Gene expression after cerebral ischemia

Neuroscientist

Volumn 5, Issue 4, 1999, Pages 238-253

  Savitz, Sean I ^a   Rosenbaum, Daniel M ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Antioxidants; Apoptosis; Cytokines; Glutamate; Heat shock proteins; Immediate early genes

Indexed keywords

AMPA RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; GLUTAMATE RECEPTOR; HEAT SHOCK PROTEIN; INTERLEUKIN 6; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; BRAIN ISCHEMIA; CELL PROTECTION; CELL SURVIVAL; GENE EXPRESSION REGULATION; HUMAN; NERVE DEGENERATION; PROTEIN EXPRESSION; REVIEW;

EID: 0032765891     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/107385849900500413     Document Type: Review

References (137)

1. Neumann-Haefelin T, Wiessner C, Vogel P, Back T, Hossmann KA. Differential expression of the immediate early genes c-fos, c-jun, jun B and NGFI-B in the rat brain following transient forebrain ischemia. J Cereb Blood Flow Metab 1994;14:206-16.
2. An G, Lin T-N, Liu J-S, Xue J-J, He Y-Y, Hsu CY. Expression of c-fos and c-jun family genes after focal cerebral ischemia. Ann Neurol 1993;33:457-64.
3. Dragunow M, Beilharz E, Sirimanne E, Lawlor P, Williams C, Bravo R et al. Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain. Brain Res Mol Brain Res 1994;25:19-33.
4. Kiessling M, Stumm G, Xie Y, Herdegen T, Aguzzi A, Bravo R, et al. Differential transcription and translation of immediate early genes in the gerbil hippocampus after transient global ischemia. J Cereb Blood Flow Metab 1993;13:914-24.
5. Uemura Y, Kowall NW, Moskowitz MA. Focal ischemia in rats causes time-dependent expression of c-fos protein immunoreactivity in widespread regions of ipsilateral cortex. Brain Res 1991; 552:99-105.
6. Collaco-Moraes Y, Aspey BS, de Belleroche JS, Harrison MJ. Focal ischemia causes an extensive induction of immediate early genes that are sensitive to MK-801. Stroke 1994;25:1855-60.
7. Honkaniemi J, Sharp FR. Global ischemia induces immediate early genes encoding zinc finger transcription factors. J Cereb Blood Flow Metab 1996;16:557-65.
8. An G, Lin T-N, Liu J-S, Hsu CY. Induction of Knox-20 expression after focal cerebral ischemia. Biochem Biophys Res Commun 1992;188:1104-10.
9. Honkaniemi J, States BA, Weinstein PR, Espinoza J, Sharp FR. Expression of zinc finger immediate early genes in rat brain after permanent middle cerebral artery occlusion. J Cereb Blood Flow Metab 1997;17:636-46.
10. Xia Z, Dudek H, Miranti CK, Greenberg ME. Calcium influx via the NMDA receptor induces immediate early gene transcription by a MPA kinase/ERK-dependent mechanism. J Neurosci 1996;16:5425-36.
11. Sheng M, Greenberg ME. The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 1990;4:477-85.
12. Sarafian T, Bredesen D. Invited commentary: is apoptosis mediated by reactive oxygen species? Free Rad Res Commun 1994; 2:1-8.
13. Dragunow M, Young D, Hughes P, MacGibbon G, Lawlor P, Singleton K, et al. Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury? Brain Res Mol Brain Res 1993;18:347-52.
14. Estus S, Zaks WJ, Freeman RS, Gruda M, Bravo R, Johnson EM Jr. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J Cell Bio 1994;127:1717-27.
15. Ham J, Babij C, Whitfield J, Pfarr CM, Lallemand D, Yaniv M, et al. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 1995;14:927-39.
16. Chen S-C, Soares HD, Morgan JI. Novel molecular correlates of neuronal death and regeneration. Adv Neurol 1996;71:433-49.
17. Nowak TS Jr. Localization of 70 kDa stress protein mRNA induction in gerbil brain after ischemia. J Cereb Blood Flow Metab 1991;11:432-9.
