메뉴 건너뛰기




Volumn 10, Issue SUPPL. 4, 1999, Pages

Gene therapy for pancreatic and biliary malignancies

Author keywords

Cholangiocarcinoma; DNA vaccination; Gene therapy; Immunotherapy; Pancreatic cancer; Prodrug activation; ras

Indexed keywords

VIRUS VECTOR;

EID: 0032784777     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/annonc/10.suppl_4.S188     Document Type: Conference Paper
Times cited : (22)

References (76)
  • 1
    • 0030687903 scopus 로고    scopus 로고
    • Molecular advances in pancreatic cancer
    • Lemoine NR. Molecular advances in pancreatic cancer. Digest. 1997; 58: 550-6.
    • (1997) Digest. , vol.58 , pp. 550-556
    • Lemoine, N.R.1
  • 2
    • 0031950026 scopus 로고    scopus 로고
    • Recent discoveries in cancer genetics of exocrine pancreatic neoplasia
    • Hahn SA, Schmiegel WH. Recent discoveries in cancer genetics of exocrine pancreatic neoplasia. Digestion 1998; 59: 493-501.
    • (1998) Digestion , vol.59 , pp. 493-501
    • Hahn, S.A.1    Schmiegel, W.H.2
  • 3
    • 0031765767 scopus 로고    scopus 로고
    • What is the true rate of K-ras mutation in carcinoma of the pancreas?
    • Longnecker DS, Terhune PG. What is the true rate of K-ras mutation in carcinoma of the pancreas? Pancreas 1999; 17: 323-4.
    • (1999) Pancreas , vol.17 , pp. 323-324
    • Longnecker, D.S.1    Terhune, P.G.2
  • 4
    • 0345568761 scopus 로고    scopus 로고
    • Germline BRCA2 mutations in patients with apparently sporadic pancreatic carcinomas
    • Goggins M, Schutte M, Lu J, et al Germline BRCA2 mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res 1996; 56: 3808-13.
    • (1996) Cancer Res , vol.56 , pp. 3808-3813
    • Goggins, M.1    Schutte, M.2    Lu, J.3
  • 5
    • 0028875562 scopus 로고
    • Allelotype of pancreatic adenocarcinoma using xenograft enrichment
    • Hahn SA, Seymour AB, Hoque ATMS, et al Allelotype of pancreatic adenocarcinoma using xenograft enrichment. Cancer Res 1995; 55: 4670-5.
    • (1995) Cancer Res , vol.55 , pp. 4670-4675
    • Hahn, S.A.1    Seymour, A.B.2    Hoque, A.T.M.S.3
  • 6
    • 0344274730 scopus 로고    scopus 로고
    • Rule of polypeptide growth factors and their receptors in human pancreatic cancer
    • Reber H (ed) Humana Press, New Jersey
    • Korc M. Rule of polypeptide growth factors and their receptors in human pancreatic cancer. In: Reber H (ed) Pancreatic Cancer. Humana Press, New Jersey 1998.
    • (1998) Pancreatic Cancer
    • Korc, M.1
  • 7
    • 0031438036 scopus 로고    scopus 로고
    • Liver stem cells: When the going gets tough they get going
    • Alison MR, Golding M, Sarraf CE. Liver stem cells: when the going gets tough they get going. Int J Exp Path 1997; 78: 365-81.
    • (1997) Int J Exp Path , vol.78 , pp. 365-381
    • Alison, M.R.1    Golding, M.2    Sarraf, C.E.3
  • 8
  • 9
    • 0029059267 scopus 로고
    • Alpha fetoprotein-producing acinar cell carcinoma of the pancreas showing multiple lines of differentiation
    • Shinagawa T, Tadokoro M, Maeyama S, et al Alpha fetoprotein-producing acinar cell carcinoma of the pancreas showing multiple lines of differentiation. Virchows Arch 1995; 426: 419-23.
    • (1995) Virchows Arch , vol.426 , pp. 419-423
    • Shinagawa, T.1    Tadokoro, M.2    Maeyama, S.3
  • 10
    • 0026666040 scopus 로고
    • Carcinoma of the extrahepatic bile ducts: Histologic types, stage of disease, grade and survival rates
    • Henson DE, Albores-Saavedra J, Corle D. Carcinoma of the extrahepatic bile ducts: histologic types, stage of disease, grade and survival rates. Cancer 1992; 70: 1498-1501.
