Targeted gene transfer to hepatocellular carcinoma cells in vitro using a novel monoclonal antibody-based gene delivery system

Hepatology

Volumn 29, Issue 1, 1999, Pages 82-89

  Mohr, Leonhard ^a   Schauer, Julia I ^b   Boutin, Raymond H ^b   Moradpour, Darius ^a,c   Wands, Jack R ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Apollon Inc   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

^d MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOPHILE; CHOLESTEROL; FLUORESCEIN ISOTHIOCYANATE; IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY; PLASMID DNA; SPERMINE;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; DNA BINDING; GENE TARGETING; GENE THERAPY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-PRESENTING CELLS; ANTIGENS, NEOPLASM; BETA-GALACTOSIDASE; CARCINOMA, HEPATOCELLULAR; FLUORESCENT ANTIBODY TECHNIQUE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; LUCIFERASES; MICE; MICROSCOPY, CONFOCAL; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032901036     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510290148     Document Type: Article

References (29)

1. Wang S, Lee RJ, Cauchon G, Gorenstein DG, Low PS. Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol. Proc Natl Acad Sci U S A 1995;92:3318-3322.
2. Wills KN, Huang WM, Harris MP, Machemer T, Maneval DC, Gregory RJ. Gene therapy for hepatocellular carcinoma: chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene. Cancer Gene Ther 1995;2:191-197.
3. Kuriyama S, Nakatani T, Masui K, Sakamoto T, Tominaga K, Yoshikawa M, Fukui H, et al. Bystander effect caused by suicide gene expression indicates the feasibility of gene therapy for hepatocellular carcinoma. HEPATOLOGY 1995;22:1838-1846.
4. Huang H, Chen SH, Kosai K, Finegold MJ, Woo SL. Gene therapy for hepatocellular carcinoma: long-term remission of primary and metastatic tumors in mice by interleukin-2 gene therapy in vivo. Gene Ther 1996;3:980-987.
5. Cao G, Kuriyama S, Du P, Sakamoto T, Kong X, Masui K, Qi Z. Complete regression of established murine hepatocellular carcinoma by in vivo tumor necrosis factor alpha gene transfer. Gastroenterology 1997;112:501-510.
6. Arbuthnot P, Bralet MP, Thomassin H, Danan JL, Brechet C, Ferry N. Hepatoma cell-specific expression of a retrovirally transferred gene is achieved by alpha-fetoprotein but not insulinlike growth factor 11 regulatory sequences. HEPATOLOGY 1995;22:1788-1796.
7. Kaneko S, Hallenbeck P, Kotani T, Nakabayashi H, McGarrity G, Tamaoki T, Anderson WF, et al. Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression. Cancer Res 1995;55:5283-5287.
8. Ido A, Nakata K, Kato Y, Nakao K, Murata K, Fujita M, Ishii N, et al. Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter. Cancer Res 1995;55:3105-3109.
9. Wu GY, Wu CH. Receptor-mediated gene delivery and expression in vivo. J Biol Chem 1988;263:14621-14624.
10. Midoux P, Medes C, Legrand A, Raimond J, Mayer R, Monsigy M, Roche AC. Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells. Nucleic Acids Res 1993;21:871-878.
11. Perales JC, Ferkol T, Beegen H, Ratnoff OD, Hanson RW. Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake. Proc Natl Acad Sci U S A 1994;91:4086-4090.
12. Remy JS, Kichler A, Mordvinov V, Schuber F, Behr JP. Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artificial viruses. Proc Natl Acad Sci U S A 1995;92:1744-1748.
13. Watkins SJ, Mesyanzhinov W, Kurochkina LP, Hawkins RE. The 'adenobody' approach to viral targeting: specific and enhanced adenoviral gene delivery. Gene Ther 1997;4:1004-1012.
14. Somia NV, Zoppe M, Verma IM. Generation of targeted retroviral vectors by using single-chain variable fragment: an approach to in vivo gene delivery. Proc Natl Acad Sci U S A 1995;92:7570-7574.
15. Miller N, Vile R. Targeted vectors for gene therapy. FASEB J 1995;9:190-199.
16. Wagner E, Cotten M, Foisner R, Birnstiel ML. Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells. Proc Natl Acad Sci U S A 1991;88:4255-4259.
17. Curiel DT, Agarwal S, Wagner E, Gotten M. Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proc Natl Acad Sci U S A 1991;88:8850-8854.
18. Kircheis R, Kichler A, Wallner G, Kursa M, Ogris M, Felzmann T, Buchberger M, et al. Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery. Gene Ther 1997;4:409-418.
19. Wilson B, Ozturk M, Takahashi H, Motte P, Kew M, Isselbacher K, Wands JR. Cell-surface changes associated with transformation of human hepatocytes to the malignant phenotype. Proc Natl Acad Sci USA 1988;85:3140-3144.
20. Moradpour D, Compagnon B, Wilson BE, Nicolau C, Wands JR. Specific targeting of human hepatocellular carcinoma cells by immunoliposomes in vitro. HEPATOLOGY 1995;22:1527-1537.
21. Takahashi H, Ozturk M, Wilson B, Maki A, Ozawa K, Koizumi M, Endo K, et al. In vivo expression of two novel tumor-associated antigens and their use in immunolocalization of human hepatocellular carcinoma. HEPATOLOGY 1989;9:625-634.
22. Compagnon B, Moradpour D, Alford D, Larsen C, Stevenson M, Mohr L, Wands JR, et al. Enhanced gene delivery and expression in human hepatocellular carcinoma cells by cationic immunoliposomes. J Liposome Res 1997;7:127-141.
23. He L, Isselbacher KJ, Wands JR, Goodman HM, Shih C, Quaroni A. Establishment and characterization of a new human hepatocellular carcinoma cell line. In Vitro 1984;20:493-504.
24. Nakabayashi H, Taketa K, Miyano K, Yamane T, Sato J. Growth of human hepatoma cells lines with differentiated functions in chemically defined medium. Cancer Res 1982;42:3858-3863.
25. Ełlman G. Tissue sulfhydryl groups. Arch Biochem Biophys 1959;82:70-77.
26. Moradpour D, Schauer JI, Zurawski VR, Jr., Wands JR, Boutin RH. Efficient gene transfer into mammalian cells with cholesteryl-spermidine. Biochem Biophys Res Commun 1996;221:82-88.
27. Ausubel F, Brent R, Kingston RE, Moore DD, Seidmann JG, Smith JA, Struhl K. Current Protocols in Molecular Biology. New York: Wiley & Sons, 1996.
28. Ledley F. Nonviral gene therapy: the promise of genes as pharmaceutical products. Hum Gene Ther 1995;6:1129-1144.
29. Mulligan R. The basic science of gene therapy. Science 1993;260:926-932.