Is cancer dangerous to the immune system?

Seminars in Immunology

Volumn 8, Issue 5, 1996, Pages 271-280

  Fuchs, Ephraim J ^a   Matzinger, Polly ^b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b Building 10   (United States)

Author keywords

Antigen presenting cells; Immune surveillance; Immunologic tolerance; T lymphocytes; Tumor immunology

Indexed keywords

TUMOR ANTIGEN;

ANTIGEN PRESENTING CELL; CANCER IMMUNOLOGY; IMMUNOLOGICAL TOLERANCE; IMMUNOSURVEILLANCE; REVIEW;

EID: 0030272703     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1996.0035     Document Type: Review

References (46)

1. 1. Burnet FM (1969) Cellular Immunology. Cambridge University Press, London
2. 2. Burnet FM (1970) The concept of immunological surveillance. Prog Exp Tumor Res 13:1-27
3. 3. Matzinger P (1994) Tolerance, danger, and the extended family. Annu Rev Immunol 12:991-1045
4. 4. Owen RD (1945) Immunogenetic consequences of vascular anastomoses between bovine twins. Science 102:400-401
5. 5. Burnet FM, Fenner F (1949) The Production of Antibodies, 2nd edn. Macmillan, London
6. 6. Lederberg J (1959) Genes and antibodies: Do antigens bear instructions for antibody specificity or do they select cell lines that arise by mutation? Science 129:1649-1653
7. 7. Thomas L (1959) Discussion, in Cellular and Humoral Aspects of the Hypersensitive State (Lawrence HS, ed.) p.529. Hoeber, New York
8. 8. Weigert MG, Cesari IM, Yonkovich SJ, Cohn M (1970) Variability in the lambda light chain sequences of mouse antibody. Nature 228:1045-1047
9. 9. Bretscher P, Cohn M (1970) A theory of self-nonself discrimination: paralysis and induction involve the recognition of one and two determinants on an antigen, respectively. Science 169:1042-1049
10. 10. Lafferty KJ, Cunningham AJ (1975) A new analysis of allogeneic interactions. Aust J Exp Biol Med Sci 53:27-42
11. 11. Ashwell JD, Jenkins MK, Schwartz RH (1988) Effect of gamma radiation on resting B lymphocytes. II. Functional characterization of the antigen-presentation defect. J Immunol 141:2536-2544
12. 12. Lassila O, Vainio O, Matzinger P (1988) Can B cells turn on virgin T cells? Nature 334:253-255
13. 13. Fuchs EJ, Matzinger P (1992) B cells turn off virgin but not memory T cells. Science 258:1156-1159
14. 14. Guerder S, Matzinger P (1989) Activation versus tolerance: a decision made by T helper cells. Cold Spring Harb Symp Quant Biol 54:799-805
15. 15. Cobbold SP, Martin G, Waldmann H (1990) The induction of skin graft tolerance in major histocompatibility complex-mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti-CD4 and anti-CD8 antibodies. Eur J Immunol 20:2747-2755
16. 16. Matzinger P, Guerder S (1989) Does T-cell tolerance require a dedicated antigen-presenting cell? Nature 338:74-76
17. 17. Shimonkevitz RP, Bevan MJ (1988) Split tolerance induced by the intrathymic transfer of thymocyte stem cells. J Exp Med 168:143-156
18. 18. Ramsdell F, Lantz T, Fowlkes BJ (1989) A nondeletional mechanism of thymic self tolerance. Science 246:1038-1041
19. 19. Bonomo A, Matzinger P (1993) Thymus epithelium induces tissue-specific tolerance. J Exp Med 117:1153-1164
20. 20. Posselt AM, Barker CF, Tomaszewski JE, Markmann JF, Choti MA, Naji A (1990) Induction of donor-specific unresponsiveness by intrathymic islet transplantation. Science 249:1293-1295
21. 21. Donohoe JA, Andrus L, Bowen KM, Simeonovic C, Prowse SJ, Lafferty KJ (1983) Cultured thyroid allografts induce a state of partial tolerance in adult recipient mice. Transplantation 35:62-67
22. 22. Snell GD (1957) The homograft reaction. Annu Rev Microbiol 11:439-458
23. 23. Ranheim EA, Kipps TJ (1993) Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J Exp Med 177:925-935
24. 24. Green DR, Scott DW (1994) Activation-induced apoptosis in lymphocytes. Curr Opin Immunol 6:476-487
25. 25. Bellamy CO, Malcomson RD, Harrison DJ, Wyllie AH (1995) Cell death in health and disease: the biology and regulation of apoptosis. Semin Cancer Biol 6:3-16
26. 26. Janeway CA, Jr (1989) Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 54:1-13
27. 27. Janeway CA, Jr (1992) The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol Today 13:11-16
28. 28. (1991) Heat shock proteins and the immune system. Immunol Rev 121:5-220
29. 29. Suto R, Srivastava PK (1995) A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 269:1585-1588
30. + T Cells in vivo. Proc Natl Acad Sci USA 91:3077-3081
31. 31. Nauts HC (1980) The beneficial effects of bacterial infections on host resistance to cancer: end results in 449 cases. 2nd edn Cancer Research Institute, Inc. New York
32. 32. Miller GF, Ketchum AS (1962) Effect of bacterial infection on tumor cell contamination of operative wounds. Surg Forum 13:98-99
33. 33. Everson TC, Cole WH (1966) Spontaneous Regression of Cancer. W.B. Saunders, Philadelphia
34. 34. Cole WH (1981) Efforts to explain spontaneous regression of cancer. J Surg Oncol 17:201-209
35. 35. Dupre de Lisle (1774) Traite du vice cancereux. Couturier fils, Paris
36. 36. Coley WB (1894) Treatment of inoperable malignant tumors with toxins of erysipelas and the Bacillus prodigiosus. Trans Am Surg Assoc 12:183-212
37. 37. Lamm DL, Blumenstein BA, Crawford ED, Montie JE, Scardino P, Grossman HB, et al (1991) A randomized trial of intravesical doxorubicin and immunotherapy with bacille Calmette-Guerin for transitional-cell carcinoma of the bladder. N Engl J Med 325:1205-1209
38. 38. Gorelik E (1983) Concomitant tumor immunity and the resistance to a second tumor challenge. Adv Cancer Res 39:71-120
39. + effector T cells. J Exp Med 159:1295-1311
40. 40. Monaco JJ (1995) Pathways for the processing and presentation of antigens to T cells. J Leuk Biol 57:543-547
41. 41. Boon T (1993) Teaching the immune system to fight cancer. Sci Am 268:82-89
42. 42. Vaux DL, Aguila HL, Weissman IL (1992) Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell-mediated killing. Int Immunol 4:821-824
43. 43. Fuchs EJ, Bedi A, Jones RJ, Hess AD (1995) Cytotoxic T cells overcome BCR-ABL-mediated resistance to apoptosis. Cancer Res 55:463-466
44. 44. Horowitz MM, Gale RP, Sondel PM, Goldman JM, Kersey J, Kolb H-J, et al (1990) Graft-versus-leukemia reactions after bone marrow transplantation. Blood 75:555-562
45. 45. Kolb H-J, Schattenberg A, Goldman JM, Hertenstein B, Jacobsen N, Arcese W, et al (1995) Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood 86:2041-2050
46. 46. Harada M, Matsunaga K, Oguchi Y, Iijima H, Ito O, Tamada K, et al (1995) The involvement of transforming growth factor β in the impaired antitumor T cell response at the gut-associated lymphoid tissue (GALT). Cancer Res 55:6146-6151