18. Abe H, Nowak Jr TS. The stress response and its role in cellular defense mechanisms after ischemia. Advances in Neurology 1996;71:451-67.
19. Kawagoe J, Abe K, Aoki M, Kogure K. Induction of HSP 90 alpha heat shock mRNA after transient global ischemia in gerbil hippocampus. Brain Res 1993;621:121-5.
20. Abe K, Kawagoe J, Aoki M, Kogure K. Changes of mitochondrial DNA and heat shock protein gene expression in gerbil hippocampus after transient forebrain ischaemia. J Cereb Blood Flow Metab 1993;13:773-80.
21. Gonzalez MF, Shiraishi K, Hisanaga K, Sagar SM, Mandabach M, Sharp FR. Heat shock proteins as marks of neural injury. Brain Res Mol Brain Res 1989;6:93-100.
22. Suzuki H, Abe K, Tojo S, Morooka S, Kimura K, Mizugaki M, et al. Expressions of P-selectin- and HSP72-like immunoreactivities in rat brain after transient middle cerebral artery occlusion. Brain Res 1997;759:321-9.
23. Wagstaff MJ, Collaco-Moraes Y, Aspey BS, Coffin RS, Harrison MJ, Latchman DS, et al. Focal cerebral ischaemia increases the levels of several classes of heat shock proteins and their corresponding mRNAs. Brain Res Mol Brain Res 1996;42:236-44.
24. Sei Y, Vitkovic L, Yokoyama MM. Cytokines in the central nervous system: regulatory roles in neuronal function, cell death and repair. Neuroimmunomodulation 1995;2:121-33.
25. Price BD, Calderwood SK. Ca is essential for multistep activation of the heat shock factor in permeabilized cells. Mol Cell Biol 1991;11:3365-8.
26. Benjamin IJ, Kroger B, Williams RS. Activation of the heat shock transcription factor by hypoxia in mammalian cells. Proc Nat Acad Sci U S A 1990;87:6263-7.
27. Aoki M, Abe K, Kawagoe J, Nakamura S, Kogure K. Acceleration of HSP70 and HSC70 heat shock gene expression following transient ischemia in the preconditioned gerbil hippocampus. J Cereb Blood Flow Metab 1993;13:781-8.
28. Chen J, Graham SH, Zhu RL, Simon RP. Stress proteins and tolerance to focal cerebral ischemia. J Cereb Blood Flow Metab 1996;16:566-77.
29. Ohtsuki T, Ruetzler CA, Tasaki K, Hallenbeck JM. Interleukin-1 mediates induction of tolerance to global ischemia in gerbil hippocampal CA1 neurons. J Cereb Blood Flow Metab 1996;16: 1137-12.
30. Kato H, Kogure K, Araki T, Liu XH, Kato K, Itoyama Y. Immunohistochemical localization of superoxide dismutase in the rat hippocampus following ischemia in a gerbil model of ischemic tolerance. J Cereb Blood Flow Metab 1995;15:60-70.
31. Takeda A, Onodera H, Sugimoto A, Itoyama A, Kogure K, Shibahara S. Increased expression of heme oxygenase mRNA in rat brain following transient forebrain ischemia. Brain Res 1994; 666:120-4.
32. Nimura T, Weinstein PR, Massa SM, Panter S, Sharp FR. Heme oxygenase-1 (HO-1) protein induction in rat brain following focal ischemia. Brain Res Mol Brain Res 1996;37:201-8.
33. Kato H, Liu Y, Araki T, Kogure K. MK-801, but not aniomycin, inhibits the induction to ischemia in the gerbil hippocampus. Neurosci Lett 1992;139:118-21.
34. Yenari MA, Fink SL, Sun GH, Chang LK, Patel MK, Kunis DM, et al. Gene transfer using hsp72 protein in a model of transient focal cerebral ischemia. Neurology 1997;48:A410.
35. Morikawa E, Mori H, Kiyama Y, Mishina M, Asano T, Kirino T. Attenuation of focal ischemic brain injury in mice deficient in the ε1 (NR2A) subunit of NMDA receptor. J Neurosci 1998; 18:9727-32.
