메뉴 건너뛰기




Volumn 39, Issue 1, 1999, Pages 129-141

Genomic amplification of the human DHFR/MSH3 locus remodels mismatch recognition and repair activities

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DIHYDROFOLATE REDUCTASE; DNA; DNA BINDING PROTEIN; HUMAN MISMATCH REPAIR PROTEIN 1; METHOTREXATE;

EID: 0032833671     PISSN: 00652571     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2571(98)00013-2     Document Type: Conference Paper
Times cited : (7)

References (60)
  • 1
    • 0024328152 scopus 로고
    • Isolation and characterization of cDNA clones derived from the divergently transcribed gene in the region upstream from the human dihydrofolate reductase gene
    • H. FUJII and T. SHIMADA, Isolation and characterization of cDNA clones derived from the divergently transcribed gene in the region upstream from the human dihydrofolate reductase gene, J. Biol. Chem. 264, 10057-10064 (1989).
    • (1989) J. Biol. Chem. , vol.264 , pp. 10057-10064
    • Fujii, H.1    Shimada, T.2
  • 2
    • 0031059532 scopus 로고    scopus 로고
    • MutS homologs in mammalian cells
    • R. FISHEL and T. WILSON, MutS homologs in mammalian cells, Curr. Opin. Genet. Dev. 7, 105-113 (1997).
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 105-113
    • Fishel, R.1    Wilson, T.2
  • 3
    • 0026355962 scopus 로고
    • Mechanisms and biological effects of mismatch repair
    • P. MODRICH, Mechanisms and biological effects of mismatch repair, Annu. Rev. Genet. 25, 229-253 (1991).
    • (1991) Annu. Rev. Genet. , vol.25 , pp. 229-253
    • Modrich, P.1
  • 4
    • 0028023976 scopus 로고
    • Transcriptional regulation of the dihydrofolate reductase/rep-3 locus
    • L. J. SCHILLING and P. J. FARNHAM, Transcriptional regulation of the dihydrofolate reductase/rep-3 locus, Crit. Rev. Eukaryot. Gene Exp. 4, 19-53 (1994).
    • (1994) Crit. Rev. Eukaryot. Gene Exp. , vol.4 , pp. 19-53
    • Schilling, L.J.1    Farnham, P.J.2
  • 5
    • 0029063032 scopus 로고
    • The bidirectionally transcribed dihydrofolate reductase and rep-3a promoters are growth regulated by distinct mechanisms
    • L. J. SCHILLING and P. J. FARNHAM, The bidirectionally transcribed dihydrofolate reductase and rep-3a promoters are growth regulated by distinct mechanisms, Cell Growth Differ. 6, 541-548 (1995).
    • (1995) Cell Growth Differ. , vol.6 , pp. 541-548
    • Schilling, L.J.1    Farnham, P.J.2
  • 6
    • 0030030358 scopus 로고    scopus 로고
    • Protein-DNA interactions at the major and minor promoters of the divergently transcribed dhfr and rep3 genes during the Chinese hamster ovary cell cycle
    • J. WELLS, P. HELD, S. ILLENYE and N. H. HEINTZ, Protein-DNA interactions at the major and minor promoters of the divergently transcribed dhfr and rep3 genes during the Chinese hamster ovary cell cycle, Mol. Cell. Biol. 16, 634-647 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 634-647
    • Wells, J.1    Held, P.2    Illenye, S.3    Heintz, N.H.4
  • 8
    • 0029659046 scopus 로고    scopus 로고
    • hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA
    • F. PALOMBO, I. IACCARINO, E. NAKAJIMA, M. IKEJIMA, T. SHIMADA and J. JIRICNY, hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA, Curr. Biol. 6, 1181-1184 (1996).
