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Volumn 9, Issue 5, 1999, Pages 588-594

The ins and outs of circadian timekeeping

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EID: 0032845797     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(99)00009-X     Document Type: Review
Times cited : (74)

References (57)
  • 3
    • 0033593306 scopus 로고    scopus 로고
    • Molecular bases for circadian clocks
    • Dunlap JC Molecular bases for circadian clocks. Cell. 96:1999;271-290.
    • (1999) Cell , vol.96 , pp. 271-290
    • Dunlap, J.C.1
  • 4
    • 0032483510 scopus 로고    scopus 로고
    • Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria
    • Many different clock mutations were mapped to the three kai genes. Subsequent deletion and overexpression of each gene product individually showed that the kaiC gene product repressed the kaiBC promoter, whereas the kaiA product activated it. From these data, the authors propose a negative feedback loop of kai function.
    • Ishiura M, Kutsuna S, Aoki S, Iwasaki H, Andersson CR, Tanabe A, Golden SS, Johnson CH, Kondo T Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria. Science. 281:1998;1519-1523. Many different clock mutations were mapped to the three kai genes. Subsequent deletion and overexpression of each gene product individually showed that the kaiC gene product repressed the kaiBC promoter, whereas the kaiA product activated it. From these data, the authors propose a negative feedback loop of kai function.
    • (1998) Science , vol.281 , pp. 1519-1523
    • Ishiura, M.1    Kutsuna, S.2    Aoki, S.3    Iwasaki, H.4    Andersson, C.R.5    Tanabe, A.6    Golden, S.S.7    Johnson, C.H.8    Kondo, T.9
  • 5
    • 0032192136 scopus 로고    scopus 로고
    • Circadian rhythms: Molecular basis of the clock
    • Good review of the central clock mechanism in Drosophila and mammals, a subject beyond the scope of this review.
    • Wilsbacher LD, Takahashi JS Circadian rhythms: molecular basis of the clock. Curr Opin Genet Dev. 8:1998;595-602. Good review of the central clock mechanism in Drosophila and mammals, a subject beyond the scope of this review.
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 595-602
    • Wilsbacher, L.D.1    Takahashi, J.S.2
  • 6
    • 0032778040 scopus 로고    scopus 로고
    • PER and TIM inhibit the DNA binding activity of a dCLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: A basis for circadian transcription
    • Lee C, Bae K, Edery I PER and TIM inhibit the DNA binding activity of a dCLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription. Mol Cell Biol. 19:1999;5316-5325.
    • (1999) Mol Cell Biol , vol.19 , pp. 5316-5325
    • Lee, C.1    Bae, K.2    Edery, I.3
  • 7
    • 0032486432 scopus 로고    scopus 로고
    • Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim
    • After identifying the Drosophila orthologs of the mammalian Clock and Bmal genes, the authors demonstrate that Clock and Bmal proteins can activate period and timeless expression via an E-box motif, and that Period and Timeless proteins can repress this activation.
    • Darlington TK, Wager-Smith K, Ceriano MF, Staknis D, Gekakis N, Steeves TDL, Weitz CJ, Takahashi JS, Kay SA Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science. 280:1998;1599-1603. After identifying the Drosophila orthologs of the mammalian Clock and Bmal genes, the authors demonstrate that Clock and Bmal proteins can activate period and timeless expression via an E-box motif, and that Period and Timeless proteins can repress this activation.
    • (1998) Science , vol.280 , pp. 1599-1603
    • Darlington, T.K.1    Wager-Smith, K.2    Ceriano, M.F.3    Staknis, D.4    Gekakis, N.5    Steeves, T.D.L.6    Weitz, C.J.7    Takahashi, J.S.8    Kay, S.A.9
  • 9
    • 0032504041 scopus 로고    scopus 로고
    • The Drosophila clock gene doubletime encodes a protein closely related to human casein kinase 1 epsilon
    • •] report the isolation and cloning of a novel Drosophila clock gene, Double-time, and its effects upon Per protein phosphorylation and accumulation. In double-time mutants, period proteins constitutively accumulate in hypophosphorylated form. This observation suggests that Double-time functions by phosphorylating and thereby destabilizing Period protein.
