Activation of the AP-1 transcription factor by inflammatory cytokines of the TNF family

Gene Expression

Volumn 7, Issue 4-6, 1999, Pages 217-231

  Kyriakis, John M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

AP 1; c Jun; JNK; p38; SAPK; TNF; TRAF

Indexed keywords

CYTOKINE; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR;

CONFERENCE PAPER; ENZYME INDUCTION; ENZYME STRUCTURE; HUMAN; MOLECULAR DYNAMICS; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; GENE EXPRESSION REGULATION; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEINS; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 1; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032780309     PISSN: 10522166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (76)

1. Akiba, H.; Nakano, H.; Nishinaka, S.; Shindo, M.; Kobata, T.; Atsuta, M.; Morimoto, C.; Ware, C. F.; Malinin, N.; Wallach, D.; Yagita, H.; Okumura, K. CD27, a member of the tumor necrosis factor receptor super-family, activates NF-κB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5 and NF-κB-inducing kinase. J. Biol. Chem. 273:13353-13358; 1998.
2. Arch, R. H.; Gedrich, R. W.; Thompson, C. B. Tumor necrosis factor receptor-associated factors (TRAFs) - a family of adapter proteins that regulates life and death. Genes Dev. 12:2821-2830; 1998.
3. Avruch, J.; Zhang, X.-f.; Kyriakis, J. M. Raf meets Ras: Completing the framework of a signal transduction pathway. Trends Biochem. Sci. 19:279-283; 1994.
4. Blank, J. L.; Gerwins, P.; Elliot, E. M.; Sather, S.; Johnson, G. L. Molecular cloning of mitogen activated protein/ERK kinase kinases (MEKK) 2 and 3. J. Biol. Chem. 271:5361-5368; 1996.
5. Chang, H. Y.; Nishitoh, H.; Yang, X.; Ichijo, H.; Baltimore, D. Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science 281:1860-1863; 1998.
6. Cuenda, A.; Alonso, G.; Morrice, N.; Jones, M.; Meier, R.; Cohen, P.; Nebreda, A. Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells. EMBO J. 15:4156-4164; 1996.
7. Dérijard, B.; Hibi, M.; Wu, I.-H.; Barrett, T.; Su, B.; Deng, T.; Karin, M.; Davis, R. J. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun transactivation domain. Cell 76:1025-1037; 1994.
8. Dérijard, B.; Raingeaud, J.; Barrett, T.; Wu, L.-H.; Han, J.; Ulevitch, R. J.; Davis, R. J. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267:682-685; 1995.
9. Diener, K.; Wang, X. S.; Chen, C.; Meyer, C. F.; Keesler, G.; Zukowski, M.; Tan, T.-H.; Yao, Z. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc. Natl. Acad. Sci. USA 94:9687-9692; 1997.
10. Dorow, D. S.; Devereux, L.; Dietzsch, E.; De Kretser, T. Identification of a new family of hyman epithelial protein kinases containing two leucine/isoleucine-zipper domains. Eur. J. Biochem. 213:701-710; 1993.
11. mapk but not ERK2. J. Biol. Chem. 271:24788-24793; 1996.
12. Galibert, L.; Tometsko, M. E.; Anderson, D. M.; Cosman, D.; Dougall, W. C. The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-κB, a member of the TNFR superfamily. J. Biol. Chem. 273:34120-34127; 1998.
13. Gallo, K.; Mark, M. R.; Scadden, D. T.; Wang, Z.; Gu, Q.; Godowski, P. Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity. J. Biol. Chem. 269:15092-15100; 1994.
14. Gerwins, P.; Blank, J. L.; Johnson, G. L. Cloning of a novel mitogen-activated protein kinase-kinase-kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. J. Biol. Chem. 272:8288-8295; 1997.