    • (1992) Cancer , vol.70 , pp. 1498-1501
    • Henson, D.E.1    Albores-Saavedra, J.2    Corle, D.3
  • 11
    • 0025933890 scopus 로고
    • Multiple K-ras codon mututions in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique
    • Levi S, Urbano-Ispizua A, Gill R, et al Multiple K-ras codon mututions in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique. Cancer Res 1991; 51: 3497-502.
    • (1991) Cancer Res , vol.51 , pp. 3497-3502
    • Levi, S.1    Urbano-Ispizua, A.2    Gill, R.3
  • 12
    • 0027771839 scopus 로고
    • Mutations of the p53 suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand
    • Kiba T, Tsuda H, Pairojkul C, et al Mutations of the p53 suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand. Molec Carcinog 1993; 8: 312-8.
    • (1993) Molec Carcinog , vol.8 , pp. 312-318
    • Kiba, T.1    Tsuda, H.2    Pairojkul, C.3
  • 13
    • 0029763279 scopus 로고    scopus 로고
    • Ki-ras point mutations and proliferative activity in biliary tract carcinomas
    • Ohashi K, Tsutsumi M, Nakajima Y, et al Ki-ras point mutations and proliferative activity in biliary tract carcinomas. Brit J Cancer 1996; 74: 930-5.
    • (1996) Brit J Cancer , vol.74 , pp. 930-935
    • Ohashi, K.1    Tsutsumi, M.2    Nakajima, Y.3
  • 14
    • 0031902607 scopus 로고    scopus 로고
    • Dysregulation of apoptosis in the cholangiopathies and cholangiocarcinoma
    • Celli A, Que FG. Dysregulation of apoptosis in the cholangiopathies and cholangiocarcinoma. Semin Liver Dis 1998; 18: 177-85.
    • (1998) Semin Liver Dis , vol.18 , pp. 177-185
    • Celli, A.1    Que, F.G.2
  • 15
    • 0028143201 scopus 로고
    • Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model
    • Fujiwara T, Cai DW, Georges RN, et al Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model. J Natl Cancer Inst 1994; 86: 1458-62.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1458-1462
    • Fujiwara, T.1    Cai, D.W.2    Georges, R.N.3
  • 16
    • 0028403234 scopus 로고
    • High-efficiency gene transfer and high-level expression of wild-lype p53 in human lung cancer cells mediated by recombinant adenovirus
    • Zhang WW, Fang X, Mazur W, et al High-efficiency gene transfer and high-level expression of wild-lype p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gene Ther 1994; 1: 5-13.
    • (1994) Cancer Gene Ther , vol.1 , pp. 5-13
    • Zhang, W.W.1    Fang, X.2    Mazur, W.3
  • 17
    • 0028069906 scopus 로고
    • Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus
    • Liu TJ, Zhang WW, Taylor DL, et al Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus. Cancer Res 1994; 54: 3662-7.
    • (1994) Cancer Res , vol.54 , pp. 3662-3667
    • Liu, T.J.1    Zhang, W.W.2    Taylor, D.L.3
  • 18
    • 0031648811 scopus 로고    scopus 로고
    • Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer
    • Bouvet M, Bold RJ, Lee J, et al Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer. Ann Surg Oncol 1998; 5: 681-688.
    • (1998) Ann Surg Oncol , vol.5 , pp. 681-688
    • Bouvet, M.1    Bold, R.J.2    Lee, J.3
  • 19
    • 0028231586 scopus 로고
    • Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene
    • Fujiwara T, Grimm EA, Mukhopadhyay T, et al Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res 1994; 54: 2287-91.
    • (1994) Cancer Res , vol.54 , pp. 2287-2291
    • Fujiwara, T.1    Grimm, E.A.2    Mukhopadhyay, T.3
  • 20
    • 0030917202 scopus 로고    scopus 로고
    • ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumor efficacy that can be augmented by standard chemotherapeutic agents
    • Heise C, Sampson-Joannes A, Williams A, et al ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumor efficacy that can be augmented by standard chemotherapeutic agents. Nature Med 1997; 3: 639-45.
    • (1997) Nature Med , vol.3 , pp. 639-645
    • Heise, C.1    Sampson-Joannes, A.2    Williams, A.3
  • 21
    • 0031759169 scopus 로고    scopus 로고
    • ONYX-015: Clinical data are encouraging
    • Kirn D, Hermiston T, McCormick F. ONYX-015: Clinical data are encouraging. Nature Med 1998; 4: 1341-2.