    • •] report the isolation and cloning of a novel Drosophila clock gene, Double-time, and its effects upon Per protein phosphorylation and accumulation. In double-time mutants, period proteins constitutively accumulate in hypophosphorylated form. This observation suggests that Double-time functions by phosphorylating and thereby destabilizing Period protein.
    • (1998) Cell , vol.94 , pp. 97-107
    • Kloss, B.1    Price, J.L.2    Saez, L.3    Blau, J.4    Rothenfluh, A.5    Wesley, C.S.6    Young, M.W.7
  • 11
    • 0032214514 scopus 로고    scopus 로고
    • Mammalian circadian autoregulatory loop: A Timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription
    • •] report the cloning of a mammalian homolog of the Drosophila Timeless gene from EST sequences. Both show constant low expression of timeless RNA, though they use different assays to come to different conclusions about the ability of mTimeless to interact with mammalian Period proteins
    • •] report the cloning of a mammalian homolog of the Drosophila Timeless gene from EST sequences. Both show constant low expression of timeless RNA, though they use different assays to come to different conclusions about the ability of mTimeless to interact with mammalian Period proteins.
    • Neuron , vol.21 , pp. 1101-1113
    • Sangoram, A.M.1    Saez, L.2    Antoch, M.P.3    Gekakis, N.4    Staknis, D.5    Whiteley, A.6    Fruechte, E.M.7    Vitaterna, M.H.8    Shimomura, K.9    King, D.P.10
  • 12
    • 0026757788 scopus 로고
    • Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms
    • Ewer J, Frisch B, Hamblen-Coyle MJ, Rosbash M, Hall JC Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms. J Neurosci. 12:1992;3321-3349.
    • (1992) J Neurosci , vol.12 , pp. 3321-3349
    • Ewer, J.1    Frisch, B.2    Hamblen-Coyle, M.J.3    Rosbash, M.4    Hall, J.C.5
  • 13
    • 0028915430 scopus 로고
    • Molecular neurobiology and genetics of circadian rhythms in mammals
    • Takahashi JS Molecular neurobiology and genetics of circadian rhythms in mammals. Annu Rev Neurosci. 18:1995;531-553.
    • (1995) Annu Rev Neurosci , vol.18 , pp. 531-553
    • Takahashi, J.S.1
  • 14
    • 0025938395 scopus 로고
    • Rhythmic regulation of retinal melatonin: Metabolic pathways, neurochemical mechanisms, and the ocular circadian clock
    • Cahill GM, Grace MS, Besharse JC Rhythmic regulation of retinal melatonin: metabolic pathways, neurochemical mechanisms, and the ocular circadian clock. Cell Mol Neurobiol. 11:1991;529-569.
    • (1991) Cell Mol Neurobiol , vol.11 , pp. 529-569
    • Cahill, G.M.1    Grace, M.S.2    Besharse, J.C.3
  • 15
    • 0029967843 scopus 로고    scopus 로고
    • Circadian rhythms in cultured mammalian retina
    • Tosini G, Menaker M Circadian rhythms in cultured mammalian retina. Science. 272:1996;419-421.
    • (1996) Science , vol.272 , pp. 419-421
    • Tosini, G.1    Menaker, M.2
  • 17
    • 0030656411 scopus 로고    scopus 로고
    • Independent photoreceptive circadian clocks throughout Drosophila
    • Plautz JD, Kaneko M, Hall JC, Kay SA Independent photoreceptive circadian clocks throughout Drosophila. Science. 278:1997;1632-1635.
    • (1997) Science , vol.278 , pp. 1632-1635
    • Plautz, J.D.1    Kaneko, M.2    Hall, J.C.3    Kay, S.A.4
  • 18
    • 0032234896 scopus 로고    scopus 로고
    • Zebrafish Clock rhythmic expression reveals independent peripheral circadian oscillators
    • Circadian cycling of the zebrafish homolog of the mammalian Clock gene was demonstrated for periods of several days in explanted kidney and heart tissues. Thus, self-sustaining circadian oscillators exist in several vertebrate organs.
    • Whitmore D, Foulkes NS, Strahle U, Sassone-Corsi P Zebrafish Clock rhythmic expression reveals independent peripheral circadian oscillators. Nature Neurosci. 1:1998;701-707. Circadian cycling of the zebrafish homolog of the mammalian Clock gene was demonstrated for periods of several days in explanted kidney and heart tissues. Thus, self-sustaining circadian oscillators exist in several vertebrate organs.