15. Goossens, V.; Grooten, J.; De Vos, K.; Fiers, W. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc. Natl. Acad. Sci. USA 92:8115-8119; 1995.
16. Gotoh, Y.; Cooper, J. A. Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-α signal transduction. J. Biol. Chem. 273:17477-17482; 1998.
17. Gupta, S.; Campbell, D.; Dörijard, B.; Davis, R. J. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science. 267:389-393; 1995.
18. Han, J.; Jiang, Y.; Li, Z.; Kravchenko, V. V.; Ulevitch, R. J. MEF2C participates in inflammatory responses via p38-mediated activation. Nature 386:563-566; 1997.
19. Herskowitz, I. MAP kinase pathways in yeast: For mating and more. Cell 80:187-197; 1995.
20. Hirai, S.-i.; Katoh, M.; Terada, M.; Kyriakis, J. M.; Zon, L. I.; Rana, A.; Avruch, J.; Ohno, S. MST/MLK2, a member of the miked lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase. J. Biol. Chem. 272:15167-15173; 1997.
21. Hirai, S.-i.; Noda, K.; Moriguchi, T.; Nishida, E.; Yamashita, A.; Deyama, T.; Fukuyama, K.; Ohno, S. Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2. J. Biol. Chem. 273:7406-7412; 1998.
22. Holland, P. M.; Suzanne, M.; Campbell, J. S.; Noselli, S.; Cooper, J. A. MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemopterous. J. Biol. Chem. 272:24994-24998; 1997.
23. Holtzman, L. B.; Merritt, S. E.; Fan, G. Identification, molecular cloning and characterization of dual leucine zipper bearing kinase. J. Biol. Chem. 269:30808-30817; 1994.
24. Hsu, H.; Xiong, J.; Goeddel, D. V. The TNF receptor-1-associated protein TRADD signals cell death and NF-κB activation. Cell 81:495-504; 1995.
25. Hsu, H.; Shu, H.-B.; Pan, M.-G.; Goeddel, D. V. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84:299-308; 1996.
26. Hsu, H.; Huang, J.; Shu, H.-B.; Baichwal, V.; Goeddel, D. V. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4:387-396; 1996.
27. Hu, M. C.-T.; Qiu, W. R.; Wang, X.; Meyer, C. F.; Tan, T.-H. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Genes Dev. 10:2251-2264; 1996.
28. Hutchison, M.; Berman, K. S.; Cobb, M. H. Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J. Biol. Chem. 273:28625-28632; 1998.
29. Ichijo, H.; Nishida, E.; Irie, K.; ten Dijke, P.; Saitoh, M.; Moriguchi, T.; Takagi, M.; Matsumoto, K.; Miyazono, K.; Gotoh, Y. (1997) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/ JNK and p38 signaling pathways. Science 275:90-94; 1997.
30. Karin, M.; Liu, Z.-g.; Zandi, E. AP-1 function and regulation. Curr. Opin. Cell Biol. 9:240-246; 1997.
31. Katz, P.; Whalen, G.; Kehrl, J. H. Differential expression of a novel protein kinase in human B lymphocytes: Preferential localization in the germinal center. J. Biol. Chem. 269:16802-16809; 1994.
32. Kelliher, M. A.; Grimm, S.; Ishida, Y.; Kuo, F.; Stanger, B. Z.; Leder, P. The death domain kinase RIP mediates the TNF-induced NF-κB signal. Immunity 8:297-303; 1998.
33. Kiefer, F.; Tibbles, L. A.; Anafi, M.; Janssen, A.; Zanke, B. W.; Lassam, N.; Pawson, T.; Woodgett, J. R.; Iscove, N. R. HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 15:7013-7025; 1996.
34. Kyriakis, J. M.; Banerjee, P.; Nikolakaki, E.; Dai, T.; Rubie, E. A.; Ahmad, M. F.; Avruch, J.; Woodgett, J. R. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369:156-160; 1994.
35. Kyriakis, J. M.; Avruch, J. Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays 18:567-577; 1996.
