Analysis of in vivo correction of defined mismatches in the DNA mismatch repair mutants msh2, msh3 and msh6 of Saccharomyces cerevisiae

Molecular and General Genetics

Volumn 257, Issue 3, 1998, Pages 362-367

  Luhr B ^a,b   Scheller, J ^a   Meyer, P ^a   Kramer, W ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Jerini Bio Tools GmbH   (Germany)

Author keywords

DNA mismatch repair; Mismatch recognition; Yeast

Indexed keywords

FUNGAL DNA; HETERODUPLEX;

ARTICLE; BASE MISPAIRING; CONTROLLED STUDY; DNA REPAIR; GENE CONSTRUCT; GENETIC TRANSFORMATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

DNA REPAIR; DNA, FUNGAL; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENES, FUNGAL; MUTS HOMOLOG 2 PROTEIN; NUCLEIC ACID HETERODUPLEXES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 0031908637     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380050658     Document Type: Article

References (33)

1. Acharya S, Wilson T, Gradia S, Kane MF, Guerette S, Marsischky GT, Kolodner R, Fishel R (1996) hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc Natl Acad Sci USA 93:13629-13634
2. Alani E (1996) The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairs. Mol Cell Biol 16:5604-5615
3. Alani E, Cao L, Kleckner N (1987) A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains. Genetics 116:541-545
4. Alani E, Chi N-W, Kolodner R (1995) The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions. Genes Dev 9:234-247
5. Bishop DK, Andersen J, Kolodner RD (1989) Specificity of mismatch repair following transformation of Saccharomyces cerevisiae with heteroduplex plasmid DNA. Proc Natl Acad Sci USA 86:3713-3717
6. Grouse GF (1997) Mismatch repair systems in yeast. In: Hoekstra MF, Nickoloff JA (eds) DNA damage and repair, vol 1: DNA repair in prokaryotes and lower eukaryotes. Humana Press, Totowa N.J., in press
7. Dohet C, Wagner R, Radman M (1985) Repair of defined single base-pair mismatches in Escherichia coli. Proc Natl Acad Sci USA 82:503-505
8. Drummond JT, Li G-M, Longley MJ, Modrich P (1995) Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair of tumor cells. Science 268:1909-1912
9. Gietz D, St Jean A, Woods RA, Schiestl RH (1992) Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res 16:1425
10. Habraken Y, Sung P, Prakash E, Prakash S (1996) Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3. Curr Biol 6:1185-1187
11. Jeyaprakash A, Das Gupta R, Kolodner R (1996) Saccharomyces cerevisiae pms2 mutations are alleles of MLH1, and pms2-2 corresponds to a hereditary nonpolyposis colorectal carcinoma-causing missense mutation. Mol Cell Biol 16:3008-3011
12. Johnson RE, Kovvali GK, Prakash L, Prakash S (1996a) Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability. J Biol Chem 271:7285-7288
13. Johnson RE, Kovvali GK, Guzder SN, Amin NS, Holm C, Habraken Y, Sung P, Prakash L, Prakash S (1996b) Evidence for involvement of yeast proliferating cell nuclear antigen in DNA mismatch repair. J Biol Chem 271: 27987-27990
14. Kramer B (1986) Untersuchungen zur DNA-Mismatch-Reparatur in Escherichia coli. Ph.D. thesis, University of Cologne
15. Kramer B, Kramer W, H-J Fritz (1984) Different base/base mismatches are corrected with different efficiencies by the methyl-directed DNA mismatch-repair system of E. coli. Cell 38:879-887
16. Kramer B, Kramer W, Williamson MS, Fogel S (1989a) Heteroduplex DNA correction in Saccharomyces cerevisiae is mismatch specific and requires functional PMS genes. Mol Cell Biol 9:4432-4440
17. Kramer W, Kramer B, Williamson MS, Fogel S (1989b) Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology of PMS1 to procaryotic MutL and HexB. J Bacteriol 171: 5339-5346
18. Kramer W, Fartmann B, Ringbeck EC (1996) Transcription of mutS- and mutL-homologous genes in Saccharomyces cerevisiae during the cell cycle. Mol Gen Genet 252:275-283
19. Marsischky GT, Filosi N, Kane MF, Kolodner R (1996) Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. Genes Dev 10:407-420
20. Modrich P (1987) DNA mismatch correction. Annu Rev Biochem 56:435-466
21. Modrich P (1991) Mechanisms and biological effects of mismatch repair. Annu Rev Genet 25:229-253
22. Modrich P, Lahue R (1996) Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochem 65:101-133
23. New L, Liu K., Crouse GF (1993) The yeast gene MSH3 defines a new class of eucaryotic mutS homologs. Mol Gen Genet 239:97-108
24. Paithankar KR, Prasad KSN (1991) Precipitation of DNA by polyethylene glycol and ethanol. Nucleic Acids Res 19:1346
25. Palombe F, Iaccarino I, Nakajima E, Ikejima M, Shimada T, Jiricny J (1996) hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA. Curr Biol 6:1181-1184
26. Rothstein R (1991) Targeting, disruption, replacement and allele rescue: integrative DNA transformation in yeast. Methods Enzymol 194: 281-301
27. Sia EA, Kokoska RJ, Dominska M, Greenwell P, Petes TD (1997) Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes. Mol Cell Biol 17:2851-2858
28. Sikorski RS, Boeke JD (1991) In vitro mutagenesis and plasmid shuffling: from cloned genes to mutant yeast. Methods Enzymol 194: 302-318
29. Sikorski RS, Hieter P (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19-27
30. Strand M, Earley MC, Crouse GF, Petes TD (1995) Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 92:10418-10421
31. Su S-S, Lahue RS, Au KG, Modrich P (1988) Mispair specificity of methyl-directed DNA mismatch correction in vitro. J Biol Chem 263:6829-6835
32. Umar A, Buermeyer AB, Simon JA, Thomas DC, Clark AB, Liskay RM, Kunkel TA (1996) Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. Cell 87:65-73
33. Yang Y, Johnson AL, Johnston LH, Siede W, Friedberg EC, Ramachandran K, Kunz BA (1996) A mutation in a Saccharomyces cerevisiae gene (RAD3) required for nucleotide excision repair and transcription increases the efficiency of mismatch correction. Genetics 144:459-466