    • (1998) Nature Neurosci , vol.1 , pp. 701-707
    • Whitmore, D.1    Foulkes, N.S.2    Strahle, U.3    Sassone-Corsi, P.4
  • 19
    • 0032511229 scopus 로고    scopus 로고
    • A serum shock induces circadian gene expression in mammalian tissue culture cells
    • Cultured immortalized rat fibroblast and hepatoma cell lines demonstrated circadian oscillations of RNAs of known mammalian clock and clock output genes for many days following treatment with high concentrations of growth serum. This result suggests that the clock machinery may found in all cells.
    • Balsalobre A, Damiola F, Schibler U A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell. 93:1998;929-937. Cultured immortalized rat fibroblast and hepatoma cell lines demonstrated circadian oscillations of RNAs of known mammalian clock and clock output genes for many days following treatment with high concentrations of growth serum. This result suggests that the clock machinery may found in all cells.
    • (1998) Cell , vol.93 , pp. 929-937
    • Balsalobre, A.1    Damiola, F.2    Schibler, U.3
  • 20
    • 0032491503 scopus 로고    scopus 로고
    • Homoral signals mediate the circadian expression of rat period homologue (rPer2) mRNA in peripheral tissues
    • Oishi K, Sakamoto K, Okada T, Nagase T, Ishida N Homoral signals mediate the circadian expression of rat period homologue (rPer2) mRNA in peripheral tissues. Neurosci Lett. 256:1998;117-119.
    • (1998) Neurosci Lett , vol.256 , pp. 117-119
    • Oishi, K.1    Sakamoto, K.2    Okada, T.3    Nagase, T.4    Ishida, N.5
  • 21
    • 0004150445 scopus 로고
    • R.W. Schrier. New York: Raven Press
    • Schrier RW Vasopressin. 1985;Raven Press, New York.
    • (1985) Vasopressin
  • 22
    • 0033534628 scopus 로고    scopus 로고
    • A molecular mechanism for regulating rhythmic output from the suprachiasmatic circadian clock
    • The authors of this paper demonstrate that the expression of the vasopressin gene is abolished in clock mutant mice. They then use transient transfection studies to demonstrate that an E-box motif mediates the effects of transfected Clock upon the vasopressin gene, and that this activation can be abolished by cotransfecting Period or Timeless expression plasmids.
    • Jin X, Shearman LP, Weaver DR, Zylka MJ, de Vries GJ, Reppert SM A molecular mechanism for regulating rhythmic output from the suprachiasmatic circadian clock. Cell. 96:1999;57-68. The authors of this paper demonstrate that the expression of the vasopressin gene is abolished in clock mutant mice. They then use transient transfection studies to demonstrate that an E-box motif mediates the effects of transfected Clock upon the vasopressin gene, and that this activation can be abolished by cotransfecting Period or Timeless expression plasmids.
    • (1999) Cell , vol.96 , pp. 57-68
    • Jin, X.1    Shearman, L.P.2    Weaver, D.R.3    Zylka, M.J.4    De Vries, G.J.5    Reppert, S.M.6
  • 23
    • 0027428137 scopus 로고
    • Circadian regulation of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP
    • Lavery DJ, Schibler U Circadian regulation of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP. Genes Dev. 7:1993;1871-1884.
    • (1993) Genes Dev , vol.7 , pp. 1871-1884
    • Lavery, D.J.1    Schibler, U.2
  • 24
    • 0030729774 scopus 로고    scopus 로고
    • The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior
    • Lopez-Molina L, Conquet F, Dubois-Dauphin M, Schibler U The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior. EMBO J. 16:1997;6762-6771.
    • (1997) EMBO J , vol.16 , pp. 6762-6771
    • Lopez-Molina, L.1    Conquet, F.2    Dubois-Dauphin, M.3    Schibler, U.4
  • 25
    • 0032007019 scopus 로고    scopus 로고
    • A molecular rhythm mediating circadian clock output in Drosophila
    • McNeil GP, Zhang X, Genova G, Jackson FR A molecular rhythm mediating circadian clock output in Drosophila. Neuron. 20:1998;297-303.