    • (1996) Curr. Biol. , vol.6 , pp. 1181-1184
    • Palombo, F.1    Iaccarino, I.2    Nakajima, E.3    Ikejima, M.4    Shimada, T.5    Jiricny, J.6
  • 9
    • 0030885951 scopus 로고    scopus 로고
    • DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair
    • J. T. DRUMMOND, J. GENSCHEL, E. WOLF and P. MODRICH, DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair, Proc. Natl. Acad. Sci. USA 94, 10144-10149 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10144-10149
    • Drummond, J.T.1    Genschel, J.2    Wolf, E.3    Modrich, P.4
  • 10
    • 0032584384 scopus 로고    scopus 로고
    • Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha
    • J. GENSCHEL, S. J. LITTMAN, J. T. DRUMMOND and P. MODRICH, Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha, J. Biol. Chem. 273, 19895-19901 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 19895-19901
    • Genschel, J.1    Littman, S.J.2    Drummond, J.T.3    Modrich, P.4
  • 12
    • 0030803659 scopus 로고    scopus 로고
    • Strand-specific mismatch repair in mammalian cells
    • P. MODRICH, Strand-specific mismatch repair in mammalian cells, J. Biol. Chem. 272, 24727-24730 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 24727-24730
    • Modrich, P.1
  • 13
    • 0029943449 scopus 로고    scopus 로고
    • Mismatch repair in replication fidelity, genetic recombination, and cancer biology
    • P. MODRICH and R. LAHUE, Mismatch repair in replication fidelity, genetic recombination, and cancer biology, Annu. Rev. Biochem. 65, 101-133 (1996).
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 101-133
    • Modrich, P.1    Lahue, R.2
  • 14
    • 0029784320 scopus 로고    scopus 로고
    • Biochemistry and genetics of eukaryotic mismatch repair
    • R. KOLODNER, Biochemistry and genetics of eukaryotic mismatch repair, Genes. Dev. 10, 1433-1442 (1996).
    • (1996) Genes. Dev. , vol.10 , pp. 1433-1442
    • Kolodner, R.1
  • 15
    • 0029837248 scopus 로고    scopus 로고
    • Mismatch repair defects in human carcinogenesis
    • J. R. ESHLEMAN and S. D. MARKOWITZ, Mismatch repair defects in human carcinogenesis, Hum. Mol. Genet. 5, 1489-1494 (1996).
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1489-1494
    • Eshleman, J.R.1    Markowitz, S.D.2
  • 16
    • 0026446241 scopus 로고
    • Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins
    • R. A. REENAN and R. D. KOLODNER, Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins, Genetics 132, 963-973 (1992).
    • (1992) Genetics , vol.132 , pp. 963-973
    • Reenan, R.A.1    Kolodner, R.D.2
  • 17
    • 0026445628 scopus 로고
    • Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: Evidence for separate mitochondrial and nuclear functions
    • R. A. REENAN and R. D. KOLODNER, Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions, Genetics 132, 975-985 (1992).
    • (1992) Genetics , vol.132 , pp. 975-985
    • Reenan, R.A.1    Kolodner, R.D.2
  • 18
    • 0027742295 scopus 로고
    • The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
    • R. FISHEL, M. K. LESCOE, M. R. RAO, N. G. COPELAND, N. A. JENKINS, J. GARBER, M. KANE and R. KOLODNER, The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer, Cell 75, 1027-1038 (1993).
    • (1993) Cell , vol.75 , pp. 1027-1038
    • Fishel, R.1    Lescoe, M.K.2    Rao, M.R.3    Copeland, N.G.4    Jenkins, N.A.5    Garber, J.6    Kane, M.7    Kolodner, R.8
  • 20
    • 0029070143 scopus 로고
    • Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells
    • J. T. DRUMMOND, G. M. LI, M. J. LONGLEY and P. MODRICH, Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells, Science 268, 1909-1912 (1995).
    • (1995) Science , vol.268 , pp. 1909-1912
    • Drummond, J.T.1    Li, G.M.2    Longley, M.J.3    Modrich, P.4
  • 22
    • 0029868110 scopus 로고    scopus 로고
    • Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair
    • G. T. MARSISCHKY, N. FILOSI, M. F. KANE and R. KOLODNER, Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair, Genes. Dev. 10, 407-420 (1996).