36. Buchan AM, Li H, Cho SH, Pulsinelli WA. Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats. Neurosci Lett 1991;132:255-8.
37. Ying H, Weishaupt J, Grabb M, Canzoniero LMT, Sensi SL, Sheline CT, et al. Sublethal oxygen-glucose deprivation alters hippocampal neuronal AMPA receptor expression and vulnerability to kainate-induced death. J Neurosci 1997;17:9536-44.
38. Gorter J, Petrozzino J, Aronica EM, Rosenbaum DM, Opitz T, Bennett MVL, et al. Global ischemia induces downregulation of Glur2 mRNA and increases AMPA receptor-mediated Ca influx in hippocampal CA1 neurons of gerbil. J Neurosci 1997;17: 6179-88.
39. Aronica EM, Gorter JA, Grooms S, Kessler JA, Bennett MV, Zukin RS, et al. Aurintricarboxylic acid prevents Glur2 mRNA down-regulation and delayed neurodegeneration in hippocampal CA1 neurons of gerbil after global ischemia. Proc Nat Acad Sci U S A 1998;95):7115-20.
40. Zhang L, Hsu JC, Takagi N, Gurd JW, Wallace MC, Eubanks JH. Transient global ischemia alters NMDA receptor expression in rat hippocampus: correlation with decreased immunoreactive protein levels of the NR2A/NR2B subunits, and an altered NMDA receptor functionality. J Neurochem 1997;69:1983-94.
41. Koh J-Y, Suh SW, Gwag BJ, He YY, Hsu CY, Choi DW. The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 1996;272:1013-6.
42. Sensi SL, Canzoniero LMT, Yu SP, Ying HS, Koh JY, Kerchner GA, et al. Measurement of intracellular free zinc in living cortical neurons: routes of entry. J Neurosci 1997;17:9554-64.
43. Tsuda M, Imaizumi K, Katayama T, Kitagawa K, Wanaka A, Tohyama M, et al. Expression of zinc transporter gene, ZnT-1, is induced after transient forebrain ischemia in the gerbil. J Neurosci 1997;17:6678-84.
44. Clark W. Cytokines and reperfusion injury. Neurology 1997; 49(Suppl 4):S10-S14.
45. Feuerstein GZ, Wang X, Barone FC. Inflammatory gene expression in cerebral ischemia and trauma. Ann NY Acad Sci 1997; 825:179-93.
46. Wang XK, Yue T-L, Barone F, White RF, Gagnon RC, Feuerstein GZ. Concomitant cortical expression of TNF-a and IL-1β mRNA following transient focal ischemia. Mol Chem Neuropathol 1994;23:103-14.
47. Liu T, Clark RK, McDonnell PC, Young PR, White RF, Barone FC, et al. Tumor necrosis factor-alpha expression in ischemic neurons. Stroke 1994;25:1481-8.
48. Yabuuchi K, Minami M, Katsumata S, Yamzaki A, Satoh M. An in situ hybridization study of interleukin-1β mRNA induced by transient forebrain ischemia in the rat. Brain Res Mol Brain Res 1994;26:135-42.
49. Minami M, Kuraishi Y, Yabuuchi K, Yamazaki A, Satoh M. Induction of interleukin-1β mRNA in rat brain after transient forebrain ischemia. J Neurochem 1992;58:390-2.
50. Liu T, McDonnell PC, Young PR, White RF, Siren AL, Hallenbeck JM, et al. Interleukin-1β mRNA expression in ischemic rat cortex. Stroke 1993;24:1746-51.
51. Wang X, Yue T-L, Young PR, Barone FC, Feuerstein GZ. Expression of interleukin-6, c-fos, and zif268 MRNA in rat ischemic cortex. J Cereb Blood Flow Metab 1995;15:166-71.
52. Clark W, Lauten J, Coull B, Cherry N, Woodard W. ICAM-1 and IL-6 changes in the hippocampus following transient forebrain ischemia in the rat. Proc Soc Neurosci 1993;19:1664.