    • (1998) Neuron , vol.20 , pp. 297-303
    • McNeil, G.P.1    Zhang, X.2    Genova, G.3    Jackson, F.R.4
  • 26
    • 0029089791 scopus 로고
    • The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions, and target promoter preferences
    • Falvey E, Fleury-Olela F, Schibler U The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions, and target promoter preferences. EMBO J. 14:1995;4307-4317.
    • (1995) EMBO J , vol.14 , pp. 4307-4317
    • Falvey, E.1    Fleury-Olela, F.2    Schibler, U.3
  • 27
    • 0030045791 scopus 로고    scopus 로고
    • The two PAR leucine zipper proteins TEF and DBP display similar circadian and tissue-specific expression but have different target promoter preferences
    • Fonjallez P, Ossipow V, Wanner G, Schibler U The two PAR leucine zipper proteins TEF and DBP display similar circadian and tissue-specific expression but have different target promoter preferences. EMBO J. 15:1996;351-362.
    • (1996) EMBO J , vol.15 , pp. 351-362
    • Fonjallez, P.1    Ossipow, V.2    Wanner, G.3    Schibler, U.4
  • 28
    • 0027495101 scopus 로고
    • Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland
    • Stehle JH, Foulkes NS, Molina CA, Simmoneaux V, Pevet P, Sassone-Corsi P Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland. Nature. 365:1993;314-320.
    • (1993) Nature , vol.365 , pp. 314-320
    • Stehle, J.H.1    Foulkes, N.S.2    Molina, C.A.3    Simmoneaux, V.4    Pevet, P.5    Sassone-Corsi, P.6
  • 29
  • 30
    • 0024503345 scopus 로고
    • Rhythms of serum melatonin in patients with spinal lesions at the cervical, thoracic, and lumbar regions
    • Li Y, Jiang DH, Wang ML, Jiao DR, Pang SF Rhythms of serum melatonin in patients with spinal lesions at the cervical, thoracic, and lumbar regions. Clin Endocrinol. 30:1989;47-56.
    • (1989) Clin Endocrinol , vol.30 , pp. 47-56
    • Li, Y.1    Jiang, D.H.2    Wang, M.L.3    Jiao, D.R.4    Pang, S.F.5
  • 31
    • 0031658816 scopus 로고    scopus 로고
    • Output signals of the SCN
    • Lesauter J, Silver R Output signals of the SCN. Chronobiol Int. 15:1998;535-550.
    • (1998) Chronobiol Int , vol.15 , pp. 535-550
    • Lesauter, J.1    Silver, R.2
  • 32
    • 0027564206 scopus 로고
    • Behavior in light-dark cycles of Drosophila mutants that are arrhythmic, blind, or both
    • Wheeler DA, Hamblen-Coyle MJ, Dushay MS, Hall JC Behavior in light-dark cycles of Drosophila mutants that are arrhythmic, blind, or both. J Biol Rhythms. 8:1993;67-94.
    • (1993) J Biol Rhythms , vol.8 , pp. 67-94
    • Wheeler, D.A.1    Hamblen-Coyle, M.J.2    Dushay, M.S.3    Hall, J.C.4
  • 34
    • 0023852355 scopus 로고
    • Circadian clock in cell culture: II. In vitro photic entrainment of melatonin oscillation from dissociated chick pineal cells
    • Robertson LM, Takahashi JS Circadian clock in cell culture: II. In vitro photic entrainment of melatonin oscillation from dissociated chick pineal cells. J Neurosci. 8:1988;22-30.
    • (1988) J Neurosci , vol.8 , pp. 22-30
    • Robertson, L.M.1    Takahashi, J.S.2
  • 35
    • 0023807125 scopus 로고
    • Loss of entrainment and anatomical plasticity after lesions of the hamster retinohypothalamic tract
    • Johnson RF, Moore RY, Morin LP Loss of entrainment and anatomical plasticity after lesions of the hamster retinohypothalamic tract. Brain Res. 460:1988;297-313.
    • (1988) Brain Res , vol.460 , pp. 297-313
    • Johnson, R.F.1    Moore, R.Y.2    Morin, L.P.3
  • 37
    • 0033574769 scopus 로고    scopus 로고
    • Regulation of the mammalian pineal by non-rod, non-cone ocular photoreceptors
    • ••] used a transgenic diptheria toxin fusion to destroy all retinal cone cells, and the previously characterized rdta mutation to eliminate rod cells. The resulting mice showed normal circadian photosensitivity, suggesting that another type of ocular cell is responsible for circadian photoreception.