    • (1996) Genes. Dev. , vol.10 , pp. 407-420
    • Marsischky, G.T.1    Filosi, N.2    Kane, M.F.3    Kolodner, R.4
  • 23
    • 0031908637 scopus 로고    scopus 로고
    • Analysis of in vivo correction of defined mismatches in the DNA mismatch repair mutants msh2, msh3 and msh6 of Saccharomyces cerevisiae
    • B. LUHR, J. SCHELLER, P. MEYER and W. KRAMER, Analysis of in vivo correction of defined mismatches in the DNA mismatch repair mutants msh2, msh3 and msh6 of Saccharomyces cerevisiae, Mol. Gen. Genet. 257, 362-367 (1998).
    • (1998) Mol. Gen. Genet. , vol.257 , pp. 362-367
    • Luhr, B.1    Scheller, J.2    Meyer, P.3    Kramer, W.4
  • 24
    • 0028981276 scopus 로고
    • The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions
    • E. ALANI, N. W. CHI and R. KOLODNER, The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions, Genes Dev. 9, 234-247 (1995).
    • (1995) Genes Dev. , vol.9 , pp. 234-247
    • Alani, E.1    Chi, N.W.2    Kolodner, R.3
  • 25
    • 0031051010 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognises Holliday junctions in DNA
    • E. ALANI, S. LEE, M. F. KANE, J. GRIFFITH and R. KOLODNER, Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognises Holliday junctions in DNA, J. Mol. Biol. 265, 289-301 (1997).
    • (1997) J. Mol. Biol. , vol.265 , pp. 289-301
    • Alani, E.1    Lee, S.2    Kane, M.F.3    Griffith, J.4    Kolodner, R.5
  • 27
    • 0030044804 scopus 로고    scopus 로고
    • Genomic organisation and expression of the human MSH3 gene
    • A. WATANABE, M. IKEJIMA, N. SUZUKI and T. SHIMADA, Genomic organisation and expression of the human MSH3 gene, Genomics 31(3), 311-318 (1996).
    • (1996) Genomics , vol.31 , Issue.3 , pp. 311-318
    • Watanabe, A.1    Ikejima, M.2    Suzuki, N.3    Shimada, T.4
  • 31
    • 0025200832 scopus 로고
    • Increased rate of base substitution in a hamster mutator strain obtained during serial selection for gene amplification
    • M. A. CALIGO, W. ARMSTRONG, B. J. ROSSITER and M. MEUTH, Increased rate of base substitution in a hamster mutator strain obtained during serial selection for gene amplification, Mol. Cell. Biol. 10, 6805-6808 (1990).
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 6805-6808
    • Caligo, M.A.1    Armstrong, W.2    Rossiter, B.J.3    Meuth, M.4
  • 32
    • 0021888284 scopus 로고
    • Opposite-strand RNAs from the 5′ flanking region of the mouse dihydrofolate reductase gene
    • P. J. FARNHAM, J. M. ABRAMS and R. T. SCHIMKE, Opposite-strand RNAs from the 5′ flanking region of the mouse dihydrofolate reductase gene, Proc. Natl. Acad. Sci. USA 82, 3978-3982 (1985).
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 3978-3982
    • Farnham, P.J.1    Abrams, J.M.2    Schimke, R.T.3
  • 33
    • 0021807101 scopus 로고
    • Analysis of the mouse dhfr promoter region: Existence of a divergently transcribed gene
    • G. F. GROUSE, E. J. LEYS, R. N. MCEWAN, E. G. FRAYNE and R. E. KELLEMS, Analysis of the mouse dhfr promoter region: existence of a divergently transcribed gene, Mol. Cell. Biol. 5, 1847-1858 (1985).
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 1847-1858
    • Grouse, G.F.1    Leys, E.J.2    Mcewan, R.N.3    Frayne, E.G.4    Kellems, R.E.5
  • 34
    • 0024994313 scopus 로고
    • Analysis of the mouse Dhfr/ Rep-3 major promoter region by using linker-scanning and internal deletion mutations and DNase I footprinting
    • M. L. SMITH, P. J. MITCHELL and G. F. GROUSE, Analysis of the mouse Dhfr/ Rep-3 major promoter region by using linker-scanning and internal deletion mutations and DNase I footprinting, Mol. Cell. Biol. 10, 6003-6012 (1990).
