor-β-mediated down-regulation of anti-tumor cytotoxicity of spleen cells from MOPC-315 tumor-bearing mice engaged in tumor eradication following melphalan therapy
    • Weiskirch LM, Bar-Dagan Y, Modyr MB. Transforming growth factor-β-mediated down-regulation of anti-tumor cytotoxicity of spleen cells from MOPC-315 tumor-bearing mice engaged in tumor eradication following melphalan therapy. Cancer Immunol Immunother 1994; 38: 215-235.
    • (1994) Cancer Immunol Immunother , vol.38 , pp. 215-235
    • Weiskirch, L.M.1    Bar-Dagan, Y.2    Modyr, M.B.3
  • 148
    • 0026059996 scopus 로고
    • Human anti-murine immunoglobulin responses and immune function in cancer patients receiving murine monoclonal antibody therapy
    • Blottiere HM, Steplewski Z, Herlyn D, Douillard JY. Human anti-murine immunoglobulin responses and immune function in cancer patients receiving murine monoclonal antibody therapy. Hum Antibodies Hybridomas 1991; 2: 16-25.
    • (1991) Hum Antibodies Hybridomas , vol.2 , pp. 16-25
    • Blottiere, H.M.1    Steplewski, Z.2    Herlyn, D.3    Douillard, J.Y.4
  • 150
    • 0028202976 scopus 로고
    • A pilot clinical trial of two murine monoclonal antibodies fixing human complement in patients with chronic lymphatic leukemia
    • Greenaway S, Henniker AJ, Walsh M, Bradstock KF. A pilot clinical trial of two murine monoclonal antibodies fixing human complement in patients with chronic lymphatic leukemia. Leuk Lymphoma 1994; 13: 323-331.
    • (1994) Leuk Lymphoma , vol.13 , pp. 323-331
    • Greenaway, S.1    Henniker, A.J.2    Walsh, M.3    Bradstock, K.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.