메뉴 건너뛰기




Volumn 131, Issue 2, 1998, Pages 191-200

Inhibition of K-ras-transformed rodent and human cancer cell growth via induction of apoptosis by irreversible inhibitors of ras endoprotease

Author keywords

Apoptosis; Cancer cells; Cell growth; Endoprotease; Inhibitors; Ras

Indexed keywords

KETONE DERIVATIVE; PROTEINASE INHIBITOR; UM 96001; UNCLASSIFIED DRUG;

EID: 0031756961     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(98)00146-3     Document Type: Article
Times cited : (22)

References (44)
  • 1
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos J.L. ras oncogenes in human cancer: a review. Cancer Res. 49:1989;4682-4689.
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 4
    • 0030992130 scopus 로고    scopus 로고
    • Protein prenylation, et cetera: Signal transduction in two dimensions
    • Gelb M.H. Protein prenylation, et cetera: signal transduction in two dimensions. Science. 275:1997;1750-1751.
    • (1997) Science , vol.275 , pp. 1750-1751
    • Gelb, M.H.1
  • 5
    • 0026735063 scopus 로고
    • Protein isoprenylation and methylation at carboxyl-terminal cysteine residues
    • S. Clarke, Protein isoprenylation and methylation at carboxyl-terminal cysteine residues, Annu. Rev. Biochem. 61 (1992) 355-386; P.J. Casey, Protein lipidation in cell signaling, Science 268 (1995) 221-225; A. Hall, Rho GTPases and the actin cytoskeleton, Science 279 (1998) 509-514; R.B. Lobell, Prenylation of Ras GTPase superfamily proteins and their function in immunology, Adv. Immunol. 68 (1998) 145-189.
    • (1992) Annu. Rev. Biochem. , vol.61 , pp. 355-386
    • Clarke, S.1
  • 6
    • 0028935780 scopus 로고
    • Protein lipidation in cell signaling
    • S. Clarke, Protein isoprenylation and methylation at carboxyl-terminal cysteine residues, Annu. Rev. Biochem. 61 (1992) 355-386; P.J. Casey, Protein lipidation in cell signaling, Science 268 (1995) 221-225; A. Hall, Rho GTPases and the actin cytoskeleton, Science 279 (1998) 509-514; R.B. Lobell, Prenylation of Ras GTPase superfamily proteins and their function in immunology, Adv. Immunol. 68 (1998) 145-189.
    • (1995) Science , vol.268 , pp. 221-225
    • Casey, P.J.1
  • 7
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • S. Clarke, Protein isoprenylation and methylation at carboxyl-terminal cysteine residues, Annu. Rev. Biochem. 61 (1992) 355-386; P.J. Casey, Protein lipidation in cell signaling, Science 268 (1995) 221-225; A. Hall, Rho GTPases and the actin cytoskeleton, Science 279 (1998) 509-514; R.B. Lobell, Prenylation of Ras GTPase superfamily proteins and their function in immunology, Adv. Immunol. 68 (1998) 145-189.
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 8
    • 0031978007 scopus 로고    scopus 로고
    • Prenylation of Ras GTPase superfamily proteins and their function in immunology
    • S. Clarke, Protein isoprenylation and methylation at carboxyl-terminal cysteine residues, Annu. Rev. Biochem. 61 (1992) 355-386; P.J. Casey, Protein lipidation in cell signaling, Science 268 (1995) 221-225; A. Hall, Rho GTPases and the actin cytoskeleton, Science 279 (1998) 509-514; R.B. Lobell, Prenylation of Ras GTPase superfamily proteins and their function in immunology, Adv. Immunol. 68 (1998) 145-189.
    • (1998) Adv. Immunol. , vol.68 , pp. 145-189
    • Lobell, R.B.1
  • 9
    • 0029817090 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors: A new class of cancer chemotherapeutics
    • K.S. Koblan, N.E. Kohl, C.A. Omer, N.J. Anthony, M.W. Conner, S.J. deSolms, T.M. Williams, S.L. Graham, G.D. Hartman, A. Oliff, J.B. Gibbs, Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics, Biochem. Soc. Trans. 24 (1996) 688-692; G.J. Kelloff, R.A. Lubet, J.R. Fay, V.E. Steele, C.W. Boone, J.A. Crowell, C.C. Sigman, Farnesyl protein transferase inhibitors as potential cancer chemopreventives, Cancer Epidemiol. Biomarkers Prev. 6 (4) (1997) 267-282; A.D. Cox, C.J. Der, Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?, Biochim. Biophys. Acta 1333 (1997) F51-F71.