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 6003-6012
    • Smith, M.L.1    Mitchell, P.J.2    Grouse, G.F.3
  • 35
    • 0030028934 scopus 로고    scopus 로고
    • Transcriptional regulation of the dihydrofolate reductase gene
    • J. E. SLANSKY and P. J. FARNHAM, Transcriptional regulation of the dihydrofolate reductase gene, Bioessays 18, 55-62 (1996).
    • (1996) Bioessays , vol.18 , pp. 55-62
    • Slansky, J.E.1    Farnham, P.J.2
  • 36
    • 0022642942 scopus 로고
    • Murine dihydrofolate reductase transcripts through the cell cycle
    • P. J. FARNHAM and R. T. SCHIMKE, Murine dihydrofolate reductase transcripts through the cell cycle, Mol. Cell. Biol. 6, 365-371 (1986).
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 365-371
    • Farnham, P.J.1    Schimke, R.T.2
  • 37
    • 0030071187 scopus 로고    scopus 로고
    • Isolation and characterization of the human mismatch repair gene hMSH2 promoter region
    • S. J. SCHERER, T. SEIB, G. SEITZ, S. DOOLEY and C. WELTER, Isolation and characterization of the human mismatch repair gene hMSH2 promoter region, Hum. Genet. 97, 114-116 (1996).
    • (1996) Hum. Genet. , vol.97 , pp. 114-116
    • Scherer, S.J.1    Seib, T.2    Seitz, G.3    Dooley, S.4    Welter, C.5
  • 40
    • 0030834260 scopus 로고    scopus 로고
    • Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination
    • N. SUGAWARA, F. PAQUES, M. COLAIACOVO and J. E. HABER, Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination, Proc. Natl. Acad. Sci. USA 94, 9214-9219 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9214-9219
    • Sugawara, N.1    Paques, F.2    Colaiacovo, M.3    Haber, J.E.4
  • 41
    • 0000899457 scopus 로고
    • Dihydrofolate reductase
    • (R. L. Blakley and S. J. Benkovic, eds.). Wiley, New York
    • R. L. Blakley, Dihydrofolate reductase, in Folates and Pterins. Vol. 1 (R. L. Blakley and S. J. Benkovic, eds.). Wiley, New York (1984).
    • (1984) Folates and Pterins , vol.1
    • Blakley, R.L.1
  • 42
    • 0025309892 scopus 로고
    • Frameshift errors initiated by nucleotide misincorporation
    • K. BEBENEK and T. A. KUNKEL, Frameshift errors initiated by nucleotide misincorporation, Proc. Natl. Acad. Sci. USA 87, 4946-4950 (1990).
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 4946-4950
    • Bebenek, K.1    Kunkel, T.A.2
  • 43
    • 0026714957 scopus 로고
    • The effects of dNTP pool imbalances on frameshift fidelity during DNA replication
    • K. BEBENEK, J. D. ROBERTS and T. A. KUNKEL, The effects of dNTP pool imbalances on frameshift fidelity during DNA replication, J. Biol. Chem. 267, 3589-3596 (1992).
    • (1992) J. Biol. Chem. , vol.267 , pp. 3589-3596
    • Bebenek, K.1    Roberts, J.D.2    Kunkel, T.A.3
  • 47
    • 0029783835 scopus 로고    scopus 로고
    • Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair
    • J. I. RISINGER, A. UMAR, J. BOYD, A. BERCHUCK, T. A. KUNKEL and J. C. BARRETT, Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair, Nat. Genet. 14, 102-105 (1996).
    • (1996) Nat. Genet. , vol.14 , pp. 102-105
    • Risinger, J.I.1    Umar, A.2    Boyd, J.3    Berchuck, A.4    Kunkel, T.A.5    Barrett, J.C.6
  • 48
    • 0027351189 scopus 로고
    • Karnofsky memorial lecture. Ode to methotrexate
    • J. R. BERTINO, Karnofsky memorial lecture. Ode to methotrexate, J. Clin. Oncol. 11, 5-14 (1993).
