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Volumn 125, Issue 1, 1998, Pages 1-9

Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues

Author keywords

Cell death; Cell proliferation; Drosophila; Hyperplasia; Imaginal disc; Ras1

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; RAS PROTEIN;

EID: 0031964429     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (265)

References (42)
  • 1
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand, A. H. and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 2
    • 0028328631 scopus 로고
    • A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signalling pathways
    • Brunner, D., Oellers, N., Szabad, J., Biggs, W. H., Zipursky, S. L. and Hafen, E. (1994). A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signalling pathways. Cell 76, 875-888.
    • (1994) Cell , vol.76 , pp. 875-888
    • Brunner, D.1    Oellers, N.2    Szabad, J.3    Biggs, W.H.4    Zipursky, S.L.5    Hafen, E.6
  • 3
    • 0030272587 scopus 로고    scopus 로고
    • Cell proliferation control in Drosophila: Flies are not worms
    • Bryant, P. J. (1996). Cell proliferation control in Drosophila: flies are not worms. BioEssays 18, 781-784.
    • (1996) BioEssays , vol.18 , pp. 781-784
    • Bryant, P.J.1
  • 4
    • 0027818550 scopus 로고
    • Tumor suppressor genes encoding proteins required for cell interactions and signal transduction
    • Bryant, P. J., Watson, K. L., Justice, R. W. and Woods, D. F. (1993). Tumor suppressor genes encoding proteins required for cell interactions and signal transduction. Development 1993 Supplement, 239-249.
    • (1993) Development , vol.1993 SUPPLEMENT , pp. 239-249
    • Bryant, P.J.1    Watson, K.L.2    Justice, R.W.3    Woods, D.F.4
  • 6
    • 0028803222 scopus 로고
    • Uncoupling cell fate determination from patterned cell division in the Drosophila eye
    • de Nooij, J. C. and Hariharan, I. K. (1995). Uncoupling cell fate determination from patterned cell division in the Drosophila eye. Science 270, 983-985.
    • (1995) Science , vol.270 , pp. 983-985
    • De Nooij, J.C.1    Hariharan, I.K.2
  • 7
    • 0028343745 scopus 로고
    • The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development
    • Diaz-Benjumea, F. J. and Hafen, E. (1994). The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development. Development 120, 569-578.
    • (1994) Development , vol.120 , pp. 569-578
    • Diaz-Benjumea, F.J.1    Hafen, E.2
  • 8
    • 0029837986 scopus 로고    scopus 로고
    • Developmental control of cell cycle regulators: A fly's perspective
    • Edgar, B. A. and Lehner, C. F. (1996). Developmental control of cell cycle regulators: A fly's perspective. Science 274, 1646-1652.
    • (1996) Science , vol.274 , pp. 1646-1652
    • Edgar, B.A.1    Lehner, C.F.2
  • 10
    • 0026575220 scopus 로고
    • Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation
    • Fortini, M. E., Simon, M. A. and Rubin, G. M. (1992). Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature 355, 559-561.
    • (1992) Nature , vol.355 , pp. 559-561
    • Fortini, M.E.1    Simon, M.A.2    Rubin, G.M.3
  • 11
    • 0028603593 scopus 로고
    • Tumor suppressor and overgrowth suppressor genes of Drosophila melanogaster: Developmental aspects
    • Gateff, E. (1994). Tumor suppressor and overgrowth suppressor genes of Drosophila melanogaster: Developmental aspects. Int. J. Dev. Biol. 38, 565-590.
    • (1994) Int. J. Dev. Biol. , vol.38 , pp. 565-590
    • Gateff, E.1
  • 12
    • 0027496935 scopus 로고
    • The p21 Cdk-interaction protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K. and Elledge, S. J. (1993). The p21 Cdk-interaction protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 13
    • 0028141705 scopus 로고
    • Expression of baculovirus p35 prevents cell death in Drosophila
    • Hay, B. A., Wolff, T. and Rubin, G. M. (1994). Expression of baculovirus p35 prevents cell death in Drosophila. Development 120, 2121-2129.
    • (1994) Development , vol.120 , pp. 2121-2129
    • Hay, B.A.1    Wolff, T.2    Rubin, G.M.3
  • 14
    • 0030052368 scopus 로고    scopus 로고
    • Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
    • Joneson, T., White, M. A., Wigler, M. H. and Bar-Sagi, D. (1996). Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science 271, 810-812.