    • (1998) Nature Med , vol.4 , pp. 1341-1342
    • Kirn, D.1    Hermiston, T.2    McCormick, F.3
  • 23
    • 0029094704 scopus 로고
    • Cell cycle arrest and inhibition of tumour cell proliferation by the p16 INK4 gene mediated by adenovirus vector
    • Jin X, Nguyen D, Zhang WW, et al Cell cycle arrest and inhibition of tumour cell proliferation by the p16 INK4 gene mediated by adenovirus vector. Cancer Res 1995; 55: 3250-3.
    • (1995) Cancer Res , vol.55 , pp. 3250-3253
    • Jin, X.1    Nguyen, D.2    Zhang, W.W.3
  • 24
    • 0030614944 scopus 로고    scopus 로고
    • Adenovirally-transfected p16 INK4/CDKN2 and p53 genes co-operate to induce apoptotic tumor cell death
    • Sandig V, Brand K, Herwig S, et al Adenovirally-transfected p16 INK4/CDKN2 and p53 genes co-operate to induce apoptotic tumor cell death. Nature Med 1997; 3: 313-9.
    • (1997) Nature Med , vol.3 , pp. 313-319
    • Sandig, V.1    Brand, K.2    Herwig, S.3
  • 25
    • 0031721405 scopus 로고    scopus 로고
    • Suppression of proliferative cholangitis in a rat model with direct adenovirus-mediated retinoblastoma gene transfer to the biliary tract
    • Terao R, Honda K, Hatano E, et al Suppression of proliferative cholangitis in a rat model with direct adenovirus-mediated retinoblastoma gene transfer to the biliary tract. Hepalology 1998; 28: 605-12.
    • (1998) Hepalology , vol.28 , pp. 605-612
    • Terao, R.1    Honda, K.2    Hatano, E.3
  • 26
    • 0032522817 scopus 로고    scopus 로고
    • An apoptosis-inducing gene therapy for pancreatic cancer with a combination of 55-kDa tumor necrosis factor (TNF) receptor gene transfection and mutein TNF administration
    • Sato T, Yamauchi N, Sasaki H, et al An apoptosis-inducing gene therapy for pancreatic cancer with a combination of 55-kDa tumor necrosis factor (TNF) receptor gene transfection and mutein TNF administration. Cancer Res 1998; 58: 1677-83.
    • (1998) Cancer Res , vol.58 , pp. 1677-1683
    • Sato, T.1    Yamauchi, N.2    Sasaki, H.3
  • 27
    • 0030926392 scopus 로고    scopus 로고
    • Expression of Fas-estrogen receptor fusion protein induces cell death in pancreatic cancer cell lines
    • Kawaguchi Y, Takebayashi H, Kakizuka A, et al Expression of Fas-estrogen receptor fusion protein induces cell death in pancreatic cancer cell lines. Cancer Lett 1997; 116: 53-9.
    • (1997) Cancer Lett , vol.116 , pp. 53-59
    • Kawaguchi, Y.1    Takebayashi, H.2    Kakizuka, A.3
  • 28
    • 0027175360 scopus 로고
    • Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct
    • Georges RN, Mukhopadhyay, Zhung Y, et al Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct. Cancer Res 1993; 53: 1743-6.
    • (1993) Cancer Res , vol.53 , pp. 1743-1746
    • Georges, R.N.1    Mukhopadhyay2    Zhung, Y.3
  • 29
    • 0029124127 scopus 로고
    • Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumour dissemination in the murine peritoneal cavity
    • Aoki K, Yoshida T, Sugimura T, Terada M. Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumour dissemination in the murine peritoneal cavity. Cancer Res 1995; 55: 3810-6.
    • (1995) Cancer Res , vol.55 , pp. 3810-3816
    • Aoki, K.1    Yoshida, T.2    Sugimura, T.3    Terada, M.4
  • 30
    • 0029364471 scopus 로고
    • Suppression of lung cancer cell growth by ribozyme-mediated modification of p53 pre-mRNA
    • Cai DW, Mukhopadyay T, Roth JA. Suppression of lung cancer cell growth by ribozyme-mediated modification of p53 pre-mRNA. Cancer Gene Ther 1995; 2: 199-205.
    • (1995) Cancer Gene Ther , vol.2 , pp. 199-205
    • Cai, D.W.1    Mukhopadyay, T.2    Roth, J.A.3
  • 31
    • 0028139425 scopus 로고
    • ErbB-2 antisense oligonucleotides inhibit the proliferation of breast carcinoma cells with erbB-2 oncogene amplification
    • Colomer R, Lupu R, Bacus SS, Gelmann EP. ErbB-2 antisense oligonucleotides inhibit the proliferation of breast carcinoma cells with erbB-2 oncogene amplification. Br J Cancer 1994; 70: 819-25.