    • ••] used a transgenic diptheria toxin fusion to destroy all retinal cone cells, and the previously characterized rdta mutation to eliminate rod cells. The resulting mice showed normal circadian photosensitivity, suggesting that another type of ocular cell is responsible for circadian photoreception.
    • (1999) Science , vol.284 , pp. 505-507
    • Lucas, R.J.1    Freedman, M.S.2    Munoz, M.3    Garcia-Fernandez, J.M.4    Foster, R.G.5
  • 38
    • 0032535952 scopus 로고    scopus 로고
    • Extraocular circadian phototransduction in humans
    • Campbell SS, Murphy PJ Extraocular circadian phototransduction in humans. Science. 279:1998;396-399.
    • (1998) Science , vol.279 , pp. 396-399
    • Campbell, S.S.1    Murphy, P.J.2
  • 39
    • 0033153702 scopus 로고    scopus 로고
    • No evidence for extraocular photoreceptors in the circadian system of the syrian hamster
    • in press
    • Yamazaki S, Goto M, Menaker M: No evidence for extraocular photoreceptors in the circadian system of the syrian hamster. J Biol Rhythms 1999, in press.
    • (1999) J Biol Rhythms
    • Yamazaki, S.1    Goto, M.2    Menaker, M.3
  • 40
    • 0030295187 scopus 로고    scopus 로고
    • Arabidopsis cryptochrome 1 is a soluble protein mediating blue light-dependent regulation of plant growth and development
    • Lin C, Ahmad MA, Cashmore AR Arabidopsis cryptochrome 1 is a soluble protein mediating blue light-dependent regulation of plant growth and development. Plant J. 10:1996;893-902.
    • (1996) Plant J , vol.10 , pp. 893-902
    • Lin, C.1    Ahmad, M.A.2    Cashmore, A.R.3
  • 41
    • 0032570771 scopus 로고    scopus 로고
    • Regulation of flowering time by Arabidopsis photoreceptors
    • Guo G, Yang H, Mockler TC, Lin C Regulation of flowering time by Arabidopsis photoreceptors. Science. 279:1998;1360-1363.
    • (1998) Science , vol.279 , pp. 1360-1363
    • Guo, G.1    Yang, H.2    Mockler, T.C.3    Lin, C.4
  • 42
    • 0032537186 scopus 로고    scopus 로고
    • Cryptochrome blue-light photoreceptors of Arabidopsis implicated in phototropism
    • Ahmad M, Jarillo JA, Smirnova O, Cashmore AR Cryptochrome blue-light photoreceptors of Arabidopsis implicated in phototropism. Nature. 393:1998;720-723.
    • (1998) Nature , vol.393 , pp. 720-723
    • Ahmad, M.1    Jarillo, J.A.2    Smirnova, O.3    Cashmore, A.R.4
  • 44
    • 0032566970 scopus 로고    scopus 로고
    • The cryB mutation identifies cryptochrome as a circadian photoreceptor in Drosophila
    • ••] demonstrate the importance of the cry gene product for circadian photoreception in Drosophila by means of both mutation and overexpression studies. In particular, the papers show that circadian photosensitvity is increased in Drosophila strains that overexpress Cry and decreased in strains containing a mutant cry gene.
    • ••] demonstrate the importance of the cry gene product for circadian photoreception in Drosophila by means of both mutation and overexpression studies. In particular, the papers show that circadian photosensitvity is increased in Drosophila strains that overexpress Cry and decreased in strains containing a mutant cry gene.
    • (1998) Cell , vol.95 , pp. 681-692
    • Stanewsky, R.1    Kaneko, M.2    Emery, P.3    Beretta, B.4    Wager-Smith, K.5    Kay, S.A.6    Rosbash, M.7    Hall, J.C.8
  • 45
    • 0032568457 scopus 로고    scopus 로고
    • Vitamin B2-based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals
    • Miyamoto Y, Sancar A Vitamin B2-based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals. Proc Natl Acad Sci USA. 95:1998;6097-6102.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6097-6102
    • Miyamoto, Y.1    Sancar, A.2
  • 47
    • 0033560863 scopus 로고    scopus 로고
    • Mammalian cry1 and cry2 are essential for maintenance of circadian rhythms
    • This paper characterizes mouse knockouts of the cry1 and cry2 loci. Each alone affects the period length of circadian locomotor activity. In the absence of the two, an instantaneous loss of rhythmicity is observed in continuously dark conditions.