    • (1993) J. Clin. Oncol. , vol.11 , pp. 5-14
    • Bertino, J.R.1
  • 49
    • 0028315470 scopus 로고
    • The methotrexate story: A paradigm for development of cancer chemotherapeutic agents
    • F. M. HUENNEKENS, The methotrexate story: a paradigm for development of cancer chemotherapeutic agents, Advan. Enzyme Regul. 34, 397-419 (1994).
    • (1994) Advan. Enzyme Regul. , vol.34 , pp. 397-419
    • Huennekens, F.M.1
  • 50
    • 0029075026 scopus 로고
    • Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia and is correlated with p53 gene mutations
    • E. GOKER, M. WALTHAM, A. KHERADPOUR, T. TRIPPETT, M. MAZUMDAR, Y. ELISSEYEFF, B. SCHNIEDERS, P. STEINHERZ, C. TAN and E. BERMAN, Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia and is correlated with p53 gene mutations, Blood 86, 677-684 (1995).
    • (1995) Blood , vol.86 , pp. 677-684
    • Goker, E.1    Waltham, M.2    Kheradpour, A.3    Trippett, T.4    Mazumdar, M.5    Elisseyeff, Y.6    Schnieders, B.7    Steinherz, P.8    Tan, C.9    Berman, E.10
  • 51
    • 0030058722 scopus 로고    scopus 로고
    • Higher frequency of gene amplification in breast cancer patients who received adjuvant chemotherapy
    • U. LONN, S. LONN, B. NILSSON and B. STENKVIST, Higher frequency of gene amplification in breast cancer patients who received adjuvant chemotherapy, Cancer 77, 107-112 (1996).
    • (1996) Cancer , vol.77 , pp. 107-112
    • Lonn, U.1    Lonn, S.2    Nilsson, B.3    Stenkvist, B.4
  • 53
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • N. RAMPINO, H. YAMAMOTO, Y. IONOV, Y. LI, H. SAWAI, J. C. REED and M. PERUCHO, Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype, Science 275, 967-969 (1997).
    • (1997) Science , vol.275 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Ionov, Y.3    Li, Y.4    Sawai, H.5    Reed, J.C.6    Perucho, M.7
  • 54
    • 0029665878 scopus 로고    scopus 로고
    • Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct
    • D. R. DUCKETT, J. T. DRUMMOND, A. I. MURCHIE, J. T. REARDON, A. SANCAR, D. M. LILLEY and P. MODRICH, Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct, Proc. Natl. Acad. Sci. USA 93, 6443-6447 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 6443-6447
    • Duckett, D.R.1    Drummond, J.T.2    Murchie, A.I.3    Reardon, J.T.4    Sancar, A.5    Lilley, D.M.6    Modrich, P.7
  • 55
    • 0030198880 scopus 로고    scopus 로고
    • The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin
    • J. A. MELLO, S. ACHARYA, R. FISHEL and J. M. ESSIGMANN, The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin, Chem. Biol. 3, 579-589 (1996).
    • (1996) Chem. Biol. , vol.3 , pp. 579-589
    • Mello, J.A.1    Acharya, S.2    Fishel, R.3    Essigmann, J.M.4
  • 58
    • 0029812676 scopus 로고    scopus 로고
    • Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line
    • J. T. DRUMMOND, A. ANTHONEY, R. BROWN and P. MODRICH, Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line, J. Biol. Chem. 271, 19645-19648 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 19645-19648
    • Drummond, J.T.1    Anthoney, A.2    Brown, R.3    Modrich, P.4
  • 59
    • 0031906084 scopus 로고    scopus 로고
    • The role of DNA mismatch repair in drug resistance
    • D. FINK, S. AEBI and S. B. HOWELL, The role of DNA mismatch repair in drug resistance, Clin. Cancer Res. 4, 1-6 (1998).
    • (1998) Clin. Cancer Res. , vol.4 , pp. 1-6
    • Fink, D.1    Aebi, S.2    Howell, S.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.