    • (1994) Br J Cancer , vol.70 , pp. 819-825
    • Colomer, R.1    Lupu, R.2    Bacus, S.S.3    Gelmann, E.P.4
  • 32
    • 0030767762 scopus 로고    scopus 로고
    • Bcl-2 is overexpressed and allers the threshold for apoptosis in a cholangiocarcinoma cell line
    • Harnois DM, Que FG, Celli A, et al Bcl-2 is overexpressed and allers the threshold for apoptosis in a cholangiocarcinoma cell line. Hepatology 1997; 26: 884-90.
    • (1997) Hepatology , vol.26 , pp. 884-890
    • Harnois, D.M.1    Que, F.G.2    Celli, A.3
  • 33
    • 0028953137 scopus 로고
    • Antisense oligonucleotides directed against p53 have antiproliferative effects unrelated to effects on p53 expression
    • Barton CM, Lemoine NR, Antisense oligonucleotides directed against p53 have antiproliferative effects unrelated to effects on p53 expression. Br J Cancer 1995; 71: 429-37.
    • (1995) Br J Cancer , vol.71 , pp. 429-437
    • Barton, C.M.1    Lemoine, N.R.2
  • 34
    • 0001440847 scopus 로고    scopus 로고
    • Contribution of CpG motifs to the immunogenicity of DNA vaccines
    • Klinman DM, Yamshehikov G, Ishigatsubo Y. Contribution of CpG motifs to the immunogenicity of DNA vaccines. J Immunol 1997; 179: 97-106.
    • (1997) J Immunol , vol.179 , pp. 97-106
    • Klinman, D.M.1    Yamshehikov, G.2    Ishigatsubo, Y.3
  • 35
    • 0028822547 scopus 로고
    • Ligand-directed retroviral targeting of human breast cancer cells
    • USA
    • Han X, Kasahara N, Kan YW. Ligand-directed retroviral targeting of human breast cancer cells. Proc Natl Acad Sci USA 1995; 92: 9747-51.
    • (1995) Proc Natl Acad Sci , vol.92 , pp. 9747-9751
    • Han, X.1    Kasahara, N.2    Kan, Y.W.3
  • 36
    • 0032901036 scopus 로고    scopus 로고
    • Targeted gene transfer to hepatocellular carcinoma cells in vitro using a novel monoclonal antibody-based gene delivery system
    • Mohr L, Schauer JI, Boulin RH, et al Targeted gene transfer to hepatocellular carcinoma cells in vitro using a novel monoclonal antibody-based gene delivery system. Hepatology 1999; 29: 82-9.
    • (1999) Hepatology , vol.29 , pp. 82-89
    • Mohr, L.1    Schauer, J.I.2    Boulin, R.H.3
  • 37
    • 0030666663 scopus 로고    scopus 로고
    • Engineering tissue-specific expression of a recombinant adenovirus: Selective transgene transcription in the pancreas using the amylase promoter
    • Dematteo RP, McClane SJ, Fisher K, et al Engineering tissue-specific expression of a recombinant adenovirus: selective transgene transcription in the pancreas using the amylase promoter. J Surg Res 1997; 72: 155-61.
    • (1997) J Surg Res , vol.72 , pp. 155-161
    • Dematteo, R.P.1    McClane, S.J.2    Fisher, K.3
  • 38
    • 0028116059 scopus 로고
    • Gene therapy for carcinoembryonic antigen-producing lung cancer cells by cell type specific expression of herpes simplex virus thymidine kinase gene
    • Osaki T, Tanio Y, Tachibana I, et al Gene therapy for carcinoembryonic antigen-producing lung cancer cells by cell type specific expression of herpes simplex virus thymidine kinase gene. Cancer Res 1994; 54: 5258-61.
    • (1994) Cancer Res , vol.54 , pp. 5258-5261
    • Osaki, T.1    Tanio, Y.2    Tachibana, I.3
  • 39
    • 0030730794 scopus 로고    scopus 로고
    • Use of transcriptional regulatory elements of the MUC1 and ERBB2 genes to drive tumor-selective expression of a prodrug-activating enzyme
    • Ring CJA, Martin LA, Blouin P, et al Use of transcriptional regulatory elements of the MUC1 and ERBB2 genes to drive tumor-selective expression of a prodrug-activating enzyme. Gene Ther 1997; 4: 1045-52.