    • (1996) Biochem. Soc. Trans. , vol.24 , pp. 688-692
    • Koblan, K.S.1    Kohl, N.E.2    Omer, C.A.3    Anthony, N.J.4    Conner, M.W.5    Desolms, S.J.6    Williams, T.M.7    Graham, S.L.8    Hartman, G.D.9    Oliff, A.10    Gibbs, J.B.11
  • 10
    • 0030989097 scopus 로고    scopus 로고
    • Farnesyl protein transferase inhibitors as potential cancer chemopreventives
    • K.S. Koblan, N.E. Kohl, C.A. Omer, N.J. Anthony, M.W. Conner, S.J. deSolms, T.M. Williams, S.L. Graham, G.D. Hartman, A. Oliff, J.B. Gibbs, Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics, Biochem. Soc. Trans. 24 (1996) 688-692; G.J. Kelloff, R.A. Lubet, J.R. Fay, V.E. Steele, C.W. Boone, J.A. Crowell, C.C. Sigman, Farnesyl protein transferase inhibitors as potential cancer chemopreventives, Cancer Epidemiol. Biomarkers Prev. 6 (4) (1997) 267-282; A.D. Cox, C.J. Der, Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?, Biochim. Biophys. Acta 1333 (1997) F51-F71.
    • (1997) Cancer Epidemiol. Biomarkers Prev. , vol.6 , Issue.4 , pp. 267-282
    • Kelloff, G.J.1    Lubet, R.A.2    Fay, J.R.3    Steele, V.E.4    Boone, C.W.5    Crowell, J.A.6    Sigman, C.C.7
  • 11
    • 0030749458 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras?
    • K.S. Koblan, N.E. Kohl, C.A. Omer, N.J. Anthony, M.W. Conner, S.J. deSolms, T.M. Williams, S.L. Graham, G.D. Hartman, A. Oliff, J.B. Gibbs, Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics, Biochem. Soc. Trans. 24 (1996) 688-692; G.J. Kelloff, R.A. Lubet, J.R. Fay, V.E. Steele, C.W. Boone, J.A. Crowell, C.C. Sigman, Farnesyl protein transferase inhibitors as potential cancer chemopreventives, Cancer Epidemiol. Biomarkers Prev. 6 (4) (1997) 267-282; A.D. Cox, C.J. Der, Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?, Biochim. Biophys. Acta 1333 (1997) F51-F71.
    • (1997) Biochim. Biophys. Acta , vol.1333
    • Cox, A.D.1    Der, C.J.2
  • 14
    • 0027320616 scopus 로고
    • Peptidomimetic inhibitors of Ras farnesylation and function in whole cells
    • Garcia A.M., Rowell C., Ackermann K., Kowalczyk J.J., Lewis M.D. Peptidomimetic inhibitors of Ras farnesylation and function in whole cells. J. Biol. Chem. 268:1993;18415-18418.
    • (1993) J. Biol. Chem. , vol.268 , pp. 18415-18418
    • Garcia, A.M.1    Rowell, C.2    Ackermann, K.3    Kowalczyk, J.J.4    Lewis, M.D.5
  • 19
    • 0029063175 scopus 로고
    • Activated H-Ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest
    • Lin H.J., Eviner V., Prendergast G.C., White E. Activated H-Ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest. Mol. Cell. Biol. 18:1995;4536-4544.
    • (1995) Mol. Cell. Biol. , vol.18 , pp. 4536-4544
    • Lin, H.J.1    Eviner, V.2    Prendergast, G.C.3    White, E.4
  • 20
    • 0029892754 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 suppression of tumor necrosis factor alpha-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase
    • Gardner A.N., Johnson G.L. Fibroblast growth factor-2 suppression of tumor necrosis factor alpha-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase. J. Biol. Chem. 271:1996;14560-14566.
    • (1996) J. Biol. Chem. , vol.271 , pp. 14560-14566
    • Gardner, A.N.1    Johnson, G.L.2
  • 23
    • 0029872268 scopus 로고    scopus 로고
    • Normal and transforming Ras are differently regulated for posttranslational modifications
    • Yamada-Okabe T., Doi R., Yamada-Okabe H. Normal and transforming Ras are differently regulated for posttranslational modifications. J. Cell. Biochem. 61:1996;172-181.