    • (1996) Science , vol.271 , pp. 810-812
    • Joneson, T.1    White, M.A.2    Wigler, M.H.3    Bar-Sagi, D.4
  • 15
    • 0029869355 scopus 로고    scopus 로고
    • A Screen for genes that function downstream of Ras1 during Drosophila eye development
    • Karim, F. D., Chang, H. C., Therrien, M., Wassarman, D. A., Laverty, T. and Rubin, G. M. (1996). A Screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics 143, 315-329.
    • (1996) Genetics , vol.143 , pp. 315-329
    • Karim, F.D.1    Chang, H.C.2    Therrien, M.3    Wassarman, D.A.4    Laverty, T.5    Rubin, G.M.6
  • 19
    • 0025276935 scopus 로고
    • The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype
    • Kimmel, B. E., Heberlein, U. and Rubin, G. M. (1990). The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype. Genes Dev. 4, 712-727.
    • (1990) Genes Dev. , vol.4 , pp. 712-727
    • Kimmel, B.E.1    Heberlein, U.2    Rubin, G.M.3
  • 20
    • 0026783674 scopus 로고
    • Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
    • Lee, J. J., von Kessler, D. P., Parks, S. and Beachy, P. A. (1992). Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell 71, 33-50.
    • (1992) Cell , vol.71 , pp. 33-50
    • Lee, J.J.1    Von Kessler, D.P.2    Parks, S.3    Beachy, P.A.4
  • 21
    • 0027239613 scopus 로고
    • Function and regulation of Ras
    • Lowy, D. R. and Willumsen, B. M. (1993). Function and regulation of Ras. Annu. Rev. Biochem 62, 851-891.
    • (1993) Annu. Rev. Biochem , vol.62 , pp. 851-891
    • Lowy, D.R.1    Willumsen, B.M.2
  • 22
    • 0027850403 scopus 로고
    • The torso pathway in Drosophila: A model system to study receptor tyrosine kinase signal transduction
    • Lu, X., Perkins, L. A. and Perrimon, N. (1993). The torso pathway in Drosophila: a model system to study receptor tyrosine kinase signal transduction. Development 1993 Supplement 47-56.
    • (1993) Development , vol.1993 SUPPLEMENT , pp. 47-56
    • Lu, X.1    Perkins, L.A.2    Perrimon, N.3
  • 23
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase Activation
    • Marshall, C. J. (1995). Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase Activation. Cell 80, 179-185.
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 24
    • 0030071741 scopus 로고    scopus 로고
    • Cell cycling and patterned cell proliferation in the wing primordium of Drosophila
    • Milan, M., Campuzano, S. and Garcia-Bellido (1996). Cell cycling and patterned cell proliferation in the wing primordium of Drosophila. Proc. Natl. Acad. Sci. USA 93, 640-645.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 640-645
    • Milan, M.1    Campuzano, S.2    Garcia-Bellido3
  • 25
    • 0030995511 scopus 로고    scopus 로고
    • Developmental parameters of cell death in the wing disc of Drosophila
    • Milan, M., Campuzano, S. and Garcia-Bellido, A. (1997). Developmental parameters of cell death in the wing disc of Drosophila. Proc. Natl. Acad. Sci. USA 94, 5691-5696.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 5691-5696
    • Milan, M.1    Campuzano, S.2    Garcia-Bellido, A.3
  • 26
    • 0028096233 scopus 로고
    • The 3Rs of life: Ras, Raf and Growth Regulation
    • Moodie, S. A. and Wolfman, A. (1994). The 3Rs of life: Ras, Raf and Growth Regulation. Trends Genet. 10, 44-48.
    • (1994) Trends Genet. , vol.10 , pp. 44-48
    • Moodie, S.A.1    Wolfman, A.2
  • 27
    • 0016613341 scopus 로고
    • Minutes: Mutants of Drosophila autonomously affecting cell division rate
    • Morata, G. and Ripoll, P. (1975). Minutes: Mutants of Drosophila autonomously affecting cell division rate. Dev. Biol. 427, 211.
    • (1975) Dev. Biol. , vol.427 , pp. 211
    • Morata, G.1    Ripoll, P.2
  • 29
    • 0023976715 scopus 로고
    • Proliferation of both somatic and germ cells is affected in the Drosophila mutants of raf proto-oncogene
    • Nishida, Y., Hata, M., Ayaki, T., Ryo, H., Yamagata, M., Shimizu, K. and Nishizuka, Y. (1988). Proliferation of both somatic and germ cells is affected in the Drosophila mutants of raf proto-oncogene. EMBO J. 7, 775-781.
    • (1988) EMBO J. , vol.7 , pp. 775-781
    • Nishida, Y.1    Hata, M.2    Ayaki, T.3    Ryo, H.4    Yamagata, M.5    Shimizu, K.6    Nishizuka, Y.7