    • (1997) Gene Ther , vol.4 , pp. 1045-1052
    • Ring, C.J.A.1    Martin, L.A.2    Blouin, P.3
  • 40
    • 0028089989 scopus 로고
    • Expression of mucin core protein of mammary type in primary liver cancer
    • Sasaki M, Nakanuma Y. Expression of mucin core protein of mammary type in primary liver cancer. Hepatology 1994; 20: 1192-7.
    • (1994) Hepatology , vol.20 , pp. 1192-1197
    • Sasaki, M.1    Nakanuma, Y.2
  • 41
    • 0028180345 scopus 로고
    • Altered expression of MUC2, MUC4 and MUC5 mucin genes in pancreas tissues and cancer cell lines
    • Balague C, Gambus G, Carrato C, et al Altered expression of MUC2, MUC4 and MUC5 mucin genes in pancreas tissues and cancer cell lines. Gastroenterology 1994; 106: 1054-61.
    • (1994) Gastroenterology , vol.106 , pp. 1054-1061
    • Balague, C.1    Gambus, G.2    Carrato, C.3
  • 42
    • 0029820458 scopus 로고    scopus 로고
    • Expression of MUC apomucins in normal pancreas and pancreatic tumours
    • Terada T, Ohta T, Sasaki M, et al Expression of MUC apomucins in normal pancreas and pancreatic tumours. J Pathol 1996; 180: 160-5.
    • (1996) J Pathol , vol.180 , pp. 160-165
    • Terada, T.1    Ohta, T.2    Sasaki, M.3
  • 43
    • 0028276896 scopus 로고
    • Therapeutic strategies using c-erbB-2 promoter-controlled drug activation
    • Sikora K, Harris J, Hurst H, Lemoine NR. Therapeutic strategies using c-erbB-2 promoter-controlled drug activation. Ann NY Acad Sci 1994; 716: 115-24.
    • (1994) Ann NY Acad Sci , vol.716 , pp. 115-124
    • Sikora, K.1    Harris, J.2    Hurst, H.3    Lemoine, N.R.4
  • 44
    • 0030459592 scopus 로고    scopus 로고
    • Suicide gene expression induced in tumour cells transduced with recombinant adenoviral, retroviral and plasmid vectors containing the ERBB2 promoter
    • Ring CJA, Harris JD, Hurst HC, Lemoine NR. Suicide gene expression induced in tumour cells transduced with recombinant adenoviral, retroviral and plasmid vectors containing the ERBB2 promoter. Gene Ther 1996; 3: 1094-103.
    • (1996) Gene Ther , vol.3 , pp. 1094-1103
    • Ring, C.J.A.1    Harris, J.D.2    Hurst, H.C.3    Lemoine, N.R.4
  • 45
    • 0345117519 scopus 로고    scopus 로고
    • Genetic prodrug activation therapy for breast cancer targeted by the ERBB2 promoter: Results of a phase I study
    • in press
    • Pandha H, Rigg A, Martin LA, et al Genetic prodrug activation therapy for breast cancer targeted by the ERBB2 promoter: results of a phase I study. J Clin Oncol (in press).
    • J Clin Oncol
    • Pandha, H.1    Rigg, A.2    Martin, L.A.3
  • 46
    • 0027483695 scopus 로고
    • The "bystander effect": Tumor regression when a fraction of the tumor mass is genetically modified
    • Freeman SM, Abboud CN, Whartenby KA, et al The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 1993; 53: 5274-83.
    • (1993) Cancer Res , vol.53 , pp. 5274-5283
    • Freeman, S.M.1    Abboud, C.N.2    Whartenby, K.A.3
  • 47
    • 0032549688 scopus 로고    scopus 로고
    • Intercellular communication mediates the bystander effect during herpes simplex thymidine kinase / ganciclovir-based gene therapy of human gastrointestinal tumor cells
    • Yang L, Chiang Y, Lenz HJ, et al Intercellular communication mediates the bystander effect during herpes simplex thymidine kinase / ganciclovir-based gene therapy of human gastrointestinal tumor cells. Hum Gene Ther 1998; 9: 719-28.
    • (1998) Hum Gene Ther , vol.9 , pp. 719-728
    • Yang, L.1    Chiang, Y.2    Lenz, H.J.3
  • 48
    • 0014887939 scopus 로고
    • The concept of immunological surveillance
    • Burnet FM. The concept of immunological surveillance. Prog Exp Tumor Res 1970; 13: 1-27.
    • (1970) Prog Exp Tumor Res , vol.13 , pp. 1-27
    • Burnet, F.M.1
  • 49
    • 0030272703 scopus 로고    scopus 로고
    • Is cancer dangerous to the immune system?