53. Goodman Y, Mattson MP. Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid β-peptide toxicity. J Neurochem 1996;66:869-72.
54. Bruce AJ, Boling W, Kindy MS, Peschon J, Kraemer PJ, Carpenter MK, et al. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 1996;2:788-94.
55. Matsuda S, Wen T-C, Monita F, Otsuka H, Iguse K, Yoshimura H, et al. Interleukin-6 prevents ischemia-induced learning disability and neuronal and synaptic loss in gerbils. Neurosci Lett 1996;204:109-12.
56. Loddick SA, Turnbull AV, Rothwell NJ. Cerebral interleukin-6 is neurprotective during permanent focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 1998;18:176-9.
57. Barone FC, Arvin B, White RF, Miller A, Webb CL, Willette RN, et al. Tumor necrosis factor-alpha: a mediator of focal ischemic brain injury. Stroke 1997;28:1233-44.
58. Lindvall O, Kokaia Z, Bengzon J, Elmér E, Kokaia M. Expression of neurotrophin mRNAs in the postischemic phase. Adv Neurol 1996;71:405-11.
59. Takeda A, Onodera H, Sugimoto A, Kogure K, Obinata M, Shibahara S. Coordinated expression of messenger RNAs for nerve growth factor, brain-derived neurotrophic factor and neurotrophin 3 in the rat hippocampus following transient forebrain ischemia. Neuroscience 1993;55:23-31.
60. Takeda A, Onodera H, Yamasaki Y, Furukawa K, Kogure K, Obinata M, et al. Decreased expression of neurotrophin-3 mRNA in the rat hippocampus following transient forebrain ischemia. Brain Res 1992;569:177-80.
61. Kokaia Z, Zhao Q, Kokaia M, Elmer E, Metsis M, Smith ML, et al. Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage. Exp Neurol 1995;136:73-88.
62. Endoh M, Pulsinelli WA, Wagner JA. Transient global ischemia induces dynamic changes in the expression of bFGF and the FGF receptor. Brain Res Mol Brain Res 1994;22:76-88.
63. Lippoldt A, Andbjer B, Rosen L, Richter E, Ganten D, Cao Y, et al. Photochemically induced focal cerebral ischemia in rat: time dependent and global increase in expression of basic fibroblast growth factor mRNA. Brain Res 1993;625:45-56.
64. Lee WH, Wang GM, Seaman LB, Vannucci SJ. Coordinate IFG-1 and IGFBP5 gene expression in perinatal rat brain after hypoxia-ischemia. J Cereb Blood Flow Metab 1996;16:227-3.
65. Krupinski J, Kumar P, Kumar S, Kaluza J. Increased expression of TGF-β1 in brain tissue after ischemic stroke in humans. Stroke 1996;27:852-7.
66. Cheng N, Mattson MP. NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults. Brain Res 1994;640:56-67.
67. Collazo D, Takahashi H, McKay RDG. Cellular targets and trophic functions of neurotrophin-3 in the developing rat hippocampus. Neuron 1992;9:643-56.
68. Finklestein SP. The potential use of neurotrophic growth factors in the treatment of cerebral ischemia. Adv Neurol 1996;71:413-6.
69. Kawamata T, Speliotes EK, Finklestein SP. The role of polypeptide growth factors in recovery from stroke. Adv Neurol 1997;73:377-82.
70. Okada Y, Copeland B, Mon E, Tung MM, Thomas WS, del Zoppo GJ. P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion. Stroke 1994; 25:202-11.
71. Wang X, Feuerstein G. Induced expression of adhesion molecules following focal ischemia. J Neurotrauma 1995;12:825-32.
72. Connolly ES Jr, Winfree CJ, Prestigiacomo CJ, Kim SC, Choudhri TF, Hoh BL, et al. Exacerbation of cerebral injury in mice that express the P-selectin gene: identification of P-selectin blockage as a new target for the treatment of stroke. Circ Res 1997;81:304-10.
73. Schroeter M, Jander S, Witte O, Stoll G. Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion. J Neuroimmunol 1994;55:195-203.
