A phase I clinical trial of lethally irradiated allogeneic pancreatic tumor cells transfected with the GM-CSF gene for the treatment of pancreatic adenocarcinoma

Human Gene Therapy

Volumn 9, Issue 13, 1998, Pages 1951-1971

  Jaffee, Elizabeth M ^a   Abrams, Ross ^b   Cameron, John ^b   Donehower, Ross ^b   Duerr, Mary ^b   Gossett, Jeanette ^b   Greten, Tim F ^b   Grochow, Louise ^b   Hruban, Ralph ^b   Kern, Scott ^b   Lillemoe, Keith D ^b   O'Reilly, Seamus ^b   Pardoll, Drew ^b   Pitt, Henry A ^b   Sauter, Patricia ^b   Weber, Christine ^b   Yeo, Charles ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; GENETIC TRANSFECTION; HUMAN; MINIMAL RESIDUAL DISEASE; PANCREAS ADENOCARCINOMA; PANCREATICODUODENECTOMY; SAFETY; TUMOR CELL;

EID: 17344374264     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.13-1951     Document Type: Article

References (10)

1. Boring CC, Squires TS, Tong T. Cancer Statistics, 1991. CA 1991; 41:19.
2. Brennan MF, Kinsella TJ, Casper ES. Cancer of the Pancreas. In De Vita VT, ed. Principles and Practice of Oncology, Fourth Ed. Philadelphia: J.B. Lippincott Co. 1993: 864-877.
3. Douglass HO. Adjuvant Therapy for Pancreatic Cancer. World J. Surg. 19:270-274 (1995).
4. Cameron JL, Crist DW, Sitzmann JV, Hruban RH, Boitnott JK, Seidler AJ, Coleman J. Factors Influencing Survival After Pancre-aticoduodenectomy for Pancreatic Cancer. Am J Surg 161:120-125 (1991).
5. Yeo CJ, Cameron JL, Lillemoe KD, Sitzmann JV, Hruban RH, Goodman SN, Dooley WC, Coleman J, Pitt HA. Pancreaticoduo-denectomy for Cancer of the Head of the Pancreas: 201 Patients. Annals of Surg 221 (6):721-33 (1995).
6. Golumbek P, Lazenby A, Levitsky H, Jaffee E, Karasuyama H, Baker M, Pardoll D. Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science 254:713-716, 1991.
7. Dranoff G, Jaffee EM, Golumbek P, Lazenby A, Levitsky H, Brose K, Jackson V, Hamada H, Pardoll DM, Mulligan RC. Vaccination with irradiated tumor cells engineered to secrete murine GMCSF stimulates potent, specific, and long-lasting antitumor immunity. PNAS 90:3539-3543 (1993).
8. Simons JW, Jaffee EM, Weber Christine, Levitsky HI, Nelson WG, Carducci MA, Lazenby AJ, Cohen L, Finn CC, Clift SM, Hauda KM, Beck LA, Leiferman KM, Ownes AH, Piantadosi S, Dranoff G, Mulligan RC, Pardoll DM, Marshall FF. Bioactivity of Auto-logous Irradiated Renal Cell Carcinoma Vaccines Generated by ex Vivo Granulocyte-Macrophage Colony-stimulating Factor Gene Transfer. Cancer Res 57:1537-1546 (1997).
9. van der Bruggen P, Traversai C, Chomez P, Lurguin C, De Plaen E, van den Eynde B, Knuth A, Boon T. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 254:1643 (1991).
10. Brichard V, Van Pel A, Wolfel T, Wolfel C, De Plaen E, Lethe B, Coulie P, Boon T. The Tyrosinase Gene Codes for an Antigen Recognized by Autologous Cytolytic T Lymphocytes on HLA-A2 Melanomas. J Exp Med 178: 489-495 (1993).