    • Van der Horst GTJ, Muijtjiens M, Kobayashi K, Takano R, Kano S, Takao M, de Wit J, Verkerk A, Eker AP, van Leenen Det al. Mammalian cry1 and cry2 are essential for maintenance of circadian rhythms. Nature. 398:1999;627-630. This paper characterizes mouse knockouts of the cry1 and cry2 loci. Each alone affects the period length of circadian locomotor activity. In the absence of the two, an instantaneous loss of rhythmicity is observed in continuously dark conditions.
    • (1999) Nature , vol.398 , pp. 627-630
    • Van Der Horst, G.T.J.1    Muijtjiens, M.2    Kobayashi, K.3    Takano, R.4    Kano, S.5    Takao, M.6    De Wit, J.7    Verkerk, A.8    Eker, A.P.9    Van Leenen, D.10
  • 48
    • 0029989521 scopus 로고    scopus 로고
    • Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock
    • Myers MP, Wager-Smith K, Rothenfluh-Hilfiker A, Young MW Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock. Science. 271:1996;1736-1740.
    • (1996) Science , vol.271 , pp. 1736-1740
    • Myers, M.P.1    Wager-Smith, K.2    Rothenfluh-Hilfiker, A.3    Young, M.W.4
  • 49
    • 0030012253 scopus 로고    scopus 로고
    • Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex
    • Lee C, Parikh V, Itsukaichi T, Bae K, Edery I Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex. Science. 271:1996;1740-1744.
    • (1996) Science , vol.271 , pp. 1740-1744
    • Lee, C.1    Parikh, V.2    Itsukaichi, T.3    Bae, K.4    Edery, I.5
  • 50
    • 0029979174 scopus 로고    scopus 로고
    • A light-entrainment mechanism for the Drosophila circadian clock
    • Zeng H, Qian Z, Myers MP, Rosbash M A light-entrainment mechanism for the Drosophila circadian clock. Nature. 380:1996;129-135.
    • (1996) Nature , vol.380 , pp. 129-135
    • Zeng, H.1    Qian, Z.2    Myers, M.P.3    Rosbash, M.4
  • 51
    • 0029965130 scopus 로고    scopus 로고
    • Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light
    • Hunter-Ensor M, Ousley A, Sehgal A Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light. Cell. 84:1996;677-685.
    • (1996) Cell , vol.84 , pp. 677-685
    • Hunter-Ensor, M.1    Ousley, A.2    Sehgal, A.3
  • 53
    • 0345596433 scopus 로고    scopus 로고
    • A differential response of two putative mammalian circadian regulators, mpe1 and mper2, to light
    • Albrecht U, Sun Z, Eichele G, Lee CC A differential response of two putative mammalian circadian regulators, mpe1 and mper2, to light. Cell. 91:1997;1055-1064.
    • (1997) Cell , vol.91 , pp. 1055-1064
    • Albrecht, U.1    Sun, Z.2    Eichele, G.3    Lee, C.C.4
  • 54
    • 0032851147 scopus 로고    scopus 로고
    • Per1 and Per2 gene expression in the rat suprachiasmatic nucleus: circadian profile and compartment-specific response to light
    • in press
    • Yan L, Takekida S, Shigeyoshi Y, Okamura H: Per1 and Per2 gene expression in the rat suprachiasmatic nucleus: circadian profile and compartment-specific response to light. Neuroscience 1999, in press.
    • (1999) Neuroscience
    • Yan, L.1    Takekida, S.2    Shigeyoshi, Y.3    Okamura, H.4
  • 55
    • 0028580097 scopus 로고
    • Resetting the biological clock: Mediation of nocturnal circadian shifts by glutamate and NO
    • Ding JM, Chen D, Weber ET, Faiman LE, Rea MA, Gillette MU Resetting the biological clock: mediation of nocturnal circadian shifts by glutamate and NO. Science. 266:1994;1713-1717.
    • (1994) Science , vol.266 , pp. 1713-1717
    • Ding, J.M.1    Chen, D.2    Weber, E.T.3    Faiman, L.E.4    Rea, M.A.5    Gillette, M.U.6
  • 57


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