Oral tolerization to adenoviral proteins permits repeated adenovirus- mediated gene therapy in rats with pre-existing immunity to adenoviruses

Hepatology

Volumn 27, Issue 5, 1998, Pages 1368-1376

  Ilan, Yaron ^a   Sauter, Bernhard ^a   Chowdhury, Namita Roy ^a   Reddy, Bhoompally V N ^a   Thummala, Narsing R ^a   Droguett, Gustavo ^a   Davidson, Anne ^a   Olt, Michael ^a   Horwitz, Marshall S ^a   Chowdhury, Jayanta Roy ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; BOVINE SERUM ALBUMIN; GAMMA INTERFERON; GLUCURONOSYLTRANSFERASE; TRANSFORMING GROWTH FACTOR BETA1; VIRUS ANTIBODY; VIRUS PROTEIN; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; ANTIGEN PRESENTING CELL; ARTICLE; BILIRUBIN BLOOD LEVEL; CELLULAR IMMUNITY; CONTROLLED STUDY; CRIGLER NAJJAR SYNDROME; CYTOTOXIC LYMPHOCYTE; FEMALE; GENE THERAPY; GENE TRANSFER; HUMORAL IMMUNITY; IMMUNOLOGICAL TOLERANCE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; TRANSGENE; VIRUS IMMUNITY; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; BILIRUBIN; CYTOKINES; FEMALE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GLUCURONOSYLTRANSFERASE; HUMANS; IMMUNE TOLERANCE; IMMUNITY, CELLULAR; IMMUNIZATION; IMMUNOLOGIC MEMORY; MALE; RATS; RATS, INBRED STRAINS; RECOMBINANT PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; VIRAL PROTEINS;

EID: 17344370857     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510270525     Document Type: Article

References (12)

1. Jaffe HA, Danel C, Longenecker G. Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat Genet 1992;1:372-378.
2. Prevec L, Schneider M, Rosenthal KL, Belbeck LW, Derbyshire JB, Graham FL. Use of human adenovirus-based vectors for antigen expression in animals. J Gen Virol 1989;70:429-434.
3. Takahashi M, Ilan Y, Sengupta K, Roy Chowdhury N, Roy Chowdhury J. Induction of tolerance to recombinant adenoviruses by injection into newborn rats: long term amelioration of hyperbilirubinemia in Gunn rats. J Biol Chem 1996;271:26536-26542.
4. Ilan Y, Attavar P, Takahashi M, Davidson A, Horwitz M, Guida J, Roy Chowdhury N, et al. Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long term gene therapy in Gunn rats. J Clin Invest 1996;98:2640-2647.
5. Ilan Y, Prakash R, Davidson A, Jona VK, Droguett G, Horwitz MS, Roy Chowdhury N, et al. Oral tolerization to adenoviral antigens permits long term gene expression using recombinant adenoviral vectors. J Clin Invest 1997;99:1098-1106.
6. Walter J, You Q, Hagstrom JN, Sands M, High KA. Successful expression of human factor 9 following repeat administration of adenoviral vector in mice. Proc Natl Acad Sci USA 1996;93:3056-3061.
7. Yang Y, Li Q, Ertl HCJ, Wilson JM. Cellular and humoral immune responses to viral antigen create barriers to lung-directed gene therapy with recombinant adenoviruses. J Virol 1995;67:2004-2015.
8. Yang Y, Nunes FA, Berencsi K, Gonczol E, Engelhardt JR, Wilson JM. Inactivation of E2a in recombinant adenoviruses limits cellular immunity and improves the prospect of gene therapy of cystic fibrosis. Proc Natl Acad Sci USA 1994;7:362-369.
9. Dai Y, Schwarz EM, Gu D, Zhang WW, Sarvetnick N. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long term expression. Proc Natl Acad Sci USA 1995;92:1401-1405.
10. Yang Y, Nunes FA, Berencsi K, Gonczol E, Engelhardt Jr; Wilson JM. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nat Genet 1994;7:362-369.
11. Ilan Y, Jona VK, Sengupta K, Davidson A, Horwitz MS, Roy-Chowdhury N, Roy-Chowdhury J. Transient immunosuppression with fk506 permits long-term expression of therapeutic genes introduced into the liver using recombinant adenoviruses. HEPATOLOGY 1997;26:949-956.
12. Yang Y, Greenough K, Wilson JM. Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver. Gene Ther 1990;3:412-420.