    • Fuchs EJ, Matzinger P. Is cancer dangerous to the immune system? Semin Immunol 1996; 8: 271-80.
    • (1996) Semin Immunol , vol.8 , pp. 271-280
    • Fuchs, E.J.1    Matzinger, P.2
  • 50
    • 0032191916 scopus 로고    scopus 로고
    • An innate sense of danger
    • Matzinger P. An innate sense of danger. Semin Immunol 1998: 10: 399-415.
    • (1998) Semin Immunol , vol.10 , pp. 399-415
    • Matzinger, P.1
  • 51
    • 0031836938 scopus 로고    scopus 로고
    • Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression
    • Melcher A, Todryk S, Hardwick N, et al Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression. Nature Med 1998; 5: 581-7.
    • (1998) Nature Med , vol.5 , pp. 581-587
    • Melcher, A.1    Todryk, S.2    Hardwick, N.3
  • 52
    • 0033616482 scopus 로고    scopus 로고
    • Active specific immunotherapy for stage II and stage III human colon cancer: A randomised trial
    • Vermorken J, Claessen A, van Tinteren H, Gall H, et al Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial. Lancet 1999; 353: 345-50.
    • (1999) Lancet , vol.353 , pp. 345-350
    • Vermorken, J.1    Claessen, A.2    Van Tinteren, H.3    Gall, H.4
  • 53
    • 0029988368 scopus 로고    scopus 로고
    • The immunotherapy of solid cancers based on cloning the genes encoding tumor-rejection antigens
    • Rosenberg SA. The immunotherapy of solid cancers based on cloning the genes encoding tumor-rejection antigens. Annu Rev Med 1996; 47: 481-91.
    • (1996) Annu Rev Med , vol.47 , pp. 481-491
    • Rosenberg, S.A.1
  • 54
    • 2642622574 scopus 로고    scopus 로고
    • Identification of HLA-A2-restricted epitopes of the tumor-associated antigen MUC2 recognized by human cytotoxic T cells
    • Bohm CM, Hanski ML, Stefanovic S, et al Identification of HLA-A2-restricted epitopes of the tumor-associated antigen MUC2 recognized by human cytotoxic T cells. Int J Cancer 1998; 75: 688-93.
    • (1998) Int J Cancer , vol.75 , pp. 688-693
    • Bohm, C.M.1    Hanski, M.L.2    Stefanovic, S.3
  • 55
    • 0032525876 scopus 로고    scopus 로고
    • Targeting p53 for adoptive T-cell immunotherapy
    • McCarty TM, Liu X, Sun JY, et al Targeting p53 for adoptive T-cell immunotherapy. Cancer Res 1998; 58: 2601-5.
    • (1998) Cancer Res , vol.58 , pp. 2601-2605
    • McCarty, T.M.1    Liu, X.2    Sun, J.Y.3
  • 56
    • 0027281983 scopus 로고
    • Cytotoxic T-cell response and in vivo protection against tumor cells harboring activated ras proto-oncogenes
    • Fenton RG, Taub DD, Kwak LW, et al Cytotoxic T-cell response and in vivo protection against tumor cells harboring activated ras proto-oncogenes. J Natl Cancer Inst 1993; 85: 1294-302.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1294-1302
    • Fenton, R.G.1    Taub, D.D.2    Kwak, L.W.3
  • 57
    • 0028098172 scopus 로고
    • Lysis of Ras oncogene-transformed cells by specific cytotoxic T lymphocytes elicited by primary in vitru immunisation with mutated Ras peptide
    • Peace DJ, Smith JW, Chen W, et al Lysis of Ras oncogene-transformed cells by specific cytotoxic T lymphocytes elicited by primary in vitru immunisation with mutated Ras peptide. J Exp Med 1994; 179: 473-9.
    • (1994) J Exp Med , vol.179 , pp. 473-479
    • Peace, D.J.1    Smith, J.W.2    Chen, W.3
  • 58
    • 0029825827 scopus 로고    scopus 로고
    • Characterisation of immune responses in pancreatic carcinoma patients after mutant p21 ras peptide vaccination
    • Gjertsen MK, Saeterdal I, Thorsby E, et al Characterisation of immune responses in pancreatic carcinoma patients after mutant p21 ras peptide vaccination. Br J Cancer 1996; 74: 1828-33.
    • (1996) Br J Cancer , vol.74 , pp. 1828-1833
    • Gjertsen, M.K.1    Saeterdal, I.2    Thorsby, E.3
  • 59
    • 0024166189 scopus 로고
    • Use of tumor infiltrating lymphocytes and IL-2 in the immunotherapy of patients with metastatic melanoma
    • Rosenberg S, Packard B, Aebersold P. Use of tumor infiltrating lymphocytes and IL-2 in the immunotherapy of patients with metastatic melanoma. N Engl J Med 1988; 319: 1676-9.