    • (1996) J. Cell. Biochem. , vol.61 , pp. 172-181
    • Yamada-Okabe, T.1    Doi, R.2    Yamada-Okabe, H.3
  • 24
    • 0031050738 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment
    • Lebowitz P.F., Sakamuro D., Prendergast G.C. Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment. Cancer Res. 57:1997;708-713.
    • (1997) Cancer Res. , vol.57 , pp. 708-713
    • Lebowitz, P.F.1    Sakamuro, D.2    Prendergast, G.C.3
  • 25
  • 27
    • 0026747866 scopus 로고
    • Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity
    • Kato K., Cox A.D., Hisaka M.M., Graham S.M., Buss J.E., Der C.J. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc. Natl. Acad. Sci. USA. 89:1992;6403-6407.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6403-6407
    • Kato, K.1    Cox, A.D.2    Hisaka, M.M.3    Graham, S.M.4    Buss, J.E.5    Der, C.J.6
  • 28
    • 25044466946 scopus 로고
    • Selective and irreversible inhibition of Ras protease by tosyl-L-phenylalanine chloromethyl ketone, ASBMB/DBC-ACS Joint Meeting in San Francisco, Late Breaking Abstract LB 46
    • (Addendum to
    • Y. Chen, Selective and irreversible inhibition of Ras protease by tosyl-L-phenylalanine chloromethyl ketone, ASBMB/DBC-ACS Joint Meeting in San Francisco, Late Breaking Abstract LB 46 (Addendum to FASEB J. 9 (6) (1995)).
    • (1995) FASEB J. , vol.9 , Issue.6
    • Chen, Y.1
  • 29
    • 0029990398 scopus 로고    scopus 로고
    • Solubilization, partial purification, and affinity labeling of the membrane-bound isoprenylated protein endoprotease
    • Chen Y., Ma Y.-T., Rando R.R. Solubilization, partial purification, and affinity labeling of the membrane-bound isoprenylated protein endoprotease. Biochemistry. 35:1996;3227-3237.
    • (1996) Biochemistry , vol.35 , pp. 3227-3237
    • Chen, Y.1    Ma, Y.-T.2    Rando, R.R.3
  • 30
    • 0030909336 scopus 로고    scopus 로고
    • Modulation of Ras and a-factor function by carboxyl-terminal proteolysis
    • Boyartchuk V.L., Ashby M.N., Rine J. Modulation of Ras and a-factor function by carboxyl-terminal proteolysis. Science. 275:1997;1796-1800.
    • (1997) Science , vol.275 , pp. 1796-1800
    • Boyartchuk, V.L.1    Ashby, M.N.2    Rine, J.3
  • 31
    • 0030779945 scopus 로고    scopus 로고
    • Partial purification and characterization of a CAAX-motif-specific protease from bovine brain using a novel fluorometric assay
    • Nishii W., Muramatsu T., Kuchino Y., Yokoyama S., Takahashi K. Partial purification and characterization of a CAAX-motif-specific protease from bovine brain using a novel fluorometric assay. J. Biochem. 122:1997;402-408.
    • (1997) J. Biochem. , vol.122 , pp. 402-408
    • Nishii, W.1    Muramatsu, T.2    Kuchino, Y.3    Yokoyama, S.4    Takahashi, K.5
  • 33
    • 0026521412 scopus 로고
    • Endoproteolytic processing of a farnesylated peptide in vitro
    • M.N. Ashby, D.S. King, J. Rine, Endoproteolytic processing of a farnesylated peptide in vitro, Proc. Natl. Acad. Sci. USA 89 (1992) 4613-4617; Y.-T. Ma, R.R. Rando, A microsomal endoprotease that specifically cleaves isoprenylated peptides, Proc. Natl. Acad. Sci. USA 89 (1992) 6275-6279; G.-F. Jang, K. Yokoyama, M.H. Gelb, A prenylated protein-specific endoprotease in rat liver microsomes that produces carboxyl-terminal tripeptide, Biochemistry 32 (1993) 9500-9507.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4613-4617
    • Ashby, M.N.1    King, D.S.2    Rine, J.3
  • 34
    • 0026680433 scopus 로고
    • A microsomal endoprotease that specifically cleaves isoprenylated peptides