74. Lindsberg PJ, Carpen O, Paetau A, Karjalainen-Lindsberg ML, Kaste M. Endothelial ICAM-1 expression associated with inflammatory cell response in human ischemic stroke. Circulation 1996; 94:939-45.
75. Connolly ES Jr, Winfree CJ, Springer TA, Naka Y, Liao H, Yan SD, et al. Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke. J Clin Invest 1996;97:209-16.
76. Bowes MP, Zivin JA, Rothlein R. Monoclonal antibody to the ICAM-1 adhesion site reduces neurological damage in a rabbit cerebral embolism stroke model. Experimental Neurology 1993; 119:215-9.
77. Sherman DG and the Enlimomab acute stroke trial investigators. Enlimomab acute stroke trial: final results. Neurology 1997;48: A270.
78. Zhang ZG, Chopp M, Zaloga C, Pollack JS, Forstermann U. Cerebral endothelial nitric oxide synthase expression after focal cerebral ischemia in rats. Stroke 1993;24:2016-21.
79. Huang Z, Huang PL, Ma J, Meng W, Ayata C, Fishman MC, et al. Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine. J Cereb Blood Flow Metab 1996;16:981-7.
80. Zhang ZG, Chopp M, Gautam S, Zaloga C, Zhang RL, Schmidt HH, et al. Upregulation of neuronal nitric oxide synthase and mRNA, and selective sparing of nitric oxide synthase-containing neurons after focal cerebral ischemia in rat. Brain Res 1994;654: 85-95.
81. Panahian N, Yoshida T, Huang PK, Hedley-Whyte ET, Dalkara T, Fishman MC, et al. Attenuated hippocampal damage after global cerebral ischemia in mice mutant in neuronal nitric oxide synthase. Neuroscience 1996;72:343-54.
82. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 1994;265:1883-5.
83. Eliasson MJ, Sampei K, Mandir AS, Hum PD, Traystman RJ, Bao J, et al. Poly (ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med 1997;3:1089-95.
84. Iadecola C, Zhang F, Xu S, Casey R, Ross ME. Inducible nitric oxide synthase gene expression in brain following cerebral ischemia. J Cereb Blood Flow Metab 1995;15:378-84.
85. Samdani AF, Dawson TM, Dawson VL. Nitric oxide synthase in models of focal ischemia. Stroke 1997;28:1283-8.
86. Iadecola C, Zhang F, Casey R, Nagayama M, Ross ME. Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J Neurosci 1997;17:9157-64.
87. Matsuyama T, Michishita H, Nakamura H, Tsuchiyama M, Shimizu S, Watanabe K, et al. Induction of copper-zinc superoxide dismutase in gerbil hippocampus after ischemia. J Cereb Blood Flow Metab 1993;13:135-44.
88. Kondo T, Reaume AG, Huang T-T, Carlson E, Murakami K, Chen SF, et al. Reduction of CuZn-superoxide dismutase activity exacerbates neuronal injury and edema formation after transient focal cerebral ischemia. J Neurosci 1997;17:4180-9.
89. Kinouchi H, Epstein CJ Mizui T, Carlson E, Chen SF, Chan PH. Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase. Proc Nat Acad Sci U S A 1991;88:11158-62.
90. Murakami K, Kondo T, Epstein CJ, Chan PK. Overexpression of CuZn-superoxide dismutase reduces hippocampal injury after global ischemia in transgenic mice. Stroke 1996;28:1797-804.
91. Mikawa S, Li Y, Huang T-T, Carlson E, Chen S, Kondo T, et al. Cerebral infarction is exacerbated in mitochondrial manganese superoxide dismutase (Sod-2) knockout mice after focal cerebral ischemia and reperfusion. Soc Neurosci Abstr 1995;21: 1268.
92. Keller JN, Kindy MS, Holtsberg FW, St Clair DK, Yen HC, Germeyer A, et al. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J Neurosci 1998;18:687-97.
93. Patel M, Day BJ, Crapo JD, Fridovich I, McNamara JO. Requirement for superoxide in excitotoxic cell death: Neuron 1996; 16:345-55.