36. Kyriakis, J. M.; Avruch, J. Sounding the alarm: Protein kinase cascades activated by stress and inflammation. J. Biol. Chem. 271:24313-24316; 1996.
37. Kyriakis, J. M. Signaling by the germinal center kinase family of protein kinases. J. Biol. Chem. 274:5259-5262; 1999.
38. Lange-Carter, C. A.; Pleiman, C. M.; Gardner, A. M.; Blumer, K. J.; Johnson, G. L. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260:315-319; 1993.
39. Lawler, S.; Fleming, Y.; Goedert, M.; Cohen, P. Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro. Curr. Biol. 8:1387-1390; 1998.
40. Liu, Z.-g.; Hsu, H.; Goeddel, D. V.; Karin, M. Dissection of TNF receptor-1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87:565-576; 1996.
41. Malinin, N. L.; Boldin, M. P.; Kovalenko, A. V.; Wallach, D. MAP3K-related kinase involved in NF-κB induction by TNF, CD-95 and IL-1. Nature 385:540-544; 1997.
42. Moriguchi, T.; Kuroyanagi, N.; Yamaguchi, K.; Gotoh, Y.; Irie, K.; Kano, T.; Shirakabe, K.; Muro, Y.; Shibuya, H.; Matsumoto, K.; Nishida, E.; Hagiwara, M. A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J. Biol. Chem. 271:13675-13679; 1996.
43. Natoli, G.; Costanzo, A.; Ianni, A.; Templeton, D. J.; Woodgett, J. R.; Balsano, C.; Levrero, M. Activation of SAPK/JNK by TNF receptor-1 through a noncytotoxic TRAF2-dependent pathway. Science 275:200-203; 1997.
44. Nishitoh, H.; Saitoh, M.; Mochida, Y.; Takeda, K.; Nakano, H.; Rothe, M.; Miyazono, K.; Ichijo, H. ASK1 is essential for JNK/SAPK activation by TRAF2. Mol. Cell 2:389-395; 1998.
45. Pombo, C. M.; Kehrl, J. H.; Sánchez, I.; Katz, P.; Avruch, J.; Zon, L. I.; Woodgett, J. R.; Force, T.; Kyriakis, J. M. Activation of the SAPK pathway by the human STE20 homologue germinal center kinase. Nature 377:750-754; 1995.
46. Raingeaud, J.; Whitmarsh, A. J.; Barett, T.; Dérijard, B.; Davis, R. J. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell. Biol. 16:1247-1255; 1996.
47. Rana, A.; Gallo, K.; Godowski, P.; Hirai, S.-i.; Ohno, S.; Zon, L. I.; Kyriakis, J. M.; Avruch, J. The mixed lineage protein kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK1. J. Biol. Chem. 271:19025-19028; 1996.
48. Rothe, M.; Wong, S. C.; Henzel, W. J.; Goeddel, D. V. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75-kDa tumor necrosis factor receptor. Cell 78:681-692; 1994.
49. Saitoh, M.; Nishitoh, H.; Fujii, M.; Takeda, K.; Tobiume, K.; Sawada, Y.; Kawabata, M.; Miyazono, K.; Ichijo, H. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J. 17:2596-2606; 1998.
50. Salmerón, A.; Ahmad, T. B.; Carlile, G. W.; Pappin, D.; Narsimhan, R. P.; Ley, S. C. Activation of MEK-1 and SEK-1 by Tpl-2 proto oncoprotein, a novel MAP kinase kinase kinase. EMBO J:15:817-826; 1996.
51. Sánchez, I.; Hughes, R. T.; Mayer, B. J.; Yee, K.; Woodgett, J. R.; Avruch, J.; Kyriakis, J. M.; Zon, L. I. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 372:794-798; 1994.
52. Shi, C.-S.; Kehrl, J. H. Activation of stress-activated protein kinase/c-Jun N-terminal kinase, but not NF-κB, by the tumor necrosis factor (TNF) receptor 1 through a TNF receptor-associated factor 2- and germinal center kinase related-dependent pathway. J. Biol. Chem. 272:32102-32107; 1997.
53. Smith, C. A.; Farrah, T.; Goodwin, R. G. The TNF receptor superfamily of cellular and viral proteins: Ac-tivation, costimulation and death. Cell 76:959-962; 1994.
