Identification of HLA-A2-restricted epitopes of the tumor-associated antigen MUC2 recognized by human cytotoxic T cells

International Journal of Cancer

Volumn 75, Issue 5, 1998, Pages 688-693

  Böhm, Christian M ^a   Hanski, Marie Luise ^a   Stefanović, Stefan ^b   Rammensee, Hans Georg ^b   Stein, Harald ^a   Taylor Papadimitriou, Joyce ^c   Riecken, Ernst Otto ^a   Hanski, Christoph ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GENE PRODUCT; HLA A2 ANTIGEN; MUCIN; TUMOR ANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; BREAST CARCINOMA; COLON CARCINOMA; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN TISSUE; MUCINOUS CARCINOMA; OVARY CARCINOMA; PANCREAS CARCINOMA; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANTIGENS, NEOPLASM; CYTOTOXICITY, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; HLA-A2 ANTIGEN; HUMANS; MUCINS; NEOPLASM PROTEINS; OLIGOPEPTIDES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 2642622574     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980302)75:5<688::AID-IJC5>3.0.CO;2-V     Document Type: Article

References (25)

1. BAKKER, A.B.H., MARLAND, G., DE BOER, A.J., HUIJBENS, R.J.F., DANEN, E.H.J., ADEMA, G.J. and FIGDOR, C.G., Generation of antimelanoma cytotoxic T lymphocytes from healthy donors after presentation of melanoma-associated antigen-derived epitopes by dendritic cells in vitro. Cancer Res., 55, 5330-5334 (1995).
2. BOON, T. and VAN DER BRUGGEN, P., Human tumor antigens recognized by T lymphocytes. J. exp. Med., 183, 125-129 (1996).
3. CELIS, E., TSAI V., CRIMI, C., DE MARS, R., WENTWORTH, P.A., CHESNUT, R.W., GREY, H.M., SETTE, A. and SERRA, H.M., Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes. Proc. nat. Acad. Sci. (Wash.), 91, 2105-2109 (1994).
4. CORREALE, P., WALMSLEY, K., NIERODA, C., ZAREMBA, S., ZHU, M., SCHLOM, J. and TSANG, K.Y., In vitro generation of human cytotoxic T lymphocytes specific for peptides derived from prostate specific antigen. J. nat. Cancer Inst., 89, 293-300 (1997).
5. COULIE, P.C., LEHMANN, F., LETHÉ, B., HERMAN, J., LURQUIN, C., ANDRAWISS, M. and BOON, T., A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma. Proc. nat. Acad. Sci. (Wash.), 92, 7976-7980 (1995).
6. DAVENPORT, M.P., HO SHON, I. and HILL, A.V.S., An empirical method for the prediction of T-cell epitopes. Immunogenetics, 42, 392-397 (1995).
7. FISK, B., BLEVINS, T.L., WHARTON, J.T. and IOANNIDES, C.G., Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines. J. exp. Med., 181, 2109-2117 (1995).
8. HANSKI, C., Is mucinous carcinoma of the colorectum a distinct genetic entity? Brit. J. Cancer, 72, 1350-1356 (1995).
9. HANSKI, C., HOFMEIER, M., RIEDE, E., HANSKI, M.L., BORCHARD, F., SIEBER, E., NIEDOBITEK, F., FOSS, H.D., STEIN, H. and RIECKEN, E.O., Overexpression or ectopic expression of MUC2 is the common property of mucinous carcinomas of the colon, pancreas, breast, and ovary. J. Pathol., 182, 385-391 (1997a).
10. HANSKI, C. and 12 OTHERS MUC2 gene suppression in human colorectal carcinomas and their metastases: in vitro evidence for modulatory role of DNA methylation. Lab. Invest., 77, 1-11 (1997b).
11. HERMANEK, P., GOSPODAROWICZ, M.K., HENSEN, D.E., MUTTER, R.V.P. and SOBIN, L.H. (eds.), Prognostic factors in cancer, UICC, Springer, Berlin (1995).
12. HO, S.B., NIEHANS, G.A., LYFTOGT, C., YAN, P.S., CHERWITZ, D.L., GUM, E.T., DAHIYA, R. and KIM, S.Y., Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res., 53, 641-651 (1993).
13. RAMMENSEE, H.-G., BACHMANN, J. and STEFANOVIĆ, S., MHC ligands and peptide motifs. Landes Bioscience Publ., Georgetown. TX (1997).
14. 2-microglobulin in metastatic melanomas from five patients receiving immunotherapy. J. nat. Cancer Inst., 88, 100-108 (1996).
15. ROBBINS, P.F., EL-GAMIL, M., LI, Y.F., KAWAKAMI, Y., LOFTUS, D., APPELLA, E. and ROSENBERG, S.A., A mutated β-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes. J. exp. Med., 183, 1185-1192 (1996).
16. RÖPKE, M., HALD, J., GULDEBERG, R. ZEUTHEN, J., NORGAARD, L., FUGGER, L., SVEJGAARD, A., VAN DER BURG, S., NIJMAN, H.W., MELIEF, C.J.M. and CLAESSON, M.H., Spontaneous human squamous cell carcinomas are killed by a human cytotoxic T lymphocyte clone recognizing a wild-type p53-derived peptide. Proc. nat. Acad. Sci. (Wash.), 93, 14704-14707 (1996).
17. ROSENBERG, S.A., Cancer vaccines based on the identification of genes encoding cancer regression antigens. Immunol. Today, 18, 175-182 (1997).
18. SALLUSTO, F. and LANZAVECCHIA, A., Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. exp. Med., 179, 1109-1118 (1994).
19. THEOBALD, M., BIGGS, J., DITTMER, D., LEVINE, A.J. and SHERMAN, L.A., Targeting p53 as a general tumor antigen. Proc. nat. Acad. Sci. (Wash.), 92, 11993-11997 (1995).
20. TORIBARA, N.W., GUNN, J.R., CULHANE, P.J., LAGACE, R.E., HICKS, J.W., PETERSEN, G.M. AND KIM, Y.S., J. Clin. Invest., 88, 1005-1013 (1991).
21. TSANG, K.Y., ZAREMBA, S., NIERODA, C.A., ZHU, M.Z., HAMILTON, J.M. and SCHLOM, J., Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine. J. nat. Cancer Inst., 87, 982-990 (1995).
22. VAN DER BRUGGEN, P., BASTIN, J., GAJEWSKI, T., COULIE, P., BOEL, P., DE SMET, C., TRAVERSARI, C., TOWNSEND, A. and BOON, T., A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3. Europ. J. Immunol., 24, 3038-3043 (1994).
23. VAN DER BURG, S.H., VISSEREN, M.J.W., BRANDT, R.M.P., KAST, W.M. and MELIEF, C.J.M., Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability. J. Immunol., 156, 3308-3314 (1996).
24. INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science, 269, 1281-1284 (1995).
25. YONEZAWA, S., SUEYOSHI, K., NOMOTO, M., KITAMURA, H., NAGATA, K., ARIMURA, Y., TANAKA, S., HOLLINGSWORTH, M.A., SIDDIKI, B., KIM, Y.S. and SATO, E., MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: its close relationship with prognosis of the patients. Hum. Pathol., 28, 344-352 (1997).