    • M.N. Ashby, D.S. King, J. Rine, Endoproteolytic processing of a farnesylated peptide in vitro, Proc. Natl. Acad. Sci. USA 89 (1992) 4613-4617; Y.-T. Ma, R.R. Rando, A microsomal endoprotease that specifically cleaves isoprenylated peptides, Proc. Natl. Acad. Sci. USA 89 (1992) 6275-6279; G.-F. Jang, K. Yokoyama, M.H. Gelb, A prenylated protein-specific endoprotease in rat liver microsomes that produces carboxyl-terminal tripeptide, Biochemistry 32 (1993) 9500-9507.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6275-6279
    • Ma, Y.-T.1    Rando, R.R.2
  • 35
    • 0027527703 scopus 로고
    • A prenylated protein-specific endoprotease in rat liver microsomes that produces carboxyl-terminal tripeptide
    • M.N. Ashby, D.S. King, J. Rine, Endoproteolytic processing of a farnesylated peptide in vitro, Proc. Natl. Acad. Sci. USA 89 (1992) 4613-4617; Y.-T. Ma, R.R. Rando, A microsomal endoprotease that specifically cleaves isoprenylated peptides, Proc. Natl. Acad. Sci. USA 89 (1992) 6275-6279; G.-F. Jang, K. Yokoyama, M.H. Gelb, A prenylated protein-specific endoprotease in rat liver microsomes that produces carboxyl-terminal tripeptide, Biochemistry 32 (1993) 9500-9507.
    • (1993) Biochemistry , vol.32 , pp. 9500-9507
    • Jang, G.-F.1    Yokoyama, K.2    Gelb, M.H.3
  • 36
    • 0017841848 scopus 로고
    • Isolation and characterization of E-64, a new thiol protease inhibitor
    • K. Hanada, M. Tamai, M. Yamagishi, Isolation and characterization of E-64, a new thiol protease inhibitor, Agric. Biol. Chem. 42 (1978) 523-528; A. Albeck, S. Fluss, R. Persky, Peptidyl epoxides - novel selective inactivators of cysteine proteases, J. Am. Chem. Soc. 118 (1996) 3591-3596.
    • (1978) Agric. Biol. Chem. , vol.42 , pp. 523-528
    • Hanada, K.1    Tamai, M.2    Yamagishi, M.3
  • 37
    • 0029984218 scopus 로고    scopus 로고
    • Peptidyl epoxides - Novel selective inactivators of cysteine proteases
    • K. Hanada, M. Tamai, M. Yamagishi, Isolation and characterization of E-64, a new thiol protease inhibitor, Agric. Biol. Chem. 42 (1978) 523-528; A. Albeck, S. Fluss, R. Persky, Peptidyl epoxides - novel selective inactivators of cysteine proteases, J. Am. Chem. Soc. 118 (1996) 3591-3596.
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 3591-3596
    • Albeck, A.1    Fluss, S.2    Persky, R.3
  • 39
    • 0029959632 scopus 로고    scopus 로고
    • Specific cleavage of alpha-fodrin during Fas- And tumor necrosis factor-induced apoptosis is mediated by an interleukin-1beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease
    • Cryns V.L., Bergeron L., Zhu H., Li H., Yuan J. Specific cleavage of alpha-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease. J. Biol. Chem. 271:1996;31277-31282.
    • (1996) J. Biol. Chem. , vol.271 , pp. 31277-31282
    • Cryns, V.L.1    Bergeron, L.2    Zhu, H.3    Li, H.4    Yuan, J.5
  • 40
    • 0029898894 scopus 로고    scopus 로고
    • Protein prenylation: Molecular mechanisms and functional consequences
    • Zhang F.L., Casey P.J. Protein prenylation: molecular mechanisms and functional consequences. Annu. Rev. Biochem. 65:1996;241-269.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 241-269
    • Zhang, F.L.1    Casey, P.J.2
  • 42
    • 0029959434 scopus 로고    scopus 로고
    • Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells
    • Oldham S.M., Clark G.J., Gangarosa L.M., Coffey R.J. Jr., Der C.J. Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells. Proc. Natl. Acad. Sci. USA. 93:1996;6924-6928.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 6924-6928
    • Oldham, S.M.1    Clark, G.J.2    Gangarosa, L.M.3    Coffey R.J., Jr.4    Der, C.J.5
  • 44
    • 0030790547 scopus 로고    scopus 로고
    • Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid-dependent signaling
    • Lacal J.C. Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid-dependent signaling. FEBS Lett. 410:1997;73-77.
    • (1997) FEBS Lett. , vol.410 , pp. 73-77
    • Lacal, J.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.