54. Song, H. Y.; Régnier, C. H.; Kirschning, C. J.; Goeddel, D. V.; Rothe, M. Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of nuclear factor-B and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2 Proc. Natl. Acad. Sci. USA 94:9792-9796; 1997.
55. Staal, F. J. T.; Roederer, M.; Herzenberg, L. A.; Herzenberg, L. A. Intracellular thiols regulate activation of nuclear factor κB and transcription of human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 87:9943-9947; 1990.
56. Stanger, B. Z.; Leder, P.; Lee, T.-H.; Kim, E.; Seed, B. RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81:513-523; 1995.
57. Su, Y.-C.; Han, J.; Xu, S.; Cobb, M.; Skolnik, E. Y. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. EMBO J. 16:1279-1290; 1997.
58. Su, Y.-C.; Treisman, J. E.; Skolnik, E. Y. The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway. Genes Dev. 12:2371-2380; 1998.
59. Takekawa, M.; Posas, F.; Saito, H. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. EMBO J. 16:4973-4982; 1997.
60. Takekawa, M.; Saito H. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95:521-530; 1998.
61. Takeuchi, M.; Rothe, M.; Goeddel, D. V. Anatomy of TRAF2. J. Biol. Chem. 271:19935-19942; 1996.
62. 2-terminal kinase. Proc. Natl. Acad. Sci. USA 94:7337-7342; 1997.
63. Tracey, K. J.; Cerami, A. Tumor necrosis factor, other cytokines and disease. Annu. Rev. Cell Biol. 9:317-343; 1993.
64. Treisman, R. Regulation of transcription by MAP kinase cascades. Curr. Opin. Cell. Biol. 8:205-215; 1996.
65. Tung, R. M.; Blenis, J. A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase. Oncogene 14:653-659; 1997.
66. Van Aelst, L.; D'Souza-Schorey, C. Rho GTPases and signaling networks. Genes Dev. 11:2295-2322; 1997.
67. Vandenabeele, P.; Declercq, W.; Beyaert, R.; Fiers, W. Two tumour necrosis factor receptors: Structure and function. Trends Cell Biol. 5:392-399; 1995.
68. Wallach, D. Cell death induction by TNF: A matter of self control. Trends Biochem. Sci. 22:107-109; 1997.
69. Whitmarsh, A. J.; Shore, P.; Sharrocks, A. D.; Davis, R. J. Integration of MAP kinase signal transduction pathways at the serum response element. Science 269:403-407; 1995.
70. Xu, S.; Robbins, D. J.; Christerson, L. B.; English, J. M.; Vanderbilt, C.; Cobb, M. H. Cloning of Rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proc. Natl. Acad. Sci. USA 93:5291-5295; 1996.
71. Yamaguchi, K.; Shirakabi, K.; Shibuya, H.; Irie, K.; Oishi, I.; Ueno, N.; Taniguchi, T.; Nishida, E.; Matsumoto, K. Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science 270:2008-2011; 1995.
72. Van, M.; Dai, T.; Deak, J. C.; Kyriakis, J. M.; Zon, L. I.; Woodgett, J. R.; Templeton, D. J. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 372:798-800; 1994.
73. Yang, X.; Khosravi-Far, R.; Chang, H. Y.; Baltimore, D. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89:1067-1076; 1997.
74. Yeh, W.-C.; Shahinian, A.; Speiser, D.; Kraunus, J.; Billia, F.; Wakeham, A.; de la Pompa, J. L.; Ferrick, D.; Hum, B.; Iscove, N.; Ohashi, P.; Rothe. M.; Goeddel, D. V.; Mak, T. W. Early lethality, functional NF-κB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity 7:715-725; 1997.
75. Yuan, J. Transducing signals of life and death. Curr. Opin. Cell Biol. 9:247-251; 1997.
76. 2-terminal kinase (JNK) and p38. J. Biol. Chem. 273:22681-22692; 1998.