94. Mattson MP, Lovell MA, Furukawa K, Markesbery WR. Neurotrophic factors attentuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons. J Neurochem 1995;65:1740-51.
95. Grilli M, Pizzi M, Memo M, Spano P. Neuroprotection by aspirin and sodium salicylate through blockade of NF-κB activation. Science 1996;274:1383-5.
96. Qin Z-H, Wang Y, Nakai M, Chase TN. Nuclear factor-κB contributes to excitotoxin-induced apoptosis in rat striatum. Mol Pharm 1998;53:33-42.
97. Mattson MP, Goodman Y, Luo H, Fu W, Furukawa K. Activation of NF-κB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of Mn-SOD and suppression of peroxynitrite production and protein tyrosine nitration. J Neurosci Res 1997;49:681-97.
98. Bredesen DE. Neural apoptosis. Ann Neurol 1995;38:839-51.
99. Linnik MD, Zobrist RH, Hatfield MD. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 1993;24:2002-9.
100. Gwag BJ, Lobner D, Koh JY, Wie MB, Choi DW. Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro. Neuroscience 1995;68:615-9.
101. MacManus J and Linnik M. Gene expression induced by cerebral ischemia: an apoptotic perspective. J Cereb Blood Flow Metab 1997;17:815-32.
102. Vaux D, Cory S, Adams J. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B-cells. Nature 1988;335:440-2.
103. Deckwerth TL, Elliott JL, Knudson CM, Johnson EM Jr, Snider WD, Korsmeyer SJ. Bax is required for neuronal death after trophic factor deprivation and during development. Neuron 1996; 17:401-11.
104. Shindler KS, Latham CB, Roth KA. bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice. J Neurosci 1997;17:3112-9.
105. Parsadanian AS, Cheng Y, Keller-Peck CR, Holtzman DM, Snider WD. Bcl-x-L is an antiapoptotic regulator for postnatal CNS neurons. J Neurosci 1998;18:1009-19.
106. Chen J, Graham SH, Nakayama M, Zhu RL, Jin K, Stetler RA, et al. Apoptosis repressor genes Bcl-2 and Bcl-x-long are expressed in the rat brain following global ischemia. J Cereb Blood Flow Metab 1997;17:2-10.
107. Chen J, Graham SH, Chan PH, Lan J, Zhou RL, Simon RP. Bcl-2 is expressed in neurons that survive focal ischemia in the rat. Neuroreport 1995;6:394-8.
108. Krajewski S, Mai JK, Krajewska M, Sikorska M, Mossakowski MJ, Reed JC. Upregulation of bax protein levels in neurons following cerebral ischemia. J Neurosci 1995;15:6364-76.
109. Matsushita K, Matsuyama T, Kitagawa K, Matsumoto M, Yanagihara T, Sugita M. Alterations of bcl-2 family proteins precede cytoskeletal proteolysis in the penumbra, but not in infarct centers following focal cerebral ischemia in mice. Neuroscience 1998;83:439-48.
110. Xiang H, Kinoshita Y, Knudson CM, Korsmeyer SJ, Schwartzkroin, Morrison R. Bax involvement in p53-mediated neuronal cell death. J Neurosci 1998;18:1363-73.
111. Martinou J, Dubois-Dauphin M, Staple JK, Rodriguez I, Frankowski H, Missotten M, et al. Overexpression of bcl-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 1994;13:1017-30.
112. Linnik MD, Zahos PZ, Geschwind MD, Federoff HJ. Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. Stroke 1995;26:1670-5.
113. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, et al. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 1993;262:1274-7.
114. Jacobson MD, Raff MC. Programmed cell death and Bcl-2 protection in very low oxygen. Nature 1995;374:814-6.
115. Reed JC. Double identity for proteins of the Bcl-2 family. Nature 1997;387:773-6.
116. Rossé T, Olivier R, Monney L, Rager M, Conus S, Fellay I, et al. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature 1998;391:496-9.
117. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997;275:1129-32.
118. Del Peso L, Gonzales-Garcia M, Page C, Herrera R, Nunez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 1997;278:687-90.
119. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, et al. Akt phosphorylation of bad couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231-41.
120. Asahi M, Hoshimaru M, Uemura Y, Tokime T, Kojima M, Ohtsuka T, et al. Expression of interleukin-1 beta converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery. J Cereb Blood Flow Metab 1997;17:11-8.
121. Schielke GP, Yang G-Y, Shivers BD, Betz AL. Reduced ischemic brain injury in interleukin-1β converting enzyme-deficient mice. J Cereb Blood Flow Metab 1998;18:180-5.
122. Kinoshita M, Tomimoto H, Kinoshita A, Kumar S, Noda M. Up-regulation of the Nedd2 gene encoding an ICE/Ced-3 like cysteine protease in the gerbil brain after transient global ischemia J Cereb Blood Flow Metab 1997;17:507-14.
123. Ni B, Wu X, Su Y, Stephenson D, Smalstig EB, Clemens J, et al. Transient global forebrain ischemia induces a prolonged expression of the caspase-3 mRNA in rat hippocampus CA1 pyramidal neurons. J Cereb Blood Flow Metab 1998;248-56.
124. Bhat RV, DiRocco R, Marcy VR, Flood OG, Zhu Y, Dobrzanski P, et al. Increased expression of IL-1β converting enzyme in hippocampus after ischemia: selective localization in microglia. J Neurosci 1996;16:4146-54.
125. Chopp M, Li Y, Zhang ZG, Freytag SO. p53 expression in brain after middle cerebral artery occlusion in the rat. Biochem Biophys Res Commun 1992;182:1201-7.
126. Crumrine RC, Thomas AL, Morgan PF. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice. J Cereb Blood Flow Metab 1994;14:887-91.
127. Xiang H, Hochman DW, Saya H, Fujiwara T, Schwartzkroin PA, Morrison RS. Evidence for p53-mediated modulation of neuronal viability. J Neurosci 1996;16:6753-65.
128. Morrison RS, Wenzel HJ, Kinoshita Y, Robbins CA, Donehower LA, Schwartzkroin PA. Loss of p53 tumor suppressor gene protects neurons from kainate-induced cell death. J Neurosci 1996; 16:1337-15.
129. Matsuyama T, Hata R, Tagaya M, Yamamoto Y, Nakajima T, Furuyama J, et al. Fas antigen mRNA induction in postischemic murine brain. Brain Res 1994;657:342-6.
130. Rosenbaum DM, D'Amore JZ, Gomes WA, Kassler JA. Mice deficient in fas expression are resistant to focal ischemic damage. J Cereb Blood Flow Metab 1997;17(suppl):484.
131. Roy N, Mahadevan MS, McLean M, Shutler G, Yaraghi Z, Farahani R, et al. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell 1995;80:167-78.
132. Xu DG, Crocker SJ, Doucet J-P, St-Jean M, Tamai K, Hakim AM, et al. Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus. Nat Med 1997;3:997-1004.
133. Finkbeiner S, Greenberg ME. Spatial features of calcium-regulated gene expression. BioEssays 1997;19:657-60.
134. Kamii H, Kinouchi H, Sharp FR, Epstein CJ, Sagar SM, Chan PK. Expression of c-fos mRNA after a mild focal cerebral ischemia in SOD-1 transgenic mice. Brain Res 1994;662:240-4.
135. Kondo T, Murakami K, Honkaniemi J, Sharp FR, Epstein CJ, Chan PK. Expression of hsp70 mRNA is induced in the brain of transgenic mice overexpressing human CuZn-superoxide dismutase following transient global cerebeal ischemia. Brain Res 1996;737:321-6.
136. Bonetti B, Raine C. Multiple sclerosis: oligodendrocytes display cell death-related molecules in situ but do not undergo apoptosis. Ann Neurol 1997;42:74-84.
137. Kessler JA, Ludlam WH, Freidin MM, Hall OH, Michaelson MD, Spray DC, et al. Cytokine-induced programmed death of cultured sympathetic neurons. Neuron 1993;11:1123-32.