  • 30
    • 0027279176 scopus 로고
    • How receptor tyrosine kinases activate Ras
    • Schlessinger, J. (1993). How receptor tyrosine kinases activate Ras. Trends Biochem. Sci. 18, 273-275.
    • (1993) Trends Biochem. Sci. , vol.18 , pp. 273-275
    • Schlessinger, J.1
  • 31
    • 0023408608 scopus 로고
    • Changing spatial patterns of DNA replication in the developing wing of Drosophila
    • Schubiger, M. and Palka, J. (1987). Changing spatial patterns of DNA replication in the developing wing of Drosophila. Dev. Biol. 123, 145-153.
    • (1987) Dev. Biol. , vol.123 , pp. 145-153
    • Schubiger, M.1    Palka, J.2
  • 33
    • 0025997867 scopus 로고
    • Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
    • Simon, M. A., Bowtell, D. L., Dodson, G. S., Laverty, T. R. and Rubin, G. M. (1991). Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell 67, 701-716.
    • (1991) Cell , vol.67 , pp. 701-716
    • Simon, M.A.1    Bowtell, D.L.2    Dodson, G.S.3    Laverty, T.R.4    Rubin, G.M.5
  • 34
    • 84861107941 scopus 로고
    • Cell death during the development of the imaginai discs of Calliphora erythrocephalia
    • Spreij, H. E. (1971). Cell death during the development of the imaginai discs of Calliphora erythrocephalia. Netherlands J. Zool. 21, 221-264.
    • (1971) Netherlands J. Zool. , vol.21 , pp. 221-264
    • Spreij, H.E.1
  • 35
    • 0028068362 scopus 로고
    • Specificity of bone morphogenetic protein-related factors: Cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic but not 60A
    • Staehling-Hampton, K., Jackson, P. D., Clark, M. J., Brand, A. H. and Hoffmann, F. M. (1994). Specificity of bone morphogenetic protein-related factors: cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic but not 60A. Cell Growth and Diff. 5, 585-593.
    • (1994) Cell Growth and Diff. , vol.5 , pp. 585-593
    • Staehling-Hampton, K.1    Jackson, P.D.2    Clark, M.J.3    Brand, A.H.4    Hoffmann, F.M.5
  • 36
    • 0030160592 scopus 로고    scopus 로고
    • Control and integration of cell signaling pathways during C. elegans vulval development
    • Sundaram, M. and Han, M. (1996). Control and integration of cell signaling pathways during C. elegans vulval development. BioEssays 18, 473-480.
    • (1996) BioEssays , vol.18 , pp. 473-480
    • Sundaram, M.1    Han, M.2
  • 37
    • 0024210345 scopus 로고
    • Vectors for Drosophila P-element-mediated transformation and tissue culture transfection
    • Thummel, C. S., Boulet, A. M. and Lipshitz, H. D. (1988). Vectors for Drosophila P-element-mediated transformation and tissue culture transfection. Gene 7, 445-456.
    • (1988) Gene , vol.7 , pp. 445-456
    • Thummel, C.S.1    Boulet, A.M.2    Lipshitz, H.D.3
  • 38
    • 0023876550 scopus 로고
    • Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogaster
    • Truman, J. W. and Bate, M. (1988). Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogaster Dev. Biol. 125, 145-157.
    • (1988) Dev. Biol. , vol.125 , pp. 145-157
    • Truman, J.W.1    Bate, M.2
  • 39
    • 0028170817 scopus 로고
    • Receptor protein-tyrosine kinases and their signal transduction pathways
    • van der Geer, P., Hunter, T. and Lindberg, R. A. (1994). Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol. 10, 251-337.
    • (1994) Annu. Rev. Cell Biol. , vol.10 , pp. 251-337
    • Van Der Geer, P.1    Hunter, T.2    Lindberg, R.A.3
  • 40
    • 0002580245 scopus 로고    scopus 로고
    • RAS1-Mediated Photoreceptor Development in Drosophila
    • Wassarman, D. A. and Therrien, M. (1997). RAS1-Mediated Photoreceptor Development in Drosophila. Advances in Dev. Biol. 5, 1-41.
    • (1997) Advances in Dev. Biol. , vol.5 , pp. 1-41
    • Wassarman, D.A.1    Therrien, M.2
  • 42
    • 0031003117 scopus 로고    scopus 로고
    • Ras is Required for a Limited Number of Cell Fates and Not for General Proliferation in Caenorhabditis elegans
    • Yochem, J., Sundaram, M. and Han, M. (1997). Ras is Required for a Limited Number of Cell Fates and Not for General Proliferation in Caenorhabditis elegans. Molec. Cell Biol. 17, 2716-2722.
    • (1997) Molec. Cell Biol. , vol.17 , pp. 2716-2722
    • Yochem, J.1    Sundaram, M.2    Han, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.