    • (1988) N Engl J Med , vol.319 , pp. 1676-1679
    • Rosenberg, S.1    Packard, B.2    Aebersold, P.3
  • 60
    • 0030944023 scopus 로고    scopus 로고
    • Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex-vivo granulocyte-macrophagecolony-stimulating factor gene transfer
    • Simons JW, Jaffee EM, Weber C, et al Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex-vivo granulocyte-macrophagecolony-stimulating factor gene transfer. Cancer Res 1997; 57: 1537-46.
    • (1997) Cancer Res , vol.57 , pp. 1537-1546
    • Simons, J.W.1    Jaffee, E.M.2    Weber, C.3
  • 61
    • 17344374264 scopus 로고    scopus 로고
    • Clinical protocol: A phase I clinical trial of lethally irradiated allogeneic pancreatic tumor cells transfected with the GM-CSF gene for the treatment of pancreatic adenocarcinoma
    • Jaffee EM, Abrams R, Cameron J, et al Clinical protocol: a phase I clinical trial of lethally irradiated allogeneic pancreatic tumor cells transfected with the GM-CSF gene for the treatment of pancreatic adenocarcinoma. Hum Gene Ther 1998; 9: 1951-71.
    • (1998) Hum Gene Ther , vol.9 , pp. 1951-1971
    • Jaffee, E.M.1    Abrams, R.2    Cameron, J.3
  • 62
    • 0028223557 scopus 로고
    • T-helper and accessory-cell independent cytotoxic responses to human tumor cells transfected with a B7 retorviral vector
    • Dohring C, Angman L, Spagnoli G, Lanzavecchia A. T-helper and accessory-cell independent cytotoxic responses to human tumor cells transfected with a B7 retorviral vector. Int J Cancer 1994; 57: 754-9.
    • (1994) Int J Cancer , vol.57 , pp. 754-759
    • Dohring, C.1    Angman, L.2    Spagnoli, G.3    Lanzavecchia, A.4
  • 63
    • 0031875403 scopus 로고    scopus 로고
    • Experimental vaccine strategies for cancer immunotherapy
    • Chen C-H, Wu T-C. Experimental vaccine strategies for cancer immunotherapy. J Biomed Sci 1998; 5: 231-52.
    • (1998) J Biomed Sci , vol.5 , pp. 231-252
    • Chen, C.-H.1    Wu, T.-C.2
  • 64
    • 0031758688 scopus 로고    scopus 로고
    • Modulating the immune response to genetic immunization
    • Cohen AD, Boyer JD, Weiner DB. Modulating the immune response to genetic immunization. FASEB J 1998; 12: 1611-26.
    • (1998) FASEB J , vol.12 , pp. 1611-1626
    • Cohen, A.D.1    Boyer, J.D.2    Weiner, D.B.3
  • 65
    • 0033051081 scopus 로고    scopus 로고
    • Dendritic cell vaccines for cancer immunotherapy
    • Timmerman JT, Levy R. Dendritic cell vaccines for cancer immunotherapy. Annu Rev Med 1999; 50: 507-29.
    • (1999) Annu Rev Med , vol.50 , pp. 507-529
    • Timmerman, J.T.1    Levy, R.2
  • 66
    • 0031863853 scopus 로고    scopus 로고
    • Eradication of established murine tumours using a novel cell-free vaccine: Dendritic cell-derived exosomes
    • Zilvogel L, Regnault A, Lozier A, et al Eradication of established murine tumours using a novel cell-free vaccine: dendritic cell-derived exosomes. Nature Med 1998; 4: 594-600.
    • (1998) Nature Med , vol.4 , pp. 594-600
    • Zilvogel, L.1    Regnault, A.2    Lozier, A.3
  • 67
    • 0030817590 scopus 로고    scopus 로고
    • Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo
    • Pederson LC, Buchsbaum DJ, Vickers SM, et al Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo. Cancer Res 1997; 57: 4315-32.
    • (1997) Cancer Res , vol.57 , pp. 4315-4332
    • Pederson, L.C.1    Buchsbaum, D.J.2    Vickers, S.M.3
  • 68
    • 0032503659 scopus 로고    scopus 로고
    • A novel three-pronged approach to kill cancer cells selectively: Concomitanl viral, double suicide gene and radiotherapy
    • Freytag SO, Rogulski KR, Paielli DL, et al A novel three-pronged approach to kill cancer cells selectively: concomitanl viral, double suicide gene and radiotherapy. Hum Gene Ther 1998; 9: 1323-33.
