Characterization of the immune response after local delivery of recombinant adenovirus in murine pancreas and successful strategies for readministration

Human Gene Therapy

Volumn 8, Issue 18, 1997, Pages 2207-2216

  Mcclane, Steven J ^a   Chirmule, Narendra ^a   Burke, Charlotte V ^a   Raper, Steven E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GLYCOPROTEIN GP 39; NEUTRALIZING ANTIBODY;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; EXPRESSION VECTOR; FEMALE; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; HELPER CELL; IMMUNE RESPONSE; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PANCREAS; SPLEEN CELL; TRANSGENE; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALIA; MURINAE;

EID: 0031564327     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.18-2207     Document Type: Article

References (7)

1. BERGELSON, J.M., CUNNINGHAM, J.A., DROGUETT, G., KURTJONES, E.A., KRITHIVAS, A., HONG, J.S., HORWITZ, M.S., CROWELL, R.L., and FINBERG, R.W. (1997). Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 275, 1320-1323.
2. DAVIDSON, B.L., ALLEN, E.D., KOZARSKY, K.F., WILSON, J.M., and ROESSLER, B.J. (1993). A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nature Genet. 3, 219-223.
3. DEMATTEO, R.P., MARKMANN, J.F., KOZARSKY, K.F., BARKER, C.F., and RAPER, S.E. (1996). Prolongation of adenoviral transgene expression in mouse liver by T lymphocyte subset depletion. Gene Ther. 3, 4-12.
4. DURIE, F.H., FOY, T.M., MASTERS, S.R., LAMAN, J.D., and NOELLE, R.J. (1994). The role of CD40 in the regulation of humoral and cell-mediated immunity. Immunol. Today 15, 406-411.
5. ENGELHARDT, J.F., YE, X., DORANZ, B., and WILSON, J.M. (1994a). Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. USA 91, 6196-6200.
6. ENGELHARDT, J.F., LITZKY, L., and WILSON, J.M. (1994b). Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a. Hum. Gene Ther. 5, 1217-1229.
7. EVOY, D., HIRSCHOWITZ, E.A., NAAMA, H.A., LI, X.K., CRYSTAL, R., and DALY, J.M. (1997). In vivo adenoviral-mediated gene transfer in the treatment of pancreatic cancer. J. Surg. Res. 69, 226-231.