    • (1998) Hum Gene Ther , vol.9 , pp. 1323-1333
    • Freytag, S.O.1    Rogulski, K.R.2    Paielli, D.L.3
  • 69
    • 0033032916 scopus 로고    scopus 로고
    • Vascular attack and immunotherapy: A 'two hits' approach to improve biological treatment of cancer
    • Dellabona P, Moro M, Crosti MC, et al Vascular attack and immunotherapy: a 'two hits' approach to improve biological treatment of cancer. Gene Ther 1999; 6: 153-4.
    • (1999) Gene Ther , vol.6 , pp. 153-154
    • Dellabona, P.1    Moro, M.2    Crosti, M.C.3
  • 70
    • 0031564327 scopus 로고    scopus 로고
    • Characterization of the immune response after local delivery of recombinant adenovirus in murine pancreas and successful strategies for readministration
    • McClane SJ, Chirmule N, Burke CV, Raper SE. Characterization of the immune response after local delivery of recombinant adenovirus in murine pancreas and successful strategies for readministration. Hum Gene Ther 1997; 8: 2207-16.
    • (1997) Hum Gene Ther , vol.8 , pp. 2207-2216
    • McClane, S.J.1    Chirmule, N.2    Burke, C.V.3    Raper, S.E.4
  • 71
    • 17344370857 scopus 로고    scopus 로고
    • Oraltolerization to adenoviral proteins permits repeated adenovirus-mediated gene therapy in rats with pre-existing immunity to adenoviruses
    • Ilan Y, Sauter B, Chowdhury NR, et al Oraltolerization to adenoviral proteins permits repeated adenovirus-mediated gene therapy in rats with pre-existing immunity to adenoviruses. Hepatology 1998; 27: 1368-76.
    • (1998) Hepatology , vol.27 , pp. 1368-1376
    • Ilan, Y.1    Sauter, B.2    Chowdhury, N.R.3
  • 72
    • 0030983596 scopus 로고    scopus 로고
    • Functional consequences of adenovirus-mediated murine pancreatic gene transfer
    • McClane SJ, Hamilton TE, Burke CV et al Functional consequences of adenovirus-mediated murine pancreatic gene transfer. Hum Gene Ther 1997; 8: 739-46.
    • (1997) Hum Gene Ther , vol.8 , pp. 739-746
    • McClane, S.J.1    Hamilton, T.E.2    Burke, C.V.3
  • 73
    • 0031981317 scopus 로고    scopus 로고
    • Direct gene transfer into the rat pancreas using DNA-liposomes
    • Schmid RM, Weidenbach H, Yamagushi H, et al Direct gene transfer into the rat pancreas using DNA-liposomes. Eur J Clin Invest 1998; 28: 220-6.
    • (1998) Eur J Clin Invest , vol.28 , pp. 220-226
    • Schmid, R.M.1    Weidenbach, H.2    Yamagushi, H.3
  • 74
    • 0032469372 scopus 로고    scopus 로고
    • Transient human gene therapy: A novel cytokine regulatory strategy for experimental pancreatitis
    • Denham W, Denham D, Yang J, et al Transient human gene therapy: a novel cytokine regulatory strategy for experimental pancreatitis. Ann Surg 1998; 227: 812-20.
    • (1998) Ann Surg , vol.227 , pp. 812-820
    • Denham, W.1    Denham, D.2    Yang, J.3
  • 75
    • 0032080867 scopus 로고    scopus 로고
    • Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene sensitizes cancer cells to low concentrations of 5-fluorouracil
    • Kanai F, Kawakami T, Hamada H, et al Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene sensitizes cancer cells to low concentrations of 5-fluorouracil. Cancer Res 1998; 58: 1946-51.
    • (1998) Cancer Res , vol.58 , pp. 1946-1951
    • Kanai, F.1    Kawakami, T.2    Hamada, H.3
  • 76
    • 0031756961 scopus 로고    scopus 로고
    • Inhibition of K-ras-transformed rodent and human cancer cell growth via induction of apoptosis by irreversible inhibitors of ras endoprotease
    • Chen Y. Inhibition of K-ras-transformed rodent and human cancer cell growth via induction of apoptosis by irreversible inhibitors of ras endoprotease. Cancer Lett 1998; 131: 191-200.
    • (1998) Cancer Lett , vol.131 , pp. 191-200
    • Chen, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.